LOCUS       NM_001170336            5157 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus latent transforming growth factor beta binding
            protein 4 (Ltbp4), mRNA.
ACCESSION   NM_001170336 XM_001077795 XM_238093
VERSION     NM_001170336.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5157)
  AUTHORS   Barallobre-Barreiro,J., Gupta,S.K., Zoccarato,A.,
            Kitazume-Taneike,R., Fava,M., Yin,X., Werner,T., Hirt,M.N.,
            Zampetaki,A., Viviano,A., Chong,M., Bern,M., Kourliouros,A.,
            Domenech,N., Willeit,P., Shah,A.M., Jahangiri,M., Schaefer,L.,
            Fischer,J.W., Iozzo,R.V., Viner,R., Thum,T., Heineke,J.,
            Kichler,A., Otsu,K. and Mayr,M.
  TITLE     Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin
            Activity in Human Atrial Fibrillation
  JOURNAL   Circulation 134 (11), 817-832 (2016)
   PUBMED   27559042
REFERENCE   2  (bases 1 to 5157)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   3  (bases 1 to 5157)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   4  (bases 1 to 5157)
  AUTHORS   Didangelos,A., Yin,X., Mandal,K., Baumert,M., Jahangiri,M. and
            Mayr,M.
  TITLE     Proteomics characterization of extracellular space components in
            the human aorta
  JOURNAL   Mol Cell Proteomics 9 (9), 2048-2062 (2010)
   PUBMED   20551380
REFERENCE   5  (bases 1 to 5157)
  AUTHORS   Koli,K., Hyytiainen,M., Ryynanen,M.J. and Keski-Oja,J.
  TITLE     Sequential deposition of latent TGF-beta binding proteins (LTBPs)
            during formation of the extracellular matrix in human lung
            fibroblasts
  JOURNAL   Exp Cell Res 310 (2), 370-382 (2005)
   PUBMED   16157329
REFERENCE   6  (bases 1 to 5157)
  AUTHORS   Sterner-Kock,A., Thorey,I.S., Koli,K., Wempe,F., Otte,J.,
            Bangsow,T., Kuhlmeier,K., Kirchner,T., Jin,S., Keski-Oja,J. and von
            Melchner,H.
  TITLE     Disruption of the gene encoding the latent transforming growth
            factor-beta binding protein 4 (LTBP-4) causes abnormal lung
            development, cardiomyopathy, and colorectal cancer
  JOURNAL   Genes Dev 16 (17), 2264-2273 (2002)
   PUBMED   12208849
REFERENCE   7  (bases 1 to 5157)
  AUTHORS   Saharinen,J. and Keski-Oja,J.
  TITLE     Specific sequence motif of 8-Cys repeats of TGF-beta binding
            proteins, LTBPs, creates a hydrophobic interaction surface for
            binding of small latent TGF-beta
  JOURNAL   Mol Biol Cell 11 (8), 2691-2704 (2000)
   PUBMED   10930463
REFERENCE   8  (bases 1 to 5157)
  AUTHORS   Saharinen,J., Taipale,J., Monni,O. and Keski-Oja,J.
  TITLE     Identification and characterization of a new latent transforming
            growth factor-beta-binding protein, LTBP-4
  JOURNAL   J Biol Chem 273 (29), 18459-18469 (1998)
   PUBMED   9660815
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Dec 19, 2009 this sequence version replaced
            XM_001077795.1, XM_238093.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.2032.1,
                                           SRR26643299.1753.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-143               JAXUCZ010000001.1  91759665-91759807   c
            144-202             JAXUCZ010000001.1  91757742-91757800   c
            203-341             JAXUCZ010000001.1  91757478-91757616   c
            342-451             JAXUCZ010000001.1  91756945-91757054   c
            452-643             JAXUCZ010000001.1  91752243-91752434   c
            644-891             JAXUCZ010000001.1  91751693-91751940   c
            892-994             JAXUCZ010000001.1  91751509-91751611   c
            995-1069            JAXUCZ010000001.1  91751080-91751154   c
            1070-1192           JAXUCZ010000001.1  91750846-91750968   c
            1193-1357           JAXUCZ010000001.1  91750151-91750315   c
            1358-1507           JAXUCZ010000001.1  91749594-91749743   c
            1508-1651           JAXUCZ010000001.1  91749321-91749464   c
            1652-1783           JAXUCZ010000001.1  91748740-91748871   c
            1784-1909           JAXUCZ010000001.1  91748521-91748646   c
            1910-2035           JAXUCZ010000001.1  91747703-91747828   c
            2036-2278           JAXUCZ010000001.1  91747054-91747296   c
            2279-2404           JAXUCZ010000001.1  91746428-91746553   c
            2405-2524           JAXUCZ010000001.1  91746221-91746340   c
            2525-2653           JAXUCZ010000001.1  91745195-91745323   c
            2654-2779           JAXUCZ010000001.1  91744866-91744991   c
            2780-2902           JAXUCZ010000001.1  91744351-91744473   c
            2903-3034           JAXUCZ010000001.1  91744077-91744208   c
            3035-3166           JAXUCZ010000001.1  91741934-91742065   c
            3167-3292           JAXUCZ010000001.1  91741719-91741844   c
            3293-3439           JAXUCZ010000001.1  91736947-91737093   c
            3440-3706           JAXUCZ010000001.1  91733029-91733295   c
            3707-3778           JAXUCZ010000001.1  91732682-91732753   c
            3779-3907           JAXUCZ010000001.1  91731738-91731866   c
            3908-4054           JAXUCZ010000001.1  91731411-91731557   c
            4055-4207           JAXUCZ010000001.1  91730416-91730568   c
            4208-4588           JAXUCZ010000001.1  91729207-91729587   c
            4589-4741           JAXUCZ010000001.1  91728669-91728821   c
            4742-5157           JAXUCZ010000001.1  91727769-91728184   c
FEATURES             Location/Qualifiers
     source          1..5157
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..5157
                     /gene="Ltbp4"
                     /note="latent transforming growth factor beta binding
                     protein 4"
                     /db_xref="GeneID:292734"
                     /db_xref="RGD:1307033"
     CDS             1..4896
                     /gene="Ltbp4"
                     /codon_start=1
                     /product="latent-transforming growth factor beta-binding
                     protein 4 precursor"
                     /protein_id="NP_001163807.1"
                     /db_xref="GeneID:292734"
                     /db_xref="RGD:1307033"
                     /translation="MRRPGLGCHCPLLLLLLLPAATSASGPSSSPSPIQAVEDAVVPG
                     HQAGAAACRCCLAQTPRSSHCTRASCRVRSCPPGRCTDQQGCLTPTPSVPSPSRSPVE
                     KRQVSLNWQPLTLQEARALLRQRRPRGPWARALLKRRPPHRAPAGQARVLCPLICHNG
                     GVCVKPDRCLCPPDFAGKFCQLHSSGARPPAPAMPGLTRSVYTMPLANHRDDEHGVAS
                     MVSVHVEHPQEASVVVHQVERVSGPWEEANSEALARAEAAARAEAAAPYTVLAQSAPR
                     EDGYSDASGFGYCFRELRGSECASPLPGLRTQEVCCRGEGLAWGVHDCHPCAEHLGNS
                     NRVSGPNGLCPTGFERVNGSCVDVDECATGGRCQHGECANTRGGYTCVCPDGFLLDSS
                     RSSCISQHVISEAKGPCYRVLQDGGCSLPILRNITKQICCCSRVGKAWGRGCQLCPPY
                     GSEGFREICPAGPGYHYSASDLRYNTRPLNPDPPRVTFNQPRAPPVTLRPPTGFLPTR
                     RPEPRPDPGPQPELRPRPEPQPRPEFPLPSIPAWTGPEIPESGTSSSMCQRNPQVCGP
                     GRCVSRPGGYTCACDPGFRLGPQGTRCIDVDECRRVPTPCAPGRCENTPGSFRCVCGT
                     GFRAGPRATECLDVDECRRVPPPCDRGRCENTPGSFLCVCPAGYQAAPHGASCQDVDE
                     CTQSPGLCGRGACENLPGSFRCVCPAGFLGSACEEDVDECAQQPPPCGPGRCDNTLGS
                     FHCACPAGFRSRGPGAPCQDVDECARSPSPCAYGRCENTEGSFKCVCPTGFQPNAAGS
                     ECEDVDECENHLACPGQECVNSPGSFQCRACPVGYHLHRGRCTDVDECNSGTPCGLHG
                     QCTNAQGSFHCSCSTGYRAPSGRPGPCADINECLEGDFCFPHGECLNTDGSFTCTCAP
                     GYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDIDEC
                     RERGPALCGSQRCENSPGSYRCVRDCDPGYHPGPEGTCDDVDECREYGSAICGAQRCE
                     NTPGSYRCTPACDPGYQPTPGGGCQDVDECRNRSFCGAHAMCQNLPGSFQCVCDQGYE
                     GARDGRHCVDVNECETLQGVCGSALCENVEGSFLCVCPTSPEEFDPMTGRCVPPRTPA
                     GTFPGSQPQAPASPSLPARPPAPPPPRRPSPPRQGPVSSGRRECYFDTAAPDACDNIL
                     ARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLVPSGDLSARRDVD
                     ECQLFQDQVCKSGVCVNTAPGYSCYCNNGFYYHAHRLECVDNDECADEEPACEGGRCV
                     NTVGSYHCTCEPPLVLDGSRRRCVSNESQSLDDNLGVCWQEVGPDLVCSRPRLDRQAT
                     YTECCCLYGEAWGMDCALCPAQDSDDFEALCNVLRPPAYGPPRPGGFGLPYEYGPDIG
                     PPYQSLPYGPDLYPPPVLPYDPYPPPPGPFARREAPYGAPPFEMPDFEDDGDPYGETE
                     APDPPSRGTGWPYRSRDTRGSFPEPEESSERGSYTGALSEPYEGLEAEECGILDGCAH
                     GRCVRVPEGFTCDCFDGYRLDITRMSCVDINECDEAEATSPLCVNARCVNTDGSFRCI
                     CRPGFAPTHQPHHCAPARPRA"
     exon            1..143
                     /gene="Ltbp4"
                     /inference="alignment:Splign:2.1.0"
     exon            144..202
                     /gene="Ltbp4"
                     /inference="alignment:Splign:2.1.0"
     exon            203..341
                     /gene="Ltbp4"
                     /inference="alignment:Splign:2.1.0"
     exon            342..451
                     /gene="Ltbp4"
                     /inference="alignment:Splign:2.1.0"
     exon            452..643
                     /gene="Ltbp4"
                     /inference="alignment:Splign:2.1.0"
     exon            644..891
                     /gene="Ltbp4"
                     /inference="alignment:Splign:2.1.0"
     exon            892..994
                     /gene="Ltbp4"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1069
                     /gene="Ltbp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1192
                     /gene="Ltbp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1357
                     /gene="Ltbp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1507
                     /gene="Ltbp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1651
                     /gene="Ltbp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1783
                     /gene="Ltbp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1909
                     /gene="Ltbp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1910..2035
                     /gene="Ltbp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..2278
                     /gene="Ltbp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2279..2404
                     /gene="Ltbp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2405..2524
                     /gene="Ltbp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2525..2653
                     /gene="Ltbp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2654..2779
                     /gene="Ltbp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2780..2902
                     /gene="Ltbp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2903..3034
                     /gene="Ltbp4"
                     /inference="alignment:Splign:2.1.0"
     exon            3035..3166
                     /gene="Ltbp4"
                     /inference="alignment:Splign:2.1.0"
     exon            3167..3292
                     /gene="Ltbp4"
                     /inference="alignment:Splign:2.1.0"
     exon            3293..3439
                     /gene="Ltbp4"
                     /inference="alignment:Splign:2.1.0"
     exon            3440..3706
                     /gene="Ltbp4"
                     /inference="alignment:Splign:2.1.0"
     exon            3707..3778
                     /gene="Ltbp4"
                     /inference="alignment:Splign:2.1.0"
     exon            3779..3907
                     /gene="Ltbp4"
                     /inference="alignment:Splign:2.1.0"
     exon            3908..4054
                     /gene="Ltbp4"
                     /inference="alignment:Splign:2.1.0"
     exon            4055..4207
                     /gene="Ltbp4"
                     /inference="alignment:Splign:2.1.0"
     exon            4208..4588
                     /gene="Ltbp4"
                     /inference="alignment:Splign:2.1.0"
     exon            4589..4741
                     /gene="Ltbp4"
                     /inference="alignment:Splign:2.1.0"
     exon            4742..5157
                     /gene="Ltbp4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgcgccggc ctggcctcgg ctgccactgc cccctcctcc tcctgctgct gctcccagcc
       61 gccacatctg ctagcggccc cagttccagt cccagcccta tccaggccgt cgaggacgcg
      121 gtggtcccgg gccaccaggc cggtgctgct gcctgtcgtt gctgcttagc ccagacacct
      181 aggagtagcc actgcacccg agcttcctgc agggtccgga gctgcccacc cggcaggtgt
      241 acagatcaac aggggtgcct gaccccaaca ccttcggtgc ccagccccag ccgcagtccg
      301 gtggagaaga gacaggtatc cctcaactgg cagccactga ctttgcagga ggcccgagct
      361 ctgctgaggc aaaggcggcc ccgagggccg tgggcccggg cattgctgaa aagaaggccc
      421 ccacatcgcg cccctgccgg ccaggcccgg gttctatgtc ccttgatctg tcacaacggt
      481 ggtgtgtgtg tgaagcctga ccgctgcctt tgccccccgg acttcgctgg caaattctgt
      541 caattgcatt cttcgggggc ccggcccccg gccccagcca tgccgggcct tacccgttcg
      601 gtttacacaa tgccactagc caatcaccgc gatgatgaac acggcgtagc atcgatggtg
      661 agtgtgcacg tggagcaccc tcaggaggca tcggtggtgg tgcaccaggt ggaacgtgtg
      721 tctggcccct gggaggaggc gaactctgaa gccctagcca gggctgaagc ggcagcacgg
      781 gccgaggcgg cggcgcccta cacagtgctg gcacagagcg cgccacgcga ggacggctac
      841 tcagacgcct ccggctttgg ttactgtttc agggaactgc gcggaagcga atgtgcatcg
      901 ccgctgccgg gactccggac gcaggaagta tgctgccgag gggagggctt ggcctggggt
      961 gttcatgatt gtcacccgtg cgcggaacac ttggggaact ccaaccgagt gagtggtcca
     1021 aatgggcttt gtccaaccgg attcgaaaga gttaatgggt cctgtgtaga tgtggatgag
     1081 tgcgccacag gtgggcgttg ccaacacgga gagtgtgcca acactcgtgg cgggtacacg
     1141 tgtgtatgtc cggatggttt cctcctagac tcttcccgca gcagctgcat ctcccaacac
     1201 gtgatctcgg aggcaaaggg gccctgctac agagtgctcc aagatggcgg atgctcgctg
     1261 cccattcttc gaaatatcac caaacagatc tgctgctgta gccgcgtggg caaggcgtgg
     1321 ggccgaggct gccagctctg tccaccttat ggttcagagg gttttcggga gatctgtcca
     1381 gctggccctg gttaccacta ttcagcttct gacctccgct acaacaccag acccctaaac
     1441 ccggatccac ctcgagtgac tttcaatcag ccacgtgctc cacctgtcac tcttaggcca
     1501 cccacaggtt ttctgcccac tcgtcgacct gagccccgtc ctgaccctgg gccacagcct
     1561 gaactccggc ctcgacctga accccagcct cggcctgaat ttcccctgcc cagcatccct
     1621 gcttggaccg gtccagagat tcctgaatca ggtacctctt ccagcatgtg tcagcgaaat
     1681 ccccaggttt gtggtcctgg acgctgcgtt tctcggccag gcggctacac ctgtgcctgc
     1741 gacccaggtt tccggctcgg cccccagggc actcgctgta ttgacgtaga tgaatgtcgc
     1801 cgcgtcccta caccctgtgc tcctggacgc tgcgagaata caccaggcag ctttcgctgc
     1861 gtgtgcggca ccggcttccg agcaggccca cgggctacag agtgtttgga tgtggacgag
     1921 tgccgccgag tgccgccgcc gtgtgaccgc gggcgctgcg agaacacacc aggaagtttc
     1981 ctatgtgtgt gtcccgccgg gtaccaggca gcaccgcacg gagccagctg ccaggatgtt
     2041 gatgaatgca cccagagccc aggcctctgt ggccgcgggg cctgcgaaaa cctgcccggc
     2101 tctttccgct gtgtttgccc ggctggtttc ctcggctcag cgtgtgaaga agatgtggac
     2161 gaatgtgccc agcagcctcc gccctgcggg ccaggccgct gcgacaacac cttgggttca
     2221 ttccactgtg cctgtccagc tggcttccgc tcccgagggc caggggcccc ctgccaagat
     2281 gtggacgaat gtgcccggag cccctcacct tgtgcctatg gccgctgtga aaacacggaa
     2341 gggagcttca agtgtgtctg ccctacaggc ttccaaccca acgctgcggg ctccgagtgc
     2401 gaggatgtgg atgagtgtga gaaccacttg gcctgtcctg ggcaggagtg tgtgaactca
     2461 ccaggctcct tccagtgccg ggcctgccct gttggctacc accttcaccg tggcagatgc
     2521 actgacgtgg acgaatgcaa ttccggcacc ccttgtggtc tccatggcca atgcacgaat
     2581 gcccaaggct ccttccactg cagctgctcg acaggttacc gggcaccatc tggtcgaccc
     2641 gggccctgtg cagatataaa tgagtgtctg gaaggcgact tctgcttccc ccatggagag
     2701 tgcctcaaca ccgacggctc ctttacctgt acctgtgccc ctggctatcg gcctggacct
     2761 cgtggagcat cttgtctgga cgtggacgag tgcagtgagg aggatctttg ccagagcggc
     2821 atctgtacca acactgacgg ctccttcgaa tgcatctgtc ctcctggaca ccgtgctggc
     2881 cctgaccttg cctcctgcct tgacattgac gagtgtcgtg aacggggacc tgccctgtgc
     2941 gggtctcagc gctgtgaaaa ttctcctggc tcctaccgct gtgtgcggga ctgcgatcca
     3001 ggttaccacc ctggccccga gggcacctgt gatgacgtgg acgagtgccg agaatatggc
     3061 tctgcgattt gcggcgccca gcgctgtgag aacacccctg gctcctaccg atgcacgcca
     3121 gcctgcgacc ctggctatca acctactcca gggggcgggt gccaggatgt ggatgagtgc
     3181 cggaaccggt ctttctgcgg tgcccatgct atgtgccaga atctgcctgg ctccttccag
     3241 tgcgtctgtg accaaggcta cgagggggca cgggacgggc gtcactgcgt ggatgtgaat
     3301 gagtgtgaga cactacaggg tgtctgtggc tccgcactgt gtgaaaatgt tgagggctcc
     3361 ttcctgtgtg tctgccccac cagccctgag gagttcgatc ccatgactgg acgttgtgtt
     3421 ccccctcgga ctcctgcagg cacgttccca ggctcgcagc cccaagcacc tgccagcccc
     3481 agtcttccag ccaggcctcc cgcccctccc ccacctcgaa gacccagtcc tcccaggcag
     3541 ggtcccgtga gcagtgggcg tcgtgagtgc tactttgaca cggcagctcc agatgcgtgt
     3601 gacaatatct tggctcgtaa cgtgacgtgg caggagtgct gctgtactgt gggagaaggc
     3661 tggggcagcg ggtgccgcat ccagcagtgc ccgggcacgg agacagctga ataccagtca
     3721 ttgtgtcctc acggccgggg ctacctagtg cccagtggag acctgagtgc ccggagagat
     3781 gtggatgaat gccaactctt ccaggaccag gtgtgcaaga gcggagtgtg tgtgaacact
     3841 gccccaggct actcttgcta ttgcaacaac ggcttctact atcatgcgca caggctggaa
     3901 tgcgttgata atgacgaatg tgccgacgag gagcccgctt gtgaaggtgg ccgctgcgtg
     3961 aacacggtgg gctcttacca ctgtacctgc gagcccccac tggtgctgga cggctccagg
     4021 cgacgctgcg tctccaatga gagccagagc cttgatgaca atctgggagt gtgctggcag
     4081 gaagtcgggc ctgatctcgt ctgcagtcgc ccacgactag accggcaggc cacctacaca
     4141 gagtgctgct gtctctatgg tgaagcctgg ggtatggact gtgctctctg tcctgcccag
     4201 gactcagatg attttgaggc tctttgcaat gtgctgcgcc cacctgctta tggcccgcca
     4261 cgcccgggtg gctttggact tccttatgaa tatggcccag atataggccc accttatcag
     4321 agtctcccct atgggccaga tctgtatcca ccacctgtgc taccctatga cccctaccca
     4381 cccccacctg gaccttttgc tcgccgggag gccccttatg gtgccccgcc cttcgaaatg
     4441 ccggactttg aggatgatgg tgacccctat ggcgagactg aggctcctga cccaccaagc
     4501 cgaggcactg gttggccata tcggtccaga gacacccgtg gctccttccc agagcctgag
     4561 gaatcctctg agcgtggaag ctatacagga gccttgtctg agccctatga gggcctagag
     4621 gccgaggagt gtggtatcct ggatggctgc gcccacggcc gctgtgtacg tgttccagaa
     4681 ggcttcacct gtgattgttt cgacggctac cgcctggaca tcacccgcat gtcctgcgtc
     4741 gacatcaacg agtgtgacga ggctgaggca acctccccac tctgcgtcaa tgcgcgctgt
     4801 gtcaacactg atggttcctt ccgctgtatt tgccgtccgg gatttgcacc cacgcaccaa
     4861 ccacatcact gtgcgcctgc tcgacctcgg gcctgagcag ctgcgtgcgc ctagcctccc
     4921 attataactg agcactagga gcttccagag tgcacctagc cttcctctag tctgcatgtg
     4981 tgtgaggatg tcagacagtc tcgatgtagg atggacggac acagaggggt gccttctatg
     5041 gcaccagttc atcatgccta gcccctccca ccagtgccct gggcctgtcc tgggttccct
     5101 gacacatttc ttgccctttt atacaatttt caattaaacc acctattttg tactttc
//
