LOCUS       NM_212507               1195 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus lymphotoxin beta (Ltb), mRNA.
ACCESSION   NM_212507 XM_342090
VERSION     NM_212507.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1195)
  AUTHORS   Xu G, Liu D, Fan Y, Yang X, Korner H, Fu YX and Uzonna JE.
  TITLE     Lymphotoxin alpha beta 2 (membrane lymphotoxin) is critically
            important for resistance to Leishmania major infection in mice
  JOURNAL   J Immunol 179 (8), 5358-5366 (2007)
   PUBMED   17911622
  REMARK    Erratum:[J Immunol. 2007 Nov 15;179(10):7185]
REFERENCE   2  (bases 1 to 1195)
  AUTHORS   Lee CM, Knight B, Yeoh GC, Ramm GA and Olynyk JK.
  TITLE     Lymphotoxin-beta production following bile duct ligation: possible
            role for Kupffer cells
  JOURNAL   J Gastroenterol Hepatol 20 (11), 1762-1768 (2005)
   PUBMED   16246198
  REMARK    GeneRIF: Hepatic lymphotoxin-beta(LT-beta) expression is induced
            early following bile duct ligation. Kupffer cells may be an
            intrahepatic source of LT-beta.
REFERENCE   3  (bases 1 to 1195)
  AUTHORS   Wilhelm P, Riminton DS, Ritter U, Lemckert FA, Scheidig C, Hoek R,
            Sedgwick JD and Korner H.
  TITLE     Membrane lymphotoxin contributes to anti-leishmanial immunity by
            controlling structural integrity of lymphoid organs
  JOURNAL   Eur J Immunol 32 (7), 1993-2003 (2002)
   PUBMED   12115620
REFERENCE   4  (bases 1 to 1195)
  AUTHORS   Rennert PD, Hochman PS, Flavell RA, Chaplin DD, Jayaraman S,
            Browning JL and Fu YX.
  TITLE     Essential role of lymph nodes in contact hypersensitivity revealed
            in lymphotoxin-alpha-deficient mice
  JOURNAL   J Exp Med 193 (11), 1227-1238 (2001)
   PUBMED   11390430
REFERENCE   5  (bases 1 to 1195)
  AUTHORS   Sacca R, Cuff CA, Lesslauer W and Ruddle NH.
  TITLE     Differential activities of secreted lymphotoxin-alpha3 and membrane
            lymphotoxin-alpha1beta2 in lymphotoxin-induced inflammation:
            critical role of TNF receptor 1 signaling
  JOURNAL   J Immunol 160 (1), 485-491 (1998)
   PUBMED   9552007
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC088208.1.
            
            On Jan 2, 2005 this sequence version replaced NM_212507.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088208.1, CO570735.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1195
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..1195
                     /gene="Ltb"
                     /note="lymphotoxin beta"
                     /db_xref="GeneID:361795"
                     /db_xref="RGD:1303162"
     exon            1..245
                     /gene="Ltb"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..1004
                     /gene="Ltb"
                     /note="lymphotoxin B; lymphotoxin beta (TNF superfamily,
                     member 3)"
                     /codon_start=1
                     /product="lymphotoxin-beta"
                     /protein_id="NP_997672.1"
                     /db_xref="GeneID:361795"
                     /db_xref="RGD:1303162"
                     /translation="MGTRGLQGLGGRPQGRGCLLLAVAGATSLVTLLLAVPITVLAVL
                     ALVPQDQGRQVEKIVIGSGAQAQKGLDNKPSCISPSPSSLSETPDPRLHPQRSYSSRN
                     LDPTSQRPVAQPSREASAWVTTLSPAVDSILDPGVQQLPLGEPETDFSPELPAAHLIG
                     AWMSGQGLSWEASQEEAFLRSGAQFSRTHGLALPQDGVYYLYCHVGYRGRTPPAGRSR
                     ARLFTLRSALYRAGGAYGRGSPELLLEGAETVTPVVDPIGYGSLWYTSVGFGGLAQLR
                     SGERIYVNISHPDMVDYRRGKTFFGAVMVG"
     exon            246..561
                     /gene="Ltb"
                     /inference="alignment:Splign:2.1.0"
     exon            562..1168
                     /gene="Ltb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcaggtgtt tgggtctgca gggaggggtg gccctacccc tgaggtatga aagcccctgc
       61 ccgggtccta gctctgagtc tggatgggga cacggggact gcagggcctg ggtgggaggc
      121 cccaggggag gggctgcctc ttgctggctg tggcaggagc tacatcgctg gtgaccctgc
      181 tgttggcagt gcctatcact gtcctggctg tgctggccct ggtgccccag gatcagggac
      241 gtcaggttga gaagatcgtt attggctcgg gagcacaggc tcaaaaagga ctggacaaca
      301 aaccctcgtg catctcgccc tcaccctcta gcctctcaga gactcccgat ccccgtctgc
      361 atcctcagag atcctattct tccaggaatc tagatcccac atcccagcgc cctgttgcac
      421 agccctctcg ggaggcatct gcatgggtga ccaccctgtc cccagctgtg gattctatac
      481 tagatccagg ggttcaacag ctgccattgg gggaaccaga aactgacttc agccccgagc
      541 ttcctgctgc ccacctcata ggcgcttgga tgagcgggca agggctcagc tgggaggcga
      601 gccaagaaga agcgtttctg agaagcggtg cgcagttctc ccgcacccat gggctggcgc
      661 tgcctcagga cggcgtctac tatctctact gccatgtcgg gtatcggggc cggacgcccc
      721 ctgccggccg aagccgcgct cgcttgttca cgctgcgcag cgccctgtac cgcgcggggg
      781 gcgcctatgg gcggggctcc cccgagctgc tgctggaggg cgcggagacc gtgacccctg
      841 ttgtggatcc catcgggtac gggtctttgt ggtacacgag cgtggggttc ggcggcctgg
      901 cgcagctccg gagcggcgag aggatatacg tcaacatcag tcatcccgac atggtggact
      961 acaggagagg gaagaccttc ttcggggcgg tgatggtggg gtgacagcca actgcattcc
     1021 tggaggatct actgacggtg cgaatgtgtg aatcatgatg tctggcgagt caagaagcct
     1081 gggaccccag gatccgggac agctaggggc gtggcgcggg gttcgggaga tgtaggacac
     1141 gaattttgaa aataaagaat gtaaactaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
