LOCUS       NM_021587               6232 bp    mRNA    linear   ROD 13-OCT-2024
DEFINITION  Rattus norvegicus latent transforming growth factor beta binding
            protein 1 (Ltbp1), mRNA.
ACCESSION   NM_021587
VERSION     NM_021587.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6232)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   2  (bases 1 to 6232)
  AUTHORS   Li,Y., Klena,N.T., Gabriel,G.C., Liu,X., Kim,A.J., Lemke,K.,
            Chen,Y., Chatterjee,B., Devine,W., Damerla,R.R., Chang,C., Yagi,H.,
            San Agustin,J.T., Thahir,M., Anderton,S., Lawhead,C., Vescovi,A.,
            Pratt,H., Morgan,J., Haynes,L., Smith,C.L., Eppig,J.T.,
            Reinholdt,L., Francis,R., Leatherbury,L., Ganapathiraju,M.K.,
            Tobita,K., Pazour,G.J. and Lo,C.W.
  TITLE     Global genetic analysis in mice unveils central role for cilia in
            congenital heart disease
  JOURNAL   Nature 521 (7553), 520-524 (2015)
   PUBMED   25807483
REFERENCE   3  (bases 1 to 6232)
  AUTHORS   Zanivan,S., Maione,F., Hein,M.Y., Hernandez-Fernaud,J.R.,
            Ostasiewicz,P., Giraudo,E. and Mann,M.
  TITLE     SILAC-based proteomics of human primary endothelial cell
            morphogenesis unveils tumor angiogenic markers
  JOURNAL   Mol Cell Proteomics 12 (12), 3599-3611 (2013)
   PUBMED   23979707
REFERENCE   4  (bases 1 to 6232)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   5  (bases 1 to 6232)
  AUTHORS   Didangelos,A., Yin,X., Mandal,K., Baumert,M., Jahangiri,M. and
            Mayr,M.
  TITLE     Proteomics characterization of extracellular space components in
            the human aorta
  JOURNAL   Mol Cell Proteomics 9 (9), 2048-2062 (2010)
   PUBMED   20551380
REFERENCE   6  (bases 1 to 6232)
  AUTHORS   Nakajima,Y., Miyazono,K., Kato,M., Takase,M., Yamagishi,T. and
            Nakamura,H.
  TITLE     Extracellular fibrillar structure of latent TGF beta binding
            protein-1: role in TGF beta-dependent endothelial-mesenchymal
            transformation during endocardial cushion tissue formation in mouse
            embryonic heart
  JOURNAL   J Cell Biol 136 (1), 193-204 (1997)
   PUBMED   9008713
REFERENCE   7  (bases 1 to 6232)
  AUTHORS   Saharinen,J., Taipale,J. and Keski-Oja,J.
  TITLE     Association of the small latent transforming growth factor-beta
            with an eight cysteine repeat of its binding protein LTBP-1
  JOURNAL   EMBO J 15 (2), 245-253 (1996)
   PUBMED   8617200
REFERENCE   8  (bases 1 to 6232)
  AUTHORS   Dallas,S.L., Miyazono,K., Skerry,T.M., Mundy,G.R. and Bonewald,L.F.
  TITLE     Dual role for the latent transforming growth factor-beta binding
            protein in storage of latent TGF-beta in the extracellular matrix
            and as a structural matrix protein
  JOURNAL   J Cell Biol 131 (2), 539-549 (1995)
   PUBMED   7593177
REFERENCE   9  (bases 1 to 6232)
  AUTHORS   Miyazono,K., Olofsson,A., Colosetti,P. and Heldin,C.H.
  TITLE     A role of the latent TGF-beta 1-binding protein in the assembly and
            secretion of TGF-beta 1
  JOURNAL   EMBO J 10 (5), 1091-1101 (1991)
   PUBMED   2022183
REFERENCE   10 (bases 1 to 6232)
  AUTHORS   Tsuji,T., Okada,F., Yamaguchi,K. and Nakamura,T.
  TITLE     Molecular cloning of the large subunit of transforming growth
            factor type beta masking protein and expression of the mRNA in
            various rat tissues
  JOURNAL   Proc Natl Acad Sci U S A 87 (22), 8835-8839 (1990)
   PUBMED   2247454
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Feb 26, 2021 this sequence version replaced NM_021587.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M55431.1, SRR26643295.24436.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-797               JAXUCZ010000006.1  26176505-26177301   c
            798-868             JAXUCZ010000006.1  26175476-26175546   c
            869-1160            JAXUCZ010000006.1  26115339-26115630   c
            1161-1330           JAXUCZ010000006.1  26024149-26024318   c
            1331-1498           JAXUCZ010000006.1  25996830-25996997   c
            1499-1723           JAXUCZ010000006.1  25954457-25954681   c
            1724-1998           JAXUCZ010000006.1  25952721-25952995   c
            1999-2101           JAXUCZ010000006.1  25931327-25931429   c
            2102-2173           JAXUCZ010000006.1  25927911-25927982   c
            2174-2296           JAXUCZ010000006.1  25912439-25912561   c
            2297-2464           JAXUCZ010000006.1  25901671-25901838   c
            2465-2692           JAXUCZ010000006.1  25898923-25899150   c
            2693-2715           JAXUCZ010000006.1  25896664-25896686   c
            2716-2815           JAXUCZ010000006.1  25893143-25893242   c
            2816-2914           JAXUCZ010000006.1  25892576-25892674   c
            2915-3040           JAXUCZ010000006.1  25886063-25886188   c
            3041-3166           JAXUCZ010000006.1  25884805-25884930   c
            3167-3289           JAXUCZ010000006.1  25883586-25883708   c
            3290-3409           JAXUCZ010000006.1  25879806-25879925   c
            3410-3532           JAXUCZ010000006.1  25866456-25866578   c
            3533-3655           JAXUCZ010000006.1  25863696-25863818   c
            3656-3778           JAXUCZ010000006.1  25861854-25861976   c
            3779-3901           JAXUCZ010000006.1  25852322-25852444   c
            3902-4027           JAXUCZ010000006.1  25846210-25846335   c
            4028-4153           JAXUCZ010000006.1  25824979-25825104   c
            4154-4297           JAXUCZ010000006.1  25821182-25821325   c
            4298-4477           JAXUCZ010000006.1  25814878-25815057   c
            4478-4564           JAXUCZ010000006.1  25813375-25813461   c
            4565-4693           JAXUCZ010000006.1  25811504-25811632   c
            4694-4834           JAXUCZ010000006.1  25810667-25810807   c
            4835-5005           JAXUCZ010000006.1  25809627-25809797   c
            5006-5128           JAXUCZ010000006.1  25788548-25788670   c
            5129-5278           JAXUCZ010000006.1  25783374-25783523   c
            5279-6232           JAXUCZ010000006.1  25781638-25782591   c
FEATURES             Location/Qualifiers
     source          1..6232
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q13"
     gene            1..6232
                     /gene="Ltbp1"
                     /note="latent transforming growth factor beta binding
                     protein 1"
                     /db_xref="GeneID:59107"
                     /db_xref="RGD:68379"
     exon            1..797
                     /gene="Ltbp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             322..5460
                     /gene="Ltbp1"
                     /note="LTBP-1; TGF-beta-1-BP-1; transforming growth factor
                     beta-1-binding protein 1; transforming growth factor
                     beta-1-masking protein large subunit; LanC (bacterial
                     lantibiotic synthetase component C)-like 1; transforming
                     growth factor-beta (TGF-beta) masking protein large
                     subunit"
                     /codon_start=1
                     /product="latent-transforming growth factor beta-binding
                     protein 1 precursor"
                     /protein_id="NP_067598.2"
                     /db_xref="GeneID:59107"
                     /db_xref="RGD:68379"
                     /translation="MAGAWLRWGLLLWAGLLAWSAHGRVRRITYVVRPGPGLPAGTLP
                     LAGPPRTFNVALDARYSRSSTATSSRSLAGPPAERTRRTSQPGGAALPGLRSPLPPEP
                     ARPGAPSRQLHSKAGAQTAVTRFAKHGRQVVRSKVQQDTQSSGGSRLQVQQKQQLQGI
                     NVCGGQCCHGWSKAPGSQRCTKPSCVPPCQNGGMCLRPQFCVCKPGTKGKACEITAAQ
                     DTMSPVFGGQNPGSSWVPPEPAAKRTSTKKADTLPRVSPVAQMTLTLKPKPSMGLSQQ
                     IHSQVAPLSSQNVMIRHGQTQEYVLKPKYFPAPKVVSGEQSTEGSFSLRYGQEQGTAP
                     FQVSNHTGRIKVVFTPSICKVTCTKGNCHNSCQKGNTTTLISENGHAADTLTATNFRV
                     VICHLPCMNGGQCSSRDKCQCPPNFTGKLCQIPVLGASMPKLYQHAQQPGKALGSHVI
                     HSTHTLPLTMTNQQGVKVKFPPNIVNIHVKHPPEASVQIHQVSRIDGPVGQRVKEVQP
                     GQSQVSYQGLPVQKTQTVHSTYSHQQVIPHVYPVAAKTQLGRCFQETIGSQCGKALPG
                     LSKQEDCCGTVGTSWGFNKCQKCPKKQSYHGYTQMMECLQGYKRVNNTFCQDINECQL
                     QGVCPNGECLNTMGSYRCSCKMGFGPDPTFSSCVPDPPMISEEKGPCYRLVSPGRQCM
                     HPLSVHLTKQICCCSVGKAWGPQCEKCPLPGTAAFKEICPGGMGYTVSGIHRRRPIHQ
                     HIGKEAVFVKPKNTQPVAKSTHPPPLPAKEEPVEALTSSREHGPGVAEPEVVTAPPEK
                     EIPSLDQEKTRLEPGQPQLSPGVSTIHLHPQFPVVVEKTSPPVPVEVAPEGSTSSASQ
                     VIAPTQVTEINECTVNPDICGAGHCINLPVRYTCICYEGYKFSEQQRKCIDIDECAQA
                     QHLCSQGRCENTEGSFLCICPAGFMASEEGSNCIDVDECLRPDVCRDGRCINTAGAFR
                     CEYCDSGYRMSRRGHCEDIDECLTPSTCPEEQCVNSPGSYQCVPCTEGFRGWNGQCLD
                     VDECLQPKVCTNGSCTNLEGSYMCSCHKGYSPTPDHRHCQDIDECQQGNLCMNGQCKN
                     TDGSFRCTCGQGYQLSAAKDQCEDIDECEHRHLCSHGQCRNTEGSFQCLCNQGYRASV
                     LGDHCEDINECLEDSSVCQGGDCINTAGSYDCTCPDGLQLNDNKGCQDINECAQPGLC
                     GPHGECLNTQGSFHCVCEQGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCL
                     CYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCR
                     SRATEDSGVDRQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIF
                     PCPVQGTAEFSEMCPRGKGFVPAGESSYETGGENYKDADECLLFGEEICKNGYCLNTQ
                     PGYECYCKEGTYYDPVKLQCFDMDECQDPNSCIDGQCVNTEGSYNCFCTHPMVLDASE
                     KRCVQPTESNEQIEETDVYQDLCWEHLSEEYVCSRPLVGKQTTYTECCCLYGEAWGMQ
                     CALCPMKDSDDYAQLCNIPVTGRRRPYGRDALVDFSEQYGPETDPYFIQDRFLNSFEE
                     LQAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDMAKMTCVDVNECSELNNRMSLCK
                     NAKCINTEGSYKCVCLPGYVPSDKPNYCTPLNTALNLDKDSDLE"
     exon            798..868
                     /gene="Ltbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            869..1160
                     /gene="Ltbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1330
                     /gene="Ltbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1498
                     /gene="Ltbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1723
                     /gene="Ltbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1998
                     /gene="Ltbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1999..2101
                     /gene="Ltbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2102..2173
                     /gene="Ltbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2296
                     /gene="Ltbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2297..2464
                     /gene="Ltbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2465..2692
                     /gene="Ltbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2693..2715
                     /gene="Ltbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2716..2815
                     /gene="Ltbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2816..2914
                     /gene="Ltbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2915..3040
                     /gene="Ltbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3041..3166
                     /gene="Ltbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3167..3289
                     /gene="Ltbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3290..3409
                     /gene="Ltbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3410..3532
                     /gene="Ltbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3533..3655
                     /gene="Ltbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3656..3778
                     /gene="Ltbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3779..3901
                     /gene="Ltbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3902..4027
                     /gene="Ltbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            4028..4153
                     /gene="Ltbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            4154..4297
                     /gene="Ltbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            4298..4477
                     /gene="Ltbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            4478..4564
                     /gene="Ltbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            4565..4693
                     /gene="Ltbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            4694..4834
                     /gene="Ltbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            4835..5005
                     /gene="Ltbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            5006..5128
                     /gene="Ltbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            5129..5278
                     /gene="Ltbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            5279..6232
                     /gene="Ltbp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgctcacggt cgtcctcgcc caccctcgcg gggtcggcgc ccatagcacc tcagcagcac
       61 ccggcgacac cccggctgag ccaggggacc ctcaccttga gcagcccgcg cccctcccct
      121 cctctccacc ccagctcccg ccccctgctc gcctccgctc ccggctgggg tccgctgccg
      181 ctcagccgcc cgcaaagctc cctccctgcg gccacccagt tggcctccac cccgcggcgc
      241 acaggctctc cgcggagtcc tcggggatac cgagggagtg cgccggggca gggcgagtcg
      301 cacggccgga gactgcccgc gatggcggga gcctggctca ggtggggact cctgctctgg
      361 gcagggctgc tagcgtggtc tgcgcacggc cgggtgcgga ggatcacgta cgtggtgcgc
      421 ccgggcccgg gactgccggc cggaaccctg cctctggctg ggcccccgcg gaccttcaac
      481 gtcgcactgg acgccaggta cagccggagc tcaacagcca cctccagccg ctccttggcc
      541 gggcccccag ccgagcggac ccggcgcacc agccagcctg gcggcgcggc cctgcccggg
      601 ctccgatctc cgctgccacc cgagcccgcg cgtccggggg cgcccagccg gcagctccac
      661 tcaaaggccg gtgctcagac cgcggtcact cgcttcgcca aacatggcag gcaagtcgtg
      721 cgctccaaag tgcagcagga cacgcagagc tccgggggct ccagactgca ggttcagcag
      781 aagcagcagc tgcaggggat caatgtctgt ggagggcagt gctgccatgg gtggagtaag
      841 gccccgggct cccagaggtg caccaaacca agctgtgttc caccatgcca gaatggaggg
      901 atgtgtctcc ggcctcagtt ctgtgtgtgt aagccaggga caaagggcaa agcctgcgag
      961 atcacagctg cccaggacac catgtcacca gtgtttggag ggcagaaccc tggctcctcg
     1021 tgggtccctc ctgagccagc agcaaagcgt acttcaacca agaaggcaga caccttacca
     1081 agggtcagtc cagtggccca gatgaccttg accctcaagc cgaagccgtc catgggactc
     1141 tcccagcaga tacattctca agtggcaccc ttgtcttccc agaatgtgat gattcggcat
     1201 ggccagaccc aggagtatgt gctcaagccc aagtacttcc cagccccaaa ggtggtctct
     1261 ggagagcagt ccacagaagg ctctttctct ttaagatatg ggcaggagca aggcacagca
     1321 ccctttcagg tgagtaacca cactggtcgc atcaaggtgg tctttactcc gagcatctgt
     1381 aaagtgacct gcaccaaggg caactgtcac aacagctgcc agaaggggaa taccaccact
     1441 ctcattagtg agaacggcca tgcagccgac accctgacag ccacgaactt ccgagtggta
     1501 atttgccatc ttccatgtat gaatggtggc cagtgcagtt caagggacaa atgtcagtgc
     1561 cctccaaatt tcacaggaaa gctttgccag atccctgtcc ttggtgccag tatgcctaaa
     1621 ctctaccagc acgcccagca gccaggcaag gcactgggga gtcacgtcat ccattccaca
     1681 cataccttgc ctctaaccat gaccaaccag caaggggtca aagtgaaatt tccccccaac
     1741 atagtcaata tccatgtgaa gcatcctcct gaggcttctg tgcagataca ccaggtttcc
     1801 agaattgatg gcccagtggg ccagagggtg aaagaagtgc aaccgggcca gtcccaagtc
     1861 tcttaccaag ggctgcccgt ccagaagacc cagacagtcc attccacata ctcccaccag
     1921 caggtcattc cgcatgtgta tcccgtggct gctaagacac aacttggacg atgcttccag
     1981 gaaaccattg ggtcacagtg tggcaaagcg ctccctggcc tttcaaagca agaggactgc
     2041 tgtgggacag tggggacctc ctggggcttt aacaaatgcc agaaatgccc caagaagcaa
     2101 tcctatcatg gatatactca aatgatggaa tgcctacaag gatataaacg ggttaacaac
     2161 accttttgtc aagatattaa tgaatgtcag ctccaaggcg tatgccctaa tggggagtgt
     2221 ttgaatacca tgggcagcta cagatgctcc tgcaaaatgg gatttgggcc tgaccctacc
     2281 ttttcaagtt gtgtgccgga tccccctatg atctcagaag agaaagggcc ctgctaccgc
     2341 ctcgtcagtc ctgggaggca gtgtatgcac cctctctctg ttcacctcac caagcagatc
     2401 tgctgttgta gtgtgggcaa ggcctggggc ccacagtgtg agaaatgtcc cctcccgggc
     2461 acagctgctt ttaaggaaat ctgtcctggt ggaatgggtt atacggtttc tggcattcat
     2521 agacgcaggc caatccatca gcatataggt aaagaagctg tatttgtcaa gccaaagaac
     2581 actcaacctg ttgctaaaag tactcatcct ccacctctcc cagccaagga agagcctgtg
     2641 gaggccctga cctcctcgcg ggaacatggg ccgggagtgg cagagcctga agtggtaaca
     2701 gcacctcctg agaaggaaat accctcactg gatcaagaga aaacaagact tgaacctggg
     2761 caaccccagc tctccccagg ggtttcaact attcatctgc acccacagtt cccagtagtg
     2821 gttgaaaaga catcccctcc tgtgcctgtg gaggtggctc ctgaaggttc tacatcaagt
     2881 gccagccaag tgattgctcc tacgcaagta acagaaatca acgaatgtac tgtgaacccg
     2941 gatatttgcg gagcaggaca ctgcatcaac ctgccggtga ggtatacctg catatgctac
     3001 gagggctaca agttcagtga gcagcagagg aagtgcattg acattgatga atgtgctcag
     3061 gcccagcatc tctgctccca gggtcgctgt gagaacacag agggaagttt cctgtgtatt
     3121 tgcccagcag ggtttatggc cagtgaggag ggttctaact gtatagatgt ggatgaatgt
     3181 ctgaggcccg atgtgtgtag ggacggccgc tgcatcaaca ctgctggggc cttccgatgc
     3241 gaatactgtg acagtgggta ccggatgtca cgacggggcc actgtgagga tatcgatgag
     3301 tgtctgaccc caagtacctg tcccgaggaa caatgcgtga attccccagg ttcttaccag
     3361 tgtgtgccct gcacagaagg gttccgtggc tggaatggac aatgcctcga tgtggacgag
     3421 tgcctgcagc caaaggtctg taccaatggt tcctgcacca acctggaagg ctcctacatg
     3481 tgttcctgcc acaagggcta cagccccaca ccagaccata gacactgtca agatattgat
     3541 gaatgtcagc aagggaacct gtgcatgaac gggcagtgca aaaacactga cggctccttc
     3601 cggtgtacct gtgggcaggg ctatcagctg tcagcggcta aagaccaatg tgaagatatt
     3661 gacgaatgcg agcaccgtca cctctgctct cacgggcagt gcaggaacac agagggctcc
     3721 ttccagtgtt tgtgcaacca gggttacaga gcatctgtgc ttggagacca ctgcgaggat
     3781 atcaatgaat gcttggagga cagtagtgtc tgccagggag gtgactgcat caatacagca
     3841 gggtcctatg actgcacgtg cccggatgga ctccagctga atgacaataa gggctgtcaa
     3901 gacattaatg aatgtgcaca gccaggactc tgtggacctc atggggagtg tctaaacaca
     3961 caaggctcat tccactgtgt ctgtgaacaa gggttctcca tctctgcaga tggtcgtact
     4021 tgtgaagata ttgatgagtg tgttaacaac actgtgtgtg acagtcacgg cttctgtgac
     4081 aacacagccg gctctttccg ctgcctctgt tatcagggct ttcaagcccc acaggatggg
     4141 caagggtgtg tggatgtgaa cgaatgtgaa ctgctcagtg gtgtatgtgg ggaggctttc
     4201 tgtgaaaatg tggaagggtc cttcctgtgc gtgtgtgccg atgagaacca ggagtacagc
     4261 cccatgactg ggcagtgtcg ctcccgggct actgaagatt caggtgtgga tcgtcagccc
     4321 aaagaagaaa agaaggagtg ttattataat ctcaatgatg ccagtctctg tgataacgtg
     4381 ctggccccca acgtcaccaa acaagagtgc tgctgtacat cgggcgccgg ctggggagac
     4441 aattgtgaga tcttcccttg cccagtccag gggactgctg agttctcgga aatgtgccct
     4501 agaggaaaag gttttgtccc tgctggagaa tcctcttacg aaaccggtgg tgagaactac
     4561 aaagatgctg acgaatgcct gctgtttgga gaggaaatct gcaaaaacgg ttactgtttg
     4621 aacactcagc ctgggtatga atgctactgc aaggaaggga catactacga tcctgtcaaa
     4681 ttacagtgtt ttgatatgga tgaatgccaa gaccctaaca gttgtatcga tggccagtgt
     4741 gttaatacag agggctctta caactgcttt tgcacccacc caatggtcct ggatgcctct
     4801 gagaagagat gtgtgcagcc aactgaatca aatgaacaaa tagaagaaac cgatgtctat
     4861 caagatctgt gctgggagca tctgagtgag gagtacgtgt gtagccgtcc tcttgtaggc
     4921 aagcagacga catacacaga gtgctgctgt ttgtacgggg aggcatgggg catgcagtgt
     4981 gctctctgcc ccatgaagga ctcagatgac tatgcccagc tgtgcaacat ccctgtgaca
     5041 ggacggcggc gaccatatgg acgggatgcg ttggtggact tcagtgaaca gtatggccca
     5101 gaaacagacc cttacttcat tcaggatcgc tttctaaaca gctttgagga gctacaggct
     5161 gaggaatgtg gcatcctcaa cggctgtgaa aatggccgct gtgtaagggt tcaggaaggt
     5221 tatacttgcg attgctttga tggatatcat ctggatatgg ccaagatgac ctgtgttgat
     5281 gtaaatgaat gcagcgagct gaataatcgg atgtctctct gcaagaacgc caagtgcatt
     5341 aacacagaag gctcctacaa atgcgtgtgt ctaccaggct acgtaccatc tgacaagccc
     5401 aactactgta caccactgaa caccgctttg aatttagaca aagacagtga cctggagtga
     5461 aggagaagct acgtaaccta tgcccatata ctctgcactg tgtaaaggaa aagggagaga
     5521 ggtatacttg agacactgca cctaatccag accatggcaa agaaggaaac aacgtggagt
     5581 tgcgtgaacc cccaaagaaa gtgagcggat ggagtagcag cctgagaggt gcgacagacc
     5641 aaatggacat ttcctcaaaa acccagtata tatagtctgt tcatatgtaa aattcaatgg
     5701 aaaagaggca ggatgcggct gtcattttaa acagaggttg tattattatc ttgttttgat
     5761 tttttttttt actattgctt aaatttggct tttaaatagt ggtgacgatg ttttatatga
     5821 gtcttctctg tgctgtgcag atccccagcc accatttttt cttcagcgat aatctcaagt
     5881 gcaaacatct ttgataacgt attgttaaac tgtattataa gtatgacaca gggttgtgct
     5941 gtcccttggt ccggagactt tgaaaaacaa attgtctgtc ctgtggagca ggcagtgact
     6001 gttaaacttt tatctacatt tagagtgggt gggaaaacac ctttattttc aatgtattat
     6061 cggattgcct gtcaattgga tcccttactt gggtggaaat ggaggagttt cttagcattt
     6121 attagcactg tgttgtgtaa agtcaaccca gaaaaattta aaaacctgaa atccccccct
     6181 caaaatattt accattgtat gttataagaa aataaaatcg ccatttttgt ag
//
