LOCUS       NM_001024279             492 bp    mRNA    linear   ROD 04-JUN-2023
DEFINITION  Rattus norvegicus lymphocyte antigen 96 (Ly96), mRNA.
ACCESSION   NM_001024279 XM_003749879 XM_003753993 XM_006225164 XM_006237726
            XM_008763483
VERSION     NM_001024279.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Okechukwu CC, Pirro NT and Chappell MC.
  TITLE     Evidence that angiotensin II does not directly stimulate the
            MD2-TLR4 innate inflammatory pathway
  JOURNAL   Peptides 136, 170436 (2021)
   PUBMED   33181267
  REMARK    GeneRIF: Evidence that angiotensin II does not directly stimulate
            the MD2-TLR4 innate inflammatory pathway.
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Fang Q, Wang J, Zhang Y, Wang L, Li W, Han J, Huang W, Liang G and
            Wang Y.
  TITLE     Inhibition of myeloid differentiation factor-2 attenuates
            obesity-induced cardiomyopathy and fibrosis
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1864 (1), 252-262 (2018)
   PUBMED   28965884
  REMARK    GeneRIF: MD2 is essential to obesity-related cardiac hypertrophy
            through activating JNK/ERK and NF-kappaB-dependent cardiac
            inflammatory pathways. Targeting MD2 would be a therapeutic
            approach to prevent obesity-induced cardiac injury and remodeling.
REFERENCE   3  (bases 1 to 492)
  AUTHORS   Ren W, Wang Z, Hua F and Zhu L.
  TITLE     Plasminogen activator inhibitor-1 regulates LPS-induced TLR4/MD-2
            pathway activation and inflammation in alveolar macrophages
  JOURNAL   Inflammation 38 (1), 384-393 (2015)
   PUBMED   25342286
  REMARK    GeneRIF: Up-regulation of MD-2 in alveolar macrophages was
            attenuated after PAI-1 gene knockdown.
REFERENCE   4  (bases 1 to 492)
  AUTHORS   Tanimura N, Saitoh S, Ohto U, Akashi-Takamura S, Fujimoto Y, Fukase
            K, Shimizu T and Miyake K.
  TITLE     The attenuated inflammation of MPL is due to the lack of
            CD14-dependent tight dimerization of the TLR4/MD2 complex at the
            plasma membrane
  JOURNAL   Int Immunol 26 (6), 307-314 (2014)
   PUBMED   24380872
REFERENCE   5  (bases 1 to 492)
  AUTHORS   Wang X, Grace PM, Pham MN, Cheng K, Strand KA, Smith C, Li J,
            Watkins LR and Yin H.
  TITLE     Rifampin inhibits Toll-like receptor 4 signaling by targeting
            myeloid differentiation protein 2 and attenuates neuropathic pain
  JOURNAL   FASEB J 27 (7), 2713-2722 (2013)
   PUBMED   23568774
  REMARK    GeneRIF: Data show that rifampin binds to myeloid differentiation
            protein 2 (MD-2), the key coreceptor for innate immune TLR4.
REFERENCE   6  (bases 1 to 492)
  AUTHORS   Park BS, Song DH, Kim HM, Choi BS, Lee H and Lee JO.
  TITLE     The structural basis of lipopolysaccharide recognition by the
            TLR4-MD-2 complex
  JOURNAL   Nature 458 (7242), 1191-1195 (2009)
   PUBMED   19252480
REFERENCE   7  (bases 1 to 492)
  AUTHORS   Du XH, Yao YM, Li R, Shen CA and Yin HN.
  TITLE     [Influence of sexual difference on expression of Toll-like receptor
            4 and myeloid differential protein-2 mRNA in the lung in septic
            rats]
  JOURNAL   Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 17 (12), 726-728 (2005)
   PUBMED   16386178
  REMARK    GeneRIF: After LPS challenge, gene expressions of TLR4, MD-2 and
            TNF-alpha were significantly lower in females.
REFERENCE   8  (bases 1 to 492)
  AUTHORS   Schroder NW, Morath S, Alexander C, Hamann L, Hartung T, Zahringer
            U, Gobel UB, Weber JR and Schumann RR.
  TITLE     Lipoteichoic acid (LTA) of Streptococcus pneumoniae and
            Staphylococcus aureus activates immune cells via Toll-like receptor
            (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14,
            whereas TLR-4 and MD-2 are not involved
  JOURNAL   J Biol Chem 278 (18), 15587-15594 (2003)
   PUBMED   12594207
REFERENCE   9  (bases 1 to 492)
  AUTHORS   da Silva Correia J, Soldau K, Christen U, Tobias PS and Ulevitch
            RJ.
  TITLE     Lipopolysaccharide is in close proximity to each of the proteins in
            its membrane receptor complex. transfer from CD14 to TLR4 and MD-2
  JOURNAL   J Biol Chem 276 (24), 21129-21135 (2001)
   PUBMED   11274165
REFERENCE   10 (bases 1 to 492)
  AUTHORS   Ogata H, Su I, Miyake K, Nagai Y, Akashi S, Mecklenbrauker I,
            Rajewsky K, Kimoto M and Tarakhovsky A.
  TITLE     The toll-like receptor protein RP105 regulates lipopolysaccharide
            signaling in B cells
  JOURNAL   J Exp Med 192 (1), 23-29 (2000)
   PUBMED   10880523
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY963291.1.
            
            On or before Aug 24, 2014 this sequence version replaced
            XM_008763483.1, XM_006225164.2, XM_006237726.1, XM_003753993.1,
            XM_003749879.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY963291.1, FQ234779.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16093046, SAMN16676807
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q11"
     gene            1..492
                     /gene="Ly96"
                     /gene_synonym="MD-2; MD2"
                     /note="lymphocyte antigen 96"
                     /db_xref="GeneID:448830"
                     /db_xref="RGD:1302993"
     exon            1..121
                     /gene="Ly96"
                     /gene_synonym="MD-2; MD2"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..492
                     /gene="Ly96"
                     /gene_synonym="MD-2; MD2"
                     /note="LPS co-receptor MD-2"
                     /codon_start=1
                     /product="lymphocyte antigen 96 precursor"
                     /protein_id="NP_001019450.1"
                     /db_xref="GeneID:448830"
                     /db_xref="RGD:1302993"
                     /translation="MLPFFLFSTLLSPIFTESERQQWICNSSDAIISYSYCDHMKIPI
                     SISSEPCIRLKGTNGFVHVEFIPRGNLKNLYFNLFININSIELPKRKEIVCHGYDDDY
                     SFCRALKGEAVNTAIPFSFDGILFPKGHHRCVAEAIAGDTEEKLFCLNFTIIHHHNVN
                     "
     exon            122..211
                     /gene="Ly96"
                     /gene_synonym="MD-2; MD2"
                     /inference="alignment:Splign:2.1.0"
     exon            212..340
                     /gene="Ly96"
                     /gene_synonym="MD-2; MD2"
                     /inference="alignment:Splign:2.1.0"
     exon            341..393
                     /gene="Ly96"
                     /gene_synonym="MD-2; MD2"
                     /inference="alignment:Splign:2.1.0"
     exon            394..492
                     /gene="Ly96"
                     /gene_synonym="MD-2; MD2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tattaaatca tgttgccatt ttttctcttt tcgacgctgc tttctcccat atttactgaa
       61 tctgagaggc aacagtggat ctgcaactcc tccgatgcaa ttatttccta cagttactgt
      121 gatcacatga aaatccctat ttcaattagt tctgaaccct gtataagatt gaagggaacc
      181 aatggatttg tgcatgttga gttcattcca agaggaaact taaaaaattt atatttcaac
      241 ctgttcatca atatcaactc catagaattg ccgaagcgca aggaaattgt ttgccatgga
      301 tatgatgatg attattcttt ttgcagagct ctgaaagggg aggctgtcaa cacagcaata
      361 ccattttcct tcgacggaat actatttcct aagggccatc acagatgtgt tgcagaagcc
      421 attgctgggg atacagaaga aaagctgttt tgtttgaatt tcaccatcat tcaccaccat
      481 aatgttaatt ag
//
