LOCUS       NM_001191775            2792 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus MET transcriptional regulator MACC1 (Macc1),
            mRNA.
ACCESSION   NM_001191775 XM_234727
VERSION     NM_001191775.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2792)
  AUTHORS   Bahr,I., Jaeschke,L., Nimptsch,K., Janke,J., Herrmann,P.,
            Kobelt,D., Kielstein,H., Pischon,T. and Stein,U.
  TITLE     Obesity, colorectal cancer and MACC1 expression: A possible novel
            molecular association
  JOURNAL   Int J Oncol 60 (2) (2022)
   PUBMED   35014688
  REMARK    GeneRIF: Obesity, colorectal cancer and MACC1 expression: A
            possible novel molecular association.
REFERENCE   2  (bases 1 to 2792)
  AUTHORS   Xia,J., Wang,H., Huang,H., Sun,L., Dong,S., Huang,N., Shi,M.,
            Bin,J., Liao,Y. and Liao,W.
  TITLE     Elevated Orai1 and STIM1 expressions upregulate MACC1 expression to
            promote tumor cell proliferation, metabolism, migration, and
            invasion in human gastric cancer
  JOURNAL   Cancer Lett 381 (1), 31-40 (2016)
   PUBMED   27431311
REFERENCE   3  (bases 1 to 2792)
  AUTHORS   Stein,U., Walther,W., Arlt,F., Schwabe,H., Smith,J., Fichtner,I.,
            Birchmeier,W. and Schlag,P.M.
  TITLE     MACC1, a newly identified key regulator of HGF-MET signaling,
            predicts colon cancer metastasis
  JOURNAL   Nat Med 15 (1), 59-67 (2009)
   PUBMED   19098908
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            [WARNING] On Oct 17, 2024 this sequence was replaced by
            NM_001191775.2.
            
            On Jul 17, 2010 this sequence version replaced XM_234727.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.29212.1,
                                           SRR26643294.27001.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN09345330, SAMN13663595
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               JAXUCZ010000006.1  146554712-146554826
            116-2151            JAXUCZ010000006.1  146556535-146558570
            2152-2340           JAXUCZ010000006.1  146561237-146561425
            2341-2792           JAXUCZ010000006.1  146572788-146573239
FEATURES             Location/Qualifiers
     source          1..2792
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q33"
     gene            1..2792
                     /gene="Macc1"
                     /gene_synonym="7a5; RGD1309838"
                     /note="MET transcriptional regulator MACC1"
                     /db_xref="GeneID:314539"
                     /db_xref="RGD:1309838"
     CDS             1..2553
                     /gene="Macc1"
                     /gene_synonym="7a5; RGD1309838"
                     /note="putative binding protein 7a5; metastasis associated
                     in colon cancer 1; MACC1, MET transcriptional regulator"
                     /codon_start=1
                     /product="metastasis-associated in colon cancer protein 1"
                     /protein_id="NP_001178704.1"
                     /db_xref="GeneID:314539"
                     /db_xref="RGD:1309838"
                     /translation="MLISERAYYWPQGIGRSRSEGNLIDMEASKLSKHHNITAWQGRG
                     LPYNWPDASTLHGDRDAKATNPFWSELSASNPFLEDITQLRNNKKKDNMSILKEDPFL
                     FLRQIEIGNSFDSSGDELDVDQGLRSSSSRTSGRSKSVSELLDALGGTTHTHHSIQSS
                     DQILVQDLEWLQNDREAYKMAWLSQRQLARSCLDLNTINQSPGWAQTQTAETIAVCTL
                     NHQGGSVQLPDSDITVHVPQGHVAIGEFQEVSLRAFLDPPPKLNHDLSCTISPLLEIR
                     LSNLNTMEAILLEMKTGTEVKTDPLSQVMTKIVCLHSLDREGPFQELNNCYVYKDTIQ
                     AKLLDLSHVMYIVIAAQATIIQPPAATIWDYLHKTTSIGIYGPKHLHPSFTAVFTVCG
                     HNYVPGKFTVSDIRKGGKNTSPVVFHLWGKHSFSLDKPQDLIISAFSCDPDVKEEGER
                     KVIAQGQLEAGAVVHQQVFFSSVGHREMHLFVFRVQVKAPSGKPVTQFFVTSPDPAPN
                     LKSFSYLPDIFQKKREDRRASLLSSGLVKYPTFQNKNLNFTSYGVTLKTVLRQSKIDY
                     LLEYLKGDTIALLGEGTVRAIGQSKVKEWYVGVLRGKIGLVHCKNVKVISKEQVMSMS
                     DGILTTKNLLEQIALPFKNLTYVYSVVLTLVSEKVDDWQVLANVLGYSNLAQEDFDRI
                     QADKEPERVSYIVKKLKEDCHEDKNTRKFLYELIVALLKMDCQGLVARLIQEAVILTS
                     AVKLGRGWRELAEKSAGLTKHQMQAYENPHRGKSGEVSAETMWKPAYDFLYAWSYHYG
                     NSYRDVLQDLQSALDRMKNPVTKRWRDLTGILILVNSLEILRVTAFSTSQEI"
     exon            1..115
                     /gene="Macc1"
                     /gene_synonym="7a5; RGD1309838"
                     /inference="alignment:Splign:2.1.0"
     exon            116..2151
                     /gene="Macc1"
                     /gene_synonym="7a5; RGD1309838"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2340
                     /gene="Macc1"
                     /gene_synonym="7a5; RGD1309838"
                     /inference="alignment:Splign:2.1.0"
     exon            2341..2792
                     /gene="Macc1"
                     /gene_synonym="7a5; RGD1309838"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgctaatca gtgaaagagc ctattattgg ccacaaggaa ttggtcgaag tagatctgaa
       61 gggaatttga ttgacatgga agcctcgaaa ctctcaaaac atcacaatat tacagcgtgg
      121 caagggcgag gcttgcctta caactggcca gatgcttcta ctctccatgg tgatagagat
      181 gccaaagcta caaatccatt ctggagtgaa ctgtctgcct caaacccatt tctggaggac
      241 atcacgcagc taagaaataa caaaaagaaa gataacatgt ctatattgaa ggaagatcct
      301 ttcctttttt taagacaaat agaaatagga aattcttttg attcctctgg tgatgaacta
      361 gatgtggatc aggggcttag gtcatcttcc tcaaggacgt caggaaggtc taagagtgtt
      421 tcagagctcc tggatgcctt aggtggtaca acacacactc accacagtat acaaagctct
      481 gatcagatcc tagtacaaga cttagaatgg cttcaaaacg accgggaggc atataaaatg
      541 gcttggctaa gtcaacgtca gctggctcgc tcttgcttag atctgaatac aattaatcag
      601 agtcctgggt gggctcaaac acaaactgca gagaccattg cagtttgtac attaaatcac
      661 caaggagggt cagttcagtt acctgactca gacatcactg ttcatgtacc tcaaggacac
      721 gtagctatcg gagaattcca ggaggtatct ctgagagcat tcctggatcc tccaccaaag
      781 ctgaaccatg atctctcctg tactataagc cctctcttgg aaatcaggtt aagcaacctg
      841 aataccatgg aagctatttt gttggagatg aaaactggaa cagaagtgaa aacagatcct
      901 ctgagccaag tcatgacaaa aatagtgtgt ttacacagcc tggacagaga aggccctttc
      961 caagagctaa acaactgcta tgtctacaaa gataccatcc aagctaagct tcttgatctg
     1021 agccacgtaa tgtatatagt catagctgca caagctacga tcattcagcc accagctgct
     1081 actatttggg attatctcca caaaaccacc tccattggaa tttatggacc aaaacatctc
     1141 catccaagct ttactgctgt tttcactgtt tgtggacaca actatgtgcc aggaaagttt
     1201 acagtctccg acattaggaa gggtggaaaa aacacatctc cagtcgtatt tcacctctgg
     1261 gggaagcatt cgttttcact tgacaagcca caagatttaa ttatttcagc tttttcatgt
     1321 gatcctgacg taaaggaaga gggagaaaga aaagtaattg ctcaagggca attggaagca
     1381 ggtgcggtag tccatcaaca agttttcttt tcttcagttg gccacagaga gatgcacttg
     1441 tttgttttcc gggttcaggt aaaggccccc agcggaaaac cagtcacaca gttctttgtc
     1501 acttcacctg atccagcccc aaatctaaaa agtttctcat atctgccaga cattttccag
     1561 aagaagagag aagataggag agcgtcttta ttgtcatcag gacttgttaa gtatcccaca
     1621 ttccaaaata aaaacttgaa ctttaccagt tatggggtca cactgaagac agtactgagg
     1681 caaagtaaga ttgactattt acttgagtat ttaaaggggg acacaattgc cctccttggc
     1741 gaaggtacgg taagggccat cggacagtcc aaagtgaaag aatggtacgt aggagtcctc
     1801 cgaggtaaga tcggacttgt gcattgcaaa aatgtcaagg tgatttccaa agaacaagtg
     1861 atgtctatgt ctgatggcat tttgacaacc aagaatcttc tggaacaaat tgccttgcca
     1921 tttaaaaatc tgacttacgt atactccgtt gtattgactt tggtgtcaga aaaagttgat
     1981 gactggcaag ttttagctaa tgtcctgggt tactcaaatc tggcacagga agattttgat
     2041 agaattcaag ctgacaagga accagaaagg gtttcttaca ttgtcaagaa gttaaaggaa
     2101 gattgccatg aagataaaaa taccaggaag tttctttatg aactgattgt ggctctgcta
     2161 aaaatggact gccaaggatt agtggcacgt cttatccaag aggctgttat tttgacgtca
     2221 gctgtaaagc ttggaagagg ctggagggaa cttgctgaga agtctgcagg actcactaag
     2281 catcagatgc aggcatatga aaatcctcac agaggaaaat ctggagaagt ttcagcagag
     2341 acaatgtgga aacctgccta tgattttctc tatgcgtgga gttatcacta tggaaatagc
     2401 tacagagatg tgttacaaga ccttcaatca gctttggaca gaatgaaaaa ccctgtcact
     2461 aaacggtgga gagatttaac tggaatctta atacttgtaa attctttaga gattttgaga
     2521 gtaactgctt tctctacttc tcaggaaata tagaatgaag caaatttggg gagaaagaat
     2581 ggtaaaggga aaagggtgtg tatgtgtgtg tgtgtgtgtg tgtgtgtgtg tatccgcaca
     2641 taacaaagaa ggagaatgaa ctcatagaga tgtcttacat ttggaaaact aagtgcagaa
     2701 atcaaatgtg gaagactacc cacgagtcta gtgtaaagta ggttttctgc cttaaaaagc
     2761 tggttctaat ttttgaaaaa ccataccaca aa
//
