LOCUS       NM_021759               1637 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus Ly6/Plaur domain containing 3 (Lypd3), mRNA.
ACCESSION   NM_021759
VERSION     NM_021759.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1637)
  AUTHORS   Ngora,H., Galli,U.M., Miyazaki,K. and Zoller,M.
  TITLE     Membrane-bound and exosomal metastasis-associated C4.4A promotes
            migration by associating with the alpha(6)beta(4) integrin and
            MT1-MMP
  JOURNAL   Neoplasia 14 (2), 95-107 (2012)
   PUBMED   22431918
  REMARK    GeneRIF: the first explanation for the C4.4A contribution to wound
            healing and metastasis.
REFERENCE   2  (bases 1 to 1637)
  AUTHORS   Kriegbaum,M.C., Jacobsen,B., Hald,A. and Ploug,M.
  TITLE     Expression of C4.4A, a structural uPAR homolog, reflects squamous
            epithelial differentiation in the adult mouse and during
            embryogenesis
  JOURNAL   J Histochem Cytochem 59 (2), 188-201 (2011)
   PUBMED   21339181
  REMARK    GeneRIF: a possible functional role of C4.4A in early
            differentiation of stratified squamous epithelia
REFERENCE   3  (bases 1 to 1637)
  AUTHORS   Palmer,D.J., Kelly,V.C., Smit,A.M., Kuy,S., Knight,C.G. and
            Cooper,G.J.
  TITLE     Human colostrum: identification of minor proteins in the aqueous
            phase by proteomics
  JOURNAL   Proteomics 6 (7), 2208-2216 (2006)
   PUBMED   16502470
REFERENCE   4  (bases 1 to 1637)
  AUTHORS   Paret,C., Bourouba,M., Beer,A., Miyazaki,K., Schnolzer,M.,
            Fiedler,S. and Zoller,M.
  TITLE     Ly6 family member C4.4A binds laminins 1 and 5, associates with
            galectin-3 and supports cell migration
  JOURNAL   Int J Cancer 115 (5), 724-733 (2005)
   PUBMED   15729693
REFERENCE   5  (bases 1 to 1637)
  AUTHORS   Wurfel,J., Seiter,S., Stassar,M., Claas,A., Klas,R., Rosel,M.,
            Marhaba,R., Savelyeva,L., Schwab,M., Matzku,S. and Zoller,M.
  TITLE     Cloning of the human homologue of the metastasis-associated rat
            C4.4A
  JOURNAL   Gene 262 (1-2), 35-41 (2001)
   PUBMED   11179665
REFERENCE   6  (bases 1 to 1637)
  AUTHORS   Rosel,M., Claas,C., Seiter,S., Herlevsen,M. and Zoller,M.
  TITLE     Cloning and functional characterization of a new
            phosphatidyl-inositol anchored molecule of a metastasizing rat
            pancreatic tumor
  JOURNAL   Oncogene 17 (15), 1989-2002 (1998)
   PUBMED   9788443
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AJ001043.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ001043.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132302, SAMN16676810
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1637
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BDIX"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1637
                     /gene="Lypd3"
                     /gene_synonym="C4.4a"
                     /note="Ly6/Plaur domain containing 3"
                     /db_xref="GeneID:60378"
                     /db_xref="RGD:69053"
     exon            1..165
                     /gene="Lypd3"
                     /gene_synonym="C4.4a"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..1139
                     /gene="Lypd3"
                     /gene_synonym="C4.4a"
                     /note="ly6/PLAUR domain-containing protein 3; GPI-anchored
                     metastasis-associated protein C4.4A; metastasis-associated
                     GPI-anchored protein; metastasis-associated molecule;
                     GPI-anchored metastasis-associated protein homolog"
                     /codon_start=1
                     /product="ly6/PLAUR domain-containing protein 3 precursor"
                     /protein_id="NP_068527.1"
                     /db_xref="GeneID:60378"
                     /db_xref="RGD:69053"
                     /translation="MDAARRGDTQPVMWTTRWLLLLPLLLCEGAQALECYSCVQKADD
                     GCSPHKMKTVKCGPGVDVCTEAVGAVESIHGQFSVAVRGCGSGIPGKNDRGLDLHGLL
                     AFIQLQQCTEDRCNAKLNLTLRGLNPAGNESAYEHNGAECYSCMGLSREKCQGAMPPV
                     VNCYNASGRVYKGCFDGNVTLTAANVTVSLPVRGCVQDEACTRDGVTGPGFTLSGSCC
                     QGPRCNSDLRNKTYFSPRIPPLVLLPPPTTPAPSTRTQNSSSTTSTTAPTTATTTIKP
                     TTVQASHTSSTHETEHEVIQEEGSHLSGGATGHQDRSNMGKFPEKGGAQIPSKGGSDA
                     LGSWLSAILLTVVAGAML"
     exon            166..297
                     /gene="Lypd3"
                     /gene_synonym="C4.4a"
                     /inference="alignment:Splign:2.1.0"
     exon            298..468
                     /gene="Lypd3"
                     /gene_synonym="C4.4a"
                     /inference="alignment:Splign:2.1.0"
     exon            469..630
                     /gene="Lypd3"
                     /gene_synonym="C4.4a"
                     /inference="alignment:Splign:2.1.0"
     exon            631..1637
                     /gene="Lypd3"
                     /gene_synonym="C4.4a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcatctaag gctcaggtaa gagggcccgg gttggaaggt ggcacaccca ggggggactc
       61 ggagagagca ggacacagct atggatgctg ccaggagagg agatacacag ccagtgatgt
      121 ggaccaccag atggctgctg ctgctaccgc tactgctgtg tgaaggagcg caagccctgg
      181 agtgctacag ctgcgtgcaa aaggcggatg atggatgctc tccgcacaag atgaagacag
      241 tcaaatgtgg tcccggagtg gacgtctgta ccgaggccgt gggggcggtg gagagcatcc
      301 acgggcaatt ctctgtggca gtgcggggct gcggttccgg aatcccgggc aagaacgacc
      361 gcggactgga ccttcacggg ctcctggcct tcattcagct acagcagtgc accgaggacc
      421 gatgcaacgc caaactcaac ctcactttgc gaggcctcaa ccctgcaggc aatgagagtg
      481 cgtatgagca caacggcgca gagtgctaca gctgtatggg gctgagccgc gagaagtgcc
      541 agggcgctat gccgcctgtc gtgaattgct acaatgccag cggccgtgtc tacaagggct
      601 gcttcgatgg taacgtcacc ttgaccgcag ccaatgtgac cgtgtcctta cctgtccgag
      661 gctgcgtcca ggacgaagcc tgcacccggg atggggtgac gggtccagga ttcacactca
      721 gcggttcctg ctgtcaaggg ccccgctgta actctgacct tcgcaacaag acctatttct
      781 cccctcgaat cccaccccta gtcctgctgc cccctccaac caccccagcc ccatccactc
      841 ggacccagaa ctcctccagc acaacctcta caacagctcc aaccacggcc accactacca
      901 tcaagcccac cacagtccaa gccagtcata cttcttcaac ccatgaaaca gagcacgagg
      961 tcatacagga agaggggtcg catttgagtg gaggtgctac gggccaccaa gaccgcagca
     1021 atatggggaa gtttccagaa aaaggtggag cccaaatccc atctaaagga ggctctgacg
     1081 ctctggggtc ctggttgtca gcaattctgt tgactgtggt tgctggcgcg atgctgtgaa
     1141 cgtctcctgt cgcggtccat ctcaccttgt ttccctggcc ccgtggtacc aactccttcc
     1201 atttcccact tgactggact ggctccgccc ccatcctcca gcatccgcag ttccaactgc
     1261 actggtttgc agcttcggga aacagtctac tgttgtaaat actccgctgg ggtggcccta
     1321 ctttttggat gcggccacag cattccccct gacggtgacc aggacagaag gaagagaaat
     1381 ctacaggctg agagaggccc ggagagtcca cggcaaacct cctcttcccg ttttcctgac
     1441 caggctagaa gattacccgg caggtggaca atagattcat cctctgagcg ctgcgcttgc
     1501 ccggcatctg tgcaggaatc tggtcgcctg tcttccttag gagactgtga acaactccac
     1561 gacagggtct tgcctctggc ctctctatgt gttctgtctg gcacaagaaa gtgtcaataa
     1621 agatttagtt actttgt
//
