LOCUS       NP_001163807            1631 aa            linear   ROD 28-MAR-2024
DEFINITION  latent-transforming growth factor beta-binding protein 4 precursor
            [Rattus norvegicus].
ACCESSION   NP_001163807 XP_001077795 XP_238093
VERSION     NP_001163807.1
DBSOURCE    REFSEQ: accession NM_001170336.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1631)
  AUTHORS   Barallobre-Barreiro,J., Gupta,S.K., Zoccarato,A.,
            Kitazume-Taneike,R., Fava,M., Yin,X., Werner,T., Hirt,M.N.,
            Zampetaki,A., Viviano,A., Chong,M., Bern,M., Kourliouros,A.,
            Domenech,N., Willeit,P., Shah,A.M., Jahangiri,M., Schaefer,L.,
            Fischer,J.W., Iozzo,R.V., Viner,R., Thum,T., Heineke,J.,
            Kichler,A., Otsu,K. and Mayr,M.
  TITLE     Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin
            Activity in Human Atrial Fibrillation
  JOURNAL   Circulation 134 (11), 817-832 (2016)
   PUBMED   27559042
REFERENCE   2  (residues 1 to 1631)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   3  (residues 1 to 1631)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   4  (residues 1 to 1631)
  AUTHORS   Didangelos,A., Yin,X., Mandal,K., Baumert,M., Jahangiri,M. and
            Mayr,M.
  TITLE     Proteomics characterization of extracellular space components in
            the human aorta
  JOURNAL   Mol Cell Proteomics 9 (9), 2048-2062 (2010)
   PUBMED   20551380
REFERENCE   5  (residues 1 to 1631)
  AUTHORS   Koli,K., Hyytiainen,M., Ryynanen,M.J. and Keski-Oja,J.
  TITLE     Sequential deposition of latent TGF-beta binding proteins (LTBPs)
            during formation of the extracellular matrix in human lung
            fibroblasts
  JOURNAL   Exp Cell Res 310 (2), 370-382 (2005)
   PUBMED   16157329
REFERENCE   6  (residues 1 to 1631)
  AUTHORS   Sterner-Kock,A., Thorey,I.S., Koli,K., Wempe,F., Otte,J.,
            Bangsow,T., Kuhlmeier,K., Kirchner,T., Jin,S., Keski-Oja,J. and von
            Melchner,H.
  TITLE     Disruption of the gene encoding the latent transforming growth
            factor-beta binding protein 4 (LTBP-4) causes abnormal lung
            development, cardiomyopathy, and colorectal cancer
  JOURNAL   Genes Dev 16 (17), 2264-2273 (2002)
   PUBMED   12208849
REFERENCE   7  (residues 1 to 1631)
  AUTHORS   Saharinen,J. and Keski-Oja,J.
  TITLE     Specific sequence motif of 8-Cys repeats of TGF-beta binding
            proteins, LTBPs, creates a hydrophobic interaction surface for
            binding of small latent TGF-beta
  JOURNAL   Mol Biol Cell 11 (8), 2691-2704 (2000)
   PUBMED   10930463
REFERENCE   8  (residues 1 to 1631)
  AUTHORS   Saharinen,J., Taipale,J., Monni,O. and Keski-Oja,J.
  TITLE     Identification and characterization of a new latent transforming
            growth factor-beta-binding protein, LTBP-4
  JOURNAL   J Biol Chem 273 (29), 18459-18469 (1998)
   PUBMED   9660815
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Dec 19, 2009 this sequence version replaced
            XP_001077795.1, XP_238093.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.2032.1,
                                           SRR26643299.1753.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1631
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     Protein         1..1631
                     /product="latent-transforming growth factor beta-binding
                     protein 4 precursor"
                     /calculated_mol_wt=172024
     sig_peptide     1..24
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2517
     Region          357..>387
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain; smart00179"
                     /db_xref="CDD:214542"
     Site            order(357,360,374)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          418..459
                     /region_name="TB"
                     /note="TB domain; pfam00683"
                     /db_xref="CDD:459903"
     Region          595..631
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain; smart00179"
                     /db_xref="CDD:214542"
     Site            order(595,598,613)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          637..678
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain; smart00179"
                     /db_xref="CDD:214542"
     Site            order(637,640,655)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          679..716
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(679,682,697)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          718..752
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain; smart00179"
                     /db_xref="CDD:214542"
     Site            order(718,721,736)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          760..801
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain; smart00179"
                     /db_xref="CDD:214542"
     Site            order(760,763,778)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          802..837
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain; smart00179"
                     /db_xref="CDD:214542"
     Region          842..874
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(842,845,860)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          885..921
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain; smart00179"
                     /db_xref="CDD:214542"
     Site            order(885,888,903)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          927..962
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain; smart00179"
                     /db_xref="CDD:214542"
     Site            order(927,930,944)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          968..1006
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain; smart00179"
                     /db_xref="CDD:214542"
     Region          1056..1097
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain; smart00179"
                     /db_xref="CDD:214542"
     Site            order(1056,1059,1074)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          1098..1126
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cl21504"
                     /db_xref="CDD:473889"
     Region          1200..1242
                     /region_name="TB"
                     /note="TB domain; pfam00683"
                     /db_xref="CDD:459903"
     Region          1303..>1332
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(1303,1306,1321)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          1367..1409
                     /region_name="TB"
                     /note="TB domain; pfam00683"
                     /db_xref="CDD:459903"
     Region          1581..>1615
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain; smart00179"
                     /db_xref="CDD:214542"
     Site            order(1581,1584,1602)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     CDS             1..1631
                     /gene="Ltbp4"
                     /coded_by="NM_001170336.1:1..4896"
                     /db_xref="GeneID:292734"
                     /db_xref="RGD:1307033"
ORIGIN      
        1 mrrpglgchc plllllllpa atsasgpsss pspiqaveda vvpghqagaa acrcclaqtp
       61 rsshctrasc rvrscppgrc tdqqgcltpt psvpspsrsp vekrqvslnw qpltlqeara
      121 llrqrrprgp warallkrrp phrapagqar vlcplichng gvcvkpdrcl cppdfagkfc
      181 qlhssgarpp apampgltrs vytmplanhr ddehgvasmv svhvehpqea svvvhqverv
      241 sgpweeanse alaraeaaar aeaaapytvl aqsapredgy sdasgfgycf relrgsecas
      301 plpglrtqev ccrgeglawg vhdchpcaeh lgnsnrvsgp nglcptgfer vngscvdvde
      361 catggrcqhg ecantrggyt cvcpdgflld ssrsscisqh viseakgpcy rvlqdggcsl
      421 pilrnitkqi cccsrvgkaw grgcqlcppy gsegfreicp agpgyhysas dlryntrpln
      481 pdpprvtfnq prappvtlrp ptgflptrrp eprpdpgpqp elrprpepqp rpefplpsip
      541 awtgpeipes gtsssmcqrn pqvcgpgrcv srpggytcac dpgfrlgpqg trcidvdecr
      601 rvptpcapgr centpgsfrc vcgtgfragp ratecldvde crrvpppcdr grcentpgsf
      661 lcvcpagyqa aphgascqdv dectqspglc grgacenlpg sfrcvcpagf lgsaceedvd
      721 ecaqqpppcg pgrcdntlgs fhcacpagfr srgpgapcqd vdecarspsp caygrcente
      781 gsfkcvcptg fqpnaagsec edvdecenhl acpgqecvns pgsfqcracp vgyhlhrgrc
      841 tdvdecnsgt pcglhgqctn aqgsfhcscs tgyrapsgrp gpcadinecl egdfcfphge
      901 clntdgsftc tcapgyrpgp rgascldvde cseedlcqsg ictntdgsfe cicppghrag
      961 pdlascldid ecrergpalc gsqrcenspg syrcvrdcdp gyhpgpegtc ddvdecreyg
     1021 saicgaqrce ntpgsyrctp acdpgyqptp gggcqdvdec rnrsfcgaha mcqnlpgsfq
     1081 cvcdqgyega rdgrhcvdvn ecetlqgvcg salcenvegs flcvcptspe efdpmtgrcv
     1141 pprtpagtfp gsqpqapasp slparppapp pprrpspprq gpvssgrrec yfdtaapdac
     1201 dnilarnvtw qeccctvgeg wgsgcriqqc pgtetaeyqs lcphgrgylv psgdlsarrd
     1261 vdecqlfqdq vcksgvcvnt apgyscycnn gfyyhahrle cvdndecade epaceggrcv
     1321 ntvgsyhctc epplvldgsr rrcvsnesqs lddnlgvcwq evgpdlvcsr prldrqatyt
     1381 eccclygeaw gmdcalcpaq dsddfealcn vlrppaygpp rpggfglpye ygpdigppyq
     1441 slpygpdlyp ppvlpydpyp pppgpfarre apygappfem pdfeddgdpy geteapdpps
     1501 rgtgwpyrsr dtrgsfpepe essergsytg alsepyegle aeecgildgc ahgrcvrvpe
     1561 gftcdcfdgy rlditrmscv dinecdeaea tsplcvnarc vntdgsfrci crpgfapthq
     1621 phhcaparpr a
//
