LOCUS       NM_001108326            2779 bp    mRNA    linear   ROD 25-APR-2023
DEFINITION  Rattus norvegicus leucine zipper like post translational regulator
            1 (Lztr1), mRNA.
ACCESSION   NM_001108326 XM_001066088 XM_341017
VERSION     NM_001108326.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2779)
  AUTHORS   Sewduth RN, Pandolfi S, Steklov M, Sheryazdanova A, Zhao P, Criem
            N, Baietti MF, Lechat B, Quarck R, Impens F and Sablina AA.
  TITLE     The Noonan Syndrome Gene Lztr1 Controls Cardiovascular Function by
            Regulating Vesicular Trafficking
  JOURNAL   Circ Res 126 (10), 1379-1393 (2020)
   PUBMED   32175818
REFERENCE   2  (bases 1 to 2779)
  AUTHORS   Jenkins J, Barnes A, Birnbaum B, Papagiannis J, Thiffault I and
            Saunders CJ.
  TITLE     LZTR1-Related Hypertrophic Cardiomyopathy Without Typical Noonan
            Syndrome Features
  JOURNAL   Circ Genom Precis Med 13 (2), e002690 (2020)
   PUBMED   32004086
REFERENCE   3  (bases 1 to 2779)
  AUTHORS   Chinton J, Huckstadt V, Mucciolo M, Lepri F, Novelli A, Gravina LP
            and Obregon MG.
  TITLE     Providing more evidence on LZTR1 variants in Noonan syndrome
            patients
  JOURNAL   Am J Med Genet A 182 (2), 409-414 (2020)
   PUBMED   31825158
REFERENCE   4  (bases 1 to 2779)
  AUTHORS   Castel P, Cheng A, Cuevas-Navarro A, Everman DB, Papageorge AG,
            Simanshu DK, Tankka A, Galeas J, Urisman A and McCormick F.
  TITLE     RIT1 oncoproteins escape LZTR1-mediated proteolysis
  JOURNAL   Science 363 (6432), 1226-1230 (2019)
   PUBMED   30872527
REFERENCE   5  (bases 1 to 2779)
  AUTHORS   Bigenzahn JW, Collu GM, Kartnig F, Pieraks M, Vladimer GI, Heinz
            LX, Sedlyarov V, Schischlik F, Fauster A, Rebsamen M, Parapatics K,
            Blomen VA, Muller AC, Winter GE, Kralovics R, Brummelkamp TR,
            Mlodzik M and Superti-Furga G.
  TITLE     LZTR1 is a regulator of RAS ubiquitination and signaling
  JOURNAL   Science 362 (6419), 1171-1177 (2018)
   PUBMED   30442766
REFERENCE   6  (bases 1 to 2779)
  AUTHORS   Caltabiano R, Magro G, Polizzi A, Pratico AD, Ortensi A, D'Orazi V,
            Panunzi A, Milone P, Maiolino L, Nicita F, Capone GL, Sestini R,
            Paganini I, Muglia M, Cavallaro S, Lanzafame S, Papi L and Ruggieri
            M.
  TITLE     A mosaic pattern of INI1/SMARCB1 protein expression distinguishes
            Schwannomatosis and NF2-associated peripheral schwannomas from
            solitary peripheral schwannomas and NF2-associated vestibular
            schwannomas
  JOURNAL   Childs Nerv Syst 33 (6), 933-940 (2017)
   PUBMED   28365909
REFERENCE   7  (bases 1 to 2779)
  AUTHORS   Smith MJ, Isidor B, Beetz C, Williams SG, Bhaskar SS, Richer W,
            O'Sullivan J, Anderson B, Daly SB, Urquhart JE, Fryer A, Rustad CF,
            Mills SJ, Samii A, du Plessis D, Halliday D, Barbarot S, Bourdeaut
            F, Newman WG and Evans DG.
  TITLE     Mutations in LZTR1 add to the complex heterogeneity of
            schwannomatosis
  JOURNAL   Neurology 84 (2), 141-147 (2015)
   PUBMED   25480913
REFERENCE   8  (bases 1 to 2779)
  AUTHORS   Piotrowski A, Xie J, Liu YF, Poplawski AB, Gomes AR, Madanecki P,
            Fu C, Crowley MR, Crossman DK, Armstrong L, Babovic-Vuksanovic D,
            Bergner A, Blakeley JO, Blumenthal AL, Daniels MS, Feit H, Gardner
            K, Hurst S, Kobelka C, Lee C, Nagy R, Rauen KA, Slopis JM,
            Suwannarat P, Westman JA, Zanko A, Korf BR and Messiaen LM.
  TITLE     Germline loss-of-function mutations in LZTR1 predispose to an
            inherited disorder of multiple schwannomas
  JOURNAL   Nat Genet 46 (2), 182-187 (2014)
   PUBMED   24362817
REFERENCE   9  (bases 1 to 2779)
  AUTHORS   Frattini V, Trifonov V, Chan JM, Castano A, Lia M, Abate F, Keir
            ST, Ji AX, Zoppoli P, Niola F, Danussi C, Dolgalev I, Porrati P,
            Pellegatta S, Heguy A, Gupta G, Pisapia DJ, Canoll P, Bruce JN,
            McLendon RE, Yan H, Aldape K, Finocchiaro G, Mikkelsen T, Prive GG,
            Bigner DD, Lasorella A, Rabadan R and Iavarone A.
  TITLE     The integrated landscape of driver genomic alterations in
            glioblastoma
  JOURNAL   Nat Genet 45 (10), 1141-1149 (2013)
   PUBMED   23917401
REFERENCE   10 (bases 1 to 2779)
  AUTHORS   Nacak TG, Leptien K, Fellner D, Augustin HG and Kroll J.
  TITLE     The BTB-kelch protein LZTR-1 is a novel Golgi protein that is
            degraded upon induction of apoptosis
  JOURNAL   J Biol Chem 281 (8), 5065-5071 (2006)
   PUBMED   16356934
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC169071.1.
            
            On Sep 4, 2008 this sequence version replaced NM_001108326.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC169071.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760434 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2779
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..2779
                     /gene="Lztr1"
                     /note="leucine zipper like post translational regulator 1"
                     /db_xref="GeneID:360745"
                     /db_xref="RGD:1309100"
     exon            1..229
                     /gene="Lztr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..2552
                     /gene="Lztr1"
                     /note="leucine-zipper-like transcriptional regulator, 1;
                     leucine-zipper-like transcription regulator 1"
                     /codon_start=1
                     /product="leucine-zipper-like transcriptional regulator 1"
                     /protein_id="NP_001101796.1"
                     /db_xref="GeneID:360745"
                     /db_xref="RGD:1309100"
                     /translation="MAGSGGPTGPGALTGGVSSKVAPSVDFDHSCSDSVEYLTLNFGP
                     FETVHRWRRLPPCDEFVGARRSKHTVVAYKDAIYVFGGDNGKTMLNDLLRFDVKDCSW
                     CRAFTTGTPPAPRYHHSAVVYGSSMFVFGGYTGDIYSNSNLKNKNDLFEYKFATGQWT
                     EWKIEGRLPVARSAHGATVYSDKLWIFAGYDGNARLNDMWTIGLQDRELTCWEEVAQS
                     GEIPPSCCNFPVAVCRDKMFVFSGQSGAKITNNLFQFEFKDKTWTRIPTEHLLRGSPP
                     PPQRRYGHTMVAFDRHLYVFGGAADNTLPNELHCYDVDFQTWEVVQPSSDSEVGGAEV
                     PERASSSEEASTLTSEERSSFKKSRDVFGLDFGTTSTKQPVHLASELPSGRLFHAAAV
                     ISDAMYIFGGTVDNNIRSGEMYRFQFSCYPKCTLHEDYGRLWEGRQFCDVEFVLGEKE
                     ECVQGHVAIVTARSRWLRRKIVQAREWLAQKLEEDGALAPKEAPGSTVGRARPPLLRV
                     AIREAEARPFEVLMQFLYTDKIKYPRKGHVEDVLLIMDVYKLALSFQLCRLEQLCRQY
                     IEASVDLQNVLAVCECAARLQLGQLKEHCLNFIVKESHFNQVIMMKEFERLSSPLIVE
                     IVRRKQQPPPRTPSDQPVDIGTSLIQDMKAYLEGAGSEFCDITLLLDGHPRPAHKAIL
                     AARSSYFEAMFRSFMPEDGQVNISIGEMVPSRQAFESMLRYIYYGEVNMPPEDSLYLF
                     AAPYYYGFYNNRLQAYCKQNLEMNVTVQNVLQILEAADKTQALDMKRHCLHIIVHQFT
                     KVSKLPTLRLLSQQLLLDIIDSLASHISDKQCAELGADI"
     exon            230..292
                     /gene="Lztr1"
                     /inference="alignment:Splign:2.1.0"
     exon            293..349
                     /gene="Lztr1"
                     /inference="alignment:Splign:2.1.0"
     exon            350..429
                     /gene="Lztr1"
                     /inference="alignment:Splign:2.1.0"
     exon            430..538
                     /gene="Lztr1"
                     /inference="alignment:Splign:2.1.0"
     exon            539..622
                     /gene="Lztr1"
                     /inference="alignment:Splign:2.1.0"
     exon            623..680
                     /gene="Lztr1"
                     /inference="alignment:Splign:2.1.0"
     exon            681..820
                     /gene="Lztr1"
                     /inference="alignment:Splign:2.1.0"
     exon            821..1022
                     /gene="Lztr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1178
                     /gene="Lztr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1289
                     /gene="Lztr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1382
                     /gene="Lztr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1478
                     /gene="Lztr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1644
                     /gene="Lztr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1814
                     /gene="Lztr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..1971
                     /gene="Lztr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..2098
                     /gene="Lztr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2099..2248
                     /gene="Lztr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2249..2354
                     /gene="Lztr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2355..2435
                     /gene="Lztr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2436..2765
                     /gene="Lztr1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcctgcaac ctggtggcct attcggcctg aaccagggat ggcaggctcc ggaggcccca
       61 ctgggcccgg ggccttgaca ggaggggtga gctccaaggt ggctccgagc gtggactttg
      121 accacagctg ctcagacagt gtcgagtacc tgacgctcaa ctttggaccc ttcgaaactg
      181 tgcatcgctg gcggcgcctc ccgccctgcg acgaattcgt aggcgctcgg cgcagcaaac
      241 acacagtcgt ggcgtataag gatgccatct atgtgtttgg cggagataat gggaagacga
      301 tgctcaatga tctcctgcgg ttcgacgtga aggattgctc ctggtgcaga gccttcacca
      361 ccggcactcc tccagccccc cggtaccacc actcagctgt tgtctacggg agcagcatgt
      421 tcgtcttcgg gggatatact ggagatattt attccaattc taacttgaag aataaaaatg
      481 acctctttga atacaagttt gcaactggcc agtggacaga gtggaagatt gaaggaaggt
      541 tgcctgttgc caggtcagcc catggggcta cagtgtacag tgacaagctc tggatctttg
      601 ctggctatga tggcaatgcc aggttgaacg acatgtggac aattggcctc caagaccgag
      661 agctcacatg ctgggaggag gtggcccaga gcggtgagat acccccatcc tgctgcaact
      721 tccctgtggc tgtgtgccgg gataagatgt ttgtgttctc aggacagagt ggagccaaga
      781 taaccaacaa cctcttccag tttgaattca aggacaagac gtggacacgc atccctactg
      841 agcacctgct tcggggctcc ccacccccac cacagcggcg ctatggacac accatggtgg
      901 cctttgaccg tcatctctat gtgtttgggg gtgcagcaga caatacactg cccaatgagc
      961 tgcactgtta tgatgtggac ttccagacct gggaggttgt ccaacccagc tctgacagtg
     1021 aggttggtgg ggctgaggtg cctgagcgag cttcttcttc tgaggaggca tctactctaa
     1081 cctctgaaga gcggagcagc tttaagaagt ccagagatgt gtttggccta gactttggca
     1141 ccacttcaac caagcagcca gtccacctgg catcagagct gcccagtggg aggctcttcc
     1201 atgctgctgc agtcatatct gatgccatgt acatctttgg gggcactgtg gacaacaaca
     1261 ttcgcagcgg ggaaatgtac aggttccagt tctcttgcta cccaaagtgc acactgcatg
     1321 aagattatgg gcgcctatgg gagggccgcc agttctgtga tgtggagttt gtgcttggtg
     1381 agaaggaaga gtgtgtgcag ggtcatgttg ccattgtcac tgcaaggagc cggtggcttc
     1441 gtaggaagat tgtgcaggcc cgagagtggc tggcccagaa gctggaggaa gatggggccc
     1501 tagctcccaa ggaggcccct ggctcaactg tgggcagagc acggccaccc ctgttacgtg
     1561 tggccattcg tgaggctgag gcacggccat ttgaggtgct catgcagttt ctctacacag
     1621 acaagatcaa gtacccacgg aaaggccatg tggaagacgt gctgctcatc atggatgtgt
     1681 acaagctggc actgagcttc cagctgtgtc gccttgagca gctgtgtcgg cagtacatcg
     1741 aggcctctgt ggatctgcag aatgtgctgg ctgtgtgcga gtgcgctgcc aggctacaac
     1801 tgggccagct caaggagcat tgcctgaact tcatagtgaa ggaatcccac ttcaatcagg
     1861 tgataatgat gaaggagttt gagcgcctct catccccact gattgtagag attgttcgtc
     1921 ggaagcagca gccaccccct cgcaccccct ctgatcagcc tgtggacatt ggcacatctt
     1981 tgatccagga catgaaggct tacctggagg gagcaggctc agagttctgt gacatcacac
     2041 tactgctaga tggccaccca cggccggccc acaaagccat cctggctgcc cgctctagct
     2101 actttgaggc catgtttcgg tcgttcatgc cagaggatgg gcaggtaaac atctccattg
     2161 gggagatggt tcccagcaga caggcctttg agtccatgct gcgctacatc tactatggcg
     2221 aggtcaacat gccccctgag gactcactct acctgtttgc agccccctac tactatggct
     2281 tctacaacaa ccgactgcag gcatactgca agcagaacct cgagatgaat gtaacagtgc
     2341 agaatgtgct gcagattctg gaggcagctg acaagacaca ggcactggac atgaagcggc
     2401 actgcttgca catcattgta caccaattca ctaaggtctc taagctgccc acactgcggc
     2461 tgctgagcca gcagctgctg ctggacatca tagactccct ggcctcccat atctctgaca
     2521 agcagtgtgc agagctgggt gctgacatct gaggatctct atggggaccc tacctgcttc
     2581 aagagtgagg acacccaacc aattggccac atctccacct gcagaatgat cacacctgtg
     2641 aggtcaaggg tcctcagctt ctacagagca ctgaggtgta taggaactcc caaagcctgc
     2701 atctcattga ggacaccagc cctacaggga atggcaaata aagcaaactc cctttctagc
     2761 tggcaaaaaa aaaaaaaaa
//
