LOCUS       NM_080769               1341 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus lymphotoxin alpha (Lta), mRNA.
ACCESSION   NM_080769 XM_001077049
VERSION     NM_080769.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1341)
  AUTHORS   James Bates,R.E., Browne,E., Schalks,R., Jacobs,H., Tan,L.,
            Parekh,P., Magliozzi,R., Calabrese,M., Mazarakis,N.D. and
            Reynolds,R.
  TITLE     Lymphotoxin-alpha expression in the meninges causes lymphoid tissue
            formation and neurodegeneration
  JOURNAL   Brain 145 (12), 4287-4307 (2022)
   PUBMED   35776111
  REMARK    GeneRIF: Lymphotoxin-alpha expression in the meninges causes
            lymphoid tissue formation and neurodegeneration.
REFERENCE   2  (bases 1 to 1341)
  AUTHORS   Guo,Z., Qiu,C., Mecca,C., Zhang,Y., Bian,J., Wang,Y., Wu,X.,
            Wang,T., Su,W., Li,X., Zhang,W., Chen,B. and Xiang,H.
  TITLE     Elevated lymphotoxin-alpha (TNFbeta) is associated with
            intervertebral disc degeneration
  JOURNAL   BMC Musculoskelet Disord 22 (1), 77 (2021)
   PUBMED   33441130
  REMARK    GeneRIF: Elevated lymphotoxin-alpha (TNFbeta) is associated with
            intervertebral disc degeneration.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1341)
  AUTHORS   Suna,S., Sakata,Y., Nakatani,D., Okuda,K., Shimizu,M., Usami,M.,
            Matsumoto,S., Hara,M., Ozaki,K., Mizuno,H., Minamino,T.,
            Takashima,S., Nishino,M., Matsumura,Y., Takeda,H., Tanaka,T.,
            Sato,H., Hori,M. and Komuro,I.
  TITLE     Decreased mortality associated with statin treatment in patients
            with acute myocardial infarction and lymphotoxin-alpha C804A
            polymorphism
  JOURNAL   Atherosclerosis 227 (2), 373-379 (2013)
   PUBMED   23398946
REFERENCE   4  (bases 1 to 1341)
  AUTHORS   Murdaca,G., Colombo,B.M., Contini,P. and Puppo,F.
  TITLE     Determination of lymphotoxin-alpha levels in patients with
            psoriatic arthritis undergoing etanercept treatment
  JOURNAL   J Interferon Cytokine Res 32 (6), 277-279 (2012)
   PUBMED   22480318
REFERENCE   5  (bases 1 to 1341)
  AUTHORS   Peric,A., Vojvodic,D. and Vukomanovic-Durdevid,B.
  TITLE     Influence of allergy on clinical, immunological and histological
            characteristics of nasal polyposis
  JOURNAL   B-ENT 8 (1), 25-32 (2012)
   PUBMED   22545387
REFERENCE   6  (bases 1 to 1341)
  AUTHORS   Issazadeh,S., Ljungdahl,A., Hojeberg,B., Mustafa,M. and Olsson,T.
  TITLE     Cytokine production in the central nervous system of Lewis rats
            with experimental autoimmune encephalomyelitis: dynamics of mRNA
            expression for interleukin-10, interleukin-12, cytolysin, tumor
            necrosis factor alpha and tumor necrosis factor beta
  JOURNAL   J Neuroimmunol 61 (2), 205-212 (1995)
   PUBMED   7593556
REFERENCE   7  (bases 1 to 1341)
  AUTHORS   Badenhoop,K., Schwarz,G., Schleusener,H., Weetman,A.P., Recks,S.,
            Peters,H., Bottazzo,G.F. and Usadel,K.H.
  TITLE     Tumor necrosis factor beta gene polymorphisms in Graves' disease
  JOURNAL   J Clin Endocrinol Metab 74 (2), 287-291 (1992)
   PUBMED   1346144
REFERENCE   8  (bases 1 to 1341)
  AUTHORS   Liu,S.K., Jakowatz,J.G., Pollack,R.B., Ceraldi,C., Yamamoto,R.,
            Dett,C., Lopez,F., Camacho,C., Carson,W.E., Sentovich,S.M. et al.
  TITLE     Effects of intracarotid and intravenous infusion of human TNF and
            LT on established intracerebral rat gliomas
  JOURNAL   Lymphokine Cytokine Res 10 (3), 189-194 (1991)
   PUBMED   1883913
REFERENCE   9  (bases 1 to 1341)
  AUTHORS   Imagawa,D.K., Millis,J.M., Olthoff,K.M., Seu,P., Dempsey,R.A.,
            Hart,J., Terasaki,P.I. and Busuttil,R.W.
  TITLE     Anti-tumor necrosis factor antibody enhances allograft survival in
            rats
  JOURNAL   J Surg Res 48 (4), 345-348 (1990)
   PUBMED   2338821
REFERENCE   10 (bases 1 to 1341)
  AUTHORS   Namba,Y. and Waksman,B.H.
  TITLE     Regulatory substances produced by lymphocytes. II. Lymphotoxin in
            the rat
  JOURNAL   J Immunol 115 (4), 1018-1022 (1975)
   PUBMED   1080770
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX883046.1.
            
            On Oct 2, 2009 this sequence version replaced NM_080769.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-142               BX883046.1         55301-55442         c
            143-247             BX883046.1         54833-54937         c
            248-347             BX883046.1         54651-54750         c
            348-1341            BX883046.1         53436-54429         c
FEATURES             Location/Qualifiers
     source          1..1341
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..1341
                     /gene="Lta"
                     /gene_synonym="Tnfb"
                     /note="lymphotoxin alpha"
                     /db_xref="GeneID:25008"
                     /db_xref="RGD:3020"
     exon            1..142
                     /gene="Lta"
                     /gene_synonym="Tnfb"
                     /inference="alignment:Splign:2.1.0"
     exon            143..247
                     /gene="Lta"
                     /gene_synonym="Tnfb"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..760
                     /gene="Lta"
                     /gene_synonym="Tnfb"
                     /note="tumor necrosis factor beta; LT-alpha; TNF-beta;
                     tumor necrosis factor ligand superfamily member 1;
                     lymphotoxin A; lymphotoxin alpha (TNF superfamily, member
                     1); lymphotoxin-alpha-like"
                     /codon_start=1
                     /product="lymphotoxin-alpha precursor"
                     /protein_id="NP_542947.1"
                     /db_xref="GeneID:25008"
                     /db_xref="RGD:3020"
                     /translation="MTPLGRLHLLRVLSTPPVFLLGLLLALPLGAQGLSGVRFSASRT
                     AHQPPQKHLTHGLLKPAAHLVGYPSKQNSLLWRANTDRAFLRHGFSLNNNSLLIPTSG
                     LYFVYSQVVFSGESCSPRAIPTPIYLAHEVQLFSSQYPFHVPLLSAQKSVYPGLQGPW
                     VRSMYQGAVFLLSKGDQLSTHTDGISHLHFSPSTVFFGAFAL"
     exon            248..347
                     /gene="Lta"
                     /gene_synonym="Tnfb"
                     /inference="alignment:Splign:2.1.0"
     exon            348..1341
                     /gene="Lta"
                     /gene_synonym="Tnfb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caggaccccg cacagcaggt gagcctctcc tgccctgtct ccttgggctt accccggtaa
       61 caggcatccc tcaggatcct gcctcttctc ttgagccaca gtcttttctg tacaacctgc
      121 ctggatcccc cagccttatc tggttctccc catgacacca cttggacgtc tccacctcct
      181 gagggtgctt agcacccctc ctgtcttcct cctggggctg ctgctggccc tgcctctagg
      241 ggcccaggga ctctctggtg ttcgcttctc agcttccagg acagctcacc agccccctca
      301 gaagcacttg acccatggcc tcctgaaacc tgccgctcac cttgttgggt accccagcaa
      361 acagaattca ctgctctgga gagcaaacac ggaccgcgcc tttctccgac atggcttctc
      421 tttgaacaac aactctctcc tgatccccac cagcggcctc tactttgtct actcccaggt
      481 ggttttctct ggagaaagct gctcccccag ggccattcct actcccatct acctggccca
      541 cgaggtccag ctgttttcct cccagtaccc cttccatgtg cctctcctca gcgcacagaa
      601 atctgtgtat ccggggctac aaggaccgtg ggtacgctca atgtaccagg gggctgtgtt
      661 cctgctcagt aagggggacc agctgtccac ccacacagac ggcatctccc acttacactt
      721 cagccccagc accgtgtttt ttggagcttt tgctctgtag aatctaggga aactcaggaa
      781 ctggattcca gcacctctat cctgttcatc ttgagggtca catccccagt ctccagcctt
      841 cccaaccaaa atagcctgga gctttcacgg gagtctgaag catttcaagg caccacgtct
      901 ctcccccagg gccactccag atgctcaggg ggagactcaa gcctgtctag aagttcctgc
      961 acagagcagg gtatttgtgg gtctaggcgg ggcagagacc tggacatgaa ggagggacag
     1021 acatgggggg aggtgtctgg ggacggggga ggttgactat ttatgaagag aagggttaag
     1081 ttatttattt atagggaata aaaagagggg agagatggaa agccgtcggg tgacaactag
     1141 gtcccagaca caaaggcgtc agttaccaca gaacaggact catctgagag agggacggtg
     1201 acggtgagag aagtagatgt aggtgaccaa ggggttttag aagaaagccc gaggctctaa
     1261 aagccaacca ctgcctggcc acacatccac agggagcccc tgcaccatcc gtgaatccca
     1321 ataaacctct tttccctgaa a
//
