LOCUS       NM_001191561            4389 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus latent transforming growth factor beta binding
            protein 3 (Ltbp3), mRNA.
ACCESSION   NM_001191561 XM_002728859
VERSION     NM_001191561.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4389)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   2  (bases 1 to 4389)
  AUTHORS   Sun,X., Essalmani,R., Susan-Resiga,D., Prat,A. and Seidah,N.G.
  TITLE     Latent transforming growth factor beta-binding proteins-2 and -3
            inhibit the proprotein convertase 5/6A
  JOURNAL   J Biol Chem 286 (33), 29063-29073 (2011)
   PUBMED   21700711
  REMARK    GeneRIF: Latent transforming growth factor beta-binding proteins-2
            and -3 inhibit the proprotein convertase 5/6A.
REFERENCE   3  (bases 1 to 4389)
  AUTHORS   Yang,T., Mendoza-Londono,R., Lu,H., Tao,J., Li,K., Keller,B.,
            Jiang,M.M., Shah,R., Chen,Y., Bertin,T.K., Engin,F., Dabovic,B.,
            Rifkin,D.B., Hicks,J., Jamrich,M., Beaudet,A.L. and Lee,B.
  TITLE     E-selectin ligand-1 regulates growth plate homeostasis in mice by
            inhibiting the intracellular processing and secretion of mature
            TGF-beta
  JOURNAL   J Clin Invest 120 (7), 2474-2485 (2010)
   PUBMED   20530870
REFERENCE   4  (bases 1 to 4389)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   5  (bases 1 to 4389)
  AUTHORS   Koli,K., Ryynanen,M.J. and Keski-Oja,J.
  TITLE     Latent TGF-beta binding proteins (LTBPs)-1 and -3 coordinate
            proliferation and osteogenic differentiation of human mesenchymal
            stem cells
  JOURNAL   Bone 43 (4), 679-688 (2008)
   PUBMED   18672106
REFERENCE   6  (bases 1 to 4389)
  AUTHORS   Dabovic,B., Chen,Y., Colarossi,C., Zambuto,L., Obata,H. and
            Rifkin,D.B.
  TITLE     Bone defects in latent TGF-beta binding protein (Ltbp)-3 null mice;
            a role for Ltbp in TGF-beta presentation
  JOURNAL   J Endocrinol 175 (1), 129-141 (2002)
   PUBMED   12379497
REFERENCE   7  (bases 1 to 4389)
  AUTHORS   Dabovic,B., Chen,Y., Colarossi,C., Obata,H., Zambuto,L., Perle,M.A.
            and Rifkin,D.B.
  TITLE     Bone abnormalities in latent TGF-[beta] binding protein
            (Ltbp)-3-null mice indicate a role for Ltbp-3 in modulating
            TGF-[beta] bioavailability
  JOURNAL   J Cell Biol 156 (2), 227-232 (2002)
   PUBMED   11790802
REFERENCE   8  (bases 1 to 4389)
  AUTHORS   Saharinen,J. and Keski-Oja,J.
  TITLE     Specific sequence motif of 8-Cys repeats of TGF-beta binding
            proteins, LTBPs, creates a hydrophobic interaction surface for
            binding of small latent TGF-beta
  JOURNAL   Mol Biol Cell 11 (8), 2691-2704 (2000)
   PUBMED   10930463
REFERENCE   9  (bases 1 to 4389)
  AUTHORS   Gong,W., Roth,S., Michel,K. and Gressner,A.M.
  TITLE     Isoforms and splice variant of transforming growth factor
            beta-binding protein in rat hepatic stellate cells
  JOURNAL   Gastroenterology 114 (2), 352-363 (1998)
   PUBMED   9453497
REFERENCE   10 (bases 1 to 4389)
  AUTHORS   Yin,W., Smiley,E., Germiller,J., Mecham,R.P., Florer,J.B.,
            Wenstrup,R.J. and Bonadio,J.
  TITLE     Isolation of a novel latent transforming growth factor-beta binding
            protein gene (LTBP-3)
  JOURNAL   J Biol Chem 270 (17), 10147-10160 (1995)
   PUBMED   7730318
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jul 17, 2010 this sequence version replaced XM_002728859.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-501               JAXUCZ010000001.1  212459205-212459705
            502-831             JAXUCZ010000001.1  212462462-212462791
            832-1034            JAXUCZ010000001.1  212462944-212463146
            1035-1140           JAXUCZ010000001.1  212463324-212463429
            1141-1233           JAXUCZ010000001.1  212463655-212463747
            1234-1356           JAXUCZ010000001.1  212463913-212464035
            1357-1515           JAXUCZ010000001.1  212464409-212464567
            1516-1701           JAXUCZ010000001.1  212464664-212464849
            1702-1718           JAXUCZ010000001.1  212465403-212465419
            1719-1791           JAXUCZ010000001.1  212465493-212465565
            1792-1890           JAXUCZ010000001.1  212465716-212465814
            1891-2016           JAXUCZ010000001.1  212467596-212467721
            2017-2148           JAXUCZ010000001.1  212467851-212467982
            2149-2277           JAXUCZ010000001.1  212468078-212468206
            2278-2400           JAXUCZ010000001.1  212468428-212468550
            2401-2523           JAXUCZ010000001.1  212468686-212468808
            2524-2646           JAXUCZ010000001.1  212470390-212470512
            2647-2766           JAXUCZ010000001.1  212470717-212470836
            2767-2895           JAXUCZ010000001.1  212472302-212472430
            2896-3063           JAXUCZ010000001.1  212472665-212472832
            3064-3147           JAXUCZ010000001.1  212472970-212473053
            3148-3276           JAXUCZ010000001.1  212473306-212473434
            3277-3414           JAXUCZ010000001.1  212473519-212473656
            3415-3576           JAXUCZ010000001.1  212474066-212474227
            3577-3657           JAXUCZ010000001.1  212474303-212474383
            3658-3789           JAXUCZ010000001.1  212474471-212474602
            3790-4389           JAXUCZ010000001.1  212474703-212475302
FEATURES             Location/Qualifiers
     source          1..4389
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..4389
                     /gene="Ltbp3"
                     /note="latent transforming growth factor beta binding
                     protein 3"
                     /db_xref="GeneID:83838"
                     /db_xref="RGD:62057"
     exon            1..501
                     /gene="Ltbp3"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..3941
                     /gene="Ltbp3"
                     /codon_start=1
                     /product="latent-transforming growth factor beta-binding
                     protein 3 precursor"
                     /protein_id="NP_001178490.1"
                     /db_xref="GeneID:83838"
                     /db_xref="RGD:62057"
                     /translation="MPGPRGAARGLAPAMRQAGASGLLALLLLALLGPGGGAEGGPAG
                     ERGTGGGGALARERFKVVFAPVICKRTCLKGQCRDSCQQGSNMTLIGENGHSTDTLTG
                     SGFRVVVCPLPCMNGGQCSSRNQCLCPPDFTGRFCQVPAAGTGAGTGSSGPGLARTGA
                     MSTGPLPPLVPEGESVASKHAIYAVQVIADPPGPGEGPPAQHAAFLVPLGPGQISAEV
                     QAPPPVVNVRVHHPPEASVQVHRIEGPNAEGPASSQHLLPHPKPPHPRPPTQKPLGRC
                     FQDTLPKQPCGSNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEV
                     GADCPQGYKRLNSTHCQDINECVMPGMCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCI
                     ADKPEEKSLCFRLVSTEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPADGTAAFKE
                     ICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPESPSRAPALEDTEEERG
                     VTLDPPVSEERSVQQSHPTTTTSPARPYPELISRPSPPTFHRFLPDLPPSRSAVEIAP
                     TQVTETDECRLNQNICGHGQCVPGPSDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGP
                     GRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKC
                     NCYPGYRLKTSRPPVCEDIDECRDPSTCPDGKCENKPGSFKCIACQPGYRSQGGGACR
                     DINECSEGSPCSPGWCENLPGSYRCTCAQGYEPALDGLSCIDMDECETGNICHDGICT
                     NTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLV
                     GGRKCQDIDECSQDPGLCLPHGACENLQGSYVCVCDEGFTLTQDQHGCEEVEQPHHKK
                     ECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGK
                     GYTQDNNIVNYGIPAHRDIDECILFGAEICKEGKCVNTQPGYECYCKQGFYYDGNLLE
                     CVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMEHGPERREVC
                     WGQRGEDGMCMGPLAGPALTFDDCCCRQGRGWGTQCRPCPPRGTGSQCPTSQSESNSF
                     WDTSPLLLGKSPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVD
                     IDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFTRSRPHGACVPQRRR"
     exon            502..831
                     /gene="Ltbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            832..1034
                     /gene="Ltbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1140
                     /gene="Ltbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1233
                     /gene="Ltbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1356
                     /gene="Ltbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1515
                     /gene="Ltbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1701
                     /gene="Ltbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1718
                     /gene="Ltbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1791
                     /gene="Ltbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..1890
                     /gene="Ltbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..2016
                     /gene="Ltbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..2148
                     /gene="Ltbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..2277
                     /gene="Ltbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2278..2400
                     /gene="Ltbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2401..2523
                     /gene="Ltbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2524..2646
                     /gene="Ltbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2647..2766
                     /gene="Ltbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2767..2895
                     /gene="Ltbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2896..3063
                     /gene="Ltbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3064..3147
                     /gene="Ltbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3148..3276
                     /gene="Ltbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3277..3414
                     /gene="Ltbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3415..3576
                     /gene="Ltbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3577..3657
                     /gene="Ltbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3658..3789
                     /gene="Ltbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3790..4389
                     /gene="Ltbp3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccctcagtg cagcttccat cgctctccct cgcaaccgag atcccggccg ctcctgctgt
       61 cccctccctg cccttggctt ctggccccgc tcagccctct gcagccctct cccgggctcc
      121 caacactcga tcccctgctc gggctccacc cccgatctcc gagggtcgtg cggccccgga
      181 tgcccgggcc ccgaggggct gcccgcggcc tggcccctgc gatgcgccag gcgggggcat
      241 cggggctgct ggcgctactg ctgctggcgc tgctgggccc cggcggcggg gcggaggggg
      301 ggccggccgg cgagcggggc acaggcgggg gcggggcgct ggcccgcgaa cgcttcaagg
      361 tggtctttgc gccggtgatc tgcaagcgga cctgtctgaa gggccagtgt cgggacagct
      421 gtcagcaggg ctccaatatg acgctcatcg gagagaacgg ccacagcacc gacacgctca
      481 ccggttctgg cttccgcgtg gtggtgtgcc ctctaccctg catgaacggt ggccagtgct
      541 cctcccgaaa ccagtgcctg tgtcccccgg atttcacggg gcgcttctgc caggtgcctg
      601 ccgcaggaac tggagccggc accggcagtt caggccccgg actggcccgg accggagcca
      661 tgtccacagg cccgctgccg ccccttgtcc cagaaggaga gtctgtggct agcaaacacg
      721 ccatttatgc ggtgcaggtg atcgcagatc ctcccgggcc gggggagggt cctcctgcac
      781 aacatgcagc cttcttggtg cccctggggc caggacaaat ctcagcagaa gtgcaggctc
      841 cgccccctgt ggtgaacgtg cgtgtccatc accctcctga agcttccgtt caggtgcacc
      901 gcatcgaggg gccgaatgct gaaggtccag cctcctccca gcacctgctg ccgcatccca
      961 agcccccgca cccgaggcca cccacccaaa aaccactggg ccgctgcttc caggacacac
     1021 tgcccaagca gccttgtggc agcaaccctt tgcccggcct caccaagcag gaagattgct
     1081 gcggtagcat cggtactgcc tggggacaaa gcaagtgtca caagtgccca cagcttcagt
     1141 atacaggggt gcagaagcca ggacctgtac gtggggaggt gggtgctgac tgcccccagg
     1201 gctacaagag gctcaacagc acccactgcc aggacatcaa cgaatgtgtg atgcccggca
     1261 tgtgtcgcca tggtgactgt ctcaacaacc ctggctctta ccgctgtgtc tgcccgcctg
     1321 gtcatagcct gggtccctcg cgcacacagt gcattgccga caaaccagag gagaagagcc
     1381 tgtgtttccg cctcgtgagc actgagcatc agtgccagca cccactgacc acacgcctca
     1441 cacgccagct ctgctgctgc agtgtgggta aagcctgggg cgcccggtgc cagcgctgcc
     1501 cagcagatgg tacagcagcc ttcaaggaga tctgcccggc tgggaaaggg taccatatcc
     1561 tcacctccca ccagaccctc accatccagg gtgaaagtga tttctccctc ttcctgcacc
     1621 ctgatgggcc acccaaaccc cagcagcttc ctgaaagccc cagccgagca ccagcactcg
     1681 aggacacaga ggaagagaga ggagtgacct tggacccacc agtgagcgag gagcgatcgg
     1741 tgcaacagag ccaccccact accaccacct cacctgcccg gccttaccca gagctgatct
     1801 ctcgcccctc cccacctacc ttccaccgat tcctgccaga cttgccccca tcccgaagtg
     1861 cggtggagat cgcccccact caggtcacag agaccgatga gtgccgattg aaccagaaca
     1921 tctgtggcca tggacagtgt gtgcctggcc cctcggatta ctcctgccac tgcaacccgg
     1981 gctaccggtc acatccacag caccgatatt gtgttgatgt gaacgagtgt gaggcagagc
     2041 cctgcggtcc cgggagaggc atctgcatga acactggtgg ctcctataat tgtcactgca
     2101 accgaggcta ccgcctccac gtgggtgcag ggggccgctc gtgcgtggac ctaaacgagt
     2161 gcgccaagcc tcatctgtgt ggtgacggtg gcttctgcat caactttcct ggtcactaca
     2221 aatgcaactg ctatcctggc taccggctca agacctcacg accacccgtt tgcgaagaca
     2281 tcgacgaatg tcgcgaccct agcacctgcc ctgatggcaa atgtgaaaac aaacctggca
     2341 gcttcaagtg catcgcctgc cagcctggct atcgcagcca ggggggcgga gcctgtcgtg
     2401 atatcaacga atgctccgag gggagcccct gctctcctgg atggtgtgag aacctcccgg
     2461 gctcttaccg ttgcacgtgt gcccagggat acgagcccgc actggatggc ctcagttgca
     2521 tagacatgga tgagtgtgag accgggaaca tatgccacga tggcatctgc acgaacacac
     2581 caggctcctt ccagtgtcag tgcctctctg gctatcatct gtcaagggac cggagccatt
     2641 gtgaggacat tgatgaatgt gacttccccg cggcctgcat tgggggtgac tgcatcaata
     2701 ccaatggttc ctaccgatgt ctttgtcccc aaggccatcg gctggtggga ggcaggaagt
     2761 gccaagatat agatgagtgc agccaggacc caggcctgtg cctgccccac ggggcctgcg
     2821 agaatctcca gggctcctat gtctgtgtct gcgatgaggg tttcacactc acccaggacc
     2881 agcatggatg tgaggaggtg gagcagcccc accacaagaa ggaatgctac cttaactttg
     2941 atgacacagt gttctgtgac agtgtattgg ctaccaatgt cacccagcag gagtgttgtt
     3001 gctctctggg ggccggctgg ggagaccatt gtgaaatcta tccctgtcca gtctacagct
     3061 cagctgaatt tcacagcctg tgtcctgatg gaaagggcta cactcaagac aacaacatcg
     3121 tgaactatgg cattccagcc caccgtgaca tcgacgaatg catattgttt ggggcagaga
     3181 tctgtaagga gggcaagtgc gtgaatacgc aacccggcta cgagtgctac tgcaagcagg
     3241 gcttctatta cgacggcaac ctgctggagt gcgtggatgt ggatgagtgc ttggatgagt
     3301 ccaactgcag gaacggagtg tgtgagaaca cacgcggagg ctaccgctgc gcctgcacac
     3361 cgcccgcaga gtacagcccc gcgcagcgcc agtgtctgag cccggaggag atggagcatg
     3421 gcccagagcg acgagaagta tgctggggcc agcgcggaga ggacggcatg tgtatggggc
     3481 ccctggcggg acctgccctc actttcgatg actgttgctg ccgccagggc cgtggctggg
     3541 gtacccagtg cagaccgtgc ccgccgcgtg gcactgggtc ccagtgcccg acttcacaga
     3601 gtgagagcaa ttctttctgg gatacaagtc ccctgctact ggggaagtct ccacgagatg
     3661 aggacagctc ggaagaggat tcagatgagt gccgctgtgt gagtggccgc tgtgtgccac
     3721 ggccaggagg ggcagtatgt gaatgtcctg ggggctttca gctggacgcc tcccgtgccc
     3781 gctgcgtgga cattgatgag tgccgagagc tgaaccagcg cgggctgctg tgcaagagtg
     3841 agcggtgtgt gaacaccagt ggctccttcc gctgtgtctg caaagctggc ttcacccgca
     3901 gccgccctca cggtgcctgt gtgcctcagc ggcgccgctg atgcagtctt agcccacacc
     3961 tcagtgatca tccgtcgagg gtactctcca ctgaaagtgg agacaagaac atcctttgct
     4021 tctgaccaaa tgagagcatg gacccaagga cccttctggg cccacagagc tcctgcccac
     4081 accccaaaac caagggtgct cctgtctgca gagtgctgtc tgctttcctc cctgaggatg
     4141 atttctagaa acttccaagt cagatctgcc cctttaattt actcttggct ttcaaggcaa
     4201 attgatattc acatccaaag ctggttggga cggcagcacc aagacctact gcttgggcag
     4261 gttaggctga gctggaaccc aggatgtgaa atagaattta ttgtggctct gattatgtac
     4321 actagatgtg cctgacctgc tgaccaggct gacatggttt gtacaataaa tacatcctcc
     4381 gggcctgct
//
