LOCUS       NM_001030031            2020 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus leukotriene A4 hydrolase (Lta4h), mRNA.
ACCESSION   NM_001030031 XM_235057
VERSION     NM_001030031.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2020)
  AUTHORS   Konig,S., Pace,S., Pein,H., Heinekamp,T., Kramer,J., Romp,E.,
            Strassburger,M., Troisi,F., Proschak,A., Dworschak,J.,
            Scherlach,K., Rossi,A., Sautebin,L., Haeggstrom,J.Z., Hertweck,C.,
            Brakhage,A.A., Gerstmeier,J., Proschak,E. and Werz,O.
  TITLE     Gliotoxin from Aspergillus fumigatus Abrogates Leukotriene B4
            Formation through Inhibition of Leukotriene A4 Hydrolase
  JOURNAL   Cell Chem Biol 26 (4), 524-534 (2019)
   PUBMED   30745237
  REMARK    GeneRIF: Gliotoxin suppresses the biosynthesis of the potent
            neutrophil chemoattractant LTB4 by direct interference with LTA4H
            thereby impairing neutrophil functions in invasive aspergillosis.
REFERENCE   2  (bases 1 to 2020)
  AUTHORS   Mendes,M.T. and Silveira,P.F.
  TITLE     The interrelationship between leukotriene B4 and
            leukotriene-A4-hydrolase in collagen/adjuvant-induced arthritis in
            rats
  JOURNAL   Biomed Res Int 2014, 730421 (2014)
   PUBMED   24701582
  REMARK    GeneRIF: The involvement of compartmentalized and coupled changes
            of LTB4 and LTA4H in the resistance and development of arthritis in
            CIA model was demonstrated for the first time.
REFERENCE   3  (bases 1 to 2020)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 2020)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 2020)
  AUTHORS   Tholander,F., Muroya,A., Roques,B.P., Fournie-Zaluski,M.C.,
            Thunnissen,M.M. and Haeggstrom,J.Z.
  TITLE     Structure-based dissection of the active site chemistry of
            leukotriene A4 hydrolase: implications for M1 aminopeptidases and
            inhibitor design
  JOURNAL   Chem Biol 15 (9), 920-929 (2008)
   PUBMED   18804029
REFERENCE   6  (bases 1 to 2020)
  AUTHORS   Rudberg,P.C., Tholander,F., Thunnissen,M.M. and Haeggstrom,J.Z.
  TITLE     Leukotriene A4 hydrolase/aminopeptidase. Glutamate 271 is a
            catalytic residue with specific roles in two distinct enzyme
            mechanisms
  JOURNAL   J Biol Chem 277 (2), 1398-1404 (2002)
   PUBMED   11675384
REFERENCE   7  (bases 1 to 2020)
  AUTHORS   Ishizaka,N., Nakao,A., Ohishi,N., Suzuki,M., Aizawa,T., Taguchi,J.,
            Nagai,R., Shimizu,T. and Ohno,M.
  TITLE     Increased leukotriene A(4) hydrolase expression in the heart of
            angiotensin II-induced hypertensive rat
  JOURNAL   FEBS Lett 463 (1-2), 155-159 (1999)
   PUBMED   10601658
REFERENCE   8  (bases 1 to 2020)
  AUTHORS   Baset,H.A., Ford-Hutchinson,A.W. and O'Neill,G.P.
  TITLE     Molecular cloning and functional expression of a Caenorhabditis
            elegans aminopeptidase structurally related to mammalian
            leukotriene A4 hydrolases
  JOURNAL   J Biol Chem 273 (43), 27978-27987 (1998)
   PUBMED   9774412
REFERENCE   9  (bases 1 to 2020)
  AUTHORS   Makita,N., Funk,C.D., Imai,E., Hoover,R.L. and Badr,K.F.
  TITLE     Molecular cloning and functional expression of rat leukotriene A4
            hydrolase using the polymerase chain reaction
  JOURNAL   FEBS Lett 299 (3), 273-277 (1992)
   PUBMED   1544505
REFERENCE   10 (bases 1 to 2020)
  AUTHORS   Evans,J.F., Dupuis,P. and Ford-Hutchinson,A.W.
  TITLE     Purification and characterisation of leukotriene A4 hydrolase from
            rat neutrophils
  JOURNAL   Biochim Biophys Acta 840 (1), 43-50 (1985)
   PUBMED   3995081
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001030031.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099819.1, SRR26360176.972211.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-252               JAXUCZ010000007.1  29856871-29857122
            253-383             JAXUCZ010000007.1  29863101-29863231
            384-504             JAXUCZ010000007.1  29864573-29864693
            505-573             JAXUCZ010000007.1  29868432-29868500
            574-678             JAXUCZ010000007.1  29870164-29870268
            679-731             JAXUCZ010000007.1  29871368-29871420
            732-804             JAXUCZ010000007.1  29872886-29872958
            805-945             JAXUCZ010000007.1  29873197-29873337
            946-969             JAXUCZ010000007.1  29874686-29874709
            970-1040            JAXUCZ010000007.1  29875177-29875247
            1041-1152           JAXUCZ010000007.1  29875747-29875858
            1153-1297           JAXUCZ010000007.1  29876524-29876668
            1298-1401           JAXUCZ010000007.1  29878298-29878401
            1402-1472           JAXUCZ010000007.1  29878780-29878850
            1473-1527           JAXUCZ010000007.1  29882116-29882170
            1528-1623           JAXUCZ010000007.1  29884557-29884652
            1624-1706           JAXUCZ010000007.1  29886080-29886162
            1707-1811           JAXUCZ010000007.1  29886793-29886897
            1812-2020           JAXUCZ010000007.1  29888434-29888642
FEATURES             Location/Qualifiers
     source          1..2020
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     gene            1..2020
                     /gene="Lta4h"
                     /note="leukotriene A4 hydrolase"
                     /db_xref="GeneID:299732"
                     /db_xref="RGD:1311333"
     exon            1..252
                     /gene="Lta4h"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..1929
                     /gene="Lta4h"
                     /EC_number="3.3.2.6"
                     /EC_number="3.4.11.4"
                     /note="LTA-4 hydrolase; tripeptide aminopeptidase LTA4H"
                     /codon_start=1
                     /product="leukotriene A-4 hydrolase"
                     /protein_id="NP_001025202.1"
                     /db_xref="GeneID:299732"
                     /db_xref="RGD:1311333"
                     /translation="MPEVADTCSLASPASVCRTQHLHLRCSVDFARRALTGTAALTVQ
                     SQEDNLRSLTLDTKDLTIEKVVINGQEVKYTLGESQGYKGSPMEISLPIALSKNQEVV
                     IEISFETSPKSSALQWLTPEQTSGKQHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAE
                     VSVPKELVALMSAIRDGEAPDPEDPSRKIYRFNQRVPIPCYLIALVVGALESRQIGPR
                     TLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCL
                     TFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLF
                     GEKFRHFHALGGWGELQNTIKTFGESHPFTKLVVDLKDVDPDVAYSSIPYEKGFALLF
                     YLEQLLGGPEVFLGFLKAYVEKFSYQSVTTDDWKSFLYAHFKDKVDLLNQVDWNAWLY
                     APGLPPVKPNYDVTLTNACIALSQRWVTAKEEDLNSFSIEDLKDLSSHQLNEFLAQVL
                     QKAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEEAIPLALKMATEQGRMK
                     FTRPLFKDLAAFDKSHDQAVRTYQEHKACMHPVTAMLVGKDLKVD"
     exon            253..383
                     /gene="Lta4h"
                     /inference="alignment:Splign:2.1.0"
     exon            384..504
                     /gene="Lta4h"
                     /inference="alignment:Splign:2.1.0"
     exon            505..573
                     /gene="Lta4h"
                     /inference="alignment:Splign:2.1.0"
     exon            574..678
                     /gene="Lta4h"
                     /inference="alignment:Splign:2.1.0"
     exon            679..731
                     /gene="Lta4h"
                     /inference="alignment:Splign:2.1.0"
     exon            732..804
                     /gene="Lta4h"
                     /inference="alignment:Splign:2.1.0"
     exon            805..945
                     /gene="Lta4h"
                     /inference="alignment:Splign:2.1.0"
     exon            946..969
                     /gene="Lta4h"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1040
                     /gene="Lta4h"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1152
                     /gene="Lta4h"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1297
                     /gene="Lta4h"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1401
                     /gene="Lta4h"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1472
                     /gene="Lta4h"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1527
                     /gene="Lta4h"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1623
                     /gene="Lta4h"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1706
                     /gene="Lta4h"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..1811
                     /gene="Lta4h"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..2020
                     /gene="Lta4h"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctctatgct tccctccttt ctcaggcttg cggtgaaagt ctggcggtag agtgtctggg
       61 tgctggttga cgtgcggcgg atctcccaca accatgcctg aggtcgcgga tacttgttcc
      121 ttggcttctc cagcctcggt ctgccgaacc cagcacctcc atcttcgctg cagcgtcgac
      181 ttcgctcgcc gggcactgac cgggaccgcc gcgctcacgg tccagtcaca ggaggataat
      241 ctgcgcagcc tgactttgga tacaaaagac cttacgatag aaaaagtggt gatcaacgga
      301 caagaagtca aatacactct tggagaaagc cagggttaca aaggatcgcc gatggaaatc
      361 tcccttccca tcgctctgag caaaaatcaa gaggtcgtta tagagatttc cttcgagaca
      421 tctcccaagt cctcggccct tcagtggctc actcccgagc agacttcagg aaagcagcat
      481 ccatacctct tcagtcagtg ccaggccatc cactgcaggg caatcctccc ttgccaagac
      541 actccttctg tgaagttaac ctacaccgca gaggtatctg tccccaaaga actggtggct
      601 ctcatgagtg ccatccgtga tggagaagcc cctgacccag aagaccccag caggaagata
      661 tacagattta accagagggt tcccataccg tgctacctga ttgctttagt cgttggcgct
      721 ttagaaagca ggcaaattgg cccaagaact ctggtgtggt ctgagaaaga gcaggtggag
      781 aagtctgctt atgaattctc tgagactgaa tccatgctta aaattgcaga agatctgggg
      841 ggaccctatg tttggggaca gtacgacctg ttggtcctgc ccccatcctt cccgtacgga
      901 ggcatggaga atccttgtct cacattcgta acccctactc tattggcagg tgacaagtca
      961 ctctctaatg ttattgcaca cgaaatatcg catagctgga cagggaacct agtgactaac
     1021 aagacttggg atcacttctg gttaaacgaa ggacataccg tctatttaga gcgccacatt
     1081 tgtgggcggt tgtttgggga aaaattcaga catttccacg ctttaggagg atggggagag
     1141 ctacagaaca cgataaagac tttcggggag tcccatccct tcaccaagct cgtggtcgat
     1201 ctgaaggacg tagaccccga tgtggcctac tcctccattc cctacgagaa gggcttcgcc
     1261 ttgctcttct acctggaaca acttcttggg ggaccggagg tgtttctagg attcctaaag
     1321 gcttatgtgg agaagttttc ctaccagagc gtaaccactg atgactggaa gagtttcctg
     1381 tatgctcact ttaaagataa ggtggatctt ctcaatcaag ttgattggaa tgcctggctc
     1441 tatgctcctg gcctgcctcc tgtcaaaccc aattacgatg tgactctcac gaatgcctgc
     1501 atcgccttaa gtcaaagatg ggtcactgcc aaagaggaag atttaaattc attcagcatc
     1561 gaagacctga aggacctctc gtcccatcag ctgaatgagt tcctggcaca ggtgcttcag
     1621 aaggcacctc ttcccttggg gcacataaag cgaatgcaag aggtgtacaa cttcaatgcc
     1681 attaacaatt ctgaaatacg attcagatgg ttacggctct gcattcaatc gaagtgggaa
     1741 gaagcaattc ctttggccct aaagatggca actgaacaag gaaggatgaa atttacacga
     1801 cctctattca aggacctcgc tgccttcgac aaatcccacg atcaagctgt ccgcacctac
     1861 caggaacata aagcctgtat gcatcccgtg accgccatgc tggtggggaa agatctgaaa
     1921 gtggattaag gaactgagtg ttgctgattt cagaaaattc ctttttttaa gaaaaaaaat
     1981 cgaacctatt aagaaataca aaattttagc tctcgttgta
//
