LOCUS       NM_053639                506 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus leukotriene C4 synthase (Ltc4s), mRNA.
ACCESSION   NM_053639
VERSION     NM_053639.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Dalli,J., Vlasakov,I., Riley,I.R., Rodriguez,A.R., Spur,B.W.,
            Petasis,N.A., Chiang,N. and Serhan,C.N.
  TITLE     Maresin conjugates in tissue regeneration biosynthesis enzymes in
            human macrophages
  JOURNAL   Proc Natl Acad Sci U S A 113 (43), 12232-12237 (2016)
   PUBMED   27791009
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Zhang,W., Zhang,X., Gonzalez-Cobos,J.C., Stolwijk,J.A.,
            Matrougui,K. and Trebak,M.
  TITLE     Leukotriene-C4 synthase, a critical enzyme in the activation of
            store-independent Orai1/Orai3 channels, is required for neointimal
            hyperplasia
  JOURNAL   J Biol Chem 290 (8), 5015-5027 (2015)
   PUBMED   25540197
  REMARK    GeneRIF: LTC4S and Orai3 altered Akt signaling to promote VSMC
            migration and neointima formation.
REFERENCE   3  (bases 1 to 506)
  AUTHORS   Chen,W., Li,C., Zhao,J., Zhang,X., Han,H., Wei,E. and Zhang,L.
  TITLE     [Expression of 5-lipoxygenase in hippocampal CA1 neuronal damage
            following global cerebral ischemia in rats]
  JOURNAL   Zhejiang Da Xue Xue Bao Yi Xue Ban 42 (1), 61-66 (2013)
   PUBMED   23505109
  REMARK    GeneRIF: 5-LOX is involved in global cerebral ischemic damage in
            rats
REFERENCE   4  (bases 1 to 506)
  AUTHORS   Okubo,M., Yamanaka,H., Kobayashi,K. and Noguchi,K.
  TITLE     Leukotriene synthases and the receptors induced by peripheral nerve
            injury in the spinal cord contribute to the generation of
            neuropathic pain
  JOURNAL   Glia 58 (5), 599-610 (2010)
   PUBMED   19908283
REFERENCE   5  (bases 1 to 506)
  AUTHORS   Strid,T., Svartz,J., Franck,N., Hallin,E., Ingelsson,B.,
            Soderstrom,M. and Hammarstrom,S.
  TITLE     Distinct parts of leukotriene C(4) synthase interact with
            5-lipoxygenase and 5-lipoxygenase activating protein
  JOURNAL   Biochem Biophys Res Commun 381 (4), 518-522 (2009)
   PUBMED   19233132
REFERENCE   6  (bases 1 to 506)
  AUTHORS   Shimada,K., Navarro,J., Goeger,D.E., Mustafa,S.B., Weigel,P.H. and
            Weinman,S.A.
  TITLE     Expression and regulation of leukotriene-synthesis enzymes in rat
            liver cells
  JOURNAL   Hepatology 28 (5), 1275-1281 (1998)
   PUBMED   9794912
REFERENCE   7  (bases 1 to 506)
  AUTHORS   Lam,B.K., Penrose,J.F., Xu,K., Baldasaro,M.H. and Austen,K.F.
  TITLE     Site-directed mutagenesis of human leukotriene C4 synthase
  JOURNAL   J Biol Chem 272 (21), 13923-13928 (1997)
   PUBMED   9153254
REFERENCE   8  (bases 1 to 506)
  AUTHORS   Lam,B.K., Penrose,J.F., Rokach,J., Xu,K., Baldasaro,M.H. and
            Austen,K.F.
  TITLE     Molecular cloning, expression and characterization of mouse
            leukotriene C4 synthase
  JOURNAL   Eur J Biochem 238 (3), 606-612 (1996)
   PUBMED   8706658
REFERENCE   9  (bases 1 to 506)
  AUTHORS   Penrose,J.F., Spector,J., Lam,B.K., Friend,D.S., Xu,K., Jack,R.M.
            and Austen,K.F.
  TITLE     Purification of human lung leukotriene C4 synthase and preparation
            of a polyclonal antibody
  JOURNAL   Am J Respir Crit Care Med 152 (1), 283-289 (1995)
   PUBMED   7599836
REFERENCE   10 (bases 1 to 506)
  AUTHORS   Petric,R., Nicholson,D.W. and Ford-Hutchinson,A.W.
  TITLE     Renal leukotriene C4 synthase: characterization, partial
            purification and alterations in experimental glomerulonephritis
  JOURNAL   Biochim Biophys Acta 1254 (2), 207-215 (1995)
   PUBMED   7827126
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB048790.2.
            
            [WARNING] On Mar 19, 2024 this sequence was replaced by
            NM_053639.3.
            
            On Feb 20, 2002 this sequence version replaced NM_053639.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB048790.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680419, SAMN13663598
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..506
                     /gene="Ltc4s"
                     /note="leukotriene C4 synthase"
                     /db_xref="GeneID:114097"
                     /db_xref="RGD:620677"
     exon            1..83
                     /gene="Ltc4s"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..478
                     /gene="Ltc4s"
                     /EC_number="4.4.1.20"
                     /note="LTC4 synthase; leukotriene-C(4) synthase;
                     glutathione S-transferase LTC4"
                     /codon_start=1
                     /product="leukotriene C4 synthase"
                     /protein_id="NP_446091.2"
                     /db_xref="GeneID:114097"
                     /db_xref="RGD:620677"
                     /translation="MKEETALLATVTLVGVLLQAYFSLQVISARRTFHVSPPLTSGPP
                     EFERVFRAQVNCSEYFPLFLATLWVAGIFFHEGAAALCGLFYLFARLRYFQGYARSAQ
                     HRLDPLYASARALWLLVAMAALGLLVHFLPGTLRAALFRWLQVLLPMA"
     exon            84..183
                     /gene="Ltc4s"
                     /inference="alignment:Splign:2.1.0"
     exon            184..254
                     /gene="Ltc4s"
                     /inference="alignment:Splign:2.1.0"
     exon            255..336
                     /gene="Ltc4s"
                     /inference="alignment:Splign:2.1.0"
     exon            337..506
                     /gene="Ltc4s"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctaattctg cctgtggctg gcaacatgaa ggaagaaaca gctcttctgg ctaccgtcac
       61 cctcgtggga gttctgctgc aagcctactt ctccctacag gtgatctctg cgcgaagaac
      121 tttccacgtg tcgccgccgc tcacctctgg ccctcccgag ttcgagcgcg tcttccgagc
      181 ccaggtaaat tgcagcgagt actttccgct gttcctcgcc acgctctggg tcgccggcat
      241 cttcttccac gaaggcgccg cagccctgtg cgggctgttc tacctgttcg cgcggctccg
      301 ctacttccag ggatacgcgc gctccgcaca gcacaggctg gatcccctgt acgcgagcgc
      361 gcgcgcgctc tggctgctag tggcaatggc tgcactgggc ttgctagtcc acttcctccc
      421 tggcacacta cgggctgcgc tcttcagatg gctccaggtg ctcctgccga tggcctgagg
      481 cgaaggccct ccgaatcagc agaact
//
