LOCUS       NM_001014247            2660 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus leucine zipper tumor suppressor 2 (Lzts2), mRNA.
ACCESSION   NM_001014247 XM_345038
VERSION     NM_001014247.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2660)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2660)
  AUTHORS   Johnson,D.T., Luong,R., Lee,S.H., Peng,Y., Shaltouki,A., Lee,J.T.,
            Lin,D., Wang,Y. and Sun,Z.
  TITLE     Deletion of leucine zipper tumor suppressor 2 (Lzts2) increases
            susceptibility to tumor development
  JOURNAL   J Biol Chem 288 (6), 3727-3738 (2013)
   PUBMED   23275340
REFERENCE   3  (bases 1 to 2660)
  AUTHORS   Peng,Y., Clark,C., Luong,R., Tu,W.H., Lee,J., Johnson,D.T., Das,A.,
            Carroll,T.J. and Sun,Z.
  TITLE     The leucine zipper putative tumor suppressor 2 protein LZTS2
            regulates kidney development
  JOURNAL   J Biol Chem 286 (46), 40331-40342 (2011)
   PUBMED   21949185
REFERENCE   4  (bases 1 to 2660)
  AUTHORS   Schmeisser,M.J., Grabrucker,A.M., Bockmann,J. and Boeckers,T.M.
  TITLE     Synaptic cross-talk between N-methyl-D-aspartate receptors and
            LAPSER1-beta-catenin at excitatory synapses
  JOURNAL   J Biol Chem 284 (42), 29146-29157 (2009)
   PUBMED   19703901
  REMARK    GeneRIF: analysis of cross-talk between N-methyl-D-aspartate
            receptors and LAPSER1-beta-catenin at excitatory synapses
REFERENCE   5  (bases 1 to 2660)
  AUTHORS   Sudo,H. and Maru,Y.
  TITLE     LAPSER1 is a putative cytokinetic tumor suppressor that shows the
            same centrosome and midbody subcellular localization pattern as p80
            katanin
  JOURNAL   FASEB J 21 (9), 2086-2100 (2007)
   PUBMED   17351128
  REMARK    GeneRIF: LAPSER1 localizes to the centrosomes & midbodies in
            mitotic cells. LAPSER1 participates in cytokinesis by interacting
            with p80 katanin, the disruption of which may potentially cause
            genetic instability and cancer.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC083580.1, DQ176638.2 and DN932851.1.
            
            On Oct 16, 2009 this sequence version replaced NM_001014247.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY928801.1, DQ176638.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               BC083580.1         50-193
            145-439             DQ176638.2         103-397
            440-1387            BC083580.1         437-1384
            1388-2061           DN932851.1         64-737
            2062-2660           BC083580.1         1868-2466
FEATURES             Location/Qualifiers
     source          1..2660
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..2660
                     /gene="Lzts2"
                     /gene_synonym="Lapser1"
                     /note="leucine zipper tumor suppressor 2"
                     /db_xref="GeneID:365468"
                     /db_xref="RGD:1359249"
     exon            1..450
                     /gene="Lzts2"
                     /gene_synonym="Lapser1"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..2055
                     /gene="Lzts2"
                     /gene_synonym="Lapser1"
                     /note="protein LAPSER1"
                     /codon_start=1
                     /product="leucine zipper putative tumor suppressor 2"
                     /protein_id="NP_001014269.2"
                     /db_xref="GeneID:365468"
                     /db_xref="RGD:1359249"
                     /translation="MAIVHTLPVPLEPARETATAPQTPAMGSVSSLISGRPCPGGPAP
                     QRHHGVPGPTFFRQQDGLLRGGYEAQEPLCPAVPPRKTVPGNSFTYVNEDFRTESPPS
                     PSSDVEDPREHQAHNAHLRGPPPKLIPVSGRLEKNMEKILIRPTAFKPVLPKPRGAPS
                     LPGFLGPRAAGLSGSQGSLTQLFGGPASSSSSSSSSSATDKPLALSGWASGCPSGTLS
                     DSGRNSLSSLPTYSTGGAEPTANSPGGHLPSHGPGRGPLPGPARGVPTGPSHSDSGRS
                     SSSKSTGSLGARVAGGLLGSGARASPGSSSGGDRSPPPPPPPPPSDEALLHCVLEGKL
                     RDREAELQQLRDSVDESEAAVCQAFGARQRRWPGEREDCASHAQQATQRVQRAQQLLQ
                     LQVFQLQQEKRQLQDDFAQLLQEREQLERRCATFEREQQELGPRLEETKWEVCQKSGE
                     ISLLKQQLKESQAELVQKGSELVALRVALREARAALRVSEGRARGLQEAARARELELE
                     ACSQELQRYRQEAEQLREKARHLDAEAAGLREPPVPPATTDPFLLAESDEAKVQRAAA
                     GTGGSLRAQVERLRQELQREQRRGDEQRNSFEGERLAWQAEKEQVIRYQKQLQHNYVQ
                     MYRRNRQLEQELQQLSLELEARELADLGLSEPAPCICLEEITATEI"
     exon            451..1113
                     /gene="Lzts2"
                     /gene_synonym="Lapser1"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1371
                     /gene="Lzts2"
                     /gene_synonym="Lapser1"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..2639
                     /gene="Lzts2"
                     /gene_synonym="Lapser1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttgccctgg aggcccctgg ccaggcctga acctctgcca ccatggccat tgtgcacact
       61 ctgccagtgc cactggagcc cgcacgtgag acagccactg ccccacaaac tccagcaatg
      121 ggcagcgtga gcagtcttat ctcaggccgg ccctgtcctg ggggacctgc tcctcaacgc
      181 caccatggtg tccctgggcc taccttcttc cgccagcagg atgggctgct ccggggtggc
      241 tatgaggccc aggaaccact ctgcccagct gtgccaccca ggaagactgt cccaggcaac
      301 agctttacct atgtcaatga ggacttccgg acagagtcac ctcccagccc aagcagtgat
      361 gtcgaagatc cccgagaaca tcaggcacac aatgcccacc tccgtgggcc cccaccaaag
      421 ctcatccctg tctctggaag gctggagaag aatatggaga agatcctgat ccgaccaaca
      481 gccttcaagc cagtgctacc caaacctcga ggggcgccat ccctacctgg cttccttggt
      541 cctcgagctg ctgggctatc tgggagccag ggcagcctga cacagctgtt tggggggcca
      601 gcctcttcct cctcctcttc ctcttcctcc tctgctactg acaaaccctt ggcactcagc
      661 ggttgggcca gtggctgccc ttcaggaaca ctgtcagact ctggccgaaa ttctttatca
      721 agcttgccca cctacagcac cggaggtgcc gagccaactg ccaactcccc aggtgggcac
      781 ctgccctccc acggccctgg ccgagggcca ctgcctggtc cagcccgagg ggtccctact
      841 gggccctccc attcagacag tggccggtcc tcctccagca aaagcacagg ttccttgggg
      901 gctcgtgtag ctggggggct cttgggcagt ggggcccggg cctcccctgg cagcagttcg
      961 ggtggagacc gctccccacc ccctccacca cctccacccc cttcggatga ggccttgcta
     1021 cactgtgtcc tggaagggaa gcttcgagac cgagaggcag agctgcagca gctgcgggac
     1081 agtgtggatg agagtgaggc cgccgtgtgt caggcattcg gggcacggca gcggcgctgg
     1141 ccaggagaac gagaggactg tgcctctcac gcacagcagg ccacacagcg tgtccagcgg
     1201 gctcaacagc tgctacaact gcaagtgttc cagctgcagc aagagaagcg ccagttgcag
     1261 gatgacttcg cccagctgct gcaggagcga gagcagctgg agcgccgctg tgctactttt
     1321 gaaagggagc agcaggaact tgggccacgg ctagaggaga ccaaatggga ggtgtgtcag
     1381 aaatcaggtg agatctccct tctgaagcag caactgaagg aatctcaggc agagctggtc
     1441 cagaagggta gtgagctggt ggcgctgcgg gtggcccttc gagaggcccg ggctgccttg
     1501 cgggtcagtg agggccgtgc ccggggcctg caggaggcag cccgagctcg ggagctggag
     1561 ctggaggcct gctcacagga gctacagcgg taccgccagg aggctgagca gctccgggag
     1621 aaggctaggc atttggatgc tgaagcagca ggactccggg agccccctgt acccccggct
     1681 accaccgacc cgttcctcct ggcggagagt gatgaggcta aggtgcagcg ggcagccgct
     1741 gggacagggg gtagcctgcg ggctcaggtg gaacggttgc gccaagaact gcagcgggag
     1801 cagcggcggg gagatgaaca acggaacagc tttgaggggg agcggctggc ctggcaggcg
     1861 gagaaggaac aggtgatccg ctaccagaag cagctgcagc acaactatgt ccagatgtac
     1921 cggcgtaacc gacagctgga gcaggaactg cagcaactga gcctagagct ggaggcccgg
     1981 gagcttgctg atttgggctt gtcggagccg gccccttgca tctgtctgga ggagatcact
     2041 gccactgaaa tctaggactt tgcaaggggt gcgagccacc gcaccacctg caccgggatc
     2101 catcgagcaa gcgctccagg tctcagagcc aaaaggcctc tgccgagcat tcgggtggcc
     2161 ccataacttg gagaagcaga atcaaccccc ctgcagttca gtgtcactgt cacccagagg
     2221 ctcctgccta cgctgccatt tcactcccca ccgccgccac tgccagtcca ctccagctgg
     2281 gaaaggaaag ggggctaacc tgtccccaca ttctacctgc ctgaagccag agagaaccag
     2341 atggcaccag ctgccccaga tgtgcctgcc ctcaatatgc ccacgtggag gggcgggact
     2401 aggaatgggg ctgatcccca tgtcccagct ccgcaagcct cttgtgggct gagggggctg
     2461 aagtcagacc aaaggaagaa ctcagcaatg tcttgtttat ttgtgttcgt gaccaagccg
     2521 ccctccctag ttccagggtt atggcctcgt tcccacttgt atatttttca cactgtaaat
     2581 ttcttgtaca aacccaaagg ggaaaaaaat taaaaaaaaa aagttttgtt aaaaaaaaaa
     2641 aaaaaaaaaa aaaaaaaaaa
//
