LOCUS       NM_031050               1728 bp    mRNA    linear   ROD 15-JUN-2024
DEFINITION  Rattus norvegicus lumican (Lum), mRNA.
ACCESSION   NM_031050
VERSION     NM_031050.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1728)
  AUTHORS   Hayes,A.J. and Melrose,J.
  TITLE     Immunolocalization of Keratan Sulfate in Rat Spinal Tissues Using
            the Keratanase Generated BKS-1(+) Neoepitope: Correlation of
            Expression Patterns with the Class II SLRPs, Lumican and Keratocan
  JOURNAL   Cells 9 (4), 826 (2020)
   PUBMED   32235499
  REMARK    GeneRIF: Immunolocalization of Keratan Sulfate in Rat Spinal
            Tissues Using the Keratanase Generated BKS-1(+) Neoepitope:
            Correlation of Expression Patterns with the Class II SLRPs, Lumican
            and Keratocan.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1728)
  AUTHORS   Barallobre-Barreiro,J., Gupta,S.K., Zoccarato,A.,
            Kitazume-Taneike,R., Fava,M., Yin,X., Werner,T., Hirt,M.N.,
            Zampetaki,A., Viviano,A., Chong,M., Bern,M., Kourliouros,A.,
            Domenech,N., Willeit,P., Shah,A.M., Jahangiri,M., Schaefer,L.,
            Fischer,J.W., Iozzo,R.V., Viner,R., Thum,T., Heineke,J.,
            Kichler,A., Otsu,K. and Mayr,M.
  TITLE     Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin
            Activity in Human Atrial Fibrillation
  JOURNAL   Circulation 134 (11), 817-832 (2016)
   PUBMED   27559042
REFERENCE   3  (bases 1 to 1728)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   4  (bases 1 to 1728)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   5  (bases 1 to 1728)
  AUTHORS   Bubenek,S., Nastase,A., Niculescu,A.M., Baila,S., Herlea,V.,
            Lazar,V., Paslaru,L., Botezatu,A., Tomescu,D., Popescu,I. and
            Dima,S.
  TITLE     Assessment of gene expression profiles in peripheral occlusive
            arterial disease
  JOURNAL   Can J Cardiol 28 (6), 712-720 (2012)
   PUBMED   22721676
REFERENCE   6  (bases 1 to 1728)
  AUTHORS   Onda,M., Ishiwata,T., Kawahara,K., Wang,R., Naito,Z. and
            Sugisaki,Y.
  TITLE     Expression of lumican in thickened intima and smooth muscle cells
            in human coronary atherosclerosis
  JOURNAL   Exp Mol Pathol 72 (2), 142-149 (2002)
   PUBMED   11890723
REFERENCE   7  (bases 1 to 1728)
  AUTHORS   Baba,H., Ishiwata,T., Takashi,E., Xu,G. and Asano,G.
  TITLE     Expression and localization of lumican in the ischemic and
            reperfused rat heart
  JOURNAL   Jpn Circ J 65 (5), 445-450 (2001)
   PUBMED   11348051
REFERENCE   8  (bases 1 to 1728)
  AUTHORS   Neame,P.J., Kay,C.J., McQuillan,D.J., Beales,M.P. and Hassell,J.R.
  TITLE     Independent modulation of collagen fibrillogenesis by decorin and
            lumican
  JOURNAL   Cell Mol Life Sci 57 (5), 859-863 (2000)
   PUBMED   10892350
REFERENCE   9  (bases 1 to 1728)
  AUTHORS   Svensson,L., Narlid,I. and Oldberg,A.
  TITLE     Fibromodulin and lumican bind to the same region on collagen type I
            fibrils
  JOURNAL   FEBS Lett 470 (2), 178-182 (2000)
   PUBMED   10734230
REFERENCE   10 (bases 1 to 1728)
  AUTHORS   Krull,N.B. and Gressner,A.M.
  TITLE     Differential expression of keratan sulphate proteoglycans
            fibromodulin, lumican and aggrecan in normal and fibrotic rat liver
  JOURNAL   FEBS Lett 312 (1), 47-52 (1992)
   PUBMED   1385211
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 26, 2020 this sequence version replaced NM_031050.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X84039.1, BC061878.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                JAXUCZ010000007.1  34245706-34245729
            25-907              JAXUCZ010000007.1  34248082-34248964
            908-1728            JAXUCZ010000007.1  34251690-34252510
FEATURES             Location/Qualifiers
     source          1..1728
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     gene            1..1728
                     /gene="Lum"
                     /note="lumican"
                     /db_xref="GeneID:81682"
                     /db_xref="RGD:620984"
     exon            1..24
                     /gene="Lum"
                     /inference="alignment:Splign:2.1.0"
     exon            25..907
                     /gene="Lum"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..1062
                     /gene="Lum"
                     /note="KSPG lumican; keratan sulfate proteoglycan lumican"
                     /codon_start=1
                     /product="lumican precursor"
                     /protein_id="NP_112312.1"
                     /db_xref="GeneID:81682"
                     /db_xref="RGD:620984"
                     /translation="MNVCTFTLVLALVGSVSGQYYDYDAPLFMYGELSPNCAPECNCP
                     HSYPTAMYCDDLKLKSVPMVPPGIKYLYLRNNQIDHIDEKAFENVTDLQWLILDHNLL
                     ENSKIKGKVFSKLKQLKKLHINYNNLTESVGPLPKSLQDLQLANNKISKLGSFDGLVN
                     LTFIYLQHNQLKEEAVSASLKGLKSLEYLDLSFNQMSKLPAGLPTSLLTLYLDNNKIT
                     NIPDEYFNRFTGLQYLRLSHNELADSGVPGNSFNISSLLELDLSYNKLKSIPTVNENL
                     ENYYLEVNKLEKFDVKSFCKILGPLSYSKIKHLRLDGNPLTQSSLPPDMYECLRVANE
                     ITVN"
     exon            908..1728
                     /gene="Lum"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggaaacagt gtcaagagag taagggcaca gaggacttgc tgaaaatgaa tgtatgtacg
       61 ttcactcttg tcttggcatt agtcggtagt gtcagtggcc aatactatga ttatgatgcc
      121 cctctcttca tgtatgggga actgtcaccc aactgtgcac cagaatgtaa ctgtccccac
      181 agctacccaa ctgccatgta ctgtgatgat ctcaagttga aaagtgtgcc catggtgccc
      241 cctggcatca agtaccttta cctgaggaat aaccagatcg accatattga tgaaaaggcc
      301 tttgagaatg taacggatct gcagtggctc attcttgacc acaatcttct agaaaactcc
      361 aagatcaaag gaaaggtctt ctctaagctg aaacaactga agaagctgca tataaactac
      421 aacaatttga ccgagtccgt gggtccgctc ccaaagtccc tacaagacct gcagctggcc
      481 aataataaga tcagcaagct gggctccttc gacgggctgg taaacctgac cttcatttac
      541 cttcaacaca accagctcaa agaggaggct gtctcggctt ctctgaaagg ccttaagtca
      601 ctcgaatacc tcgacttgag cttcaatcag atgagcaagc tgcccgctgg ccttccaaca
      661 tctcttctaa ctctctacct agacaacaat aagatcacca acattcctga tgagtatttc
      721 aatcgcttca ccgggcttca atacttgcgt ttatctcaca atgagctggc tgacagtggc
      781 gtgcctggaa actcatttaa catatcatct ctgctcgagc tcgatctctc ctacaataag
      841 ctcaagagta taccaaccgt taatgaaaac cttgaaaact attacctgga ggtcaataaa
      901 ctcgaaaagt ttgatgtcaa gagcttctgt aagatcctgg gaccactatc ttactccaag
      961 atcaagcatt tgcgcttgga tggcaatccc ctcactcaaa gcagtctgcc ccctgacatg
     1021 tacgagtgtc tacgtgtagc aaatgaaatc acggttaatt aacctcctct cattctaata
     1081 cattgaagta tgttccagag cagtacttca tggatgggta tttgctggat gtgttaaagt
     1141 tttcacaata tcctttacat tgttattgtc attgttgttg ttggtattac ttcatggatt
     1201 ttaattaata aaggaaatgt tttgtgaaca tttaccactt tttaaataaa agatgaaaag
     1261 caggcctatt tcatcgtgag aacagacaca taaaacccgt taaacttaag tctatttgtg
     1321 aatttaatgt tttctatagc tctatgttca ggtgattatg aagccttttt actgattgct
     1381 tggaagtcca ccaggtttct atggttcctc acattttaca ttagtgactt cgaaaacatg
     1441 aaacaaacat gcatggatgt ttgttatcct aatccaaatt tttgtgacat gtcaagtttg
     1501 ttttacagaa gtttagatcc tatgttttga aaccagtgat ttgcaacata ccaaagaaaa
     1561 ttactaaaga cctgtctact taaagaaatg tagttagcag taagaatttg cccagttact
     1621 taatgaaact tttcttgagt cattttcctg tcatatctat gtttctttct gattgtttgc
     1681 atgttatgat taacaagctg atagcaaaat aaaacaatgc aaatggta
//
