LOCUS       NM_001106286            3083 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus lymphatic vessel endothelial hyaluronan receptor
            1 (Lyve1), mRNA.
ACCESSION   NM_001106286 XM_001077796 XM_219001
VERSION     NM_001106286.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3083)
  AUTHORS   Mondalek,F.G., Fung,K.M., Yang,Q., Wu,W., Lu,W., Palmer,B.W.,
            Frimberger,D.C., Greenwood-Van Meerveld,B., Hurst,R.E., Kropp,B.P.
            and Lin,H.K.
  TITLE     Temporal expression of hyaluronic acid and hyaluronic acid
            receptors in a porcine small intestinal submucosa-augmented rat
            bladder regeneration model
  JOURNAL   World J Urol 33 (8), 1119-1128 (2015)
   PUBMED   25253654
  REMARK    GeneRIF: Expression of Lyve1 followed the same temporal pattern as
            hyaluronic acid deposition in a bladder regeneration model.
REFERENCE   2  (bases 1 to 3083)
  AUTHORS   Han,D.H., Song,H.K., Lee,S.Y., Song,J.H., Piao,S.G., Yoon,H.E.,
            Ghee,J.Y., Yoon,H.J., Kim,J. and Yang,C.W.
  TITLE     Upregulation of hyaluronan and its binding receptors in an
            experimental model of chronic cyclosporine nephropathy
  JOURNAL   Nephrology (Carlton) 15 (2), 216-224 (2010)
   PUBMED   20470282
  REMARK    GeneRIF: Upregulation of hyaluronan and its binding receptors CD44
            and LYVE-1 are involved in interstitial fibrosis in chronic
            cyclosporine-induced renal injury.
REFERENCE   3  (bases 1 to 3083)
  AUTHORS   Berggreen,E., Haug,S.R., Mkonyi,L.E. and Bletsa,A.
  TITLE     Characterization of the dental lymphatic system and identification
            of cells immunopositive to specific lymphatic markers
  JOURNAL   Eur J Oral Sci 117 (1), 34-42 (2009)
   PUBMED   19196316
  REMARK    GeneRIF: Immunostaining for the specific lymphatic markers LYVE-1
            revealed an extensive lymphatic vessel system in dental tissues.
            Unexpected cell staining for the above lymphatic markers was found
            in the pulp of both molars and incisors in rats.
REFERENCE   4  (bases 1 to 3083)
  AUTHORS   Sato,I., Imura,K., Miwa,Y., Miyado,M. and Sunohara,M.
  TITLE     Distribution of LYVE-1 and CD31 in postnatal rat masseter muscle
  JOURNAL   Ann Anat 190 (4), 329-338 (2008)
   PUBMED   18599277
  REMARK    GeneRIF: Different levels of protein for LYVE-1-positive cells may
            reflect alterations in the functional properties of the blood
            supply.
REFERENCE   5  (bases 1 to 3083)
  AUTHORS   Takayanagi,S., Hiroyama,T., Yamazaki,S., Nakajima,T., Morita,Y.,
            Usui,J., Eto,K., Motohashi,T., Shiomi,K., Keino-Masu,K., Masu,M.,
            Oike,Y., Mori,S., Yoshida,N., Iwama,A. and Nakauchi,H.
  TITLE     Genetic marking of hematopoietic stem and endothelial cells:
            identification of the Tmtsp gene encoding a novel cell surface
            protein with the thrombospondin-1 domain
  JOURNAL   Blood 107 (11), 4317-4325 (2006)
   PUBMED   16455951
REFERENCE   6  (bases 1 to 3083)
  AUTHORS   Prevo,R., Banerji,S., Ferguson,D.J., Clasper,S. and Jackson,D.G.
  TITLE     Mouse LYVE-1 is an endocytic receptor for hyaluronan in lymphatic
            endothelium
  JOURNAL   J Biol Chem 276 (22), 19420-19430 (2001)
   PUBMED   11278811
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473956.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_219001.4, XM_001077796.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN16676810,
                              SAMN16676811 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3083
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q33"
     gene            1..3083
                     /gene="Lyve1"
                     /gene_synonym="Xlkd1"
                     /note="lymphatic vessel endothelial hyaluronan receptor 1"
                     /db_xref="GeneID:293186"
                     /db_xref="RGD:1310864"
     exon            1..444
                     /gene="Lyve1"
                     /gene_synonym="Xlkd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             273..1304
                     /gene="Lyve1"
                     /gene_synonym="Xlkd1"
                     /note="extracellular link domain-containing 1; extra
                     cellular link domain-containing 1"
                     /codon_start=1
                     /product="lymphatic vessel endothelial hyaluronic acid
                     receptor 1"
                     /protein_id="NP_001099756.1"
                     /db_xref="GeneID:293186"
                     /db_xref="RGD:1310864"
                     /translation="MRNVFPELSILRGDCIVSLAAAVLWGVCAMLQHCSLVLLLASLW
                     TTRHPVHGTVQVQDLSISPCRIMGVALVGRNADPQMNFTEAKEVCKVLGLTLASRNQV
                     ESAQKSGFETCSYGWVGERFSVIPRISPNPKCGKNGKGVLIWNASPSQKFRVYCHNSS
                     DTWANSCFPEITTTFNTQTPAAEFSVSSDTYSASSSDSTTSASATTRAPPLTTMARKT
                     KMICITEVYTEPITMDAETEASVESGAAFKNEAAGFGGVPTTLLVLALFFFGAAAVLG
                     VCYVKRYVKAFPFTNKNQQKEMIETKVVKEEKADDVNANEESKKMVKNSEEPKSPPKT
                     TVRCLEAEV"
     exon            445..613
                     /gene="Lyve1"
                     /gene_synonym="Xlkd1"
                     /inference="alignment:Splign:2.1.0"
     exon            614..753
                     /gene="Lyve1"
                     /gene_synonym="Xlkd1"
                     /inference="alignment:Splign:2.1.0"
     exon            754..1038
                     /gene="Lyve1"
                     /gene_synonym="Xlkd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1117
                     /gene="Lyve1"
                     /gene_synonym="Xlkd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..3083
                     /gene="Lyve1"
                     /gene_synonym="Xlkd1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagagaccgt cccgggagta tatgaatgaa tgggcttcgc aaagcatcac acgggagagt
       61 gtgggaaccg agctcgcagg gggatgtagg aactggggaa atctgcagca gctgacacag
      121 tgctatctgc tttcctcact tatgtgtgct ttctgagtca gcattagcta aatgttccag
      181 aaagccatcc acaaagtaca gcctgggcgt tcgagggatg ccactcattt cctccagtgg
      241 ttttgacaaa tcagaagctt gaaagcgggg aaatgcgcaa cgtatttcca gagctctcca
      301 tcctgcgtgg tgactgcatt gtctccctgg ccgctgcagt gctctggggg gtctgcgcga
      361 tgctccagca ctgcagcctg gtgttactcc tcgcctctct ttggaccacg aggcacccag
      421 tccatggcac cgtccaagtg caagaccttt ccatttctcc atgcagaatc atgggcgtcg
      481 ccctcgtggg cagaaatgca gacccacaga tgaacttcac agaagccaag gaggtctgta
      541 aggttctggg actgactctg gccagcagga accaggtgga atccgcgcag aagtctggct
      601 tcgagacttg cagctatgga tgggttggag aacggttctc agtcatccct cggatctccc
      661 caaatcccaa gtgtgggaag aatggcaaag gtgtcctgat ttggaacgct tcccccagcc
      721 aaaagttcag agtctattgc cacaactcat ctgacacctg ggccaactcc tgctttccag
      781 aaatcactac cacattcaac actcaaaccc ctgcagcaga gttttctgtc agcagcgaca
      841 cctactcggc ttcatcctca gactccacaa cgtctgcgtc tgccaccacc cgggctccac
      901 ctttgaccac catggcacgg aagacaaaaa tgatttgtat cacggaagtt tacacagaac
      961 ctatcaccat ggatgcagaa acagaagcat ctgttgaaag tggagcagca ttcaagaatg
     1021 aagcagctgg gtttggaggt gtccccacaa ccctgctggt gctggctctc ttcttctttg
     1081 gtgctgcagc tgtgctgggt gtttgctacg tgaaaaggta tgtgaaggcc ttccctttca
     1141 caaacaagaa tcaacagaag gaaatgatcg aaaccaaggt tgtaaaggaa gagaaagctg
     1201 atgatgtcaa tgctaatgaa gaatcaaaga aaatggttaa aaactcagag gagcccaaga
     1261 gtccacccaa aactacagtg cggtgcctag aggctgaagt ttaggtgcac gagagtggag
     1321 gaggtacacc cgaggcaagt ttcatgccca aaccaaagaa gcaagccact gttggctcct
     1381 aatgagaaaa ggactgcaga cttcaccaga aggagccctt tccttactgc agtcctcccc
     1441 agactctacc ctctggcctc caaccttccc acagccttgc tagcccgtct gcgcctcatg
     1501 gcagaccaga gagtagagga agctttcgaa gcaccaggcc ctacaacagc tcctcaactc
     1561 acactcagag acaggtatcc aggctgcctg atcccagatg agggacagag tccatgagac
     1621 atggccagcc ccatagtcca aaaccttccc acagggaaac acacctcctg gccaggctct
     1681 ttggaaccag gcacatgtaa aataagcaag ggaaaacaac agaaggtcat agaaagcttg
     1741 gtgactgaga cctaatctct gggaagccaa aataaacaga gcacaagatg ggagctgggg
     1801 cccagatagc agccttgttg gcagagacta taaaatacag gcggggtcgg gaagcctctc
     1861 agttaattga tctgaatcac ttcttaggac atagacacac tttcttttct cttcattgtt
     1921 gccgatgttc tctagagata aacacgcttt tataagaaac ctaaaaacga gagaggccag
     1981 gagctgctgg ctcagtggta aagcacttgc ctggcgtgta caaacaaggc ttctagtcca
     2041 atccccagaa tccatccaac cctgcataca cacaaaggaa cgaacaaaaa catgaatttc
     2101 cattttcact tgaattacag gacccattgc tggcaaaaca actatgttaa aaggttaaga
     2161 gaaagaaaga gagaaagaaa gagagaaaga aagaaagaaa gaaagaaaga aaggaaggaa
     2221 ggaagaaaga aagaaagaaa gaaagaaaga aagaaagaaa ggaaaaaaaa aacaaagaaa
     2281 agcacacccc ccccccaaat gctgtcagct aatctactac aagctgagaa ctctttacct
     2341 gaaatgcttg gtaccaacag tgttgcaaat ttcagattat gtttgaagtc tggaatactt
     2401 gcacatacat aatgatatat tagagggcct cagtctaaat atgaacttta cttccctttc
     2461 atgcatacct tagacattta gcctggcggt cttttcagac aaaattgtaa aaataacttt
     2521 ccacatgaga taaagtttca tggtgtggca tttccccccg gaggtatcat gctgacacac
     2581 agacagctca gacttggtaa aagtttactt aaagccgtga ggtgctgtgt aaggcatgac
     2641 attccatagc tgacattact caacgcacac ttacgtatag tggagtgtgg gctgaagtta
     2701 atattttttc cagctttgat aacactagct tatctatttt cagactagtt tttgttgctg
     2761 agactaaccc attcattttc tctaatacag caacgactac aaccttaatt tattgccagt
     2821 gtatttgaaa gtgtagtatt gcctctatgt accaacatag acacttcgtg tccctttaac
     2881 aaatgcatta ccaagctctt atgttttcta tcaagaagaa tcttagagga gaagaaatgt
     2941 ttgtgtcccc aacaaataaa gcatttagaa attcctttgc tcctttattt ccatagaaac
     3001 agtatttgtg caaaagttaa gggatacatc ataatcttta cttagcaaaa gtaaaatgga
     3061 cacagaaata catatatcac cct
//
