LOCUS       NM_172022               4206 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus leucine zipper tumor suppressor family member 3
            (Lzts3), mRNA.
ACCESSION   NM_172022 XM_006235011
VERSION     NM_172022.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4206)
  AUTHORS   Reim,D., Weis,T.M., Halbedl,S., Delling,J.P., Grabrucker,A.M.,
            Boeckers,T.M. and Schmeisser,M.J.
  TITLE     The Shank3 Interaction Partner ProSAPiP1 Regulates Postsynaptic
            SPAR Levels and the Maturation of Dendritic Spines in Hippocampal
            Neurons
  JOURNAL   Front Synaptic Neurosci 8, 13 (2016)
   PUBMED   27252646
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4206)
  AUTHORS   Dolnik,A., Kanwal,N., Mackert,S., Halbedl,S., Proepper,C.,
            Bockmann,J., Schoen,M., Boeckers,T.M., Kuhl,S.J. and
            Schmeisser,M.J.
  TITLE     Sipa1l3/SPAR3 is targeted to postsynaptic specializations and
            interacts with the Fezzin ProSAPiP1/Lzts3
  JOURNAL   J Neurochem 136 (1), 28-35 (2016)
   PUBMED   26364583
  REMARK    GeneRIF: Postsynaptic proteins, including ProSAPiP1/Lzts3,
            interacts with Sipa1L/SPAR3 in brain and is localized to excitatory
            postsynapses.
REFERENCE   3  (bases 1 to 4206)
  AUTHORS   Redecker,P., Bockmann,J. and Bockers,T.M.
  TITLE     Secretory granules of hypophyseal and pancreatic endocrine cells
            contain proteins of the neuronal postsynaptic density
  JOURNAL   Cell Tissue Res 328 (1), 49-55 (2007)
   PUBMED   17120053
  REMARK    GeneRIF: ProSAP/Shank and certain ProSAP/Shank-interacting proteins
            exhibit distinct subcellular localizations in the different cell
            types, raising the possibility that the function of ProSAP/Shank
            proteins is more diverse than has been envisaged to date.
REFERENCE   4  (bases 1 to 4206)
  AUTHORS   Wendholt,D., Spilker,C., Schmitt,A., Dolnik,A., Smalla,K.H.,
            Proepper,C., Bockmann,J., Sobue,K., Gundelfinger,E.D., Kreutz,M.R.
            and Boeckers,T.M.
  TITLE     ProSAP-interacting protein 1 (ProSAPiP1), a novel protein of the
            postsynaptic density that links the spine-associated Rap-Gap (SPAR)
            to the scaffolding protein ProSAP2/Shank3
  JOURNAL   J Biol Chem 281 (19), 13805-13816 (2006)
   PUBMED   16522626
  REMARK    GeneRIF: A novel binding partner for the PDZ domain of SPAR and
            Shank3 proteins, ProSAPiP1, is reported and characterized.
REFERENCE   5  (bases 1 to 4206)
  AUTHORS   Bouwmeester,T., Bauch,A., Ruffner,H., Angrand,P.O., Bergamini,G.,
            Croughton,K., Cruciat,C., Eberhard,D., Gagneur,J., Ghidelli,S.,
            Hopf,C., Huhse,B., Mangano,R., Michon,A.M., Schirle,M., Schlegl,J.,
            Schwab,M., Stein,M.A., Bauer,A., Casari,G., Drewes,G., Gavin,A.C.,
            Jackson,D.B., Joberty,G., Neubauer,G., Rick,J., Kuster,B. and
            Superti-Furga,G.
  TITLE     A physical and functional map of the human TNF-alpha/NF-kappa B
            signal transduction pathway
  JOURNAL   Nat Cell Biol 6 (2), 97-105 (2004)
   PUBMED   14743216
  REMARK    Erratum:[Nat Cell Biol. 2004 May;6(5):465]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On or before Dec 7, 2020 this sequence version replaced
            XM_006235011.3, NM_172022.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2544082.1,
                                           SRR22582424.625833.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840107,
                                           SAMN12840109 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-124               JAXUCZ010000003.1  138313488-138313611 c
            125-287             JAXUCZ010000003.1  138308507-138308669 c
            288-770             JAXUCZ010000003.1  138307430-138307912 c
            771-1628            JAXUCZ010000003.1  138306248-138307105 c
            1629-4206           JAXUCZ010000003.1  138303378-138305955 c
FEATURES             Location/Qualifiers
     source          1..4206
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..4206
                     /gene="Lzts3"
                     /gene_synonym="Prosapip1"
                     /note="leucine zipper tumor suppressor family member 3"
                     /db_xref="GeneID:280670"
                     /db_xref="RGD:631327"
     exon            1..124
                     /gene="Lzts3"
                     /gene_synonym="Prosapip1"
                     /inference="alignment:Splign:2.1.0"
     exon            125..287
                     /gene="Lzts3"
                     /gene_synonym="Prosapip1"
                     /inference="alignment:Splign:2.1.0"
     CDS             216..2327
                     /gene="Lzts3"
                     /gene_synonym="Prosapip1"
                     /note="proSAP-interacting protein 1; leucine zipper,
                     putative tumor suppressor family member 3"
                     /codon_start=1
                     /product="leucine zipper putative tumor suppressor 3"
                     /protein_id="NP_742019.3"
                     /db_xref="GeneID:280670"
                     /db_xref="RGD:631327"
                     /translation="MAPADLASEGPKLEDPPAPHLFGKCPSGLIMAKLETLPVRADPG
                     RDPLLAFAPRPAELGPPDPRLTMGSVGGGVTHAQEFPMKSVGTRTGGGGSQGSFPGPR
                     SSGSGTNRERPGPGRYPSEDKVLANSLYLNGELRGSDHTDVCGNVVGSSGGSSSSGGS
                     DKAPPQYREPNHPPKLLTTSGKLDQCSEPLVRPSAFKPVVPKNFHSMQNLCPPQTNGT
                     PEGRQGPAGLKGGLEKSRTMTPAGGSGGGGLSDSGRNSLTSLPTYSSSYSQHLAPLSA
                     STSHINRIGTPGYSSGGGGGGSGYQDLGTSDSGRASSKSGSSSSMGRSGHLGSGEGGN
                     GGLPFAACSPPSPSALIQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWER
                     ELAELRQGCSGKLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAAQLIRQREELEDK
                     VAACQKEQADFLPRMEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLR
                     EGRASLREKEEQLLSLRDSFGSKQASLELSEGELPPACLKPALTPVDLVEPQEALASC
                     ESDEAKMRRQAGVAAAASLVSVDGEVDAGGEGGTRALRREVGRLQAELAAERRARERQ
                     GASFAEERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGAAGGSSTPTPQ
                     HGEEKKAWTPSRLERIESTEI"
     exon            288..770
                     /gene="Lzts3"
                     /gene_synonym="Prosapip1"
                     /inference="alignment:Splign:2.1.0"
     exon            771..1628
                     /gene="Lzts3"
                     /gene_synonym="Prosapip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..4206
                     /gene="Lzts3"
                     /gene_synonym="Prosapip1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggaggggcc aagagcagag ccgggccgcg ctgcgcgccc tgtggggcgg gcttcgggct
       61 gcgccagaga gcgggacagc tagcgccggt gtctgagctt ctgcgccgga ctctgaggca
      121 gtgaagaaga aaactgtagt tcgggatggc ttggtcggct agtccaaggt cgcacagctg
      181 gttctggccg agcccggact tcgagagaga gccatatggc ccctgcagac ctggcctcgg
      241 agggtcccaa gcttgaggac ccgccggccc cccacctctt tggaaagtgc ccttctggct
      301 taatcatggc gaagctggag acattacctg tgcgcgctga cccagggagg gatcctctcc
      361 tggcctttgc tccccggcct gctgagcttg gacccccaga tccccgcctg actatgggca
      421 gtgtgggtgg tggggtgacc catgctcagg agtttcctat gaaaagcgtg ggcactcgaa
      481 cagggggtgg gggcagccag ggcagtttcc ctggtccaag aagcagtggt agtgggacca
      541 acagggagag acctggccct ggccgctacc catcagagga caaggttctc gccaactctc
      601 tctacctcaa tggcgagctg cgaggcagtg accacacaga tgtctgtggt aatgtggtgg
      661 gcagcagtgg gggcagcagc agcagtgggg gcagcgacaa ggctcccccc cagtatcgtg
      721 aacccaatca cccacccaag ctcctgacca cctctggcaa gctagaccag tgctcagagc
      781 cactagttcg gccatcagcc ttcaagcctg ttgtacccaa gaacttccat tccatgcaga
      841 acctgtgtcc tccacagacc aatgggaccc ctgaaggacg acagggccct gcaggcctca
      901 aaggcggact ggagaagtct cggaccatga ctccagctgg tgggagtggg ggcggcggcc
      961 tctcagactc aggccggaac tcactcacaa gcttgcccac ctatagctcc agctatagcc
     1021 agcatctggc acccctcagt gcttccacca gccatatcaa ccgcattggc actccgggct
     1081 atagtagtgg cggcggcggt ggggggtcag gctaccagga cctggggacc tctgacagtg
     1141 ggcgggcttc cagtaagagc gggtcgtcat catccatggg gcggtcaggc cacctgggat
     1201 ctggggaggg cggaaatgga ggcctgccat ttgcagcctg ttcaccaccc tcgcccagtg
     1261 cgctgatcca ggagctggag gaacggctgt gggagaagga gcaggaggtg gcagctctgc
     1321 ggcgcagcct agaacagagc gaggcagcag tggcccaggt gttggaggag cggcagaagg
     1381 catgggagcg ggagctagcc gagctccggc agggctgcag tggaaagctg cagcaggtgg
     1441 cccgccgtgc ccagcgtgcc cagcagggcc tacagctgca ggtgctgcgg ttacagcagg
     1501 acaagaaaca gctgcaggag gaggcagccc agctgataag gcagcgggaa gagctagagg
     1561 acaaggtggc cgcctgccag aaggagcagg ccgacttcct gccccggatg gaggaaacta
     1621 agtgggaggt gtgccagaag gccggtgaga tttccctcct gaagcaacaa ctgaaggact
     1681 cacaggctga tgtgtcgcag aagttgagtg agatcgtggg actgcgctca cagctccggg
     1741 agggtagggc ctcgctccgg gagaaggagg aacagctgct cagcttgagg gactccttcg
     1801 gcagcaaaca ggccagcctg gagctgagtg aaggcgagct gccccctgcc tgcctcaagc
     1861 ctgcactgac ccctgtggac ctggttgagc cacaggaggc actggcctcc tgtgagagtg
     1921 acgaggccaa gatgcgccgg caggctgggg tggcggctgc tgcttccctg gtttctgttg
     1981 atggggaggt agatgctggg ggagagggtg ggacacgggc cctacgcagg gaggtgggga
     2041 gactgcaggc tgagctggct gctgagcgac gtgcccgtga gcgccagggt gccagctttg
     2101 cagaggagcg ccgggtgtgg ttggaggaga aggagaaggt cattgagtac cagaagcagc
     2161 tccagctgag ttacgtggag atgtaccagc gcaaccagca gctggagcgg cgacttcggg
     2221 agcgtggggc agcagggggt tccagcacgc ctactcccca gcatggagag gagaagaaag
     2281 cctggacccc ctcccgcctg gagcgcatcg agtccacaga aatctgatta tctgcgtgca
     2341 caaccttctg acaagtgccc tgtctgaagg tcggagtcac caatgtcccc ttccattcat
     2401 ctcccttccc acgtgtgctg cacatcccca gaccaaagag gttctcgaag cagctgtgac
     2461 cagccccctt gtcccccagt ccatgcagct ccagcactgc ctttgtgggt aaccactcca
     2521 gaccctcctg ccaaggagag catgggggag ggcagagtgc aatggggtga ggtcccaggc
     2581 acagggagca tgctcccttt tggggaaagc ctcttggaga tggaggcagc aggcttgtat
     2641 tgccagggag cacccctttc ccttattggg ctgctgccgc cgccgccgca accttgtgtc
     2701 cagtgctact gtctgtgcct ccttctaggc cacacagcct gaggaagcct gcgtaggtct
     2761 accagtgttg acagacccta ggctcctggt ctctctcctt cgtgtgctgc tctccttccc
     2821 caggcagatt ggcaggggaa gcgggagcag atggcctgcc tgtggttgag agggctacct
     2881 gcccaacccc tcccccacca aggtatcttg ggctcaagcc tcagagcctg gactagtcct
     2941 gagcatgtgt ccctctgtgt ttattgaggg aggtgagagc tgaggctgga agctcagtgc
     3001 ccaggggaga tctgccttcc tatccttggg aagggtcacc tagaggcttc tcagccccac
     3061 cctcaccctc tggccaggat cctacaaggc tacacatccc ctgctgcttg gttgaccccc
     3121 ccaaacccag ggtcgctgct cagctctgat tatagctata cctgcctctt agctattctg
     3181 tttgccccat ttctgaggtc agatggatgt ctgatgtctt cctgtgtttc cctgccatct
     3241 ctctcctccg cctcctttca cgcttacatt ttcccaggct gccttttctt ccaagtctca
     3301 ccttttctcc cagcagaaag ctctgcttga tttttggtgc actgctcact cccagctcca
     3361 ctggcccaag tctgagcttg gggcccttgt tctgaggggc cagtcagttg gataggactg
     3421 cccttgaaga acaaggctaa cgtgtgagga ctactgaccc ttgggttgct cgccagactc
     3481 ctgagttggc tcatttgtcc cagcagggtt ggctggtatg gtcatcagtg tgggtcgtga
     3541 ccgtcagtgt cacttccttc tctaggatct ctcagattct atctccccaa gaaaggcagg
     3601 gaaattctaa tttctctttt aagaaagtaa atttccaatt caccagcaat aacaatcaga
     3661 ggagacttgg ccctcagccc tcgtatttct ctttttcact ctctcttcca ccccaagata
     3721 gaatcctggg gtcaggattg agagggtggg taactactgt gagcaagtcc cccccccccc
     3781 caagccctga ccagcctcct cccatgactg gtgactgttt aacaaactgt gcacaccccc
     3841 acaaaaatag gagtgtccta tttgtagcct ccaactctct gcacagctcc ttctgggtgg
     3901 tcctcaacag gtttatgacc ttgattggag gctactctgg caaccactgc ccatccctct
     3961 aatccctcac tatacctgat ccagacccta agcctggtcc acaggggctg ggaaaaggca
     4021 ttaatacaaa acaaaagaga tgggggggag agaaaaatat gaacagcttt ggaatgtcca
     4081 accacaaaat aaattatata taaatatata aatatatata tatatatatc taccatatgt
     4141 gatggaaaga cttttcattt ttcctttccc aaagaaataa aatggagaaa gccccttgga
     4201 tggcaa
//
