LOCUS       NM_001007700            2282 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus mannose-6-phosphate receptor, cation dependent
            (M6pr), mRNA.
ACCESSION   NM_001007700 XM_232335
VERSION     NM_001007700.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2282)
  AUTHORS   Follett,J., Bugarcic,A., Yang,Z., Ariotti,N., Norwood,S.J.,
            Collins,B.M., Parton,R.G. and Teasdale,R.D.
  TITLE     Parkinson Disease-linked Vps35 R524W Mutation Impairs the Endosomal
            Association of Retromer and Induces alpha-Synuclein Aggregation
  JOURNAL   J Biol Chem 291 (35), 18283-18298 (2016)
   PUBMED   27385586
REFERENCE   2  (bases 1 to 2282)
  AUTHORS   Zhou,X., Sun,L., Bastos de Oliveira,F., Qi,X., Brown,W.J.,
            Smolka,M.B., Sun,Y. and Hu,F.
  TITLE     Prosaposin facilitates sortilin-independent lysosomal trafficking
            of progranulin
  JOURNAL   J Cell Biol 210 (6), 991-1002 (2015)
   PUBMED   26370502
REFERENCE   3  (bases 1 to 2282)
  AUTHORS   Carvelli,L., Bannoud,N., Aguilera,A.C., Sartor,T., Malossi,E. and
            Sosa,M.A.
  TITLE     Testosterone influences the expression and distribution of the
            cation-dependent mannose-6-phosphate receptor in rat epididymis.
            Implications in the distribution of enzymes
  JOURNAL   Andrologia 46 (3), 224-230 (2014)
   PUBMED   23290006
  REMARK    GeneRIF: expression and distribution of CD-MPR is affected by
            decrease of testosterone in the epididymis, and this could change
            the distribution of lysosomal enzymes
REFERENCE   4  (bases 1 to 2282)
  AUTHORS   Jofre,G., Carvelli,L., Aguilera,A.C., Sartor,T., Gonzalez-Jatuff,A.
            and Sosa,M.A.
  TITLE     The distribution of mannose-6-phosphate receptors changes from
            newborns to adults in rat liver
  JOURNAL   Biochem Biophys Res Commun 410 (2), 208-211 (2011)
   PUBMED   21640079
  REMARK    GeneRIF: This evidence may also suggest that CD-MPR and CI-MPR have
            different functions, mainly at early stages in the development of
            organs.
REFERENCE   5  (bases 1 to 2282)
  AUTHORS   Carvelli,L.F., Bannoud,N., Aguilera,C.A., Morales,C.R. and
            Sosa,M.A.
  TITLE     Castration induces changes in the cation-dependent
            mannose-6-phosphate receptor in rat epididymis: possible
            implications in secretion of lysosomal enzymes
  JOURNAL   J Cell Biochem 110 (5), 1101-1110 (2010)
   PUBMED   20564206
  REMARK    GeneRIF: Data show that the CD-MPR might be regulated by hormones
            and that this receptor might be involved in the secretion of
            specific enzymes into the rat epididymis.
REFERENCE   6  (bases 1 to 2282)
  AUTHORS   Gonzalez-Noriega,A., Michalak,C. and Antonio Sosa Melgarejo,J.
  TITLE     Cation-independent mannose 6-phosphate and 78 kDa receptors for
            lysosomal enzyme targeting are located in different cell
            compartments
  JOURNAL   Biochim Biophys Acta 1745 (1), 7-19 (2005)
   PUBMED   16085051
  REMARK    GeneRIF: The distribution of the cation-independent mannose
            6-phosphate receptors was studied in postnuclear subcellular
            fractions from two rat liver cell lines.
REFERENCE   7  (bases 1 to 2282)
  AUTHORS   Wang,Y., Tai,G., Lu,L., Johannes,L., Hong,W. and Tang,B.L.
  TITLE     Trans-Golgi network syntaxin 10 functions distinctly from syntaxins
            6 and 16
  JOURNAL   Mol Membr Biol 22 (4), 313-325 (2005)
   PUBMED   16154903
  REMARK    Erratum:[Mol Membr Biol. 2005 Sep-Oct;22(5):453]
REFERENCE   8  (bases 1 to 2282)
  AUTHORS   Seaman,M.N.
  TITLE     Cargo-selective endosomal sorting for retrieval to the Golgi
            requires retromer
  JOURNAL   J Cell Biol 165 (1), 111-122 (2004)
   PUBMED   15078902
REFERENCE   9  (bases 1 to 2282)
  AUTHORS   Marchand,S., Devillers-Thiery,A., Pons,S., Changeux,J.P. and
            Cartaud,J.
  TITLE     Rapsyn escorts the nicotinic acetylcholine receptor along the
            exocytic pathway via association with lipid rafts
  JOURNAL   J Neurosci 22 (20), 8891-8901 (2002)
   PUBMED   12388596
REFERENCE   10 (bases 1 to 2282)
  AUTHORS   Ma,Z.M., Grubb,J.H. and Sly,W.S.
  TITLE     Cloning, sequencing, and functional characterization of the murine
            46-kDa mannose 6-phosphate receptor
  JOURNAL   J Biol Chem 266 (16), 10589-10595 (1991)
   PUBMED   1645352
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079226.1.
            
            On Nov 29, 2004 this sequence version replaced XM_232335.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079226.1, EV772969.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2282
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..2282
                     /gene="M6pr"
                     /note="mannose-6-phosphate receptor, cation dependent"
                     /db_xref="GeneID:312689"
                     /db_xref="RGD:1359355"
     exon            1..153
                     /gene="M6pr"
                     /inference="alignment:Splign:2.1.0"
     exon            154..333
                     /gene="M6pr"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..991
                     /gene="M6pr"
                     /note="CD-MPR; CD Man-6-P receptor; cation-dependent
                     mannose-6-phosphate receptor; cation-dependent
                     mannose-6-phosphate receptor-like"
                     /codon_start=1
                     /product="cation-dependent mannose-6-phosphate receptor
                     precursor"
                     /protein_id="NP_001007701.1"
                     /db_xref="GeneID:312689"
                     /db_xref="RGD:1359355"
                     /translation="MFPLSGCWRTELLLLLLLAVAVRESWQIEEKSCDLVGEKDKESK
                     NEVALLERLRPLFNKSFESTVGQGSDTYSYIFRVCREAGNHSSGAGLVQINKSNEKET
                     VVGRINETHIFNGSNWIMLIYKGGDEYDNHCGKEQRRAVVMISCNRHTLAGNFNPVSE
                     ERGKIQDCFYLFEMDSSLACSPEVSHLSVGSILLVIFASLVAVYIIGGFLYQRLVVGA
                     KGMEQFPHLAFWQDLGNLVADGCDFVCRSKPRSVPAAYRGVGDDQLGEESEERDDHLL
                     PM"
     exon            334..500
                     /gene="M6pr"
                     /inference="alignment:Splign:2.1.0"
     exon            501..610
                     /gene="M6pr"
                     /inference="alignment:Splign:2.1.0"
     exon            611..741
                     /gene="M6pr"
                     /inference="alignment:Splign:2.1.0"
     exon            742..868
                     /gene="M6pr"
                     /inference="alignment:Splign:2.1.0"
     exon            869..2256
                     /gene="M6pr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagcgcggcg cctaagggag cgctggcttc agagaggaat cgagggactg gggtctgtgc
       61 ccccgcaccc ccgttctccg gccgcgtctc ccaaccccac agacacattc ttgggggttt
      121 ctgagcttcg gttgctctgt tttcctgtga cacgatgttc cctctctctg gctgttggag
      181 gactgaactg ttactgttgc tactcctggc tgtggctgtg agagaatcct ggcagataga
      241 agaaaaatcg tgtgacctgg taggagaaaa ggataaggag tcaaagaatg aggtggctct
      301 cctggagagg ttacggccac tgtttaacaa aagttttgag agtactgtgg gccagggctc
      361 agacacttac agctatatat tcagagtatg ccgggaagct ggcaaccact cctctggcgc
      421 aggcctggtc cagatcaaca aaagtaatga gaaggaaacg gtggttggga gaatcaacga
      481 gactcacatc ttcaatggaa gtaactggat catgttgata tataaagggg gtgacgaata
      541 tgacaaccac tgtggcaaag aacagcgccg tgcagtggtg atgatctcct gcaatcgaca
      601 cacactcgcg ggtaatttta acccagtgtc tgaggaacgc ggcaaaatcc aggattgctt
      661 ctacctcttt gagatggata gcagcctagc ctgttcacca gaggtctcac acctcagtgt
      721 gggctccatc ctccttgtca tatttgcatc attggttgct gtttacatca ttgggggttt
      781 cttataccag cgactggtag tgggggccaa ggggatggag cagtttcctc atctggcctt
      841 ctggcaggat cttggcaacc tagtagctga tggttgtgac tttgtgtgcc gttccaaacc
      901 ccgcagtgtg cctgcggcct atcgtggcgt cggggatgac cagctggggg aagagtcaga
      961 agaaagggat gaccatttgc taccaatgtg attgcacttt tcatgtccag ccacctcttc
     1021 agtccccaaa ccaaagcatc ctcagcagac ttctcgagca gtctccccct ctcacctcgc
     1081 cattaatatt cttgctttcc agttggcttt gatttgacac taacctgcct ccctttgctc
     1141 ctattgtttt tcctctgcac tagtacagtg gaaggcagac agacataggg cctgtgctgt
     1201 ggggaggcag actcctatac cccaggaaga gaaaggacag ctaactaggc agaaagaaag
     1261 ccatgagccc tggctgtaaa catttccata aattgagaca ctgggttctt tgctcgtacc
     1321 tttggttgcc tccctcatgt tgtccctgtc cccgcagtag tcccaggatc tgagtgtaac
     1381 tcgcaggtgc tctgcaggac ttcttacctg gctgtcaccc aaatactccc gtttgctttg
     1441 agcctgcaat tagtcacatg attgtccctt gtgtgggatt aggacaggga aaaaaatgtg
     1501 aactttccca acttgaggat tctaaggcgc catcacgttg cttataggtc tttgagtggc
     1561 ttgatagttt gaattgggcc ctaggctgcg gttataaatc cataggtaac ccaaatgcct
     1621 aaccaagtag tcctttctaa ttacacagac tgtgtcacct tgtggtagtc tcgctagcca
     1681 gccttattct tcctcctctc cctactggta cttgcaaacc tgagttgtac ttttctcaca
     1741 ggtctgtagt ttggcttttt atactttccc caatcttaaa ggaagggaat ggaagcagaa
     1801 gtggacgtgg aggctctgca ggtctctgct atggtgggga cactgctgca cctgtccctc
     1861 ctgctggctc agggaagtgt ctgacccact tatctatgga aaaggtcttt aatcctctat
     1921 ttctttgtgt ttaagccatg tgcccagaat cccaggctgg tctttctaaa atagtgaatt
     1981 cctaggccac taggtaacaa cacagttcat ctgaacacag gcgatgtgga aaaggcaggg
     2041 ccatttgttc cctttagaga aaatgaatga cgttattcct acttcccaat acccttgcaa
     2101 tggcaatgga aattttgttt tctttctata caggaaaaat aatgttattt ttaaaaaggc
     2161 ttctcatttg ttgtttgcat tctaacccct gtggttttaa aggaaaaata atataccact
     2221 tttgtacaaa accaataatt aaaaacataa aaaacaaaaa aaaaaaaaaa aaaaaaaaaa
     2281 aa
//
