LOCUS       NM_032616               2088 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus lipolysis stimulated lipoprotein receptor (Lsr),
            mRNA.
ACCESSION   NM_032616
VERSION     NM_032616.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2088)
  AUTHORS   Wang,J., Qin,M., Wu,Q., Yang,H., Wei,B., Xie,J., Qin,Y., Liang,Z.
            and Huang,J.
  TITLE     Effects of Lipolysis-Stimulated Lipoprotein Receptor on Tight
            Junctions of Pancreatic Ductal Epithelial Cells in
            Hypertriglyceridemic Acute Pancreatitis
  JOURNAL   Biomed Res Int 2022, 4234186 (2022)
   PUBMED   35463981
  REMARK    GeneRIF: Effects of Lipolysis-Stimulated Lipoprotein Receptor on
            Tight Junctions of Pancreatic Ductal Epithelial Cells in
            Hypertriglyceridemic Acute Pancreatitis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2088)
  AUTHORS   Sohet,F., Lin,C., Munji,R.N., Lee,S.Y., Ruderisch,N., Soung,A.,
            Arnold,T.D., Derugin,N., Vexler,Z.S., Yen,F.T. and Daneman,R.
  TITLE     LSR/angulin-1 is a tricellular tight junction protein involved in
            blood-brain barrier formation
  JOURNAL   J Cell Biol 208 (6), 703-711 (2015)
   PUBMED   25753034
REFERENCE   3  (bases 1 to 2088)
  AUTHORS   Nakatsu,D., Kano,F., Taguchi,Y., Sugawara,T., Nishizono,T.,
            Nishikawa,K., Oda,Y., Furuse,M. and Murata,M.
  TITLE     JNK1/2-dependent phosphorylation of angulin-1/LSR is required for
            the exclusive localization of angulin-1/LSR and tricellulin at
            tricellular contacts in EpH4 epithelial sheet
  JOURNAL   Genes Cells 19 (7), 565-581 (2014)
   PUBMED   24889144
REFERENCE   4  (bases 1 to 2088)
  AUTHORS   Furuse,M., Oda,Y., Higashi,T., Iwamoto,N. and Masuda,S.
  TITLE     Lipolysis-stimulated lipoprotein receptor: a novel membrane protein
            of tricellular tight junctions
  JOURNAL   Ann N Y Acad Sci 1257, 54-58 (2012)
   PUBMED   22671589
REFERENCE   5  (bases 1 to 2088)
  AUTHORS   Masuda,S., Oda,Y., Sasaki,H., Ikenouchi,J., Higashi,T., Akashi,M.,
            Nishi,E. and Furuse,M.
  TITLE     LSR defines cell corners for tricellular tight junction formation
            in epithelial cells
  JOURNAL   J Cell Sci 124 (Pt 4), 548-555 (2011)
   PUBMED   21245199
REFERENCE   6  (bases 1 to 2088)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   7  (bases 1 to 2088)
  AUTHORS   Moser,K. and White,F.M.
  TITLE     Phosphoproteomic analysis of rat liver by high capacity IMAC and
            LC-MS/MS
  JOURNAL   J Proteome Res 5 (1), 98-104 (2006)
   PUBMED   16396499
REFERENCE   8  (bases 1 to 2088)
  AUTHORS   Yagil,C., Hubner,N., Monti,J., Schulz,H., Sapojnikov,M., Luft,F.C.,
            Ganten,D. and Yagil,Y.
  TITLE     Identification of hypertension-related genes through an integrated
            genomic-transcriptomic approach
  JOURNAL   Circ Res 96 (6), 617-625 (2005)
   PUBMED   15731461
REFERENCE   9  (bases 1 to 2088)
  AUTHORS   Mesli,S., Javorschi,S., Berard,A.M., Landry,M., Priddle,H.,
            Kivlichan,D., Smith,A.J., Yen,F.T., Bihain,B.E. and Darmon,M.
  TITLE     Distribution of the lipolysis stimulated receptor in adult and
            embryonic murine tissues and lethality of LSR-/- embryos at 12.5 to
            14.5 days of gestation
  JOURNAL   Eur J Biochem 271 (15), 3103-3114 (2004)
   PUBMED   15265030
REFERENCE   10 (bases 1 to 2088)
  AUTHORS   Yen,F.T., Masson,M., Clossais-Besnard,N., Andre,P., Grosset,J.M.,
            Bougueleret,L., Dumas,J.B., Guerassimenko,O. and Bihain,B.E.
  TITLE     Molecular cloning of a lipolysis-stimulated remnant receptor
            expressed in the liver
  JOURNAL   J Biol Chem 274 (19), 13390-13398 (1999)
   PUBMED   10224102
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 26, 2020 this sequence version replaced NM_032616.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF119667.1, SRR26360181.952722.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-310               JAXUCZ010000001.1  95329045-95329354   c
            311-655             JAXUCZ010000001.1  95327858-95328202   c
            656-775             JAXUCZ010000001.1  95321993-95322112   c
            776-832             JAXUCZ010000001.1  95318934-95318990   c
            833-979             JAXUCZ010000001.1  95318220-95318366   c
            980-1141            JAXUCZ010000001.1  95315234-95315395   c
            1142-1201           JAXUCZ010000001.1  95315054-95315113   c
            1202-1333           JAXUCZ010000001.1  95314834-95314965   c
            1334-1962           JAXUCZ010000001.1  95314043-95314671   c
            1963-2088           JAXUCZ010000001.1  95313830-95313955   c
FEATURES             Location/Qualifiers
     source          1..2088
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2088
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /note="lipolysis stimulated lipoprotein receptor"
                     /db_xref="GeneID:64355"
                     /db_xref="RGD:69236"
     exon            1..310
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /inference="alignment:Splign:2.1.0"
     CDS             217..1998
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /note="lipolysis-stimulated remnant receptor;
                     liver-specific bHLH-Zip transcription factor 7;
                     lipolysis-stimulated receptor"
                     /codon_start=1
                     /product="lipolysis-stimulated lipoprotein receptor
                     precursor"
                     /protein_id="NP_116005.1"
                     /db_xref="GeneID:64355"
                     /db_xref="RGD:69236"
                     /translation="MAPAAGACAGAPDSHPATVVFVCLFLIIFCPDPASAIQVTVSDP
                     YHVVILFQPVTLPCTYQMSNTLTVPIVIWKYKSFCRDRIADAFSPASVDNQLNAQLAA
                     GNPGYNPYVECQDSVRTVRVVATKQGNAVTLGDYYQGRRITITGNADLTFEQTAWGDS
                     GVYYCSVVSAQDLDGNNEAYAELIVLGRTSEAPELLPGFRAGPLEDWLFVVVVCLASL
                     LLFLLLGICWCQCCPHTCCCYVRCPCCPDKCCCPEALYAAGKAATSGVPSIYAPSIYT
                     HLSPAKTPPPPPAMIPMGPPYGYPGDFDRHSSVGGHSSQVPLLRDVDGSVSSEVRSGY
                     RIQANQQDDSMRVLYYMEKELANFDPSRPGPPNGRVERAMSEVTSLHEDDWRSRPSRA
                     PALTPIRDEEWNRHSPQSPRTWEQEPLQEQPRGGWGSGRPRARSVDALDDINRPGSTE
                     SGRSSPPSSGRRGRAYAPPRSRSRDDLYDPDDPRDLPHSRDPHYYDDIRSRDPRADPR
                     SRQRSRDPRDAGFRSRDPQYDGRLLEEALKKKGSGERRRVYREEEEEEEGQYPPAPPP
                     YSETDSQASRERRLKKNLALSRESLVV"
     exon            311..655
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /inference="alignment:Splign:2.1.0"
     exon            656..775
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /inference="alignment:Splign:2.1.0"
     exon            776..832
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /inference="alignment:Splign:2.1.0"
     exon            833..979
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1141
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1201
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1333
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1962
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /inference="alignment:Splign:2.1.0"
     exon            1963..2088
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accgctcacc aggtcagttg tccccgggaa gccgaaggca tgagcttcgc ccaagttctt
       61 tttatgggtt agaactcctc cagagcgggg aaaaagaact tggaataggg gcgggacgga
      121 gcacgcaccc ttctccgcct tggttctcgc cgcgccccct actctcggga tacttgggag
      181 gggacgcgcg ggcaccgtcg ctgctagacg gccgcgatgg cgccggcggc cggcgcgtgt
      241 gctggggcgc ctgactccca cccagctacc gtggtcttcg tgtgtctctt tctcatcatt
      301 ttctgcccag accctgccag tgccatccag gtgactgtgt ctgaccccta ccacgtagtg
      361 atcctgttcc agccagtgac cctgccctgc acctatcaga tgagcaacac tctcacagtc
      421 cccatcgtga tctggaagta caagtcattc tgccgggacc gtattgccga tgccttctct
      481 cctgccagtg tggacaacca gctaaatgcc cagttggcag ctggcaaccc cggctacaac
      541 ccctatgtgg agtgccagga cagtgtacgc actgtcaggg tggtggccac caaacagggc
      601 aatgcggtga ccctgggaga ctactaccaa ggcaggagga tcaccataac aggaaatgct
      661 gacctgacct tcgagcagac agcctgggga gacagtggag tgtattactg ctctgtggtc
      721 tcggcccaag atctggatgg aaacaacgag gcgtacgcag agctcatcgt ccttggcagg
      781 acctcagagg cccctgagct cctacctggt tttcgggcgg ggcccttgga agattggctc
      841 tttgtggtcg tggtctgcct ggcgagcctc ctcctcttcc tcctcctggg catctgctgg
      901 tgccagtgct gtcctcacac ctgctgctgc tatgtccgat gtccctgctg cccagacaag
      961 tgctgttgcc ctgaggctct ttatgctgct ggcaaagcag ccacctcagg tgtcccgagc
     1021 atctatgccc ccagcatcta tacccacctc tcacctgcca agaccccacc acctccgcct
     1081 gccatgattc ccatgggccc tccctatggg taccctggag actttgacag acatagctca
     1141 gttggtggcc acagctccca agtacccctg ctgcgtgacg tggatggcag tgtatcttca
     1201 gaagtacgaa gtggctacag gatccaggct aaccagcaag atgactccat gagggtccta
     1261 tactatatgg agaaagagct agccaacttt gacccttccc gacctggccc tcccaatggc
     1321 agagtggaac gggccatgag tgaagtaacc tccctccatg aagatgactg gcgatcgagg
     1381 ccttccaggg ctcctgccct cacccccatc agggatgagg agtggaatcg ccactcccca
     1441 cagagtccca gaacatggga gcaggaaccc cttcaagaac aaccaagggg tggttggggg
     1501 tctggacggc ctcgggcccg ctctgtggat gctctagatg atatcaaccg gcctggctcc
     1561 actgaatcag gacggtcttc tcccccaagt agtggacgga gaggacgagc ctatgcacct
     1621 ccaagaagtc gcagccggga tgacctctat gacccggacg atcctaggga cttgccacat
     1681 tcccgagatc cccactatta tgacgacatc aggtctagag atccacgtgc tgaccccaga
     1741 tcccgtcagc gatcccgaga tcctcgggat gctggcttca ggtcaaggga ccctcagtat
     1801 gatgggcgac tattagaaga ggctttaaag aaaaaggggt cgggcgagag aaggagggtt
     1861 tacagggagg aagaagagga agaggagggc caataccccc cagcacctcc accttactca
     1921 gagactgact cgcaggcctc acgggagagg aggctgaaaa agaatttggc cctgagtcgg
     1981 gaaagtttag tcgtctgatc cacgttttgt atgtagcttt tgtacttttt tttttaattg
     2041 gaatcaatat tgatgaaact tcaagcctaa taaaatgtct aatcacaa
//
