LOCUS       NM_001106864            2761 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus lactotransferrin (Ltf), mRNA.
ACCESSION   NM_001106864 XM_001076267 XM_236657
VERSION     NM_001106864.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2761)
  AUTHORS   Ke D, Wang X, Lin Y and Wei S.
  TITLE     Lactoferrin promotes the autophagy activity during osteoblast
            formation via BCL2-Beclin1 signaling
  JOURNAL   Mol Biol Rep 49 (1), 259-266 (2022)
   PUBMED   34716503
  REMARK    GeneRIF: Lactoferrin promotes the autophagy activity during
            osteoblast formation via BCL2-Beclin1 signaling.
REFERENCE   2  (bases 1 to 2761)
  AUTHORS   Ginet V, van de Looij Y, Petrenko V, Toulotte A, Kiss J, Huppi PS
            and Sizonenko SV.
  TITLE     Lactoferrin during lactation reduces lipopolysaccharide-induced
            brain injury
  JOURNAL   Biofactors 42 (3), 323-336 (2016)
   PUBMED   27313089
  REMARK    GeneRIF: Lf supplemented in food during lactation attenuated acute
            and long-term cerebral LPS-induced alterations. This provides a new
            evidence for a promising use of Lf as a preventive neuroprotective
            approach in preterm encephalopathy.
REFERENCE   3  (bases 1 to 2761)
  AUTHORS   Picard-Jean F, Bouchard S, Larivee G and Bisaillon M.
  TITLE     The intracellular inhibition of HCV replication represents a novel
            mechanism of action by the innate immune Lactoferrin protein
  JOURNAL   Antiviral Res 111, 13-22 (2014)
   PUBMED   25193851
REFERENCE   4  (bases 1 to 2761)
  AUTHORS   Talukder JR, Griffin A, Jaima A, Boyd B and Wright J.
  TITLE     Lactoferrin ameliorates prostaglandin E2-mediated inhibition of Na+
            -glucose cotransport in enterocytes
  JOURNAL   Can J Physiol Pharmacol 92 (1), 9-20 (2014)
   PUBMED   24383868
  REMARK    GeneRIF: Lactoferrin ameliorates the prostaglandin E2 inhibition of
            Na(+)-glucose cotransport most likely via the Ca(2+)- and
            cAMP-signaling pathways.
            Erratum:[Can J Physiol Pharmacol. 2014 Jun;92(6):519]
REFERENCE   5  (bases 1 to 2761)
  AUTHORS   Pieragostino D, Agnifili L, Fasanella V, D'Aguanno S, Mastropasqua
            R, Di Ilio C, Sacchetta P, Urbani A and Del Boccio P.
  TITLE     Shotgun proteomics reveals specific modulated protein patterns in
            tears of patients with primary open angle glaucoma naive to therapy
  JOURNAL   Mol Biosyst 9 (6), 1108-1116 (2013)
   PUBMED   23580065
REFERENCE   6  (bases 1 to 2761)
  AUTHORS   Bals R, Wang X, Wu Z, Freeman T, Bafna V, Zasloff M and Wilson JM.
  TITLE     Human beta-defensin 2 is a salt-sensitive peptide antibiotic
            expressed in human lung
  JOURNAL   J Clin Invest 102 (5), 874-880 (1998)
   PUBMED   9727055
REFERENCE   7  (bases 1 to 2761)
  AUTHORS   Chapple DS, Mason DJ, Joannou CL, Odell EW, Gant V and Evans RW.
  TITLE     Structure-function relationship of antibacterial synthetic peptides
            homologous to a helical surface region on human lactoferrin against
            Escherichia coli serotype O111
  JOURNAL   Infect Immun 66 (6), 2434-2440 (1998)
   PUBMED   9596699
REFERENCE   8  (bases 1 to 2761)
  AUTHORS   Sinico RA, Pozzi C, Radice A and Tincani A.
  TITLE     ANCA with specificity for lactoferrin in systemic lupus
            erythematosus (SLE)
  JOURNAL   Adv Exp Med Biol 336, 385-387 (1993)
   PUBMED   8296641
REFERENCE   9  (bases 1 to 2761)
  AUTHORS   Bellamy W, Takase M, Yamauchi K, Wakabayashi H, Kawase K and Tomita
            M.
  TITLE     Identification of the bactericidal domain of lactoferrin
  JOURNAL   Biochim Biophys Acta 1121 (1-2), 130-136 (1992)
   PUBMED   1599934
REFERENCE   10 (bases 1 to 2761)
  AUTHORS   Cramer,E., Pryzwansky,K.B., Villeval,J.L., Testa,U. and
            Breton-Gorius,J.
  TITLE     Ultrastructural localization of lactoferrin and myeloperoxidase in
            human neutrophils by immunogold
  JOURNAL   Blood 65 (2), 423-432 (1985)
   PUBMED   2981589
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473954.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001076267.1, XM_236657.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2761
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..2761
                     /gene="Ltf"
                     /note="lactotransferrin"
                     /db_xref="GeneID:301034"
                     /db_xref="RGD:1305445"
     exon            1..81
                     /gene="Ltf"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..2168
                     /gene="Ltf"
                     /note="lactoferrin"
                     /codon_start=1
                     /product="lactotransferrin precursor"
                     /protein_id="NP_001100334.1"
                     /db_xref="GeneID:301034"
                     /db_xref="RGD:1305445"
                     /translation="MRPFITVLMFLGVLGPFLARIDTVVRWCTISRNEAQKCFMWQEM
                     LNKAGVPKLRCARKYFMPHCIQEIMMRRADAMTLSGSAIFDFYFPYKLQPIAAEVYGT
                     KEKPRIHYYAVAVVKNSSDIRLNQLQGLKSCHAGFDTSAGWIAPLGALRPYLNWDEKS
                     VSLEEAVSKFFSQSCVPGISKSRFPRLCSLCAGKGEHICDFSPQEPYAGYAGAFRCLR
                     DNAGDVAFIRESTIFEELPNEAEWDQYKLLCPDNTWKPVTEYKECHLAQIPSRAVVAH
                     VRSEKDSAIWELLHLSQEMFGKNKTSKFELFGSYLGQKDLLFKDSVIGFVRVPFTVNV
                     WLYLTFSYIMALKSLKESKENVMALRARITWCAVGSEEKLKCDQWSRVSVGKITCISC
                     TTTEQCIFSITMGDADAMNLDGGYIYSAGKCGLVPVLAEIQKSPNSNGSDCVDRPAEG
                     YLAVAAVRKEDTGFTWSTVRGKKSCHTAVDRTAGWNIPMGLLVNQTNSCQFKEFFNKS
                     CAPGSFLYSNLCALCIGDENGKDKCNPNSQERYQGYVGAFRCLAEKAGNVAFLKDATV
                     LQNTDGKNADKWAKNLKLDDFELLCLDDTRKPVTEAKNCHLAVAPNHAVVARKDKARL
                     VQQELLYQQVQFGRNGCRCPEEFCLFRSETKNLLFNDNTECLAKLPSKITWEEYLGKE
                     YVVAIAHLRQCSNITQEAYNFLALRNS"
     exon            82..245
                     /gene="Ltf"
                     /inference="alignment:Splign:2.1.0"
     exon            246..351
                     /gene="Ltf"
                     /inference="alignment:Splign:2.1.0"
     exon            352..534
                     /gene="Ltf"
                     /inference="alignment:Splign:2.1.0"
     exon            535..682
                     /gene="Ltf"
                     /inference="alignment:Splign:2.1.0"
     exon            683..738
                     /gene="Ltf"
                     /inference="alignment:Splign:2.1.0"
     exon            739..917
                     /gene="Ltf"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1092
                     /gene="Ltf"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1247
                     /gene="Ltf"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1338
                     /gene="Ltf"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1386
                     /gene="Ltf"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1542
                     /gene="Ltf"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1684
                     /gene="Ltf"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1752
                     /gene="Ltf"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1937
                     /gene="Ltf"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..2127
                     /gene="Ltf"
                     /inference="alignment:Splign:2.1.0"
     exon            2128..2761
                     /gene="Ltf"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggtttgcct cctaggtctc cgaagaccga ccacagacat gaggccgttc atcactgtct
       61 tgatgtttct tggggtcctt ggaccctttc tagctaggat agatacagtt gttcgatggt
      121 gcaccatatc aagaaatgag gcacaaaaat gtttcatgtg gcaagagatg ctgaacaaag
      181 cgggtgtccc gaagcttaga tgtgccagga agtacttcat gcctcactgt atccaggaga
      241 ttatgatgag gagagccgac gccatgactc tttctggcag cgccatattc gatttctatt
      301 ttccctacaa actgcagccg atagctgccg aagtctatgg aaccaaagag aagccccgga
      361 ttcactatta tgcggtggcc gtcgtgaaga acagcagtga cattcgtctg aaccaactcc
      421 aaggcttgaa gtcctgccat gcaggctttg acactagtgc agggtggata gcccctttag
      481 gggcacttcg tccatacctg aattgggatg agaaatctgt atcccttgag gaagcggtat
      541 ccaagttctt ctcacagagc tgtgttcctg gtatcagcaa gtctagattt cccaggttgt
      601 gtagcttgtg tgcagggaaa ggagaacaca tatgtgactt ttccccccag gaaccatacg
      661 ctggctacgc aggtgccttc aggtgtctga gagacaacgc tggagatgtg gcttttatca
      721 gagaaagcac gatatttgag gagttaccca atgaagctga atgggaccag tacaagctgc
      781 tttgcccaga taacacctgg aagccggtga cagagtacaa ggagtgccac ctggctcaaa
      841 tcccttcacg tgctgtcgta gcccatgtca gaagtgaaaa agacagtgcc atctgggagc
      901 ttctccacct gtcacaggaa atgtttggaa aaaacaaaac atcaaaattc gagctctttg
      961 gctcctatct gggacagaag gacctgctgt tcaaggactc tgtcattggc tttgtgaggg
     1021 ttccctttac agtgaatgtt tggctttacc tgaccttcag ttatatcatg gccctgaaga
     1081 gcttgaagga aagcaaggag aatgtgatgg ccttaagggc ccggatcacg tggtgtgccg
     1141 tgggcagtga ggagaagctc aagtgtgacc agtggagcag agtgagtgtt ggcaagatta
     1201 cctgcatctc atgcaccacc acggagcagt gcatcttctc tatcacgatg ggagatgctg
     1261 atgccatgaa cttggatgga ggctatatct actctgcggg caagtgtggt ttagttccag
     1321 ttttggcaga gatccagaaa tcccccaata gcaatggctc tgattgtgtg gacagaccag
     1381 cagaagggta ccttgctgta gccgcagtca gaaaagaaga tactggcttc acctggagca
     1441 ctgtgagagg gaagaaatcc tgccacaccg ctgtggacag gaccgcgggc tggaacattc
     1501 ccatgggcct gcttgtcaac cagaccaact cctgccaatt taaggaattc tttaacaaaa
     1561 gctgcgcccc tgggtctttc ctctattcca atctctgtgc cctgtgtatt ggtgacgaga
     1621 acggtaagga taagtgtaac cccaacagcc aagagaggta ccaaggctac gtcggggctt
     1681 tcaggtgtct ggctgagaag gcaggaaatg tcgcgttttt gaaggacgcc actgtcttgc
     1741 agaatacaga cgggaagaat gctgacaagt gggctaagaa cttgaagctg gatgacttcg
     1801 agctgttgtg ccttgatgac acccggaagc ctgtgactga ggctaagaac tgccacctag
     1861 ccgtagcccc aaaccatgct gtagtagctc ggaaggacaa ggcgagactc gttcagcaag
     1921 agctgcttta ccaacaggtt cagtttggga gaaatggatg caggtgtcca gaagagtttt
     1981 gcctgttcag gtctgaaacc aaaaaccttc tgttcaatga caacactgag tgtctggcca
     2041 agctccccag caaaatcaca tgggaggaat atctaggcaa ggagtacgtc gtagcgatcg
     2101 cgcatctgag gcagtgctcc aatatcactc aggaagccta caattttctt gcccttcgaa
     2161 actcctgagc aatagcagag tcttcgcagg aagcctcagc caggacccat ggtcccgggg
     2221 ccttctgacc gtcctcggga ctccctgctg tcacttatgt agaaataaaa tgaagcaatg
     2281 ttggttttca cgtcatatga agtgtcactc atcatatcaa gtgtcactca tcgcatgaag
     2341 tgtcactcat cgctccttga agtttacacg gaaatcctgt gtctgaccac atgcttgcac
     2401 acttggactt tcttctggag tttctaggtc cagccattcc tttatcctga agttccaggc
     2461 gtgacgccca gtgacctgga atctggggaa aaccaaggga cgtttctttc cctgggggat
     2521 ctggtttctt cacatagaga tcacagtgca tatgtgtgtc ctggctcatg tgtgtgtatg
     2581 ggtgaacatg tatgcctcag catgttgcgt atagactgtg tatactcctc acactaatgc
     2641 ttctgtgtgt gtgtgtgtgt gtgtgtgtgt gtgcacatgt gtgtgagggc cagaggatat
     2701 ctggaatgcc accatctacc tttttgtttt aaaaaaatta attttactta tttacatttc
     2761 a
//
