LOCUS       NM_013006               2355 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus lysophospholipase 1 (Lypla1), mRNA.
ACCESSION   NM_013006
VERSION     NM_013006.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2355)
  AUTHORS   Yokoi,N., Fukata,Y., Sekiya,A., Murakami,T., Kobayashi,K. and
            Fukata,M.
  TITLE     Identification of PSD-95 Depalmitoylating Enzymes
  JOURNAL   J Neurosci 36 (24), 6431-6444 (2016)
   PUBMED   27307232
REFERENCE   2  (bases 1 to 2355)
  AUTHORS   Koyama,K., Ogura,Y., Nakai,D., Watanabe,M., Munemasa,T., Oofune,Y.,
            Kubota,K., Shinagawa,A. and Izumi,T.
  TITLE     Identification of bioactivating enzymes involved in the hydrolysis
            of laninamivir octanoate, a long-acting neuraminidase inhibitor, in
            human pulmonary tissue
  JOURNAL   Drug Metab Dispos 42 (6), 1031-1038 (2014)
   PUBMED   24682756
REFERENCE   3  (bases 1 to 2355)
  AUTHORS   Tian,L., McClafferty,H., Knaus,H.G., Ruth,P. and Shipston,M.J.
  TITLE     Distinct acyl protein transferases and thioesterases control
            surface expression of calcium-activated potassium channels
  JOURNAL   J Biol Chem 287 (18), 14718-14725 (2012)
   PUBMED   22399288
REFERENCE   4  (bases 1 to 2355)
  AUTHORS   Bolen,A.L., Naren,A.P., Yarlagadda,S., Beranova-Giorgianni,S.,
            Chen,L., Norman,D., Baker,D.L., Rowland,M.M., Best,M.D., Sano,T.,
            Tsukahara,T., Liliom,K., Igarashi,Y. and Tigyi,G.
  TITLE     The phospholipase A1 activity of lysophospholipase A-I links
            platelet activation to LPA production during blood coagulation
  JOURNAL   J Lipid Res 52 (5), 958-970 (2011)
   PUBMED   21393252
REFERENCE   5  (bases 1 to 2355)
  AUTHORS   Dekker,F.J., Rocks,O., Vartak,N., Menninger,S., Hedberg,C.,
            Balamurugan,R., Wetzel,S., Renner,S., Gerauer,M., Scholermann,B.,
            Rusch,M., Kramer,J.W., Rauh,D., Coates,G.W., Brunsveld,L.,
            Bastiaens,P.I. and Waldmann,H.
  TITLE     Small-molecule inhibition of APT1 affects Ras localization and
            signaling
  JOURNAL   Nat Chem Biol 6 (6), 449-456 (2010)
   PUBMED   20418879
REFERENCE   6  (bases 1 to 2355)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   7  (bases 1 to 2355)
  AUTHORS   Ottolenghi,A. and Rowland,J.T.
  TITLE     Phospholipase and lysophospholipase activity of rat eosinophil
            leukocytes
  JOURNAL   Arch Biochem Biophys 406 (2), 190-202 (2002)
   PUBMED   12361707
  REMARK    GeneRIF: activity in eosinophil leukocytes
REFERENCE   8  (bases 1 to 2355)
  AUTHORS   Portilla,D., Crew,M.D., Grant,D., Serrero,G., Bates,L.M., Dai,G.,
            Sasner,M., Cheng,J. and Buonanno,A.
  TITLE     cDNA cloning and expression of a novel family of enzymes with
            calcium-independent phospholipase A2 and lysophospholipase
            activities
  JOURNAL   J Am Soc Nephrol 9 (7), 1178-1186 (1998)
   PUBMED   9644627
REFERENCE   9  (bases 1 to 2355)
  AUTHORS   Duncan,J.A. and Gilman,A.G.
  TITLE     A cytoplasmic acyl-protein thioesterase that removes palmitate from
            G protein alpha subunits and p21(RAS)
  JOURNAL   J Biol Chem 273 (25), 15830-15837 (1998)
   PUBMED   9624183
REFERENCE   10 (bases 1 to 2355)
  AUTHORS   Sugimoto,H., Hayashi,H. and Yamashita,S.
  TITLE     Purification, cDNA cloning, and regulation of lysophospholipase
            from rat liver
  JOURNAL   J Biol Chem 271 (13), 7705-7711 (1996)
   PUBMED   8631810
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            [WARNING] On Apr 23, 2024 this sequence was replaced by
            NM_013006.3.
            
            On Nov 26, 2020 this sequence version replaced NM_013006.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D63885.1, BC085750.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-140               JAXUCZ010000005.1  19506352-19506491   c
            141-172             JAXUCZ010000005.1  19505815-19505846   c
            173-238             JAXUCZ010000005.1  19491034-19491099   c
            239-286             JAXUCZ010000005.1  19489690-19489737   c
            287-357             JAXUCZ010000005.1  19488189-19488259   c
            358-431             JAXUCZ010000005.1  19486308-19486381   c
            432-533             JAXUCZ010000005.1  19483760-19483861   c
            534-710             JAXUCZ010000005.1  19482672-19482848   c
            711-2355            JAXUCZ010000005.1  19477409-19479053   c
FEATURES             Location/Qualifiers
     source          1..2355
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q12"
     gene            1..2355
                     /gene="Lypla1"
                     /gene_synonym="25KDL; Pla1a"
                     /note="lysophospholipase 1"
                     /db_xref="GeneID:25514"
                     /db_xref="RGD:3025"
     exon            1..140
                     /gene="Lypla1"
                     /gene_synonym="25KDL; Pla1a"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..764
                     /gene="Lypla1"
                     /gene_synonym="25KDL; Pla1a"
                     /EC_number="3.1.2.22"
                     /note="APT-1; LPL-I; lysoPLA I; lysophospholipase I;
                     palmitoyl-protein hydrolase"
                     /codon_start=1
                     /product="acyl-protein thioesterase 1"
                     /protein_id="NP_037138.1"
                     /db_xref="GeneID:25514"
                     /db_xref="RGD:3025"
                     /translation="MCGNNMSAPMPAVVPAARKATAAVIFLHGLGDTGHGWAEAFAGI
                     KSSHIKYICPHAPVMPVTLNMSMMMPSWFDIIGLSPDSQEDESGIKQAAETVKALIDQ
                     EVKNGIPSNRIILGGFSQGGALSLYTALTTQQKLAGVTALSCWLPLRASFSQGPINSA
                     NRDISVLQCHGDCDPLVPLMFGSLTVERLKGLVNPANVTFKVYEGMMHSSCQQEMMDV
                     KYFIDKLLPPID"
     exon            141..172
                     /gene="Lypla1"
                     /gene_synonym="25KDL; Pla1a"
                     /inference="alignment:Splign:2.1.0"
     exon            173..238
                     /gene="Lypla1"
                     /gene_synonym="25KDL; Pla1a"
                     /inference="alignment:Splign:2.1.0"
     exon            239..286
                     /gene="Lypla1"
                     /gene_synonym="25KDL; Pla1a"
                     /inference="alignment:Splign:2.1.0"
     exon            287..357
                     /gene="Lypla1"
                     /gene_synonym="25KDL; Pla1a"
                     /inference="alignment:Splign:2.1.0"
     exon            358..431
                     /gene="Lypla1"
                     /gene_synonym="25KDL; Pla1a"
                     /inference="alignment:Splign:2.1.0"
     exon            432..533
                     /gene="Lypla1"
                     /gene_synonym="25KDL; Pla1a"
                     /inference="alignment:Splign:2.1.0"
     exon            534..710
                     /gene="Lypla1"
                     /gene_synonym="25KDL; Pla1a"
                     /inference="alignment:Splign:2.1.0"
     exon            711..2355
                     /gene="Lypla1"
                     /gene_synonym="25KDL; Pla1a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcgcacgcc cttcggctgc cgggagcccg agctcccttc cgcttccgac gcgctgtccg
       61 ccagccggtg gatgtgcggc aacaacatgt ccgccccgat gcccgccgtt gtgcccgccg
      121 cccggaaggc caccgccgcg gttattttcc ttcacggatt gggagatact gggcacggat
      181 gggcagaagc cttcgcaggt atcaaaagtt cccacatcaa atacatctgt ccacatgcgc
      241 ctgttatgcc agtcacacta aacatgagta tgatgatgcc ttcttggttt gatattattg
      301 gactttcacc agattcccag gaggatgaat ctggaattaa gcaggcggca gaaactgtaa
      361 aagccttgat agatcaagaa gtgaagaatg gcattccttc taacagaatt attttgggag
      421 gattttctca gggaggcgcc ttatctttat acactgctct caccacacag cagaaactgg
      481 ctggtgtcac tgcactcagt tgctggcttc cacttcgggc ttcgttttca caggggccta
      541 tcaatagtgc taatcgagat atttctgttc tccagtgtca tggagactgt gaccctttag
      601 ttcccctaat gtttggttct cttactgttg aaagactaaa aggattggta aatccagcca
      661 atgtaacctt caaagtctat gaaggcatga tgcacagctc atgtcagcag gaaatgatgg
      721 atgtcaagta cttcattgat aagctcctac ctccaattga ttgatgtcac taagaggcct
      781 tgagtagacg ttcaccagca tcacagtagt ggagtataaa cctttcccca tgactgatca
      841 taaaactgct aatgtttgca gtgttaaaat gttttgcaaa tacataccaa tgagacagac
      901 taaatgatgt ctccctcatg ggaaatgtat gatcctttta cgtttctatg catatatttg
      961 tataatacaa ttcagaatat actagtatta cagtaggtaa gtgaagcaac tagcttcttt
     1021 gtctcaaatt aattcagcaa aataagataa cacaagcaga gttttattac atcatttcaa
     1081 ttactagtat gctctctgaa agtttgttca ggtctaaaca agctgttaag atgtaagtga
     1141 cttcttaatt ctgtgagtta gactatagtt ttactccaca agtgttgagt catcacgcag
     1201 tgtctgtgtt tctgtttgta ttcacacata cgtgactggg atacctaaga tggtattaca
     1261 tcatccctga ccatagggat cgtgctctta agtgtcaaaa gtaatactgc tctctgcaat
     1321 taatcgccct gctactgggg gaccaggctt ccccccttcg atgtaacttt tctcctttca
     1381 agaagaaaaa ggtagattct tttttggttt ccatagaaaa gtaatattgc ctccctgtca
     1441 taaagaaata tctgtcatta tatattattt tgacattctg aaacacagac atacagtatt
     1501 tccaatatag gtaatatgaa aagaaaccac acattactta agcgtacata tttcaaataa
     1561 caatcttcag accagaatct tcagtgctgg tcattaattc tgtggtttta tttttctata
     1621 aaaacttaaa gggtaaataa tatcttggcg tgtttagaaa tacttgtgac tggttttaga
     1681 atataatttc ttaaacatag cagagtttaa gtttacattt tctgtacatg ttatgcttaa
     1741 aaccaaatac tgttcaagat gagcagtcaa acttgtttta ttttcatctg ggtaacatgc
     1801 taatttgaaa ttttcatctt cagtaaagga gcttttgata atcagtctcc tgtgcaaata
     1861 ttaaaataac aatcatttga ttttaaatca tcaacatgtt caaaatactg ctgaaaatta
     1921 tttaatttat ggataataag gactggttag aacccacata tataaaccca tatttataac
     1981 tgtttccaca cagttgagta tgttacaaaa attatggtta tttctgaacg gtttcttttc
     2041 ctgctgtttt tcaaccgacc aagaagaagg aagcatcttt gtaagcagga gctaactgat
     2101 gtggggtcat ttggtgtgtc cgagatagag tgttaacaat gaagccgatt gtttatgtct
     2161 agatttaaaa caatttcaaa caatcattta ctattttgct ttactttgaa gagcatacat
     2221 ttacttcagt tattgtatct gtaaaaattt atttggggta agaaatattc tgttgaattt
     2281 gtgtgctgta atgtgggaaa atgtcatgtt tttcacagtt tctatcaatg tgaaataaaa
     2341 tttaattttg gcttt
//
