LOCUS       NM_181089               4796 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus microtubule associated serine/threonine kinase 1
            (MAST1), mRNA.
ACCESSION   NM_181089
VERSION     NM_181089.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4796)
  AUTHORS   Girard,E., Eon-Marchais,S., Olaso,R., Renault,A.L., Damiola,F.,
            Dondon,M.G., Barjhoux,L., Goidin,D., Meyer,V., Le Gal,D.,
            Beauvallet,J., Mebirouk,N., Lonjou,C., Coignard,J., Marcou,M.,
            Cavaciuti,E., Baulard,C., Bihoreau,M.T., Cohen-Haguenauer,O.,
            Leroux,D., Penet,C., Fert-Ferrer,S., Colas,C., Frebourg,T.,
            Eisinger,F., Adenis,C., Fajac,A., Gladieff,L., Tinat,J.,
            Floquet,A., Chiesa,J., Giraud,S., Mortemousque,I., Soubrier,F.,
            Audebert-Bellanger,S., Limacher,J.M., Lasset,C.,
            Lejeune-Dumoulin,S., Dreyfus,H., Bignon,Y.J., Longy,M., Pujol,P.,
            Venat-Bouvet,L., Bonadona,V., Berthet,P., Luporsi,E., Maugard,C.M.,
            Nogues,C., Delnatte,C., Fricker,J.P., Gesta,P., Faivre,L.,
            Lortholary,A., Buecher,B., Caron,O., Gauthier-Villars,M.,
            Coupier,I., Servant,N., Boland,A., Mazoyer,S., Deleuze,J.F.,
            Stoppa-Lyonnet,D., Andrieu,N. and Lesueur,F.
  TITLE     Familial breast cancer and DNA repair genes: Insights into known
            and novel susceptibility genes from the GENESIS study, and
            implications for multigene panel testing
  JOURNAL   Int J Cancer 144 (8), 1962-1974 (2019)
   PUBMED   30303537
REFERENCE   2  (bases 1 to 4796)
  AUTHORS   Tripathy,R., Leca,I., van Dijk,T., Weiss,J., van Bon,B.W.,
            Sergaki,M.C., Gstrein,T., Breuss,M., Tian,G., Bahi-Buisson,N.,
            Paciorkowski,A.R., Pagnamenta,A.T., Wenninger-Weinzierl,A.,
            Martinez-Reza,M.F., Landler,L., Lise,S., Taylor,J.C., Terrone,G.,
            Vitiello,G., Del Giudice,E., Brunetti-Pierri,N., D'Amico,A.,
            Reymond,A., Voisin,N., Bernstein,J.A., Farrelly,E., Kini,U.,
            Leonard,T.A., Valence,S., Burglen,L., Armstrong,L., Hiatt,S.M.,
            Cooper,G.M., Aldinger,K.A., Dobyns,W.B., Mirzaa,G., Pierson,T.M.,
            Baas,F., Chelly,J., Cowan,N.J. and Keays,D.A.
  TITLE     Mutations in MAST1 Cause Mega-Corpus-Callosum Syndrome with
            Cerebellar Hypoplasia and Cortical Malformations
  JOURNAL   Neuron 100 (6), 1354-1368 (2018)
   PUBMED   30449657
REFERENCE   3  (bases 1 to 4796)
  AUTHORS   Garland,P., Quraishe,S., French,P. and O'Connor,V.
  TITLE     Expression of the MAST family of serine/threonine kinases
  JOURNAL   Brain Res 1195, 12-19 (2008)
   PUBMED   18206861
  REMARK    GeneRIF: MAST1 expression patterns are evident in the hippocampus,
            cerebellum, 3rd ventricle and cerebral cortex of rats.
REFERENCE   4  (bases 1 to 4796)
  AUTHORS   Yano,R., Yap,C.C., Yamazaki,Y., Muto,Y., Kishida,H., Okada,D. and
            Hashikawa,T.
  TITLE     Sast124, a novel splice variant of syntrophin-associated
            serine/threonine kinase (SAST), is specifically localized in the
            restricted brain regions
  JOURNAL   Neuroscience 117 (2), 373-381 (2003)
   PUBMED   12614677
  REMARK    GeneRIF: Syntrophin-associated serine/threonine kinase-124
            (Sast124) is selectively localized in the nuclei of brain neurons
            and is distinct from syntrophin-associated serine/threonine
            kinase-170, which interacts with syntrophin on the cell surface.
REFERENCE   5  (bases 1 to 4796)
  AUTHORS   Lumeng,C., Phelps,S., Crawford,G.E., Walden,P.D., Barald,K. and
            Chamberlain,J.S.
  TITLE     Interactions between beta 2-syntrophin and a family of
            microtubule-associated serine/threonine kinases
  JOURNAL   Nat Neurosci 2 (7), 611-617 (1999)
   PUBMED   10404183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Dec 7, 2020 this sequence version replaced NM_181089.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY227207.1, SRR26643298.75714.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                JAXUCZ010000019.1  40121271-40121353
            84-172              JAXUCZ010000019.1  40122784-40122872
            173-248             JAXUCZ010000019.1  40123384-40123459
            249-327             JAXUCZ010000019.1  40128042-40128120
            328-488             JAXUCZ010000019.1  40129652-40129812
            489-564             JAXUCZ010000019.1  40130011-40130086
            565-774             JAXUCZ010000019.1  40130246-40130455
            775-876             JAXUCZ010000019.1  40133405-40133506
            877-1009            JAXUCZ010000019.1  40133589-40133721
            1010-1077           JAXUCZ010000019.1  40133788-40133855
            1078-1163           JAXUCZ010000019.1  40136732-40136817
            1164-1372           JAXUCZ010000019.1  40136906-40137114
            1373-1511           JAXUCZ010000019.1  40139162-40139300
            1512-1644           JAXUCZ010000019.1  40139413-40139545
            1645-1810           JAXUCZ010000019.1  40139682-40139847
            1811-1912           JAXUCZ010000019.1  40139930-40140031
            1913-2035           JAXUCZ010000019.1  40140174-40140296
            2036-2145           JAXUCZ010000019.1  40141874-40141983
            2146-2324           JAXUCZ010000019.1  40142415-40142593
            2325-2572           JAXUCZ010000019.1  40142670-40142917
            2573-2779           JAXUCZ010000019.1  40143830-40144036
            2780-3009           JAXUCZ010000019.1  40144219-40144448
            3010-3132           JAXUCZ010000019.1  40144647-40144769
            3133-3269           JAXUCZ010000019.1  40144851-40144987
            3270-3457           JAXUCZ010000019.1  40147469-40147656
            3458-4796           JAXUCZ010000019.1  40147735-40149073
FEATURES             Location/Qualifiers
     source          1..4796
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q11"
     gene            1..4796
                     /gene="MAST1"
                     /gene_synonym="Sast"
                     /note="microtubule associated serine/threonine kinase 1"
                     /db_xref="GeneID:353118"
                     /db_xref="RGD:631372"
     exon            1..83
                     /gene="MAST1"
                     /gene_synonym="Sast"
                     /inference="alignment:Splign:2.1.0"
     exon            84..172
                     /gene="MAST1"
                     /gene_synonym="Sast"
                     /inference="alignment:Splign:2.1.0"
     exon            173..248
                     /gene="MAST1"
                     /gene_synonym="Sast"
                     /inference="alignment:Splign:2.1.0"
     exon            249..327
                     /gene="MAST1"
                     /gene_synonym="Sast"
                     /inference="alignment:Splign:2.1.0"
     exon            328..488
                     /gene="MAST1"
                     /gene_synonym="Sast"
                     /inference="alignment:Splign:2.1.0"
     exon            489..564
                     /gene="MAST1"
                     /gene_synonym="Sast"
                     /inference="alignment:Splign:2.1.0"
     exon            565..774
                     /gene="MAST1"
                     /gene_synonym="Sast"
                     /inference="alignment:Splign:2.1.0"
     exon            775..876
                     /gene="MAST1"
                     /gene_synonym="Sast"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1009
                     /gene="MAST1"
                     /gene_synonym="Sast"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1077
                     /gene="MAST1"
                     /gene_synonym="Sast"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1163
                     /gene="MAST1"
                     /gene_synonym="Sast"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1372
                     /gene="MAST1"
                     /gene_synonym="Sast"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1511
                     /gene="MAST1"
                     /gene_synonym="Sast"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1644
                     /gene="MAST1"
                     /gene_synonym="Sast"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1810
                     /gene="MAST1"
                     /gene_synonym="Sast"
                     /inference="alignment:Splign:2.1.0"
     exon            1811..1912
                     /gene="MAST1"
                     /gene_synonym="Sast"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..2035
                     /gene="MAST1"
                     /gene_synonym="Sast"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..2145
                     /gene="MAST1"
                     /gene_synonym="Sast"
                     /inference="alignment:Splign:2.1.0"
     exon            2146..2324
                     /gene="MAST1"
                     /gene_synonym="Sast"
                     /inference="alignment:Splign:2.1.0"
     exon            2325..2572
                     /gene="MAST1"
                     /gene_synonym="Sast"
                     /inference="alignment:Splign:2.1.0"
     exon            2573..2779
                     /gene="MAST1"
                     /gene_synonym="Sast"
                     /inference="alignment:Splign:2.1.0"
     exon            2780..3009
                     /gene="MAST1"
                     /gene_synonym="Sast"
                     /inference="alignment:Splign:2.1.0"
     exon            3010..3132
                     /gene="MAST1"
                     /gene_synonym="Sast"
                     /inference="alignment:Splign:2.1.0"
     exon            3133..3269
                     /gene="MAST1"
                     /gene_synonym="Sast"
                     /inference="alignment:Splign:2.1.0"
     exon            3270..3457
                     /gene="MAST1"
                     /gene_synonym="Sast"
                     /inference="alignment:Splign:2.1.0"
     exon            3458..4796
                     /gene="MAST1"
                     /gene_synonym="Sast"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtctgact ctctctggac cgcgctttcc aatttctcga tgccctcctt ccccggcggc
       61 agcatgtttc gccgcaccaa gagctgccgt accagtaacc ggaaaagcct catcctgaca
      121 agcacttctc cgacgctacc gcgaccccac tccccgctgc cgggtcactt aggtagcagt
      181 cccctggaca gcccccgcaa cttctctccc aacacccctg cccatttctc gtttgcttct
      241 tcccgaaggg cggatggacg ccggtggtcc cttgcttccc ttccttcctc tggatatggc
      301 accaacaccc caagctcaac cgtctcatcc tcctgctcct cccaggagcg cctgcatcaa
      361 ctaccctacc agcccaccgt ggacgagttg cactttctgt ccaaacactt cggcagcacc
      421 gagagcatca ccgacgaaga tggtggccgc cgctcccccg ccgtgcgtcc tcgctctcgg
      481 agcctcagcc ccggacgctc cccctcctcc tacgacaacg aaatcgtgat gatgaaccat
      541 gtgtacaagg agcggttccc gaaggccacc gcgcagatgg aagagaagct gcgggacttc
      601 gcccgcgcct acgaacctga cagcgtgctg ccgctggccg acggcgtgct cagcttcatc
      661 caccaccaga tcattgaact ggcccgagac tgccttacca agtcccgcga tgggctcatc
      721 accacggtct atttctatga actgcaggaa aacctagaaa agctgctgca ggacgcctac
      781 gaacgctcgg agagcctgga ggtggccttc gtcactcagc tggtgaagaa actgctcatc
      841 atcatctctc gccctgcaag gcttctggag tgcctggaat tcaacccaga agaattctac
      901 cacctgctgg aggcagcgga aggccacgcc aaggagggcc acctggtcaa aactgacatc
      961 ccccgataca tcatccggca gctgggcctc actcgggacc cctttccaga tgtggtgcgc
     1021 ctggaggagc aggacagcgg gggctccaac acgcctgaac aagatgacac gtctgagggt
     1081 cgcagcagca cctccaaggc caagaaacct ccgggtgaaa gtgactttga cactatcaag
     1141 ctcataagca atggtgccta cggggctgtc tacctggtgc ggcaccggga cacacggcag
     1201 cgctttgcca tgaagaagat caacaaacag aacttgatcc ttcgcaacca gatccagcag
     1261 gcgttcgtgg agcgtgacat cctcacgttt gccgagaacc cgtttgtggt cggcatgttc
     1321 tgctcctttg agacccggcg ccatctttgc atggtcatgg agtatgtgga aggtggtgac
     1381 tgtgccactc tcctgaagaa cattggggca ctgcctgtgg agatggctcg aatgtatttt
     1441 gcagaaacgg ttctagctct tgaatactta cacaattatg gcattgtgca ccgtgacctc
     1501 aagccagaca acctcctcat cacttccatg ggccacatca aactcacgga ttttggcctc
     1561 tccaagatgg gactcatgag cctcaccacc aacttatatg aaggtcacat tgagaaagac
     1621 gcccgggagt tcctggacaa acaggtgtgt gggaccccgg agtacatcgc acccgaggtc
     1681 atcctgcgcc agggctacgg caagccggtg gactggtggg ctatgggcat cattctctac
     1741 gagttcctgg tgggctgtgt gcctttcttc ggggataccc cagaagagct ctttggacag
     1801 gtcatcagtg acgacatatt gtggcctgaa ggggatgagg ccctgcccac agacgcacag
     1861 cttctaatat ctagcctctt gcagaccaac cccctggtcc ggcttggggc aggcggtgct
     1921 tttgaagtaa agcagcatag cttcttccga gacctagact ggacggggct actgaggcag
     1981 aaggcagagt tcatccccca cctagagtca gaagatgaca ccagctactt tgacacccgc
     2041 tccgacaggt atcaccatgt gaactcttat gatgaggacg acaccactga ggaggagccc
     2101 gtggagatcc gccaattctc ctcctgctcg ccgcgcttca gcaaggtgta cagcagtatg
     2161 gagcagctgt ctcagcacga gcccaagact cccgtctcag catctggggc tagcaagcgg
     2221 gacccaaatg ctaagggccc ggaggagaag gtggccggaa agagggaggg actgggtggc
     2281 ctgactctgc gtgagaagac ctggagaggg ggctctccag agattaaacg cttctcagca
     2341 tctgaagcca gttttctgga gggagaggcc agtcccccgc tgggagcgcg cagacggttc
     2401 tcagcgctac tggagcccag ccgcttcact gcccctcagg aggatgaaga tgaggcccga
     2461 ctccgcagac ctcctcggcc cagctctgat ccccctagct cactggacac acgcgtcccc
     2521 aaagaagcag cacaaggaga gggcacatcc accccgggag aacccgaggc cactgagcgc
     2581 tcacatccag gtgacttctg cccaccctcc aaggatggag acccgtcagg tcctagggcc
     2641 accaatgatc tggttttgcg aagggcgagg caccagcagc tgtctgggga tctctcggtg
     2701 gagaagcgac cgtctcgaac cgggggcaaa gttatcaagt cggcgtcagc tacagccttg
     2761 tcggtcatga ttcctgcagt ggacccacac ggaggctcac ccctggctag tcccatgtcc
     2821 cctcgatctc tctcctccaa tccatcctct cgggactctt cgcctagccg agactactca
     2881 ccagctgtca gtggactccg ctcccccatc accatccaac gctccggcaa gaaatatggc
     2941 ttcacactac gagccatccg tgtctacatg ggcgactcag atgtctacag tgtccaccac
     3001 attgtttggc acgtggagga aggaggtcca gcccaagagg cagggctctg tgctggagac
     3061 ctcatcactc acgtgaacgg tgagcctgtg cacggtatgg tgcaccctga ggtggtggag
     3121 ctgattctaa agagtggcaa caaagtagct gtgaccacca caccctttga aaacacttcc
     3181 atccggattg ggccggccag gcgcagcagc tacaaagcca aaatggcccg caggaacaag
     3241 aggccttcag ctaaagatgg ccaagagagc aagaagcgga gctccctctt ccggaagatc
     3301 acaaaacagt caaacctgtt gcacactagc cgatcgctgt cctctctgaa ccggtctttg
     3361 tcgtccagcg acagtcttcc tggttcgccc acgcacggac tacccgcacg ctcgcccacg
     3421 catagctatc gctccacacc tgactccgcc tacctaggtg cctcgtcaca gagtagctct
     3481 ccagcttcca gcacacctaa ttcccccgcc tcatccgcct cgcaccacat caggcccagc
     3541 actctgcacg ggctgtcacc gaaactacac cgccagtatc gttcagcgcg ctgtaaatcg
     3601 gctggcaaca tcccgctgtc acctctggcg cacactccgt ccccgacgca ggcgtcgccg
     3661 ccgccgctgc caggccacac ggtgggcagc tcccatacca cgcagagctt ccctgccaaa
     3721 ctgcactcat cgccgcctat cgtgcgtccg cgccccaaaa gtgcagagcc accacgctcg
     3781 ccgttgctca agcgcgtgca gtcagcggaa aagctagggg cttcgctggg agcagacaag
     3841 aagggagcat tgcgcaaaca cagtctggaa gtgggtcacc ctgatttccg aaaggacttc
     3901 cacggtgagc tggcgctgca tagcctcgct gagtccgatg gtgagacgcc tcctattgag
     3961 ggtcctgggg cgacccggca ggtcgccatg agacgcctgg gccgccagga atctccccta
     4021 agcttgggcg cggacccgtt gctacccgat ggtgtccaga gacctatggc gtcaggcaag
     4081 gaggattccg cgggaggtac agaggcttgt actccacctc gcgcgactac ccctgggagc
     4141 cggaccctgg agcgtgactt gggctgcaca aggcaccaga gcgtgcagac tgaggatggc
     4201 ccaggtgggg tggccagagc cctggccaag gcagcgctaa gcccggtgca ggaacatgag
     4261 acaggccggc gcagtagctc cggtgaggca ggaacacccc cggtgcccat tgttgtagag
     4321 cctgcccggc caggggtcaa gacccagaca ccccagcctc tgggcacaga ctccaaggga
     4381 ttgaaggaac ctgtagccca gatccctctg gtgcctgatg ccccaagggt ccgggagcgc
     4441 tgggtgctag aggaggtgga agagcggacc acgttaagcg gacctcgctc taagcccgcc
     4501 tcccccaaac tctctcctga cccccagact ccaaccgtag ccccaacaaa gaatgtaccc
     4561 cgcagtgcag ctcctccagt cccacctgct tccctaatgg tcccaggtac gaagcccgaa
     4621 gcagggtcga actcccggtg tcctgctgaa ggtgtggctt cagcaggcct aaccaaaacg
     4681 ggggcaccca gtcctgcatc tttaggtcca tagcggagca ggcttccggt cctgtgctgt
     4741 acagatgcct ctgtacatat gtacacatat aaataaagtg cccgtgctgc ctgaga
//
