LOCUS       NM_030830               7472 bp    mRNA    linear   ROD 16-FEB-2025
DEFINITION  Rattus norvegicus leucine zipper protein 1 (Luzp1), mRNA.
ACCESSION   NM_030830
VERSION     NM_030830.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7472)
  AUTHORS   Fan,D., Jiang,W.L., Jin,Z.L., Cao,J.L., Li,Y., He,T., Zhang,W.,
            Peng,L., Liu,H.X., Wu,X.Y., Chen,M., Fan,Y.Z., He,B., Yu,W.X.,
            Wang,H.R., Hu,X.R. and Lu,Z.B.
  TITLE     Leucine zipper protein 1 attenuates pressure overload-induced
            cardiac hypertrophy through inhibiting Stat3 signaling
  JOURNAL   J Adv Res 63, 117-128 (2024)
   PUBMED   37806546
  REMARK    GeneRIF: Leucine zipper protein 1 attenuates pressure
            overload-induced cardiac hypertrophy through inhibiting Stat3
            signaling.
REFERENCE   2  (bases 1 to 7472)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (bases 1 to 7472)
  AUTHORS   Hsu,C.Y., Chang,N.C., Lee,M.W., Lee,K.H., Sun,D.S., Lai,C. and
            Chang,A.C.
  TITLE     LUZP deficiency affects neural tube closure during brain
            development
  JOURNAL   Biochem Biophys Res Commun 376 (3), 466-471 (2008)
   PUBMED   18801334
REFERENCE   4  (bases 1 to 7472)
  AUTHORS   Kang,D., Oh,S., Ahn,S.M., Lee,B.H. and Moon,M.H.
  TITLE     Proteomic analysis of exosomes from human neural stem cells by flow
            field-flow fractionation and nanoflow liquid chromatography-tandem
            mass spectrometry
  JOURNAL   J Proteome Res 7 (8), 3475-3480 (2008)
   PUBMED   18570454
REFERENCE   5  (bases 1 to 7472)
  AUTHORS   Lee,M.W., Chang,A.C., Sun,D.S., Hsu,C.Y. and Chang,N.C.
  TITLE     Restricted expression of LUZP in neural lineage cells: a study in
            embryonic stem cells
  JOURNAL   J Biomed Sci 8 (6), 504-511 (2001)
   PUBMED   11702014
REFERENCE   6  (bases 1 to 7472)
  AUTHORS   Sun,D.S., Chang,A.C., Jenkins,N.A., Gilbert,D.J., Copeland,N.G. and
            Chang,N.C.
  TITLE     Identification, molecular characterization, and chromosomal
            localization of the cDNA encoding a novel leucine zipper
            motif-containing protein
  JOURNAL   Genomics 36 (1), 54-62 (1996)
   PUBMED   8812416
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CH473968.1.
            
            On Feb 1, 2008 this sequence version replaced NM_030830.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132263,
                              SAMD00132264 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..7472
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..7472
                     /gene="Luzp1"
                     /gene_synonym="Luzp"
                     /note="leucine zipper protein 1"
                     /db_xref="GeneID:79428"
                     /db_xref="RGD:61839"
     exon            1..62
                     /gene="Luzp1"
                     /gene_synonym="Luzp"
                     /inference="alignment:Splign:2.1.0"
     exon            63..165
                     /gene="Luzp1"
                     /gene_synonym="Luzp"
                     /inference="alignment:Splign:2.1.0"
     exon            166..258
                     /gene="Luzp1"
                     /gene_synonym="Luzp"
                     /inference="alignment:Splign:2.1.0"
     exon            259..3436
                     /gene="Luzp1"
                     /gene_synonym="Luzp"
                     /inference="alignment:Splign:2.1.0"
     CDS             371..3592
                     /gene="Luzp1"
                     /gene_synonym="Luzp"
                     /note="leucine zipper motif-containing protein; fimbacin;
                     filamin mechanobinding actin cross-linking protein"
                     /codon_start=1
                     /product="leucine zipper protein 1"
                     /protein_id="NP_110457.2"
                     /db_xref="GeneID:79428"
                     /db_xref="RGD:61839"
                     /translation="MADIANYKDAASNRHLRFKLQSLSRRLDELEEATKNLQKAEDEL
                     LDLQDKVIQAEGSNSSMLAEIEVLRQRVLKIEGKDEEIKRAEDLCHTMKEKLEEEENL
                     TRELKSEIDRLQKRMADLEKLEEALSRSKNECSQLCLSLNEERNLTKKISSELEMLRV
                     KVKELESSEDRLEKTEQSLVSELEKLKSLTLSFVNERKYLNEKEKENEKLIKELTQKL
                     EQNKKINRDHMRNASTFLERNDLRIEDGISSTLPSKESRRKGSLDYLKQVENETRDKS
                     ENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMRAKNNDLQDNYLTELNKN
                     RSLASQLEEVKLQVKKQKELGNGDIEGEDAFLLGRGRHERTKLKGHGGEVSVSKHTSR
                     EQSPQHKRERLRNRGFALNDEHCSLSNKQVSSPAFTNKRAAKASNMGVGPDSGTQETK
                     RTEDRLAPGSSQSEGKKGREQPSVLSRYPPAAQDHTKVWRGNPKPGTESGLKGKVEKT
                     TRTFSDSAHGSVPNDVVGKGDKTSDFSSEAHCGKRGQVPGHASQVTQVAESGCSKAIG
                     ALASSQRASSEGLSKGKKAANGLETDANFPHSKAPILSKYPYSSRSQENILQGFSVPN
                     KEGVDHSVAVVMEDSSQHEALRCRVIKSSGREKPDSDDDLDIESLVTAKLVNTTITPE
                     PEPKLQPNSREKVKSRGGTRTALFENDKNAAVENDSAKSMRSSSNAVEFPDANCAGVK
                     NQRPFSPREALRSRAIIKPVIIDKDVKKIMGGSGTEVVLEKQKSTPKSVTSKVTSSIT
                     IYPSDSSGPRAVPTEAPRERHTSTSNIQVGPPELTSVSNHISSPLELSIHKHDITLQL
                     TEAERVGDGSPKNRAETVVSRSSILIKPSDSVERNSHAFPAETIRWKSHSTSSEVASS
                     DTRHITVRNAWKSKRDLKCSEDPPTRIGRNVEATNAYTQRSSTDFLELEQPRSHPPEQ
                     GTRKVGNSGDAPELSSRRTQSSLTASEVLTRRNRIGDAVTAASWNHSSNVEEGEDSTF
                     VSSRRVHNPLEHSEPPGKQGLPESERVWTEERLHPARPYAEED"
     exon            3437..7472
                     /gene="Luzp1"
                     /gene_synonym="Luzp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggtcgctgg gagctgagcg ccggatcctc tggcggcggg atcgcgggcc gcagccgctg
       61 aggtcaacaa gcagctccca gtgaaagaca gcgactgttt ccaagacagc agacagtggg
      121 gagggcaacc ataagtcccc acagaaagct cccattacct aaatggacag gatccttgtc
      181 aagaaaggag ccacacacag caggcagcag ttaacataat caacttcccc accccatgct
      241 cagtggccca tctcccaggc tgatgatggt cttcagttgc caaagaaggc tgtgggtgcc
      301 acgggaaagg tagccagttt ctccattgca gttgggtgcc tctagcagcc catctcgacg
      361 ggtcgtagac atggcagaca ttgccaacta caaggatgcc gcctccaacc gccacctgcg
      421 gtttaagttg cagagcctga gccgccgcct ggatgaatta gaggaagcca caaaaaacct
      481 ccagaaagcg gaggatgagc tcctggacct ccaggacaag gtaatccagg ccgagggcag
      541 caactccagc atgttggctg agatcgaggt gctacgccag cgggtactga agattgaagg
      601 taaggatgag gaaattaaga gagcagagga cctgtgtcat acgatgaagg agaaacttga
      661 agaggaagaa aaccttaccc gagagctaaa atctgagatc gatcggcttc agaaacgaat
      721 ggctgactta gagaagctag aggaagcttt gagcaggagt aagaacgagt gttcccagct
      781 ttgtttgagc ctcaatgaag agagaaatct gaccaagaaa atctcttctg agttggaaat
      841 gctcagggtc aaagtgaaag agctggagtc ctcagaagac cgactggaaa agactgagca
      901 gagcttagtg tcagaattag aaaagctaaa atcgttaacc ctgagctttg taaatgagag
      961 aaaatacttg aatgaaaagg agaaagaaaa tgagaaatta ataaaagagc ttactcaaaa
     1021 actggagcag aacaagaaaa taaacagaga tcacatgaga aatgcttcca cttttctgga
     1081 aaggaatgac ctacggatag aggatggcat ttcctctaca ctgccatcca aagagtcaag
     1141 aaggaagggc agtctggatt acctaaagca ggtcgagaat gaaaccagag acaaatcaga
     1201 aaacgaaaag aaccgaaatc aggaggacaa caaagtgaaa gaccttaacc aagagattga
     1261 gaaacttaag acacaaatca aacattttga atctttagag gaggagctta agaaaatgag
     1321 ggccaagaac aatgaccttc aggataatta cctaactgag ctgaataaaa acagaagctt
     1381 ggccagccag ctagaggagg taaagctgca agtcaagaaa caaaaggagt taggaaacgg
     1441 ggacatagag ggtgaagatg ctttcctttt gggcagaggc aggcatgaga ggactaagct
     1501 caaaggccat gggggtgagg tgtctgtgtc caagcacaca tcccgggaac agtcccctca
     1561 gcataagcgg gaaaggctcc ggaacagagg gtttgctctc aatgatgaac actgttctct
     1621 cagcaacaag caggtttctt ctcctgcctt cacaaacaaa agagcagcaa aagcttccaa
     1681 catgggagtg ggtccggaca gcgggactca ggaaacaaag agaactgaag accgattggc
     1741 acctgggtcc tctcagagtg aagggaaaaa gggcagggag cagccctcag tgcttagccg
     1801 ttacccgcct gctgcccagg accacactaa agtttggagg ggaaatccca agccaggcac
     1861 tgagagtgga cttaagggaa aagtagagaa gacaactcga acatttagtg attccgctca
     1921 tggatctgtg cccaatgatg tagtagggaa aggcgataaa acttctgact tctcctctga
     1981 ggcccactgt ggcaagagag gacaggtccc tggccatgca agtcaagtga cacaggttgc
     2041 agagtctggc tgctctaagg ccatcggagc tctagcctca tctcaaaggg cctcctcaga
     2101 agggctttct aagggcaaaa aggctgctaa tggcctagag actgatgcta attttccaca
     2161 ttctaaagct cctattttat caaaatatcc ttatagttca agaagccaag aaaatatcct
     2221 tcagggcttt tcagtgccaa ataaagaagg agttgatcac tctgtagcag ttgtgatgga
     2281 agacagcagt cagcatgaag ccttgaggtg ccgtgtcatt aaatccagtg gcagagagaa
     2341 gccagactca gacgatgacc tggacataga gtctcttgtt actgccaagt tggtgaacac
     2401 aactattact ccagagccag agcccaaact ccagccaaac tcaagagaaa aggttaagtc
     2461 cagaggggga acgagaacgg ccttatttga aaatgataaa aatgctgccg tagaaaatga
     2521 ctctgcgaaa tcgatgagat cttcctccaa tgctgtagaa ttcccagatg ccaactgtgc
     2581 tggggtgaaa aaccaaagac ccttcagccc tagagaggcc ctgaggtcta gagcaattat
     2641 aaaacctgtt atcattgata aggatgtgaa aaaaatcatg ggtggatctg gaactgaggt
     2701 tgtattggag aagcagaaat ccacccctaa atctgtgaca agcaaagtga caagcagcat
     2761 taccatctac ccctctgaca gcagtggtcc tagagctgtc cccactgagg ccccacggga
     2821 gaggcataca tctaccagca acatccaggt ggggcccccc gagctcacat cagttagcaa
     2881 ccacatcagc tcccctcttg agctctctat tcataaacat gacatcacct tgcagctcac
     2941 agaagctgaa agagtgggag atgggtctcc aaagaataga gcagagacgg tggtctctcg
     3001 gagcagcatt ctaatcaagc catcagattc tgtggagagg aacagtcatg ccttcccagc
     3061 ggagacaatc aggtggaaaa gccatagcac ctcttcagag gtggcctctt cagacaccag
     3121 acacatcact gtgcggaatg cctggaagag taagagagac ttgaaatgtt cagaagaccc
     3181 cccaactcga ataggtagaa atgtggaagc tactaacgcc tatacacaga ggtcttccac
     3241 agacttctta gaactggaac agcccaggtc acacccgcct gaacagggca ctcgaaaggt
     3301 aggaaattca ggggatgctc ctgagctctc ctcaagaagg acccaaagta gcctcactgc
     3361 atcagaggta ctcacccgga ggaatcggat aggagatgcc gtcaccgctg cctcctggaa
     3421 ccactcatca aacgtggagg aaggggagga cagcacattt gttagcagca ggcgagtaca
     3481 caacccgctg gaacactctg aaccgcctgg gaagcaggga ctgccagagt ctgagcgagt
     3541 ttggactgag gagcggctac acccagcaag gccttatgct gaggaagact gagccagcta
     3601 ggcgaagtct gctgctgctt cttctcctcc tgcttctcag ctcctcccca atcctggcct
     3661 gtgcaggacc caaggccagt taagcaggct ggacacaggc cttggctggg agactatgga
     3721 gagccaggct gtggctcagg taatttttgc cagttgtctg gacaggacca gaaactacaa
     3781 accagtcact caggcccagc tctccctgat gcatgagtag tcctctctcc tctctctgtc
     3841 cccaaggtag catggaccat tctctgaccc ccaaatgggg cgttatagaa acccactacc
     3901 atatagaggt agccaaaagc tctcgcccct ctccatggtg agcagtttgt atatcaaagc
     3961 ccagtccctt ttgctctgtt tgatgtcctg atttgtctcc tcaccatatc cagttggttc
     4021 tttgtttgcc ctaagagacc ccacgcactg ccaagagcac attaagaatt atcagctatc
     4081 gtttccatcc taagaggctt acattccttt gtctttgagt tcttgagaat ttggaaacag
     4141 aaaaagggtc tgctgcccct aagtaattat gggaccatcc tcgtgtagaa gcttccctga
     4201 cctgactttt ggataaccag tttcttgggg gcagagcagg atgccaaatg gaagacatca
     4261 tcctctgaca ccagctttca gctcaccttc caaaggcact ggaatcagac cgatttgtac
     4321 ctctcccttg ctgggcaccg acattgctgc tggcatcacc tttgctctct ggggctgcaa
     4381 acttcagctg acttcatcat tctcctcttg ggaaaatccc tgccctgagc cgacggaccc
     4441 ggccagccag cacactctgc cttttaggaa gtgcccagca aatgggaaac aagcaagaat
     4501 tcctttagtc actccacagg caatagctcc acgaaagaca tggactgact gctccctccc
     4561 tttgctcctc catcccctgt ggaggaggcc ttgcacttta ccatgctgac tgctgaagca
     4621 aaagcaagcc ctccggatct acgagtagac catttcagag atttcattgg aggaaagcca
     4681 atgcctgcct gttgaggtcc tcagatttat gcagttcaaa gtgcattagc cttttaggaa
     4741 ggcagataaa taaactttta tctccttaca ctaaccacat ggggaagtta agagctgttt
     4801 gcttgtcact gaattttctg aatgaagcat tgtttcaatt cgaagggatc ctccttggct
     4861 acctttgtga agtagatgtc attgccttat cactagacta ggtatttgga aagccacttt
     4921 ccccattcct cctggctttg tcactccttg ctctgtgacc tttggcaagt cttcttggag
     4981 cctccgtttt ccctatcttt agaatgagtt ggtttgtttg ttttgtgcat gtgtccccat
     5041 gtgtctgtca cctgcagatg catgctgggg attaaaaaca ggacctggtg tgctaggtca
     5101 agtgttctac cactgctgct tcccagctca gagtgagttc tatggagtgg atgatctctc
     5161 aggccttaac ttcggtgttc tacccttgtc tgacgcacca acgtgagctg actcttggtt
     5221 ttggaaggtg atgtccacgt gagtctaggg aacatctttc tttctgcctt cagttgtctt
     5281 ctgggtcttc tcttttcctc atgcctctgt catggggatg agcctgtaag gcctgttttc
     5341 agtatgaggt aaagggattg gattgtgtgg tctcaggttt atgtggcact tgctcagtgc
     5401 cacatttcct ggctttcaag ctaggtgctt tttataacgt aagtctgttt gattcctgtt
     5461 cccgtgcctt tcctgtgaat ttcctggcca cagggaagac acaggacatc tcaggaggac
     5521 tgagtagtct cccttcaccc tttgtactta gcacacacac acactggcac ttatctgccc
     5581 ttgtctgcat cagactcagc catcctgcca gggtgtgggg agatctacca cgttttgttt
     5641 gtttgctccc aaaggacagg aatgactagc tagcacttgg gttttaatgg agttttgcta
     5701 acctggggca ttgccatgtg tcttgcctcc ccttcccaac tcgatgtaca actaagacag
     5761 tgttcctgct gctgcttttg ggttactggc cagaaactcc ttaattcaag gctgcaacct
     5821 ctcacttgca gtgtcctgtc actctcctgt accagtcggc agccctgaga gtaaaggaaa
     5881 cagacccctg tggtggtcca ccgaagagta taggaaacga agtctgtggc tcttctctgc
     5941 tgataaaaac agagaggtac caagccctgc ctcaaaagat ctcaccaata ttttttgtct
     6001 ttgggtgttg aaccctggat tctggtgctg tagctcctgg tgccaaagtc tgtatctttc
     6061 cacattttag cagcaccaac acctgctgct atttgaaatg ttctgtggaa aaaggacagc
     6121 tgtgggctgc cattttgaaa gtctgagtgc aatatattgc atttgattgt aacaattatt
     6181 tcaggatatt ttgtttcttt aatctgcaca ctttgtagtc ctgccataaa gtagatttta
     6241 tttttaaatg tcttcagcat tgcaaacgtt tatactaagc aaatggaggc tagagggttt
     6301 aagtcccctg ggcttcatat ggatggctag actggctctg attccaaggt tggaaggcac
     6361 atcacttctg aagacaccaa ggtgtaacct ttgggcccac gccagaagct gcaggaagcc
     6421 tccaaataga agggagactt gtcaaaccat tgtctaatca agccaaatat cccctgaatc
     6481 cccaccgcaa gacccacttt catgacagtg ctgcttctct agtttggaaa gatggctaaa
     6541 ttgaaccagc aggtcatgtg tctgagagtt ctgagtactg gtcctggata tacttggcta
     6601 gaggatgaag agctggcgaa tgccaatgac tggtatcttc cacctgctgc tgttaccagg
     6661 tactctggta ttaaaacaat caggaaaagc tgcagggtgg caggcaagga agctgtggca
     6721 gctctgtgtg gcagtgaaac agttgagatg agttgaaggg gtatgtgtgg gccaaggctg
     6781 caggcaagct tgcacatcag ccatccgtct cctgcggcag gggctggtgc ctagagcaat
     6841 agtggatttc ttgtcctggg ctgtgttagt tgttagtagt gggtcagtaa aggaacaggg
     6901 actcagaggc tggcccctgg ctgcctttgt gggcatgggt ttctattctg acaaagactg
     6961 ctttgtaaga gctgcttttt agggattgtc ttttaaacac cctgaatggg gaacagggtt
     7021 ctcctcaacc acctcaacca gagtcatagg aaagaggtcc tattttcctg ctgcttcaca
     7081 gctcagaaca tgtattgaat ggaatgtatt tttaagagaa taaagtctat tttttgtatt
     7141 ttaaagattg agagggctag aaagatagat agcccttaaa taaacttagg catggtaggt
     7201 ccttcgctgg ggcctcagct gtggctctgg cttcaccgag gccccttgga gtctagatgc
     7261 agcagcttct acacattcct gctccaagca tgggaccaga gaggctagaa cctgcctctg
     7321 aaacgcaggg cacagccaca ggcagtggct cagggctcct tgggtgcatg tgtctagttg
     7381 aagctgcctg tctgcatgta tcctttggct gtaattctct ctgttggctc tgcagcacaa
     7441 tattgtaacc aataaagctc cctcgtttct at
//
