LOCUS       NM_001130546            4100 bp    mRNA    linear   ROD 10-APR-2024
DEFINITION  Rattus norvegicus Ly6/neurotoxin 1 (Lynx1), transcript variant 1,
            mRNA.
ACCESSION   NM_001130546 XM_001069286 XM_216965
VERSION     NM_001130546.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4100)
  AUTHORS   Thomsen,M.S., Arvaniti,M., Jensen,M.M., Shulepko,M.A.,
            Dolgikh,D.A., Pinborg,L.H., Hartig,W., Lyukmanova,E.N. and
            Mikkelsen,J.D.
  TITLE     Lynx1 and Abeta1-42 bind competitively to multiple nicotinic
            acetylcholine receptor subtypes
  JOURNAL   Neurobiol Aging 46, 13-21 (2016)
   PUBMED   27460145
  REMARK    GeneRIF: Lynx1 binds to multiple nAChR subtypes in the brain and
            that this interaction might have functional and pathophysiological
            implications in relation to Alzheimer's disease.
REFERENCE   2  (bases 1 to 4100)
  AUTHORS   Lyukmanova,E.N., Shulepko,M.A., Shenkarev,Z.O., Bychkov,M.L.,
            Paramonov,A.S., Chugunov,A.O., Kulbatskii,D.S., Arvaniti,M.,
            Dolejsi,E., Schaer,T., Arseniev,A.S., Efremov,R.G., Thomsen,M.S.,
            Dolezal,V., Bertrand,D., Dolgikh,D.A. and Kirpichnikov,M.P.
  TITLE     Secreted Isoform of Human Lynx1 (SLURP-2): Spatial Structure and
            Pharmacology of Interactions with Different Types of Acetylcholine
            Receptors
  JOURNAL   Sci Rep 6, 30698 (2016)
   PUBMED   27485575
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4100)
  AUTHORS   Lyukmanova,E.N., Shenkarev,Z.O., Shulepko,M.A., Mineev,K.S.,
            D'Hoedt,D., Kasheverov,I.E., Filkin,S.Y., Krivolapova,A.P.,
            Janickova,H., Dolezal,V., Dolgikh,D.A., Arseniev,A.S., Bertrand,D.,
            Tsetlin,V.I. and Kirpichnikov,M.P.
  TITLE     NMR structure and action on nicotinic acetylcholine receptors of
            water-soluble domain of human LYNX1
  JOURNAL   J Biol Chem 286 (12), 10618-10627 (2011)
   PUBMED   21252236
REFERENCE   4  (bases 1 to 4100)
  AUTHORS   Tekinay,A.B., Nong,Y., Miwa,J.M., Lieberam,I., Ibanez-Tallon,I.,
            Greengard,P. and Heintz,N.
  TITLE     A role for LYNX2 in anxiety-related behavior
  JOURNAL   Proc Natl Acad Sci U S A 106 (11), 4477-4482 (2009)
   PUBMED   19246390
REFERENCE   5  (bases 1 to 4100)
  AUTHORS   Arredondo,J., Chernyavsky,A.I., Jolkovsky,D.L., Webber,R.J. and
            Grando,S.A.
  TITLE     SLURP-2: A novel cholinergic signaling peptide in human
            mucocutaneous epithelium
  JOURNAL   J Cell Physiol 208 (1), 238-245 (2006)
   PUBMED   16575903
REFERENCE   6  (bases 1 to 4100)
  AUTHORS   Ibanez-Tallon,I., Miwa,J.M., Wang,H.L., Adams,N.C., Crabtree,G.W.,
            Sine,S.M. and Heintz,N.
  TITLE     Novel modulation of neuronal nicotinic acetylcholine receptors by
            association with the endogenous prototoxin lynx1
  JOURNAL   Neuron 33 (6), 893-903 (2002)
   PUBMED   11906696
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473950.2.
            
            On or before Jul 28, 2008 this sequence version replaced
            XM_001069286.1, XM_216965.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB717062.1, FM107114.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760433, SAMEA5760494
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..4100
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..4100
                     /gene="Lynx1"
                     /note="Ly6/neurotoxin 1"
                     /db_xref="GeneID:300018"
                     /db_xref="RGD:1312017"
     exon            1..122
                     /gene="Lynx1"
                     /inference="alignment:Splign:2.1.0"
     exon            123..400
                     /gene="Lynx1"
                     /inference="alignment:Splign:2.1.0"
     CDS             349..699
                     /gene="Lynx1"
                     /note="ly-6/neurotoxin-like protein 1"
                     /codon_start=1
                     /product="ly-6/neurotoxin-like protein 1 precursor"
                     /protein_id="NP_001124018.1"
                     /db_xref="GeneID:300018"
                     /db_xref="RGD:1312017"
                     /translation="MTHLLTVFLVALMGLPVAQALECHVCAYNGDNCFKPMRCPAMAT
                     YCMTTRTYFTPYRMKVRKSCVPSCFETVYDGYSKHASATSCCQYYLCNGAGFATPVTL
                     ALVPALLATFWSLL"
     exon            401..502
                     /gene="Lynx1"
                     /inference="alignment:Splign:2.1.0"
     exon            503..4100
                     /gene="Lynx1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgctgcgga tctgttgcgg tggcggagcc tactccacct gcctgcgatg cggtacaaac
       61 accgcacgaa gtgtgtacag attcactgtc agactgcggg agggacctgg gagcggccac
      121 gggtaactgg aaattagtga tacccactga gctgggaggc tcttgtgact gccccagccc
      181 agctgtcatc acaagtctct tatcatcgtc tatgcaaggc tgctttatca ctaggagacc
      241 aagagctcaa gcagggcctc tgtgtcctgc ttcttctctg acctgagttg gatccaggac
      301 cagctgctgt cctcctgttc cctccgacac tgtcctcaca gctccgtcat gacccacttg
      361 ctgacagtat tcctggtggc tctgatgggc ctgcctgtgg cccaggctct ggagtgccac
      421 gtatgtgcct acaatggaga caactgcttc aaacccatgc gatgccccgc catggccacc
      481 tactgtatga ccactcgaac ttacttcacc ccgtaccgga tgaaggtgag gaagtcctgt
      541 gttcccagct gctttgagac cgtgtacgat ggctactcca agcacgcatc tgccacctcc
      601 tgttgccagt actacctgtg caatggtgct ggctttgcta ccccagtgac cttggccctg
      661 gtcccggcac tcctagctac cttctggagc ttgctatgaa gagctttgtt ccccaaacca
      721 gaccccctca aacacaacac tctttaaaaa atacagttac cccctctcgc ccacttgctt
      781 cacccaaccc tcttccctct gagactcctc agccatgagg ttccgtggct gtctatgaaa
      841 ggactgatgc catccagata cctcactcca aggtcatttt cagaaggctg atgtatggac
      901 ctggaatgtg cccagtcatg ggtggggcag gctcggctcc tcctctaccc aggattagga
      961 gtatctggga gagtgatgtt tatgggggga gggatcattg cttaagtcaa ggaatactgg
     1021 tttaatagaa ttagtagcca aactccacct tcatagtgtc aggaccctgc ctcagtctac
     1081 ccagtagagg ataggtctcc tggaggtggg ggtgataatg aactggctag aagcagagaa
     1141 agactcagca gagctatctc ctaaatccag cagcttccca gggcaaacat gatgtggaag
     1201 ccatgtgagg aagcccttgt tgttcctact tatctgagga actctgccag acctgccctc
     1261 aggatagcca ttggccaagg gttgctagca acggcttcat ttccataggc cactgagatc
     1321 cctccagccc cagctcagcc agccctttga cctccactac agtccctcac tcacatactg
     1381 gctgctggga cttcaggctg gcagggacat gcgggcgggc gggtgaccca tgctatattt
     1441 tgtctggcct gcacactggc cagagctatt ctgggcatgg caggatggga tcagaggcag
     1501 tcagagcagg ttagtggggt aactgagaca gggacgcaga ctttagccag actacccagg
     1561 tcccgtagac agctcctatg tccttcagtc tcttggtaag ttattgggag acgagtgtac
     1621 agagagccag cccaatccct aggtgactgc ctgtgacatc tgtggtggct gaagactgct
     1681 gggtatcaag tctcaggaga acccagccca gatttaggag acacctttca tgccatgtag
     1741 ttgtctctga gagccttacc ctgctctcca actagtactc caactcatgt gccactgagg
     1801 aaccctgctg aagctggccc agcccagggg tcagaatgct ggccagtgtc catatagtgg
     1861 gattacctat ggtgagtcct agtggtcact atgtctcgaa tgttttttcc agacctccca
     1921 tggcagaagc tcagggacac agaggcccaa cctggggacc ttcctccctg ttctcggcag
     1981 acctgagctc tgtctgctgc tagagctgat gtgcttttct gcctcagttt cctcctcctc
     2041 tggggatagg ccactggagg atttgggagg gggagggcat tctgctgata ggcttgccta
     2101 gattcttagg cataggaact gtggggcttt attacatagg tgaattgggt gggaaatggc
     2161 ttggagctga ggagacattg actaccctaa gggaagacga gtctcaagga aggccaggaa
     2221 gggggagagt gaaatgcaca tgcacatgtg cacgcaggca gtggttacag atggctgtgg
     2281 tgtcccctga ggtctaggca ggatactggg atgaagccag tgctgcctgg acctgagctt
     2341 gcatggaaca cacacacacg cacgcacgca cgcacgcaca cacacacaca ccaagcagcc
     2401 agcattgggg ctgacctgtg gaagccacag gacactggca aggagggtca gaggcaggcc
     2461 cctgactcag tgggtgaggc ctgggaaaca ttatcctgtt accctgcttg tgcaagttca
     2521 ttatccccag ttaggtggca ccctcagcca aaactgggag gagcccgaga tcaggttccc
     2581 ccgcctacca caagggggtg atgtggtaga ggcttgatta tctgtggccc caaagcaaag
     2641 cgctgcggct gctgcagtgc tggggtcagc ttctttcacc tgcctctgga caccaaccag
     2701 ataggcccca cagtggccac actgccactc agccctgcag gaagctctgt gcctagctag
     2761 cctgtccttg gtgcttagca tagagcccca aaaggtgctc gattaataca gggccaagtc
     2821 tgccagtggg agatgcaggt taggggaaca gtaccagatg gcctgtcctg aatcctgtct
     2881 gggctgctgt gatgaacatc tgtctagctc actgcaggtg actctccaca ctccacagcg
     2941 gttctgcaaa agcatacggg gaggtcattc ctgcccccct ttgacaggta aagacactga
     3001 ggcacagaag agtgaggcac ttcgttctcc tcagccattc gtctttccag taccaaccca
     3061 ttcaactacg ggtgctcctc caacggctgg ggttctttga ggctgtgcac ccatgagatg
     3121 atagtgactt cataagccag agaatttcag agtgaagtgt tgtcagagcc tatgaacctg
     3181 aaactttaga tctggaggtc tgagtgattg aggggaaggc caggggtatc cagccctgaa
     3241 gatccagaga agtacaaagg aacatcagcc tttgtcaggg ctaatgctgt cagggacgag
     3301 ggctcaaggc cgttgagtgt tctcacactg tgataaacag tggcccctca acactggggt
     3361 gtccagggcg gctggcagca gttatctata gagctgccgt gtggaagtgt cttggtagtc
     3421 actggagaga ggctgctgga ccgcacagtg agacacacat ggagtgtgtg tacttccgtg
     3481 ggatttgatg aagccgggtc agcacatgaa gtcaaaacat acttcagggc agagagaggt
     3541 gtctggtctg gtccaccaga gagaagctgt ccagtgagag ccatgctctg ccaccgtctc
     3601 tgtgattggc ttccccaaaa gcagatgagg agaggagtgg tgccgagcac ccacgtcttc
     3661 atctcctgca gcaagcacat gagtcagcat tctgaaactc tagattttca ggagtagggt
     3721 agccctttgc tttggtgcgt ggttacttcc tggcaagcac catggcaccc tgtagcacgg
     3781 aacgacctgg gctcctcaag cccagactca ggttccagcc atctcatcgg tgaaatgaca
     3841 gtgacagtgc cctctctact ggctcttgga ggtcccttgc ctggggtctg cacagaggcg
     3901 gccccaaagg atgcatggat ctgtgatgtc ttgcacttcc cttggttgtg tctctgctaa
     3961 ccccaagctc tcacccagca aggacatgaa atccactttt atgccacatc tcccttctcc
     4021 cagccagctc catgtacctc tacttcagag tggccccgtc aatgtccatc cccctcggaa
     4081 tgaataaaca agtgaaggac
//
