LOCUS       NP_001019406            1767 aa            linear   ROD 30-MAR-2024
DEFINITION  E3 ubiquitin-protein ligase listerin [Rattus norvegicus].
ACCESSION   NP_001019406 XP_213672
VERSION     NP_001019406.2
DBSOURCE    REFSEQ: accession NM_001024235.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1767)
  AUTHORS   Chu,J., Hong,N.A., Masuda,C.A., Jenkins,B.V., Nelms,K.A.,
            Goodnow,C.C., Glynne,R.J., Wu,H., Masliah,E., Joazeiro,C.A. and
            Kay,S.A.
  TITLE     A mouse forward genetics screen identifies LISTERIN as an E3
            ubiquitin ligase involved in neurodegeneration
  JOURNAL   Proc Natl Acad Sci U S A 106 (7), 2097-2103 (2009)
   PUBMED   19196968
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Sep 5, 2008 this sequence version replaced NP_001019406.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.26554.1,
                                           SRR26643429.40557.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1767
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     Protein         1..1767
                     /product="E3 ubiquitin-protein ligase listerin"
                     /EC_number="2.3.2.27"
                     /note="zinc finger protein 294; ring finger protein 160"
                     /calculated_mol_wt=198868
     Region          59..>262
                     /region_name="COG5219"
                     /note="Uncharacterized conserved protein, contains RING
                     Zn-finger [General function prediction only]"
                     /db_xref="CDD:227544"
     Region          <1478..1766
                     /region_name="COG5219"
                     /note="Uncharacterized conserved protein, contains RING
                     Zn-finger [General function prediction only]"
                     /db_xref="CDD:227544"
     CDS             1..1767
                     /gene="Ltn1"
                     /gene_synonym="Rnf160; Zfp294; Znf294"
                     /coded_by="NM_001024235.2:1..5304"
                     /db_xref="GeneID:288308"
                     /db_xref="RGD:1311238"
ORIGIN      
        1 mggknkqrtk gnlrpsnsgr aaellakeqg tvpgfigfgt shsdlgyvpa iqgaedidsl
       61 vdsdfrmvlr klskkdvttk lkamqefgtm cterdteavk gvlpywprif ckisldhdrr
      121 vreatqqafe klilkvkkhl apylksvmgy wlmaqcdtyp paataakdaf eaafppskqp
      181 eaivfckeei ttvlqdhllk etpdtlsdpq tvpeeereak fhrvvtcsll alkrllcflp
      241 nneldsleek frsllsqnkf wkygkhsvpq vrsayfelvs alcqhvpqvm keeaakvsps
      301 vllsiddsdp vvcpalweav lytlttvedc wfhvnakksv fpkltamird ggrglaaviy
      361 pyllpfiskl pqsitepkld ffknfltslv tglstertrs ssaecsavia affeclrfim
      421 qqnlgeeemv qmligeqlip fidivlkdsg lqhgplfnhl adtlssweak adveqdaetv
      481 ynlekvllsf werlseicie kisepeadvk svlgvsnlvg ilqkpesslk snrkrngkvr
      541 fvidtpeapk gsekcvsseg ensegseggg tgsslsykss dvvsplrkkp ledlvcklae
      601 vsisfvneqk seqhlqflst lldsfssgqv fkillgdkqk nivkakplei tklaeknpav
      661 qflyhkligw lndsqkedgg flvdilysal rccdsdverk evlddltqed lkwssllrvi
      721 ekacsssdkh alvtpwlkgs ilgeklvala dclcgkdles tissechsse qwtllrlals
      781 qhlkndylig evyvariivk lhetlsktkd fseaadsdss vsfvcdvihs ffssagggll
      841 tpasedlllt lfqlcaqske rthlpdflic klkntllsgv nllvhqtast yeqstflrls
      901 vlwlkdqvqs svldneslqv llsavgdlls tlvesedtsl lgvyigsvmp sdsewekmrq
      961 slpvqwlhrp llegrlslny ecfktdfkdq dtktlpnhlc tssllskmil iaqkkeivle
     1021 ndvlekicae llyslqwcee ldnppsflsg fcemlqkmni tysnlsvlgn tssllqllfd
     1081 rsrkngtlws liiaklilsr sissdevkpy ykrkesffpl tegnlhtiqs lcpflskeek
     1141 kefsaqcipa flgwtkedlc singafghla ifnsclqtrs iddkqllhgi lkiitswrkq
     1201 hediflfscn lseaspevlg lnieimrfls lflkycsypl aesewdfimc smlawletas
     1261 enqalycvpl vqlfacvsfd lacdlsaffd sitpdtvdnl pvnlisewke ffskgihgll
     1321 lpllvnatge dkdlsetsfq navlkpmcet ltyiskdqll shklpkrlva sqktnlpehl
     1381 qtllntltpl llfrarpvqi aayhmlyklm aelpqhdqdn lksygdeeee palsppaalm
     1441 sllstqeell envlgcvpvg qivpikplse dfcyvlgyll twkliltffk aassqlraly
     1501 smylrktksl nkllyhlfrl mpenptyget aievsnkdpk tffteelqls iretatlpyh
     1561 iphlacsvyh mtlkdlpamv rlwwnssekr vfnivdrfts kyvssvlsfq eissvqtstq
     1621 lfngmtvkar attrevmaty tiedivieli iqlpsnyplg sitvesgkrv gvavqqwrnw
     1681 mlqlstylth qngsimdgla lwknnvdkrf egvedcmicf svihgfnysl pkkacrtckk
     1741 kfhsaclykw ftssnkstcp lcretff
//
