LOCUS       NM_031049               2853 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus lanosterol synthase (Lss), mRNA.
ACCESSION   NM_031049 XM_346599
VERSION     NM_031049.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2853)
  AUTHORS   Ma,P., Huang,J., Chen,B., Huang,M., Xiong,L., Chen,J., Huang,S. and
            Liu,Y.
  TITLE     Lanosterol Synthase Prevents EMT During Lens Epithelial Fibrosis
            Via Regulating SREBP1
  JOURNAL   Invest Ophthalmol Vis Sci 64 (15), 12 (2023)
   PUBMED   38079167
  REMARK    GeneRIF: Lanosterol Synthase Prevents EMT During Lens Epithelial
            Fibrosis Via Regulating SREBP1.
REFERENCE   2  (bases 1 to 2853)
  AUTHORS   Romano,M.T., Tafazzoli,A., Mattern,M., Sivalingam,S., Wolf,S.,
            Rupp,A., Thiele,H., Altmuller,J., Nurnberg,P., Ellwanger,J.,
            Gambon,R., Baumer,A., Kohlschmidt,N., Metze,D., Holdenrieder,S.,
            Paus,R., Lutjohann,D., Frank,J., Geyer,M., Bertolini,M.,
            Kokordelis,P. and Betz,R.C.
  TITLE     Bi-allelic Mutations in LSS, Encoding Lanosterol Synthase, Cause
            Autosomal-Recessive Hypotrichosis Simplex
  JOURNAL   Am J Hum Genet 103 (5), 777-785 (2018)
   PUBMED   30401459
REFERENCE   3  (bases 1 to 2853)
  AUTHORS   Zhao,L., Chen,X.J., Zhu,J., Xi,Y.B., Yang,X., Hu,L.D., Ouyang,H.,
            Patel,S.H., Jin,X., Lin,D., Wu,F., Flagg,K., Cai,H., Li,G., Cao,G.,
            Lin,Y., Chen,D., Wen,C., Chung,C., Wang,Y., Qiu,A., Yeh,E.,
            Wang,W., Hu,X., Grob,S., Abagyan,R., Su,Z., Tjondro,H.C.,
            Zhao,X.J., Luo,H., Hou,R., Jefferson,J., Perry,P., Gao,W.,
            Kozak,I., Granet,D., Li,Y., Sun,X., Wang,J., Zhang,L., Liu,Y.,
            Yan,Y.B. and Zhang,K.
  TITLE     Lanosterol reverses protein aggregation in cataracts
  JOURNAL   Nature 523 (7562), 607-611 (2015)
   PUBMED   26200341
  REMARK    Erratum:[Nature. 2015 Oct 22;526(7574):595. doi:
            10.1038/nature15253.. PMID: 26308894]
REFERENCE   4  (bases 1 to 2853)
  AUTHORS   Marmugi,A., Lasserre,F., Beuzelin,D., Ducheix,S., Huc,L.,
            Polizzi,A., Chetivaux,M., Pineau,T., Martin,P., Guillou,H. and
            Mselli-Lakhal,L.
  TITLE     Adverse effects of long-term exposure to bisphenol A during
            adulthood leading to hyperglycaemia and hypercholesterolemia in
            mice
  JOURNAL   Toxicology 325, 133-143 (2014)
   PUBMED   25168180
REFERENCE   5  (bases 1 to 2853)
  AUTHORS   Moessinger,C., Kuerschner,L., Spandl,J., Shevchenko,A. and
            Thiele,C.
  TITLE     Human lysophosphatidylcholine acyltransferases 1 and 2 are located
            in lipid droplets where they catalyze the formation of
            phosphatidylcholine
  JOURNAL   J Biol Chem 286 (24), 21330-21339 (2011)
   PUBMED   21498505
REFERENCE   6  (bases 1 to 2853)
  AUTHORS   Fujimoto,Y., Itabe,H., Sakai,J., Makita,M., Noda,J., Mori,M.,
            Higashi,Y., Kojima,S. and Takano,T.
  TITLE     Identification of major proteins in the lipid droplet-enriched
            fraction isolated from the human hepatocyte cell line HuH7
  JOURNAL   Biochim Biophys Acta 1644 (1), 47-59 (2004)
   PUBMED   14741744
REFERENCE   7  (bases 1 to 2853)
  AUTHORS   Abe,I. and Prestwich,G.D.
  TITLE     Molecular cloning, characterization, and functional expression of
            rat oxidosqualene cyclase cDNA
  JOURNAL   Proc Natl Acad Sci U S A 92 (20), 9274-9278 (1995)
   PUBMED   7568116
REFERENCE   8  (bases 1 to 2853)
  AUTHORS   Baker,C.H., Matsuda,S.P., Liu,D.R. and Corey,E.J.
  TITLE     Molecular cloning of the human gene encoding lanosterol synthase
            from a liver cDNA library
  JOURNAL   Biochem Biophys Res Commun 213 (1), 154-160 (1995)
   PUBMED   7639730
REFERENCE   9  (bases 1 to 2853)
  AUTHORS   Kusano,M., Shibuya,M., Sankawa,U. and Ebizuka,Y.
  TITLE     Molecular cloning of cDNA encoding rat 2,3-oxidosqualene:
            lanosterol cyclase
  JOURNAL   Biol Pharm Bull 18 (1), 195-197 (1995)
   PUBMED   7735243
REFERENCE   10 (bases 1 to 2853)
  AUTHORS   Moore,W.R. and Schatzman,G.L.
  TITLE     Purification of 2,3-oxidosqualene cyclase from rat liver
  JOURNAL   J Biol Chem 267 (31), 22003-22006 (1992)
   PUBMED   1429550
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Nov 26, 2020 this sequence version replaced NM_031049.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U31352.1, SRR26643290.54539.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                JAXUCZ010000020.1  12118176-12118230   c
            56-224              JAXUCZ010000020.1  12117832-12118000   c
            225-363             JAXUCZ010000020.1  12116042-12116180   c
            364-472             JAXUCZ010000020.1  12114294-12114402   c
            473-594             JAXUCZ010000020.1  12113512-12113633   c
            595-691             JAXUCZ010000020.1  12111399-12111495   c
            692-827             JAXUCZ010000020.1  12110107-12110242   c
            828-936             JAXUCZ010000020.1  12109499-12109607   c
            937-1055            JAXUCZ010000020.1  12108984-12109102   c
            1056-1153           JAXUCZ010000020.1  12108049-12108146   c
            1154-1181           JAXUCZ010000020.1  12107480-12107507   c
            1182-1238           JAXUCZ010000020.1  12105794-12105850   c
            1239-1310           JAXUCZ010000020.1  12105136-12105207   c
            1311-1361           JAXUCZ010000020.1  12104237-12104287   c
            1362-1511           JAXUCZ010000020.1  12103501-12103650   c
            1512-1608           JAXUCZ010000020.1  12102864-12102960   c
            1609-1714           JAXUCZ010000020.1  12102193-12102298   c
            1715-1780           JAXUCZ010000020.1  12099806-12099871   c
            1781-1861           JAXUCZ010000020.1  12099167-12099247   c
            1862-2032           JAXUCZ010000020.1  12098169-12098339   c
            2033-2111           JAXUCZ010000020.1  12093552-12093630   c
            2112-2853           JAXUCZ010000020.1  12092275-12093016   c
FEATURES             Location/Qualifiers
     source          1..2853
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..2853
                     /gene="Lss"
                     /note="lanosterol synthase"
                     /db_xref="GeneID:81681"
                     /db_xref="RGD:620955"
     exon            1..55
                     /gene="Lss"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..2243
                     /gene="Lss"
                     /EC_number="5.4.99.7"
                     /note="OSC; oxidosqualene--lanosterol cyclase;
                     2,3-epoxysqualene--lanosterol cyclase; 2,3-oxidosqualene:
                     lanosterol cyclase; lanosterol synthase
                     (2,3-oxidosqualene-lanosterol cyclase)"
                     /codon_start=1
                     /product="lanosterol synthase"
                     /protein_id="NP_112311.2"
                     /db_xref="GeneID:81681"
                     /db_xref="RGD:620955"
                     /translation="MTEGTCLRRRGGPYKTEPATDLTRWRLHNELGRQRWTYYQAEED
                     PGREQTGLEAHSLGLDTTSYFKNLPKAQTAHEGALNGVTFYAKLQAEDGHWAGDYGGP
                     LFLLPGLLITCHIAHIPLPAGYREEMVRYLRSVQLPDGGWGLHIEDKSTVFGTALSYV
                     SLRILGIGPDDPDLVRARNILHKKGGAVGIPSWGKFWLAVLNVYSWEGINTLFPEMWL
                     LPEWFPAHPSTLWCHCRQVYLPMSYCYATRLSASEDPLVQSLRQELYVEDYASIDWPA
                     QKNNVCPDDMYTPHSWLLHVVYGLLNLYERFHSTSLRKWAIQLLYEHVAADDRFTKCI
                     SIGPISKTVNMLIRWSVDGPSSPAFQEHVSRIKDYLWLGLDGMKMQGTNGSQTWDTSF
                     AVQALLEAGAHRRPEFLPCLQKAHEFLRLSQVPDNNPDYQKYYRHMHKGGFPFSTLDC
                     GWIVADCTAEALKAVLLLQERCPSITEHVPQERLYNAVAVLLSMRNSDGGFATYETKR
                     GGYLLELLNPSEVFGDIMIDYTYVECTSAVMQALRHFREYFPDHRATEIRETLNQGLD
                     FCRKKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHIYQNRTACAEVAQACHFLLSRQ
                     MADGGWGEDFESCEQRRYVQSAGSQVHSTCWALLGLMAVRHPDISAQERGIRCLLGKQ
                     LPNGDWPQENISGVFNKSCAISYTNYRNIFPIWALGRFSSLYPDNTLAGHI"
     exon            56..224
                     /gene="Lss"
                     /inference="alignment:Splign:2.1.0"
     exon            225..363
                     /gene="Lss"
                     /inference="alignment:Splign:2.1.0"
     exon            364..472
                     /gene="Lss"
                     /inference="alignment:Splign:2.1.0"
     exon            473..594
                     /gene="Lss"
                     /inference="alignment:Splign:2.1.0"
     exon            595..691
                     /gene="Lss"
                     /inference="alignment:Splign:2.1.0"
     exon            692..827
                     /gene="Lss"
                     /inference="alignment:Splign:2.1.0"
     exon            828..936
                     /gene="Lss"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1055
                     /gene="Lss"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1153
                     /gene="Lss"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1181
                     /gene="Lss"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1238
                     /gene="Lss"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1310
                     /gene="Lss"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1361
                     /gene="Lss"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1511
                     /gene="Lss"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1608
                     /gene="Lss"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1714
                     /gene="Lss"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1780
                     /gene="Lss"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..1861
                     /gene="Lss"
                     /inference="alignment:Splign:2.1.0"
     exon            1862..2032
                     /gene="Lss"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..2111
                     /gene="Lss"
                     /inference="alignment:Splign:2.1.0"
     exon            2112..2853
                     /gene="Lss"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtaaagggc tggccggccg gtggtccaga gctgtgctgt catgaccgag ggcacgtgtc
       61 tgcggcgtcg tgggggaccc tataaaactg agcccgccac cgatctcacc cgctggcggc
      121 tccataatga gttgggtcgg cagagatgga cttattatca agcggaggag gaccctggtc
      181 gagaacagac ggggctagag gcccactctt tgggactgga cacaacaagt tatttcaaga
      241 acttacctaa agctcaaaca gcccatgagg gggccctgaa cggagtaacc ttttatgcca
      301 agctgcaggc tgaggatgga cactgggctg gtgattatgg tggtccactc ttcctcttgc
      361 caggtctcct gattacgtgt cacatagcac acatccccct gccggctgga tacagagagg
      421 aaatggtacg gtacttgcgc tcagtgcagc ttcccgatgg cggctggggc ttgcacattg
      481 aggacaagtc cacggtgttt gggactgccc tgagctatgt gtctctcaga atcctgggta
      541 ttggacctga tgatcctgac cttgtgcgtg ctcggaacat tcttcacaaa aaaggtggtg
      601 cagtgggcat cccttcctgg gggaagttct ggctggctgt cctgaatgtt tacagctggg
      661 aaggaatcaa taccctcttc cctgagatgt ggctgcttcc tgaatggttt cccgcacatc
      721 cctccactct gtggtgtcac tgccggcagg tctatctgcc catgagctac tgctacgcca
      781 ctcggctaag tgcctcagag gacccactgg ttcagagcct ccgccaggaa ctctatgtgg
      841 aggattatgc cagcatcgat tggccagcac agaagaacaa cgtgtgcccc gatgacatgt
      901 acacgccaca cagttggctg ctgcacgtgg tgtatggact cctcaacctg tatgaacgtt
      961 tccacagtac cagcctgcgg aagtgggcca tccagttgct gtatgaacat gttgcagctg
     1021 atgatcggtt cacaaaatgc atcagcattg gcccgatctc aaaaactgtc aacatgctta
     1081 ttcgttggtc agtggacgga ccatcctccc ctgccttcca ggagcacgtc tcgaggatca
     1141 aagattatct ttggctgggc cttgacggca tgaaaatgca gggcaccaat ggatcacaga
     1201 cctgggacac ttcatttgct gtccaagccc tgctggaggc aggtgcacac cgaagacctg
     1261 agtttttgcc ctgcctgcag aaggctcacg agttcctgcg gctttcccag gtcccagaca
     1321 acaatcctga ctaccagaag tattatcgcc atatgcacaa gggtggtttc cccttcagca
     1381 cactggactg tggctggatc gttgctgact gcacggccga ggctttgaag gctgtgctgc
     1441 tcctgcagga gcggtgtccc tcaatcaccg agcatgtccc ccaagagcga ctctacaatg
     1501 ctgtggctgt gttgttgagc atgaggaatt ccgatggagg gtttgctacc tatgagacta
     1561 agcgtggcgg gtatttgctg gagctgctga acccctcaga ggtctttgga gacatcatga
     1621 ttgactacac gtatgtagag tgtacctccg cagtgatgca ggccctgagg cacttccgcg
     1681 agtacttccc agaccacagg gctacagaga tcagggagac cctcaatcaa ggcctggact
     1741 tctgccgaaa gaagcagaga gcggatggct cgtgggaggg ctcctggggg gtttgcttca
     1801 cctatggcac ctggtttggc ttggaagcat tcgcttgcat gggacatatc taccaaaata
     1861 ggactgcttg tgcagaagta gctcaggcct gccacttcct cctgtcgcgg cagatggcgg
     1921 atgggggctg gggggaggac tttgagtcct gtgagcagcg gcggtacgtg cagagtgccg
     1981 ggtcccaggt ccatagtacg tgctgggccc tgctgggttt gatggctgtc aggcatcccg
     2041 acatctctgc tcaggagaga ggaatcagat gtctgctagg gaaacagctc cccaacggag
     2101 actggcctca ggagaacatc tctggggtct tcaacaagtc ctgtgccatc agctacacaa
     2161 attacagaaa catcttcccc atctgggccc tgggccgctt ctccagcctg tatcctgaca
     2221 atacccttgc tggccacatt tgagcatgtg tgcgcctgtg cggcacctgg ccagcgtcag
     2281 cactgtacag gcccaggcag cccggtttct cagctgggtg ataagcgtcc tcctagccca
     2341 ctttggcatg gttctctatt tctgtagaca tgaggctggg gatagggtca gagtcggtgt
     2401 ctagacactg ggcagcatgc gctcggttct gacgctagct tcagtgagga agggaagaag
     2461 ttgagcctga gatccagaga ggcacagtgt actccgaggc tcctgggtgt cctccttgag
     2521 ggaacaagac tgtagagctt tcatgatcag tgacttccct gtgagggagc agctggcttc
     2581 ttcacttcct cccttgttga ctgtggagtg ggccccgtgg tgcaggcatg ctcagagaaa
     2641 ggctcaatgg aggaggcagg ccccttgctc attgtgtcct gagcagtgtc tgttgtccca
     2701 gacacttacc catgactgca tcactgcacg aaataccagt tttccagaaa ggaagtacaa
     2761 actcgctctg tactaaaaat gctactaaaa gtcgtttgaa tgatcaccaa ctcccttaat
     2821 aaacagaccc tgggctgatg gcccagtagt aaa
//
