LOCUS       NM_031655               1087 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus latexin (Lxn), mRNA.
ACCESSION   NM_031655
VERSION     NM_031655.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1087)
  AUTHORS   Martinez-Calleja,A., Cruz,R., Miranda-Sanchez,M.,
            Fragoso-Soriano,R., Vega-Lopez,M.A. and Kouri,J.B.
  TITLE     Latexin expression correlated with mineralization of articular
            cartilage during progression of post-traumatic osteoarthritis in a
            rat model
  JOURNAL   Histol Histopathol 35 (3), 269-278 (2020)
   PUBMED   31313823
  REMARK    GeneRIF: Latexin expression correlated with mineralization of
            articular cartilage during progression of post-traumatic
            osteoarthritis in a rat model.
REFERENCE   2  (bases 1 to 1087)
  AUTHORS   Kuhlein,H.N., Tegeder,I., Moser,C., Lim,H.Y., Haussler,A.,
            Spieth,K., Jennes,I., Marschalek,R., Beckhaus,T., Karas,M.,
            Fauth,M., Ehnert,C., Geisslinger,G. and Niederberger,E.
  TITLE     Nerve injury evoked loss of latexin expression in spinal cord
            neurons contributes to the development of neuropathic pain
  JOURNAL   PLoS One 6 (4), e19270 (2011)
   PUBMED   21572518
  REMARK    GeneRIF: Data show that latexin protein expression was reduced
            after SNI, and the decrease of latexin was associated with an
            increase of the activity of carboxypeptidase A.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1087)
  AUTHORS   Jin,M., Ishida,M., Katoh-Fukui,Y., Tsuchiya,R., Higashinakagawa,T.,
            Ikegami,S. and Arimatsu,Y.
  TITLE     Reduced pain sensitivity in mice lacking latexin, an inhibitor of
            metallocarboxypeptidases
  JOURNAL   Brain Res 1075 (1), 117-121 (2006)
   PUBMED   16469302
REFERENCE   4  (bases 1 to 1087)
  AUTHORS   Miyasaka,N., Hatanaka,Y., Jin,M. and Arimatsu,Y.
  TITLE     Genomic organization and regulatory elements of the rat latexin
            gene, which is expressed in a cell type-specific manner in both
            central and peripheral nervous systems
  JOURNAL   Brain Res Mol Brain Res 69 (1), 62-72 (1999)
   PUBMED   10350638
REFERENCE   5  (bases 1 to 1087)
  AUTHORS   Normant,E., Martres,M.P., Schwartz,J.C. and Gros,C.
  TITLE     Purification, cDNA cloning, functional expression, and
            characterization of a 26-kDa endogenous mammalian carboxypeptidase
            inhibitor
  JOURNAL   Proc Natl Acad Sci U S A 92 (26), 12225-12229 (1995)
   PUBMED   8618874
REFERENCE   6  (bases 1 to 1087)
  AUTHORS   Hatanaka,Y., Uratani,Y., Takiguchi-Hayashi,K., Omori,A., Sato,K.,
            Miyamoto,M. and Arimatsu,Y.
  TITLE     Intracortical regionality represented by specific transcription for
            a novel protein, latexin
  JOURNAL   Eur J Neurosci 6 (6), 973-982 (1994)
   PUBMED   7524963
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X76985.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X76985.1, FQ220594.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840105, SAMN12840108
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1087
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q32"
     gene            1..1087
                     /gene="Lxn"
                     /note="latexin"
                     /db_xref="GeneID:59073"
                     /db_xref="RGD:68361"
     exon            1..301
                     /gene="Lxn"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..841
                     /gene="Lxn"
                     /note="ECI; TCI; tissue carboxypeptidase inhibitor;
                     endogenous carboxypeptidase inhibitor"
                     /codon_start=1
                     /product="latexin"
                     /protein_id="NP_113843.1"
                     /db_xref="GeneID:59073"
                     /db_xref="RGD:68361"
                     /translation="MEEIPPTHYAASRAASVAENCINYQQGTPNKVFKVQTVQQASKE
                     DIPGRGHKYHLKFSVEEIIQKQVTVSCTAEVLYPRMGQGSAPEVNFTFEGEIGKNPDE
                     EDNTFYQRLMSMKEPLQAQNIPDNFGNVSPQMKPVHHLAWVACGYVMWQNSTEDTWYK
                     MAKIQTVKQVQRNDDFIELDYTVLLHDVASQEIIPWQMQVLWHPQYGTKVKHNSRLPK
                     EAPAE"
     exon            302..364
                     /gene="Lxn"
                     /inference="alignment:Splign:2.1.0"
     exon            365..542
                     /gene="Lxn"
                     /inference="alignment:Splign:2.1.0"
     exon            543..679
                     /gene="Lxn"
                     /inference="alignment:Splign:2.1.0"
     exon            680..742
                     /gene="Lxn"
                     /inference="alignment:Splign:2.1.0"
     exon            743..1073
                     /gene="Lxn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaagaggga agaaggcgct gaggaccgcg cacgcccagc ccagctgctg acttcaccac
       61 ctcaccgaga cccactccgc tggccagcac gctacactga caggatcctg gctgcaccca
      121 ctgtgatctc tttgaactag gatagcccgc gctcactgtt tccctgaaga tggaagaaat
      181 cccacccacc cactacgctg cgtccagggc tgcctcggtg gcagagaact gtataaatta
      241 tcagcaaggg acccccaaca aggtattcaa ggtgcagacg gtccagcagg caagcaagga
      301 ggatatccca ggaagaggcc acaagtacca tctgaagttt tctgtggaag aaattatcca
      361 aaaacaagtt acagtgagct gcacggctga agttctttac cctcgaatgg gacaaggctc
      421 tgcaccggaa gtcaacttca catttgaagg agaaatcggc aagaacccag atgaggaaga
      481 caacacgttt tatcaaagac tcatgtccat gaaggaacca ctacaagcac aaaatattcc
      541 agacaatttt ggaaatgtgt ctccacaaat gaagccggtc caccacttag cctgggtcgc
      601 ctgtggttat gtaatgtggc agaactcgac tgaagacaca tggtataaaa tggcaaagat
      661 tcaaacggtc aagcaagtgc aaagaaacga tgacttcatt gagttagact acaccgtcct
      721 actccacgac gttgcatcgc aggagattat cccctggcaa atgcaagttc tgtggcaccc
      781 acaatacggc acaaaagtaa agcacaacag ccgcctccca aaggaagcac cagcagagta
      841 aacaagaccc caactcggag acagccgtca acatgcccct taaccatgag tatgactgtc
      901 ctcactggca cctagctaac aggccaagtg aatcccacag tgtcgctctg tatgtcttgg
      961 ctacaggacc gagctgcata gattccacaa taaagagtag actacatgaa agtgtctttc
     1021 caatagtaat ggtactatgg ctatccacta ataaagtcaa cttcagcctc acaaaaaaaa
     1081 aaaaaaa
//
