LOCUS       NM_001107763            2252 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus leukocyte receptor tyrosine kinase (Ltk), mRNA.
ACCESSION   NM_001107763 XM_001075610 XM_001075631 XM_001075655 XM_001075682
            XM_230479
VERSION     NM_001107763.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2252)
  AUTHORS   Yamada,S., Uchimura,E., Ueda,T., Nomura,T., Fujita,S.,
            Matsumoto,K., Funeriu,D.P., Miyake,M. and Miyake,J.
  TITLE     Identification of twinfilin-2 as a factor involved in neurite
            outgrowth by RNAi-based screen
  JOURNAL   Biochem Biophys Res Commun 363 (4), 926-930 (2007)
   PUBMED   17910947
REFERENCE   2  (bases 1 to 2252)
  AUTHORS   Honda,H., Harada,K., Komuro,I., Terasaki,F., Ueno,H., Tanaka,Y.,
            Kawamura,K., Yazaki,Y. and Hirai,H.
  TITLE     Heart-specific activation of LTK results in cardiac hypertrophy,
            cardiomyocyte degeneration and gene reprogramming in transgenic
            mice
  JOURNAL   Oncogene 18 (26), 3821-3830 (1999)
   PUBMED   10445845
REFERENCE   3  (bases 1 to 2252)
  AUTHORS   Ueno,H., Honda,H., Nakamoto,T., Yamagata,T., Sasaki,K.,
            Miyagawa,K., Mitani,K., Yazaki,Y. and Hirai,H.
  TITLE     The phosphatidylinositol 3' kinase pathway is required for the
            survival signal of leukocyte tyrosine kinase
  JOURNAL   Oncogene 14 (25), 3067-3072 (1997)
   PUBMED   9223670
REFERENCE   4  (bases 1 to 2252)
  AUTHORS   Ben-Neriah,Y. and Bauskin,A.R.
  TITLE     Leukocytes express a novel gene encoding a putative transmembrane
            protein-kinase devoid of an extracellular domain
  JOURNAL   Nature 333 (6174), 672-676 (1988)
   PUBMED   2836739
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from JAXUCZ010000003.1 and
            BE106366.1.
            
            On Nov 2, 2007 this sequence version replaced NM_001107763.1.
            
            Summary: The protein encoded by this gene is a member of the
            ros/insulin receptor family of tyrosine kinases. Tyrosine-specific
            phosphorylation of proteins is a key to the control of diverse
            pathways leading to cell growth and differentiation. The mRNA for
            this gene initiates translation from a non-AUG (CUG) start codon.
            [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760383, SAMEA5760389
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            non-AUG initiation codon :: inferred from conservation
            RefSeq Select criteria   :: based on single protein-coding
                                        transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-272               JAXUCZ010000003.1  127195085-127195356 c
            273-371             JAXUCZ010000003.1  127192991-127193089 c
            372-524             JAXUCZ010000003.1  127192258-127192410 c
            525-620             JAXUCZ010000003.1  127191715-127191810 c
            621-816             JAXUCZ010000003.1  127191286-127191481 c
            817-907             JAXUCZ010000003.1  127190714-127190804 c
            908-972             JAXUCZ010000003.1  127190526-127190590 c
            973-1102            JAXUCZ010000003.1  127190264-127190393 c
            1103-1200           JAXUCZ010000003.1  127190073-127190170 c
            1201-1293           JAXUCZ010000003.1  127189838-127189930 c
            1294-1395           JAXUCZ010000003.1  127189654-127189755 c
            1396-1530           JAXUCZ010000003.1  127189389-127189523 c
            1531-1621           JAXUCZ010000003.1  127189224-127189314 c
            1622-2227           JAXUCZ010000003.1  127188488-127189093 c
            2228-2252           BE106366.1         1-25                c
FEATURES             Location/Qualifiers
     source          1..2252
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     gene            1..2252
                     /gene="Ltk"
                     /note="leukocyte receptor tyrosine kinase"
                     /db_xref="GeneID:311337"
                     /db_xref="RGD:1309323"
     exon            1..272
                     /gene="Ltk"
                     /inference="alignment:Splign:2.1.0"
     CDS             221..1954
                     /gene="Ltk"
                     /EC_number="2.7.10.1"
                     /note="non-AUG (CUG) translation initiation codon"
                     /codon_start=1
                     /product="leukocyte tyrosine kinase receptor"
                     /protein_id="NP_001101233.2"
                     /db_xref="GeneID:311337"
                     /db_xref="RGD:1309323"
                     /translation="METRAAAQGSGRRGGAAGGDTSESDLLWADGEDGISFVHPSGEL
                     YLQPLAVTEGDVEVEIRRHPNCSHCSFKDCQWQAELWRAECICPEGMELAVDNITCTG
                     LPTTTSPLIMMGAVVTALTLSLLMMCGVLILVNQKKCQSLRGTRLPGPELELSKLRTS
                     AIRTAPNPYYCQVGLSPAQAWPLPQGLTEVSPANVTLLRALGHGAFGEVYEGLVIGLP
                     GDSSPLPVAIKTLPELCSPQDELDFLMEALIISKFSHQNIVRCVGLSFQAAPRLILLE
                     LMSGGDMKSFLRHSRPHPGQLSPLTMQDLLQLAQDIAQGCHYLEENHFIHRDIAARNC
                     LLSCSGDSRVAKIGDFGMARDIYQASYYRKGGRTLLPVKWMPPEALLEGLFTSKTDSW
                     SFGVLLWEIFSLGYMPYPGHTNQEVLDFIATGNRMDPPRNCPGPVYRIMTQCWQLQPE
                     LRPDFASILERIQYCIQDPDVLNSPLPMEPGPIVEEEGASGPGNRSLEGLRSPKTLEL
                     SSQNLKSRGGDLLGSQLPSGLKTLTSRCLQPQNIWNPTYGSWTPRSPQGEDSDIDLSN
                     GPSSDSFPGEQ"
     exon            273..371
                     /gene="Ltk"
                     /inference="alignment:Splign:2.1.0"
     exon            372..524
                     /gene="Ltk"
                     /inference="alignment:Splign:2.1.0"
     exon            525..620
                     /gene="Ltk"
                     /inference="alignment:Splign:2.1.0"
     exon            621..816
                     /gene="Ltk"
                     /inference="alignment:Splign:2.1.0"
     exon            817..907
                     /gene="Ltk"
                     /inference="alignment:Splign:2.1.0"
     exon            908..972
                     /gene="Ltk"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1102
                     /gene="Ltk"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1200
                     /gene="Ltk"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1293
                     /gene="Ltk"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1395
                     /gene="Ltk"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1530
                     /gene="Ltk"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1621
                     /gene="Ltk"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..2236
                     /gene="Ltk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgggtgctg tcgcctcgac ccccagttga gtgtcccagg cccttctttc tctctcgctg
       61 ggttcccggg gctcaggacc caggcgcggt ccctgaccgg ccactggccc catagctgcg
      121 cacagggaag ccagagccgc tgctggtggc ggcgggaggt ggcgggaggt cctacaggag
      181 gcgacctgag cgcggctgga ctcaggcggc ccccgagagg ctggagaccc gcgcggcggc
      241 gcagggcagc ggcaggagag gaggcgcggc cggcggtgat acttctgagt ctgacctcct
      301 ctgggctgat ggggaagatg gcatatcctt cgtccaccct agtggcgagc tttacctaca
      361 acctctggca gtcacagagg gcgatgttga ggtggagatc cgaaggcacc ccaattgcag
      421 tcactgctct ttcaaagact gccagtggca ggcagagctc tggagggctg aatgcatatg
      481 cccagagggc atggagctag ctgtggataa tatcacatgc acgggcctgc caaccaccac
      541 aagccctctg ataatgatgg gagctgttgt gacagccttg acgctgagtc tccttatgat
      601 gtgtggagtc ctaattctag tgaaccagaa gaaatgtcag agcctgcggg gaaccaggct
      661 gccaggccct gagcttgagc tgagtaagct gagaacctct gccatcagga cagcacccaa
      721 cccatattac tgtcaggtgg ggctcagccc tgcccaggcc tggcctctgc cccaagggct
      781 cactgaggtt tccccagcca atgtcactct actcagagcc cttggccatg gtgcctttgg
      841 ggaagtgtat gagggactag tgattggtct tcctggggat tccagccctc ttccggtggc
      901 tatcaagact ctgccggagc tctgctcccc tcaggatgag ctggactttc tcatggaggc
      961 tctcatcatc agcaagttca gccatcagaa tattgtacgc tgtgtggggc tcagcttcca
     1021 ggctgcccct cgcctcattc tgctggagct gatgtctggt ggggacatga agagctttct
     1081 gaggcatagc agaccacacc cgggacaact gtcacctctg accatgcagg acctattaca
     1141 gttggcccag gatatagctc agggctgcca ctacttggag gaaaatcact ttatccacag
     1201 agacattgcc gcccgaaact gtctgcttag ctgcagtgga gacagccgag tggccaagat
     1261 tggagacttt ggaatggcaa gagatatcta ccaggccagt tattatcgca aagggggccg
     1321 gaccttgctc ccagtgaagt ggatgccccc agaagctctc ctggagggcc ttttcacatc
     1381 caagacggac tcctggtctt ttggggtcct gctctgggag atcttctcac taggttatat
     1441 gccctaccct ggacacacca accaggaggt tctagacttc attgccacag ggaacaggat
     1501 ggaccctcct aggaactgtc ctgggccagt gtaccgaatc atgacccagt gctggcagct
     1561 tcaacctgag ctccgccctg actttgccag catcttggag cgcattcaat actgcattca
     1621 ggaccctgat gtgctgaact cgcccttgcc catggaacca gggcccattg tggaggagga
     1681 aggggcctct gggccgggga acaggtcact ggaaggtctt agatccccaa agaccctgga
     1741 actgagttcc cagaacttga aaagccgggg aggagacctt cttggctctc agctgccctc
     1801 tggcctcaag accctcacat ccagatgcct tcaacctcag aacatttgga accccaccta
     1861 tggctcctgg accccaagga gcccccaggg tgaagattca gacattgacc ttagcaatgg
     1921 cccctcctcg gattcctttc caggcgagca gtagcctctg ccccctgcag tctctgctgc
     1981 atgttcaggc atgtttcagg gatgtccaag cggcctgcct ggccttttta cactggaaac
     2041 catcctcgac cctcttgggg aaggcctggg ctactctcag tctttggagt cagttgggaa
     2101 tcctggattg tccactccct ataagtatct ttcctctgac ccatgccagt gctacaaatg
     2161 tttttagtaa tggtgatggt gatgatgatg atggtgatga tgatgatgat gataataaaa
     2221 cccttctaat tcttcaaaaa aaaaaaaaaa aa
//
