LOCUS       NM_001398552            1292 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus lysosomal enzyme trafficking factor (Lyset),
            transcript variant 1, mRNA.
ACCESSION   NM_001398552 XM_002729747
VERSION     NM_001398552.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1292)
  AUTHORS   Zhang,W., Yang,X., Li,Y., Yu,L., Zhang,B., Zhang,J., Cho,W.J.,
            Venkatarangan,V., Chen,L., Burugula,B.B., Bui,S., Wang,Y., Duan,C.,
            Kitzman,J.O. and Li,M.
  TITLE     GCAF(TMEM251) regulates lysosome biogenesis by activating the
            mannose-6-phosphate pathway
  JOURNAL   Nat Commun 13 (1), 5351 (2022)
   PUBMED   36096887
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Dec 20, 2021 this sequence version replaced XM_002729747.6.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ228859.1, FQ133964.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-424               JAXUCZ010000006.1  127649463-127649886
            425-1292            JAXUCZ010000006.1  127650276-127651143
FEATURES             Location/Qualifiers
     source          1..1292
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..1292
                     /gene="Lyset"
                     /gene_synonym="RGD1566396; Tmem251"
                     /note="lysosomal enzyme trafficking factor"
                     /db_xref="GeneID:100360358"
                     /db_xref="RGD:1566396"
     exon            1..424
                     /gene="Lyset"
                     /gene_synonym="RGD1566396; Tmem251"
                     /inference="alignment:Splign:2.1.0"
     CDS             345..836
                     /gene="Lyset"
                     /gene_synonym="RGD1566396; Tmem251"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transmembrane protein 251"
                     /codon_start=1
                     /product="lysosomal enzyme trafficking factor isoform 1"
                     /protein_id="NP_001385481.1"
                     /db_xref="GeneID:100360358"
                     /db_xref="RGD:1566396"
                     /translation="MPKAPDYSELSDSCTLAGGTARFSGPLHRAWRMMNFRQRMGWIG
                     VGLYLLASAAAFYYVFEINETYNRLALEHIQQHPEEPREGTTWTHSLKARLLSLPFWL
                     WTVIFLIPYLQMFLFLYSCTRADPKTVGYCIIPICLAIICNRHQAFVKASNQISRLQL
                     IDT"
     exon            425..1292
                     /gene="Lyset"
                     /gene_synonym="RGD1566396; Tmem251"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actcaggaca ggaaggtgag acccgggttg ctcagcttgg ctgtcaggct ggcccggcgt
       61 ttagccggga gccgagctcc gggctctgca ggccaggcct ggcaccactg cccagcccag
      121 gcacggcggc gggagctgtg gggggcgggc ccggaggtcc cgtggccagg catctccagg
      181 tggtttcccc tgcctggaga tccagagggc gaccgggccc gccgccgcgt gactagccgg
      241 agtcacgctg agcttaatca ctactagctc gtgctcccgc cggccgcgct caccttcttc
      301 ttctgcgcga ccgagagggt ttctcttaag tggcttgttc tgaaatgcca aaggcacctg
      361 actattcaga actgagtgac tcttgcacgc ttgcaggggg aacagcaaga ttttcgggac
      421 cactgcacag agcatggaga atgatgaact tccgtcagcg gatgggatgg attggagtgg
      481 gattgtattt gctagcaagt gcagcagcgt tttattatgt ttttgaaatc aatgagactt
      541 acaacaggtt ggctttggaa cacattcagc agcaccctga ggagccaagg gaaggaacca
      601 catggacaca ctccttgaaa gctcggttac tttccctgcc cttctggttg tggacagtta
      661 ttttcttgat accgtactta cagatgtttt tgttccttta ttcttgtacg agagcggatc
      721 ctaaaacggt gggctactgt attattccca tatgcttggc aattatctgc aatcgccacc
      781 aggcatttgt caaggcttct aatcagatca gcagactcca actgattgac acgtaaaacg
      841 agtcaccggt ttctcttatt acaagactgt cagtgctgtt tagtggctga cctaagactg
      901 cagtttcttc acaggtctcg tctcaggaag ttgtggtgga acagagactt taaaaaaaaa
      961 aggggggggg ggacaagagg actgactact ttatccgaat aatgactttt taggtaaagc
     1021 ctgaaacata gtactacaga atcatgttga tgacttcaga ttttggaagt aaaatagtgg
     1081 cttgtaattt gcagtcttta gaaacttgaa taagcacctg aattttttta atttctattc
     1141 tatgtgcaac atagtatgat tcagaaattt ttccgttggg gaaaacaatg aatatttcca
     1201 ttgtgttaaa tgtaaaaagg tctgaccatg atcataaaat ttaaatttta tacaattact
     1261 gtgcttgctt taaagctctt cagactaaga ta
//
