LOCUS       NM_021656               1377 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus leukotriene B4 receptor (Ltb4r), mRNA.
ACCESSION   NM_021656 XM_006252011
VERSION     NM_021656.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1377)
  AUTHORS   Ye,Z.N., Zhuang,Z., Wu,L.Y., Liu,J.P., Chen,Q., Zhang,X.S.,
            Zhou,M.L., Zhang,Z.H., Li,W., Wang,X.L. and Hang,C.H.
  TITLE     Expression and cell distribution of leukotriene B4 receptor 1 in
            the rat brain cortex after experimental subarachnoid hemorrhage
  JOURNAL   Brain Res 1652, 127-134 (2016)
   PUBMED   27725151
  REMARK    GeneRIF: Study verified that both BLT1 mRNA and BLT1 protein
            expressions were markedly increased after subarachnoid hemorrhage
            and elevated BLT1 expressions were mainly found in neurons,
            microglia and endothelial cells rather than astrocytes. We also
            demonstrated that there a significant positive correlation between
            BLT1 and nuclear p65 protein expressions in the same specific time
            course.
REFERENCE   2  (bases 1 to 1377)
  AUTHORS   Zhang,S.J., Deng,Y.M., Zhu,Y.L., Dong,X.W., Jiang,J.X. and Xie,Q.M.
  TITLE     Intracerebroventricular injection of leukotriene B4 attenuates
            antigen-induced asthmatic response via BLT1 receptor stimulating
            HPA-axis in sensitized rats
  JOURNAL   Respir Res 11 (1), 39 (2010)
   PUBMED   20403205
  REMARK    GeneRIF: LTB4 down-regulates airway contraction and inflammation
            through activation of the hypothalamic-pituitary-adrenal axis via
            its BLT1 receptor.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1377)
  AUTHORS   Serezani,C.H., Aronoff,D.M., Sitrin,R.G. and Peters-Golden,M.
  TITLE     FcgammaRI ligation leads to a complex with BLT1 in lipid rafts that
            enhances rat lung macrophage antimicrobial functions
  JOURNAL   Blood 114 (15), 3316-3324 (2009)
   PUBMED   19657115
  REMARK    GeneRIF: FcgammaRI ligation leads to a complex with BLT1 in lipid
            rafts that enhances rat lung macrophage antimicrobial functions.
REFERENCE   4  (bases 1 to 1377)
  AUTHORS   Han,C.G., Huang,H.G., Hu,M., Luo,W.Y., Gao,Y., Wang,Q. and Liu,Y.X.
  TITLE     [Involvement of leukotrine B4 receptors in the inflammatory
            responses and immunological regulation in vitro]
  JOURNAL   Zhongguo Ying Yong Sheng Li Xue Za Zhi 25 (2), 273-276 (2009)
   PUBMED   21189570
  REMARK    GeneRIF: BLT1 and BLT2 were involved in synovial cell
            proliferation.
REFERENCE   5  (bases 1 to 1377)
  AUTHORS   Venerito,M., Kuester,D., Wex,T., Roessner,A., Malfertheiner,P. and
            Treiber,G.
  TITLE     The long-term effect of Helicobacter pylori eradication on COX-1/2,
            5-LOX and leukotriene receptors in patients with a risk gastritis
            phenotype--a link to gastric carcinogenesis
  JOURNAL   Cancer Lett 270 (2), 218-228 (2008)
   PUBMED   18571838
REFERENCE   6  (bases 1 to 1377)
  AUTHORS   Back,M., Bu,D.X., Branstrom,R., Sheikine,Y., Yan,Z.Q. and
            Hansson,G.K.
  TITLE     Leukotriene B4 signaling through NF-kappaB-dependent BLT1 receptors
            on vascular smooth muscle cells in atherosclerosis and intimal
            hyperplasia
  JOURNAL   Proc Natl Acad Sci U S A 102 (48), 17501-17506 (2005)
   PUBMED   16293697
REFERENCE   7  (bases 1 to 1377)
  AUTHORS   Heller,E.A., Liu,E., Tager,A.M., Sinha,S., Roberts,J.D.,
            Koehn,S.L., Libby,P., Aikawa,E.R., Chen,J.Q., Huang,P.,
            Freeman,M.W., Moore,K.J., Luster,A.D. and Gerszten,R.E.
  TITLE     Inhibition of atherogenesis in BLT1-deficient mice reveals a role
            for LTB4 and BLT1 in smooth muscle cell recruitment
  JOURNAL   Circulation 112 (4), 578-586 (2005)
   PUBMED   16043658
REFERENCE   8  (bases 1 to 1377)
  AUTHORS   Iizuka,Y., Yokomizo,T., Terawaki,K., Komine,M., Tamaki,K. and
            Shimizu,T.
  TITLE     Characterization of a mouse second leukotriene B4 receptor, mBLT2:
            BLT2-dependent ERK activation and cell migration of primary mouse
            keratinocytes
  JOURNAL   J Biol Chem 280 (26), 24816-24823 (2005)
   PUBMED   15866883
REFERENCE   9  (bases 1 to 1377)
  AUTHORS   Jala,V.R., Shao,W.H. and Haribabu,B.
  TITLE     Phosphorylation-independent beta-arrestin translocation and
            internalization of leukotriene B4 receptors
  JOURNAL   J Biol Chem 280 (6), 4880-4887 (2005)
   PUBMED   15561704
  REMARK    GeneRIF: phosphorylation-independent mechanisms regulate
            beta-arrestin association and internalization of BLT1
REFERENCE   10 (bases 1 to 1377)
  AUTHORS   Toda,A., Yokomizo,T., Masuda,K., Nakao,A., Izumi,T. and Shimizu,T.
  TITLE     Cloning and characterization of rat leukotriene B(4) receptor
  JOURNAL   Biochem Biophys Res Commun 262 (3), 806-812 (1999)
   PUBMED   10471406
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On or before Sep 13, 2022 this sequence version replaced
            XM_006252011.4, NM_021656.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.1588508.1,
                                           SRR26643295.50793.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-131               JAXUCZ010000015.1  33233120-33233250
            132-1377            JAXUCZ010000015.1  33234391-33235636
FEATURES             Location/Qualifiers
     source          1..1377
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p13"
     gene            1..1377
                     /gene="Ltb4r"
                     /gene_synonym="BLT-1; BLT1; LTB4-R1; Ltb4r1"
                     /note="leukotriene B4 receptor"
                     /db_xref="GeneID:59264"
                     /db_xref="RGD:620410"
     exon            1..131
                     /gene="Ltb4r"
                     /gene_synonym="BLT-1; BLT1; LTB4-R1; Ltb4r1"
                     /inference="alignment:Splign:2.1.0"
     exon            132..1377
                     /gene="Ltb4r"
                     /gene_synonym="BLT-1; BLT1; LTB4-R1; Ltb4r1"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..1196
                     /gene="Ltb4r"
                     /gene_synonym="BLT-1; BLT1; LTB4-R1; Ltb4r1"
                     /codon_start=1
                     /product="leukotriene B4 receptor 1"
                     /protein_id="NP_067688.1"
                     /db_xref="GeneID:59264"
                     /db_xref="RGD:620410"
                     /translation="MAANTTSTAATSSPGGMSLSLLPIVLLSVALVVGLPGNSFVVWS
                     ILKRMQKRSVTALLVLNLALADLAVLLTAPFFLHFLARGTWSFEVTGCRLCHYVCGVS
                     MYASVLLITIMSLDRSLAVARPFVSQKVRTKAFARWVLAGIWVVSFLLAIPVLVYRTV
                     TPKNKTLICDSRYPSDGHKVFHLLFEAITGFLLPFLAVVASYSDIGRRLQARRFRRSR
                     RTGRLVVLIILAFAAFWLPYHLVNLVEAGRTLAGWDKNSPAGQRLKLARYVLIALAFL
                     SSSVNPVLYACAGGGLLRSAGVGFVVKLLEGTGSEVSSTRRGGTLVQTPKATPTCPEP
                     GPTDSFMTSSTPPESSK"
ORIGIN      
        1 acttcctctc tggctgtctt agctgacaga cctagaagtg ggaccaagac cctagcacta
       61 agacagattc aaggactgta tatccaacta ctagacgtgt gttaccttct gatcagcatc
      121 tgaaaaaccc tgaccttttg atggctgcaa acactacatc tactgcagca acttcttctc
      181 ctggtggcat gtccctgtct ctgttgccca ttgtcctgct gtctgtggcc ctggttgtgg
      241 ggcttcccgg caatagcttt gtcgtgtgga gcatcctgaa aaggatgcag aaacgctctg
      301 tcaccgccct gctggtgctg aacttggccc tggccgacct ggccgtgttg ctcactgctc
      361 cctttttcct acactttctg gctcggggca cctggagttt tgaagtgacc ggttgccgcc
      421 tgtgtcacta tgtctgtgga gtaagcatgt atgccagcgt cctgcttatc actatcatga
      481 gcctggaccg ctcactggca gttgcccgcc cctttgtgtc ccaaaaggtt cgtactaaag
      541 cctttgcccg atgggtgctg gcaggtatct gggtggtgtc ttttctgctg gccataccgg
      601 tccttgtgta ccgcacagta acacccaaga acaagacgtt gatctgcgac tcgaggtatc
      661 ccagcgacgg gcataaagtc tttcatctgc tctttgaagc catcacgggc ttcctgctgc
      721 ccttcctggc ggtggtggcc agctactctg acatcgggcg caggctgcag gctcggcgct
      781 tccgccgcag ccgccgcacc ggtcgcctgg tggtgctcat tatcctggcc ttcgccgcct
      841 tctggctgcc ttatcacctg gtgaacctgg tggaagctgg ccgcacgctg gccggctggg
      901 acaagaacag ccctgctggg cagcgtctga agctggcccg ctacgtgctg atcgcgctgg
      961 ccttcctgag cagcagcgtg aacccggtgc tgtacgcgtg cgcaggcggc ggcctgcttc
     1021 gttcggcggg cgtgggcttc gtagtcaagc tgctcgaggg cactggctcc gaggtgtcca
     1081 gcacccgtcg cggaggcact ttggtccaga ccccgaaggc cacacccacc tgtcctgaac
     1141 cgggccccac cgacagcttc atgacttcct ccacccctcc tgaatcttcg aagtgaactg
     1201 tagtaggttg ggttatgaca caactcataa cttggaggag aacctggagg agaacatgtt
     1261 ggggactggg ctaaagtgga aaagagggag gggtggggca agtcagggca gagagatagc
     1321 atgctctgtc ctggcttctg caggcagcct tacgattaaa actaaagtct aaagcca
//
