LOCUS       NM_153470               4991 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus leucine zipper tumor suppressor 1 (Lzts1), mRNA.
ACCESSION   NM_153470
VERSION     NM_153470.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4991)
  AUTHORS   McKnight,N.C., Jefferies,H.B., Alemu,E.A., Saunders,R.E.,
            Howell,M., Johansen,T. and Tooze,S.A.
  TITLE     Genome-wide siRNA screen reveals amino acid starvation-induced
            autophagy requires SCOC and WAC
  JOURNAL   EMBO J 31 (8), 1931-1946 (2012)
   PUBMED   22354037
REFERENCE   2  (bases 1 to 4991)
  AUTHORS   Chen,L., Zhu,Z., Sun,X., Dong,X.Y., Wei,J., Gu,F., Sun,Y.L.,
            Zhou,J., Dong,J.T. and Fu,L.
  TITLE     Down-regulation of tumor suppressor gene FEZ1/LZTS1 in breast
            carcinoma involves promoter methylation and associates with
            metastasis
  JOURNAL   Breast Cancer Res Treat 116 (3), 471-478 (2009)
   PUBMED   18686028
REFERENCE   3  (bases 1 to 4991)
  AUTHORS   Maruoka,H., Konno,D., Hori,K. and Sobue,K.
  TITLE     Collaboration of PSD-Zip70 with its binding partner, SPAR, in
            dendritic spine maturity
  JOURNAL   J Neurosci 25 (6), 1421-1430 (2005)
   PUBMED   15703396
  REMARK    GeneRIF: PSD-Zip70 in collaboration with SPAR is critically
            involved in spine maturity, especially in the mature spine
            formation and the maintenance of spine maturity.
REFERENCE   4  (bases 1 to 4991)
  AUTHORS   Konno,D., Ko,J.A., Usui,S., Hori,K., Maruoka,H., Inui,M.,
            Fujikado,T., Tano,Y., Suzuki,T., Tohyama,K. and Sobue,K.
  TITLE     The postsynaptic density and dendritic raft localization of
            PSD-Zip70, which contains an N-myristoylation sequence and
            leucine-zipper motifs
  JOURNAL   J Cell Sci 115 (Pt 23), 4695-4706 (2002)
   PUBMED   12415013
  REMARK    GeneRIF: postsynaptic density and dendritic raft localization of
            PSD-Zip70
REFERENCE   5  (bases 1 to 4991)
  AUTHORS   Ishii,H., Baffa,R., Numata,S.I., Murakumo,Y., Rattan,S., Inoue,H.,
            Mori,M., Fidanza,V., Alder,H. and Croce,C.M.
  TITLE     The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein,
            and its expression is altered in multiple human tumors
  JOURNAL   Proc Natl Acad Sci U S A 96 (7), 3928-3933 (1999)
   PUBMED   10097140
REFERENCE   6  (bases 1 to 4991)
  AUTHORS   Apperson,M.L., Moon,I.S. and Kennedy,M.B.
  TITLE     Characterization of densin-180, a new brain-specific synaptic
            protein of the O-sialoglycoprotein family
  JOURNAL   J Neurosci 16 (21), 6839-6852 (1996)
   PUBMED   8824323
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Nov 27, 2020 this sequence version replaced NM_153470.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB075607.1, SRR26360190.206158.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-214               JAXUCZ010000016.1  25309553-25309766
            215-687             JAXUCZ010000016.1  25354312-25354784
            688-1485            JAXUCZ010000016.1  25356864-25357661
            1486-4991           JAXUCZ010000016.1  25361437-25364942
FEATURES             Location/Qualifiers
     source          1..4991
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..4991
                     /gene="Lzts1"
                     /gene_synonym="Psdzip70"
                     /note="leucine zipper tumor suppressor 1"
                     /db_xref="GeneID:266711"
                     /db_xref="RGD:708565"
     exon            1..214
                     /gene="Lzts1"
                     /gene_synonym="Psdzip70"
                     /inference="alignment:Splign:2.1.0"
     exon            215..687
                     /gene="Lzts1"
                     /gene_synonym="Psdzip70"
                     /inference="alignment:Splign:2.1.0"
     CDS             343..2148
                     /gene="Lzts1"
                     /gene_synonym="Psdzip70"
                     /note="PSD-Zip70; leucine zipper, putative tumor
                     suppressor 1"
                     /codon_start=1
                     /product="leucine zipper putative tumor suppressor 1"
                     /protein_id="NP_703200.1"
                     /db_xref="GeneID:266711"
                     /db_xref="RGD:708565"
                     /translation="MGSVSSLISGHSLHSKHCRASQYKLRKSSHLKKLNRYSDGLLRF
                     GFSQDSGRGKSSSKMGKSEDFFYIKVSQKARGSHRPDYTALSSGDMGGQTGVDFDPAT
                     PPKLMPFSSQLEMSSDKAAVRPTAFKPVLPRSGAILHSSPESTNHQLHPMPPDKPKEQ
                     ELKPGLCSGALSDSGRNSMSSLPTHSTTSSYQLDPLVTPVGPTSRFGGSAHNITQGII
                     LQDSNMMSLKALSFSDGGSKLAHPGKVEKGSSCVRSPLSTDECTIQELEQKLLQRETA
                     LQKLQRSFDEKEFASGQTFEERPRRTRDELECLEPKSKLKPASQKSQRTQQVLQLQVL
                     QLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTNFAPALEETQWEVCQKSGEISLL
                     KQQLKESQMEVNAKASEILSLKAQLKDTRGKLEGMELKTQDLESALRTKGLELEVCEN
                     ELQRKKNEAELLREKVNLLEQELLELRAQAALHRDAAPLGPPGIGLTFSEDIPALQRE
                     LDRLRAELKEERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQLQQSYLAMYQRNQRLE
                     KALQQLARGDIAGEPFEIDLEGADIPYEDIIATEI"
     exon            688..1485
                     /gene="Lzts1"
                     /gene_synonym="Psdzip70"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..4991
                     /gene="Lzts1"
                     /gene_synonym="Psdzip70"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccagctggc gggctctggg cggctgcgac aagctcagag tccgaaagtt tctctgcctt
       61 tctgctgctc ctgggagtgt gacttgagcg acgcgggatc agtcggctcc agtggctctc
      121 cagaaaaaga gaaaggggta ctacacaaaa cacaccgaaa aatcaaaatc tgcagccatt
      181 tgcagctatc tccgaggcgg aggagggcag acaggtccat ggctctctcg ggctctgaga
      241 agcttttgct ctgaccacag tcccctggct gagccaggac tacatttcgc tgctgtctcc
      301 aggcccctct tgtgccctgc aggcccttgg ttcctcgtca ccatgggcag tgtgagcagc
      361 cttatctcag gccacagtct ccacagcaag cactgtcgtg cttcccagta caaactgcgc
      421 aaatcctccc acctcaagaa gctcaaccgg tactcagatg ggcttctgag gtttggcttc
      481 tcccaggact cgggccgtgg caagtccagc tccaaaatgg ggaaaagcga agacttcttc
      541 tacatcaaag tcagccagaa ggcccgaggc tcccatcgcc cagactacac agcactgtcc
      601 agtggggaca tggggggcca gactggagta gattttgatc cagccactcc accaaagctc
      661 atgcccttct ccagtcaact ggaaatgagt tcagacaagg cggcggtgag gcccactgcc
      721 ttcaagcctg tgttgccacg gtcaggagcc attctccact cttcacctga gagtaccaac
      781 caccagcttc atcccatgcc tccagataag cccaaggaac aggagctgaa gccaggcctg
      841 tgctcagggg cactgtctga ctcgggccgg aactccatgt ctagcctgcc cacgcatagc
      901 accaccagca gctaccagct ggatcctctg gtcacccccg tggggcctac tagccgtttt
      961 gggggttcag ctcacaacat cacacaaggc atcatccttc aggacagtaa tatgatgagc
     1021 ctgaaggctc tgtcattctc tgatgggggc agcaagctgg ctcacccagg caaggtagaa
     1081 aagggctcct cctgtgtgcg ttccccactc tccacggatg agtgcaccat tcaggagctg
     1141 gagcagaagc tgctgcagcg ggagactgca ctacagaagc tacagcgcag tttcgatgag
     1201 aaggagtttg cctctggcca gaccttcgag gagcggccac ggcggactag agacgaactg
     1261 gagtgcctgg aacctaagag caagctgaag ccagcctccc agaagagcca gcgcacccag
     1321 caggtactcc agctgcaggt gttacagttg cagcaggaga aacggcagct gaggcaggag
     1381 ctagagagcc taatgaagga gcaggacctg ctggagacca agctgaggtc ctacgagcgg
     1441 gagaaaacca acttcgcccc tgcactggag gagacccaat gggaggtgtg ccagaagtca
     1501 ggtgagatct ctcttctgaa gcaacagctc aaagaatccc aaatggaggt gaatgctaag
     1561 gccagtgaga tccttagcct gaaggcacag ctgaaggaca cccggggcaa gcttgaggga
     1621 atggagttga agacacagga cttggagagc gccttgcgca ccaaggggct agagctggag
     1681 gtctgtgaga atgaactgca gcgcaagaag aatgaggcag agctgctgag agagaaggtg
     1741 aaccttttag aacaggagct gctggagctg cgggcccagg cggccctgca tcgagatgca
     1801 gcacccctgg gccctccagg gattgggctg actttctcag aggacatccc tgctctgcag
     1861 cgggagctgg atcggctgcg ggctgagctg aaggaggaga ggcaaggcca tgaccagatg
     1921 tcctcgggat tccagcatga gcggttggtg tggaaggaag agaaggagaa agtgatccag
     1981 taccaaaagc agctgcaaca gagctacttg gccatgtacc agcgcaacca gcgtctagag
     2041 aaggccctgc agcagctggc ccgtggggat attgcagggg agccctttga aattgacctg
     2101 gagggagctg acattcccta tgaggatatc atagccactg agatctgagg ggctacctcg
     2161 gggatggagg gctggggact agaccccaga aagcagggag gactgagcct gtcccaagag
     2221 cccctctgag agaagccacc tctgggatcc agattcagga gtccccagtg gtgggtaggg
     2281 gttaccacat agcctttcct cccctcctgc ctttctcagc ctaactaacc ctgctgctta
     2341 taagaccttg atctgcgaac cccaagctct cctagaggta tgctcaggga gctttatgtg
     2401 ctggttgagg tttctcttga ctttggtctc attcaaagta gtgagaaaga caccccatca
     2461 ggaaaggggg caactgccat acaggccaaa tggccaccca aggacagaaa cattttccct
     2521 gttgtcccta aacccccacc atcccctggg catcttggga tgcctttggg aatagaaaga
     2581 agccatgtgt aaccagaagc cttggacctc gtcttcacta cagcctgttc tgctctgact
     2641 gtggtggtgg aggggttgtg tcgccacgta gttgagccag caagtcatgg gaggaagggg
     2701 tagatggaca gtccgccatt acggaacctt tgcaggtctc aagaggtccg gtgggagttg
     2761 aaaggagaga accaaggcag atggggagtg gagtctaaaa tgagctgcat agcccctttg
     2821 acctcagtgg tcactctgtt taaagccata gacattgggg gtcccaggtg gggtacaggg
     2881 aactgacatg agacatagat tctcagctgt gccaggggat cctcctcagc ctccaatatt
     2941 gaatgttttt tctttccaga acactagacg ctggctcaga tccaaaatag cccatccact
     3001 tagatagtgt gcatgggagc tggacattag cctcccttgt ctgtggccca agtcagcagc
     3061 ttctctttcc cttatagcat tgtcagtgtg ctgataggct gccgtccagg caggagagat
     3121 acagggtgca taaaaagagc cttataaata tcccaaacca cccactttcc tccctccgtg
     3181 tggcagcacc ccaggctgta agaattcagt ctagaaagca gcatgtgagc ttgtgggagc
     3241 ctggccttgt cttttgaaga tagccagatc taggggcaga gggaagtgca gttgctgggt
     3301 tgaaggaatt atcttctctc tccttcccac ttccattctg tgttttccaa agcaagccag
     3361 atcaagcagg cagccaagct gctccatatt ctatttttgg cccttaccac agctgttgtt
     3421 ggtaggacac ccagcccttg ctggattcct gagccatgtg tttgcctggt gggcgggacc
     3481 caggatattg gagatgtaag ggagggtctg tgtgcttggt agtccaggaa ccaacctgag
     3541 ttctacctcc ctaatgctgg tccttaaggt ggatcccagc cctagtgacc ttgtcttccc
     3601 gtgggctttc ttcccttcct tgtatctgca ggctaggtgc ctcccctgta cgtggtacta
     3661 ctttctgtcc ctgcggttag attggccctc tcctactact gactttcaac agcacactat
     3721 tctctggtct accactgccc agagtcacat gctcacttaa atctggaatc tacaggccaa
     3781 agacgactcc cccaacttgc acggtcgtac actccactga acacaggtca cagcccagtt
     3841 taaagagtcc atagccctca gttctcagtt gtgtaccagt ctgtgccttg tctgagtcct
     3901 tcccattgag actgtccaac agacagaaag aaagatgggg gtttcctgcc tctctctaga
     3961 ttgaaggact ccttcctctg agagaagtcc agaagtccag tgctatgcta tggagtcctt
     4021 gcccagaagc agacactagg cctgggcaga cctgtgctct ctctgtgcag ggtgccttct
     4081 gttcacaggg gttctgccca gtagtcctgc cgaggtcatc gttgagacct ctgcctgggg
     4141 actgcttacc ctttaagatg gcagatgcct tcccaagact gctgtcagcc tgaggtccca
     4201 aggtagctcc aagacgcaac tgtgctgtaa cctaataacc ttgccttcgt gtgggctttc
     4261 tttcctctcc tgtcctaaag catcctcact gtttgtggcc catgcccatg ttggacggct
     4321 agatggaaca gtgactgaac agggcctcag gtgtgcaggt tcagggcaga caagtagtct
     4381 gccacacctc gtctctcagc tccacactgc tttccagagg tgtctggttc cagactgtgg
     4441 ctgctctctg aaggaagaac ggcagctagc atcacctcaa ggaagggcct tgtagtgtca
     4501 gactcccacg gggtacctcc ttgctcgatt ttgtcctctc tcggcacact tgaactttag
     4561 catgataacg ttttcagggg atcggcatca ctcctctgag agacacttgc tgatcctctc
     4621 gtcgctggct ccagcttggg ctgtgtctca ggtaagagag atgtccaagg gaaagccagg
     4681 ctggaccaga gatttcccta ggacctgagt tctcctcaga cgccatagaa caggccacag
     4741 tgcccctcag tggagactgc tttccctctt gaacactgga gccctcagta gaggctggct
     4801 tcggatggac tggcatttgg aagaccaagt acatagttat ttttctcttc cctgtttctg
     4861 gtttgctttg ctcttgatgg cttcgttttg ttttattttt gaagttcttt gttggctccg
     4921 taaactattt ctgctacttt tatgttttta tttatgaata aagaatgcca tttctcatgt
     4981 cttcacagtc a
//
