LOCUS       NM_012771               1219 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus lysozyme 2 (Lyz2), mRNA.
ACCESSION   NM_012771
VERSION     NM_012771.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1219)
  AUTHORS   Pieragostino,D., Agnifili,L., Fasanella,V., D'Aguanno,S.,
            Mastropasqua,R., Di Ilio,C., Sacchetta,P., Urbani,A. and Del
            Boccio,P.
  TITLE     Shotgun proteomics reveals specific modulated protein patterns in
            tears of patients with primary open angle glaucoma naive to therapy
  JOURNAL   Mol Biosyst 9 (6), 1108-1116 (2013)
   PUBMED   23580065
REFERENCE   2  (bases 1 to 1219)
  AUTHORS   Wyatt,A.R., Constantinescu,P., Ecroyd,H., Dobson,C.M., Wilson,M.R.,
            Kumita,J.R. and Yerbury,J.J.
  TITLE     Protease-activated alpha-2-macroglobulin can inhibit amyloid
            formation via two distinct mechanisms
  JOURNAL   FEBS Lett 587 (5), 398-403 (2013)
   PUBMED   23353684
REFERENCE   3  (bases 1 to 1219)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   4  (bases 1 to 1219)
  AUTHORS   Fornander,L., Ghafouri,B., Kihlstrom,E., Akerlind,B., Schon,T.,
            Tagesson,C. and Lindahl,M.
  TITLE     Innate immunity proteins and a new truncated form of SPLUNC1 in
            nasopharyngeal aspirates from infants with respiratory syncytial
            virus infection
  JOURNAL   Proteomics Clin Appl 5 (9-10), 513-522 (2011)
   PUBMED   21805676
REFERENCE   5  (bases 1 to 1219)
  AUTHORS   Huang,P., Li,W.S., Xie,J., Yang,X.M., Jiang,D.K., Jiang,S. and
            Yu,L.
  TITLE     Characterization and expression of HLysG2, a basic goose-type
            lysozyme from the human eye and testis
  JOURNAL   Mol Immunol 48 (4), 524-531 (2011)
   PUBMED   21093056
REFERENCE   6  (bases 1 to 1219)
  AUTHORS   Staneva-Dobrovski,L.
  TITLE     Lysozyme expression in the rat parotid gland: light and electron
            microscopic immunogold studies
  JOURNAL   Histochem Cell Biol 107 (5), 371-381 (1997)
   PUBMED   9208328
REFERENCE   7  (bases 1 to 1219)
  AUTHORS   Pepys,M.B., Hawkins,P.N., Booth,D.R., Vigushin,D.M., Tennent,G.A.,
            Soutar,A.K., Totty,N., Nguyen,O., Blake,C.C., Terry,C.J. et al.
  TITLE     Human lysozyme gene mutations cause hereditary systemic amyloidosis
  JOURNAL   Nature 362 (6420), 553-557 (1993)
   PUBMED   8464497
REFERENCE   8  (bases 1 to 1219)
  AUTHORS   Yeh,T.C., Wilson,A.C. and Irwin,D.M.
  TITLE     Evolution of rodent lysozymes: isolation and sequence of the rat
            lysozyme genes
  JOURNAL   Mol Phylogenet Evol 2 (1), 65-75 (1993)
   PUBMED   8081549
REFERENCE   9  (bases 1 to 1219)
  AUTHORS   Wei,R.Q., Yee,J.B., Straus,D.C. and Hutson,J.C.
  TITLE     Bactericidal activity of testicular macrophages
  JOURNAL   Biol Reprod 38 (4), 830-835 (1988)
   PUBMED   2840982
REFERENCE   10 (bases 1 to 1219)
  AUTHORS   White,T.J., Mross,G.A., Osserman,E.F. and Wilson,A.C.
  TITLE     Primary structure of rat lysozyme
  JOURNAL   Biochemistry 16 (7), 1430-1436 (1977)
   PUBMED   851497
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC058490.1.
            
            On Feb 21, 2013 this sequence version replaced NM_012771.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058490.1, CF111218.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1219              BC058490.1         5-1223
FEATURES             Location/Qualifiers
     source          1..1219
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..1219
                     /gene="Lyz2"
                     /gene_synonym="Lysz; Lyz; Lyz1"
                     /note="lysozyme 2"
                     /db_xref="GeneID:25211"
                     /db_xref="RGD:3026"
     exon            1..166
                     /gene="Lyz2"
                     /gene_synonym="Lysz; Lyz; Lyz1"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..477
                     /gene="Lyz2"
                     /gene_synonym="Lysz; Lyz; Lyz1"
                     /EC_number="3.2.1.17"
                     /note="lysozyme C-1; 1,4-beta-N-acetylmuramidase C"
                     /codon_start=1
                     /product="lysozyme C-1 precursor"
                     /protein_id="NP_036903.2"
                     /db_xref="GeneID:25211"
                     /db_xref="RGD:3026"
                     /translation="MKALLVLGFLLLSASVQAKIYERCEFARTLKRNGMSGYYGVSLA
                     DWVCLAQHESNYNTQARNYNPGDQSTDYGIFQINSRYWCNDGKTPRAKNACGIPCSAL
                     LQDDITQAIQCAKRVVRDPQGIRAWVAWQRHCKNRDLSGYIRNCGV"
     exon            167..331
                     /gene="Lyz2"
                     /gene_synonym="Lysz; Lyz; Lyz1"
                     /inference="alignment:Splign:2.1.0"
     exon            332..410
                     /gene="Lyz2"
                     /gene_synonym="Lysz; Lyz; Lyz1"
                     /inference="alignment:Splign:2.1.0"
     exon            411..1191
                     /gene="Lyz2"
                     /gene_synonym="Lysz; Lyz; Lyz1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agccggcagc tggtccagct tccagtcacc atgaaggctc tcctagttct ggggttcctc
       61 ctgctctctg cctctgtcca ggccaagatc tatgaacgct gtgagttcgc cagaactctg
      121 aaaaggaatg ggatgtctgg ctactatgga gtcagcctgg cagactgggt gtgtttagct
      181 cagcatgaga gcaattataa cacacaagcc agaaactaca accctggaga ccaaagcacc
      241 gactatggga tatttcagat caatagccga tactggtgta atgacggcaa aaccccaaga
      301 gcaaagaacg cctgtgggat accctgcagc gctctgctgc aggatgacat cactcaagcc
      361 atacaatgtg cgaagagagt tgtgagggat ccccaaggca ttcgagcatg ggtggcatgg
      421 caaagacact gtaaaaaccg agatctatcc gggtatattc ggaactgcgg agtctgaccg
      481 ccgtgcactt ctactcagct cacactgtct ctttctcact gtgggagtag ctatgggaaa
      541 ggtcacactt ccttgctttc ccctcaaacc aacagggctt tcacttctca gtctcccaac
      601 gcactgcaca ctgctcccag catcccgcac agtctcacca cacacatctc tgcacatcag
      661 gaagtaatgc acagtaggct ccatcgggat ccatcttcat cagccctgtg ccggatacaa
      721 acagcacata tttacaggag acgagttgat cttggggaat ggcagttgtg tgagtgccag
      781 ggctttgtat aggctcagca cccagttaga acagcctctg tggtggacct ggagggcttt
      841 tgagggccca ggactcagtg gatgagaact gagactgcct gaactcagaa acttatgaaa
      901 cgtgtgagct ttcaaaacag tatcttctta gagctggcct gtttatcctg ccttcaaaat
      961 aaattctcag cccgtatgcc cgtctgtttt aacccttgag aggatgttcc cagtcttgtg
     1021 aggtgctcag ggggaccagt gagctgtgct tgtccatatc tttcttaagt agcttcatgc
     1081 acactaacca actctgagac agatgagctt gtaacaccag acaataatca ctagaacaga
     1141 tctaatctga tagagaaaaa gtataattct cattaaatga ttttcaacgc aaaaaaaaaa
     1201 aaaaaaaaaa aaaaaaaaa
//
