LOCUS       NM_021586               6468 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Rattus norvegicus latent transforming growth factor beta binding
            protein 2 (Ltbp2), mRNA.
ACCESSION   NM_021586
VERSION     NM_021586.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6468)
  AUTHORS   Zhou,C., Sun,J., Wu,L., Liu,C., Cheng,Q., Xie,S. and Zhang,J.
  TITLE     LTBP2 down-regulated FGF2 to repress vascular smooth muscle cell
            proliferation and vascular remodeling in a rat model of
            intracranial aneurysm
  JOURNAL   Neurosci Lett 842, 137988 (2024)
   PUBMED   39288883
  REMARK    GeneRIF: LTBP2 down-regulated FGF2 to repress vascular smooth
            muscle cell proliferation and vascular remodeling in a rat model of
            intracranial aneurysm.
REFERENCE   2  (bases 1 to 6468)
  AUTHORS   Shi,Y., Jones,W., Beatty,W., Tan,Q., Mecham,R.P., Kumra,H.,
            Reinhardt,D.P., Gibson,M.A., Reilly,M.A., Rodriguez,J. and
            Bassnett,S.
  TITLE     Latent-transforming growth factor beta-binding protein-2 (LTBP-2)
            is required for longevity but not for development of zonular fibers
  JOURNAL   Matrix Biol 95, 15-31 (2021)
   PUBMED   33039488
REFERENCE   3  (bases 1 to 6468)
  AUTHORS   Park,S., Ranjbarvaziri,S., Zhao,P. and Ardehali,R.
  TITLE     Cardiac Fibrosis Is Associated With Decreased Circulating Levels of
            Full-Length CILP in Heart Failure
  JOURNAL   JACC Basic Transl Sci 5 (5), 432-443 (2020)
   PUBMED   32478206
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6468)
  AUTHORS   Pang,X.F., Lin,X., Du,J.J. and Zeng,D.Y.
  TITLE     LTBP2 knockdown by siRNA reverses myocardial oxidative stress
            injury, fibrosis and remodelling during dilated cardiomyopathy
  JOURNAL   Acta Physiol (Oxf) 228 (3), e13377 (2020)
   PUBMED   31512380
  REMARK    GeneRIF: LTBP2 knockdown by siRNA reverses myocardial oxidative
            stress injury, fibrosis and remodelling during dilated
            cardiomyopathy.
REFERENCE   5  (bases 1 to 6468)
  AUTHORS   Rauf,B., Irum,B., Khan,S.Y., Kabir,F., Naeem,M.A., Riazuddin,S.,
            Ayyagari,R. and Riazuddin,S.A.
  TITLE     Novel mutations in LTBP2 identified in familial cases of primary
            congenital glaucoma
  JOURNAL   Mol Vis 26, 14-25 (2020)
   PUBMED   32165823
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6468)
  AUTHORS   Ahmed,F., Torrado,M., Zinovieva,R.D., Senatorov,V.V., Wistow,G. and
            Tomarev,S.I.
  TITLE     Gene expression profile of the rat eye iridocorneal angle: NEIBank
            expressed sequence tag analysis
  JOURNAL   Invest Ophthalmol Vis Sci 45 (9), 3081-3090 (2004)
   PUBMED   15326124
REFERENCE   7  (bases 1 to 6468)
  AUTHORS   Oklu,R. and Hesketh,R.
  TITLE     The latent transforming growth factor beta binding protein (LTBP)
            family
  JOURNAL   Biochem J 352 Pt 3 (Pt 3), 601-610 (2000)
   PUBMED   11104663
  REMARK    Review article
REFERENCE   8  (bases 1 to 6468)
  AUTHORS   Saharinen,J., Hyytiainen,M., Taipale,J. and Keski-Oja,J.
  TITLE     Latent transforming growth factor-beta binding proteins
            (LTBPs)--structural extracellular matrix proteins for targeting
            TGF-beta action
  JOURNAL   Cytokine Growth Factor Rev 10 (2), 99-117 (1999)
   PUBMED   10743502
  REMARK    Review article
REFERENCE   9  (bases 1 to 6468)
  AUTHORS   Krohn,K.
  TITLE     TGF-beta1-dependent differential expression of a rat homolog for
            latent TGF-beta binding protein in astrocytes and C6 glioma cells
  JOURNAL   Glia 25 (4), 332-342 (1999)
   PUBMED   10028916
REFERENCE   10 (bases 1 to 6468)
  AUTHORS   Gong,W., Roth,S., Michel,K. and Gressner,A.M.
  TITLE     Isoforms and splice variant of transforming growth factor
            beta-binding protein in rat hepatic stellate cells
  JOURNAL   Gastroenterology 114 (2), 352-363 (1998)
   PUBMED   9453497
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DV213994.1, Y12760.1, CK479508.1 and CK358810.1.
            
            On Sep 28, 2011 this sequence version replaced NM_021586.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y12760.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132273,
                                           SAMD00132298 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-544               DV213994.1         103-646
            545-5076            Y12760.1           544-5075
            5077-5659           CK479508.1         97-679
            5660-6299           Y12760.1           5651-6290
            6300-6468           CK358810.1         1-169               c
FEATURES             Location/Qualifiers
     source          1..6468
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q31"
     gene            1..6468
                     /gene="Ltbp2"
                     /note="latent transforming growth factor beta binding
                     protein 2"
                     /db_xref="GeneID:59106"
                     /db_xref="RGD:68380"
     exon            1..591
                     /gene="Ltbp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..5419
                     /gene="Ltbp2"
                     /note="LTBP-2 like protein"
                     /codon_start=1
                     /product="latent-transforming growth factor beta-binding
                     protein 2"
                     /protein_id="NP_067597.2"
                     /db_xref="GeneID:59106"
                     /db_xref="RGD:68380"
                     /translation="MESTSLRGLRCPQLCSHSGAMRAPTTVRCSGRIQRARWRGFLPL
                     VLALLMGTSHAQRDSVGRYEPASRDANRLWRPVGNHPAAAAAKVYSLFREPDAPVPGL
                     SPSEWNQPGQGIPGRLAEAEARRPSRAQQLRRVQSPVQTRRSNPRGQQPPAARTAHSV
                     VRLATPQRPAAARRGRLTGRNVCGGQCCPGWTTSNSTNHCIKPVCQPPCQNRGSCSRP
                     QLCICRSGFRGARCEEVIPEEEFDPQNARPVPRRSVEGAPGPHRSSEARGSLVTRIQP
                     LLPPLPPPPSRTLSQTRPLQQHAGLSRTVRRYPATGTNGQLMSNALPSGPGPELRDSS
                     QQAAHMNHLSHPWGLNLTEKIKKIKVVFTPTICKQTCARGRCANTCEKGDTTTLYSQG
                     GHGHDPKSGFRIYFCQIPCLNGGRCIGRDECWCPANSTGKFCHLPVPQPDREPPGRGS
                     QHRALLEGPLKQSTFTLPLSNQLASVNPSLVKVQMQHPPEASVQIHQVARVRGEVDPV
                     PEDNSVETRASHRPHGSSGHSHWASNSIPARAGEAPRPPPVPSRHYGLLGQCYLSTVN
                     GQCANPLGELTSQEDCCGSVGTSWGVTSCAPCPPRPAFPVIENGQLECPQGYKRLNLS
                     HCQDINECLTLGLCKDSECVNTRGSYLCTCRPGLMLDPSRSRCVSDKAVSMKQGLCYR
                     SMVSGTCTLPLVQRITKQICCCSRVGKAWGSKCEHCPLPGTEAFREICPAGHGYAYSS
                     SDIRLSMRKAEEEELASPVREQRQQSSGPPPGAAERQPLRAATATWIEAETLPDKGDS
                     RAIQITTSAPHLPARVPGDATGRPTPSLPGQGIPEGPAEEQVIPSSDVLVTHGPPGFD
                     PCFAGASNICGPGTCVKLPNGYRCVCSPGYQLHPSQDYCTDDNECLRNPCEGRGRCVN
                     SVGSYSCLCYPGYTLATLGDTQECQDVDECEQPGVCSGGRCSNTEGSYHCECDQGYVM
                     VRRGHCQDINECRHPGTCPDGRCVNSPGSYTCLACEEGYIGQSGNCVDMNECLTPGIC
                     AHGRCINMEGSFRCSCEPGYELTPDKKGCRDVDECASRASCPTGLCLNTEGSFTCSAC
                     QSGYWVNEDGTACEDLDECAFPGVCPTGVCTNTVGSFSCKDCDRGFRPSPLGNSCEDV
                     DECEGPQNSCLGGECKNTDGSYQCLCPQGFQLANGTVCEDVDECVGEEHCAPHGECLN
                     SPGSFFCLCAPGFASAEGGTRCQDVDECATTEPCLGGHCVNTEGSFNCLCETGFQPAP
                     DSGECVDIDECANDTVCGNHGFCDNTDGSFRCLCDQGFETSPSGWECVDVNECELMLA
                     VCGDALCENVEGSFLCLCASDLEEYDAEEGHCRPRVAGAQRIPEVPTEEQAAGLTGME
                     CYAEHNGGPPCSQILGQNSTQAECCSTQGARWGETCDPCPSEDSVEFSELCPSGQGYI
                     PVEGAWTFGQAMYTDADECILFGPALCQNGRCLNTVPGYICLCNPGYHYDAVSRKCQD
                     HNECQDLACENGECVNTEGSFHCFCSPPLILDLSGQRCVNSTSSSEDFPDHDIHMDIC
                     WKKVTNDVCSQPLRGHHTTYTECCCQDGEAWSQQCALCPPRSSEVYAQLCNVARIEAE
                     REAGIHFRPGYEYGPGPDDLPETLYGPDGAPFYNYLGPEDTVPEPPFSNTASHLGDNT
                     PILEPPLQPSELQPHYIPSHSEPLASFEGLQAEECGILNGCENGRCVRVREGYTCDCF
                     EGFQLDTALMACVDVNECEDLNGPAALCAHGHCENTEGSYRCHCSPGYVAEPGPPHCA
                     AKE"
     exon            592..662
                     /gene="Ltbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            663..915
                     /gene="Ltbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1097
                     /gene="Ltbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1268
                     /gene="Ltbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1475
                     /gene="Ltbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1759
                     /gene="Ltbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..1862
                     /gene="Ltbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..1937
                     /gene="Ltbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..2060
                     /gene="Ltbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..2225
                     /gene="Ltbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2226..2441
                     /gene="Ltbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2442..2461
                     /gene="Ltbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2462..2501
                     /gene="Ltbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2502..2615
                     /gene="Ltbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2616..2744
                     /gene="Ltbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2745..2873
                     /gene="Ltbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2874..2993
                     /gene="Ltbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2994..3113
                     /gene="Ltbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            3114..3236
                     /gene="Ltbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            3237..3362
                     /gene="Ltbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            3363..3488
                     /gene="Ltbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            3489..3611
                     /gene="Ltbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            3612..3737
                     /gene="Ltbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            3738..3860
                     /gene="Ltbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            3861..3986
                     /gene="Ltbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            3987..4130
                     /gene="Ltbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            4131..4322
                     /gene="Ltbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            4323..4406
                     /gene="Ltbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            4407..4535
                     /gene="Ltbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            4536..4673
                     /gene="Ltbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            4674..4841
                     /gene="Ltbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            4842..5123
                     /gene="Ltbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            5124..5273
                     /gene="Ltbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            5274..6452
                     /gene="Ltbp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaggtcccc tagacgggaa ggggcacgcc gccaggcggg actgtggagc gaacgatgga
       61 gagcacctcc ctgcgaggtc tccggtgccc acagctctgc agccactctg gcgccatgag
      121 ggcgccgacc accgtccgct gctccggacg catccaaagg gcgcgttgga ggggcttcct
      181 gccacttgtc ctggctctct tgatggggac aagtcatgcc caaagggatt ccgtggggag
      241 atacgaacca gctagccggg atgccaatcg gttgtggcgc cccgtgggca accaccccgc
      301 agcggctgca gccaaggtgt acagtctgtt ccgagagccc gacgcgccgg tccccggctt
      361 gtcgccctct gagtggaatc agccgggcca ggggatccct gggaggctcg cagaggccga
      421 ggccaggaga ccgtcccgag cccagcagct gcgtcgagtc cagtcacctg tccagactcg
      481 gagaagcaat ccccgaggcc agcagccacc agcagcccgg accgcacatt ccgtcgtgcg
      541 cctggcgacc cctcagcgac ccgcggctgc acgccgaggg cggctcaccg ggagaaatgt
      601 ctgcggggga cagtgctgcc ctggatggac gacatcgaac agcaccaacc actgtatcaa
      661 acctgtgtgt cagcctccct gtcagaaccg gggctcctgc agccggcccc agctctgcat
      721 ctgccgttct ggcttccgtg gggcacgctg cgaggaggtc atccctgagg aggagtttga
      781 ccctcagaat gccaggcctg tgcccagacg ctcagtggag ggagcacctg gccctcacag
      841 gagcagcgag gccagaggaa gtctagtgac cagaatacag ccgctgctac caccactacc
      901 accacctcca tctaggaccc tcagccagac ccgtcccctg cagcagcatg caggactgtc
      961 cagaacagtt cgtcgttatc cggccactgg taccaatggc caactgatgt ccaacgctct
     1021 gccttcagga ccaggacctg agctgagaga cagcagccaa caggcagcac acatgaacca
     1081 tctctcacac ccctgggggc tgaacctcac cgagaaaatc aagaagatta aggtcgtctt
     1141 cactcccacc atctgcaagc agacctgtgc ccggggccgc tgtgccaaca cgtgtgagaa
     1201 gggtgacacc accaccctgt acagtcaggg cggccatggg catgacccca agtctggctt
     1261 ccgtatctat ttctgccaaa tcccctgcct gaatggaggc cgctgcattg gccgggacga
     1321 gtgctggtgt ccagccaact ctacagggaa gttctgccat ctgcctgtcc cacagccaga
     1381 cagggagcct ccaggacgag gctcccagca cagagccctg ctggaagggc cattgaagca
     1441 atccaccttc acgctgcctc tctccaacca gctggcctct gtgaacccct cgctggtgaa
     1501 ggtacaaatg cagcacccgc ctgaggcctc cgtgcagatc caccaggtgg cccgggtccg
     1561 gggtgaggtg gaccctgtgc cagaggacaa cagtgtggag accagagcct ctcatcgccc
     1621 ccatggcagc tcaggccaca gccactgggc cagcaacagc atacccgctc gggctggaga
     1681 ggcccctcgg ccaccaccag tgccgtccag gcattatgga cttctgggcc agtgttacct
     1741 gagcacggtg aatggacagt gtgctaaccc cctaggggag ctgacttctc aggaagactg
     1801 ctgtggcagt gtggggactt cttggggggt gacttcctgt gccccatgcc cacccagacc
     1861 agctttcccc gtgattgaaa acggccagct ggagtgtccc caagggtata agagactaaa
     1921 cctcagccat tgccaagaca tcaatgagtg cctgaccctg ggcctgtgca aggattcaga
     1981 gtgtgtgaac accaggggca gctacctgtg cacctgcagg cccggcctca tgctggatcc
     2041 atcaaggagc cgctgtgtat cggacaaggc tgtctccatg aaacagggac tctgttaccg
     2101 gtcaatggtg tctggcacct gcaccctgcc tttggtacaa cggatcacca agcagatatg
     2161 ctgttgcagc cgtgtgggca aagcctgggg cagcaaatgt gaacactgcc ccctgcctgg
     2221 cacagaagcc ttcagggaga tctgccctgc tggccatggc tacgcctact caagctcaga
     2281 catccgcctg tctatgagga aagctgagga agaggaactg gctagccccg taagggaaca
     2341 gagacagcag agcagtggac ccccacctgg ggcagcagaa aggcagccac tccgggcagc
     2401 cactgccacc tggattgagg ctgagaccct ccctgacaaa ggtgactctc gggctattca
     2461 gattacaacc agtgctcccc acctacctgc ccgggtacca ggggatgcca ctggaagacc
     2521 aacgccatca ttgcctggac agggcattcc agagggtcca gcagaagagc aggtgatccc
     2581 ttccagtgat gtcctggtga cgcacggtcc cccaggcttt gatccatgtt tcgctggagc
     2641 ctccaacatc tgtggccctg ggacctgtgt gaagctccca aatggataca gatgtgtctg
     2701 cagccctggt taccagctac accccagcca ggactactgt actgatgaca acgagtgtct
     2761 gaggaacccc tgtgaaggaa gagggcgctg tgtcaacagt gtgggctcct actcctgcct
     2821 ctgctaccca ggctacacac tagccaccct aggagacaca caggagtgcc aagatgtgga
     2881 tgagtgtgag cagccggggg tgtgcagcgg tggacgatgc agcaacactg agggctcgta
     2941 ccactgcgag tgtgatcagg gctacgtcat ggtcagaaga ggacactgcc aagatatcaa
     3001 cgaatgccgt caccctggta cctgccctga tgggagatgc gtcaactccc ctggctccta
     3061 cacttgtctg gcctgtgagg agggctacat agggcagagc gggaactgtg tagatatgaa
     3121 tgagtgtctg acccccggga tatgtgccca tggaaggtgc atcaacatgg aaggctcctt
     3181 tagatgctct tgtgagccag gctatgagct caccccagac aagaagggct gccgagatgt
     3241 ggacgagtgt gccagccgag cctcatgccc caccggcctc tgcctcaaca cggagggctc
     3301 cttcacctgc tcagcctgtc agagtgggta ctgggtgaac gaagatggca ctgcctgtga
     3361 agacctggat gaatgtgcct tccccggagt ctgccccaca ggcgtctgca ccaacactgt
     3421 gggctccttc tcctgcaagg actgcgacag gggcttccgg cccagccccc tgggcaacag
     3481 ctgtgaagat gtggatgagt gtgaaggtcc ccagaacagc tgcctgggag gcgagtgcaa
     3541 gaacacagat ggttcctacc agtgcctctg tccccagggc ttccagctgg ccaatggcac
     3601 cgtgtgtgag gatgtggacg aatgtgttgg ggaagaacac tgcgctcctc atggcgaatg
     3661 cctcaacagc ccggggtcct tcttctgtct ctgtgcaccc ggctttgcta gtgctgaggg
     3721 gggcaccaga tgccaggatg ttgatgaatg tgcaaccaca gagccgtgtc tgggaggaca
     3781 ctgtgtcaac accgagggct ccttcaactg tctgtgtgag actggcttcc agcccgcccc
     3841 agacagtgga gagtgtgtgg acatagatga atgtgcaaat gatactgtgt gtgggaacca
     3901 tggcttctgt gacaatacgg atggctcctt ccgctgcctg tgtgaccagg gcttcgagac
     3961 ctcaccctca ggctgggagt gtgttgatgt gaacgagtgt gagctcatgc tggcagtgtg
     4021 tggggatgca ctctgcgaga acgtggaagg ctccttcctg tgcctttgtg ccagtgacct
     4081 tgaggagtat gatgcagaag aaggacactg ccgtcctcgg gtggctggag ctcagagaat
     4141 cccagaggtc ccaacagagg agcaggctgc aggccttacc ggcatggagt gctatgctga
     4201 acacaatggt ggtcctccat gctctcaaat cttgggccag aactccacac aggctgagtg
     4261 ctgctcgacc cagggtgcca gatgggggga aacctgtgat ccctgcccat ctgaggactc
     4321 agttgaattc agtgagctgt gccccagtgg tcaaggttac atcccagtgg aaggggcctg
     4381 gacatttgga caagccatgt atacagatgc cgacgagtgc atactgtttg ggcctgctct
     4441 ctgccagaat ggccgatgcc tcaacacagt gcctggctac atttgcctgt gcaaccctgg
     4501 ctaccactat gatgccgtca gcaggaagtg ccaggatcac aacgaatgcc aggacttggc
     4561 ctgtgagaac ggcgagtgtg tgaacacaga aggctccttc cactgcttct gcagtccccc
     4621 cctcatccta gacctcagcg gacagcgctg tgtgaacagt accagcagct cagaggactt
     4681 ccctgaccat gacatccaca tggacatctg ctggaaaaaa gtcaccaatg acgtgtgcag
     4741 ccagcccttg cgtgggcacc atactaccta tacagagtgc tgctgccaag acggggaggc
     4801 ctggagccag cagtgtgctc tgtgcccccc caggagctct gaggtctatg ctcagctgtg
     4861 caatgtggct cggattgagg cagagaggga agcagggatc cacttccggc caggatatga
     4921 gtatggccct ggcccagatg atctacctga aaccctctac ggcccagatg gagccccttt
     4981 ctataactac ctgggccctg aggacactgt tcctgagcct cccttctcca acacagccag
     5041 tcatttggga gacaacacac ccatccttga gcctcctctg cagccctctg aacttcagcc
     5101 ccactatatc cccagccatt cagaacccct ggcttccttc gaaggccttc aggctgagga
     5161 atgtggcatc ctgaatggct gtgagaatgg ccgctgtgtg cgtgtgcgcg agggctacac
     5221 ttgtgactgc tttgaaggct tccagctgga tacagccctc atggcctgtg tggatgtgaa
     5281 tgagtgtgaa gacctgaacg ggcctgcggc actctgtgcg catggtcact gcgagaacac
     5341 agagggttcc tatcgctgcc actgttcccc tggttacgtg gcagagcccg ggcccccaca
     5401 ctgtgcagcc aaggagtagg agtgagagat catggtgggc agctatgtgg aaatggcttc
     5461 agccataggc tggggactta aggttgcttc cctagctggg aagacgtgac tgggaagacc
     5521 ccgtgatgcc atcaggccag ggctctggag cccagttccg ccagcctcgc ctccttttta
     5581 tctcttccgg cttaactctg ggtgtgaatt ccgtcactgc ctctatgcca ctgcttggct
     5641 cagacaccac aaatatttta atgctttagc cactggccgt gagacacagc ccacagtctg
     5701 tcctcggggc cacactttag agcgcccatc agaagagtcc tcgtgcactc ctcttaggct
     5761 gtgcagacac tgcaggcacc cccttccatc tgtgatctac acatcatctc gatggttctg
     5821 taacggggac agtggctaca tccacctggg gatggccctt cacagtgaat ggagcaggag
     5881 agggtctggg gagtagctcc aatgccacct ctcagaacca ccaccagcac tgggtggcgt
     5941 gagttctttt tgctactcct ccatcccata gacagttctg cggccccgag aagggaccag
     6001 tttccctcac ctcagaggat gaagactaat actaacttgc tgagtgtaag aaacgaaaga
     6061 agaggaataa cgagtctgag aaagtgtggc aagagagtga tacggaaaac atgggagtcc
     6121 atatgaaagg aggagccaag agttagacaa aacacgaagt cgctttgggc aaatcagtcc
     6181 aagcctcctt agagcttctg tgtgcctgca gggaggctcg ccacaagctc tggcgcccat
     6241 ctgcaaacac ctttattagg ctcatctgtt ccccacagga aaacctaaat agatggccta
     6301 acaatataaa ggcagagcaa gccagatttt caaagttgtt tctctcctcc actcagaagc
     6361 acttgccctt gcttcctcta agagatgcac ttccacacca gctagctggg ggttcaggag
     6421 cgtgggggaa taaaatgttc atctggctcc tcaaaaaaaa aaaaaaaa
//
