LOCUS       NP_116005                593 aa            linear   ROD 24-JUN-2024
DEFINITION  lipolysis-stimulated lipoprotein receptor precursor [Rattus
            norvegicus].
ACCESSION   NP_116005
VERSION     NP_116005.1
DBSOURCE    REFSEQ: accession NM_032616.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 593)
  AUTHORS   Wang,J., Qin,M., Wu,Q., Yang,H., Wei,B., Xie,J., Qin,Y., Liang,Z.
            and Huang,J.
  TITLE     Effects of Lipolysis-Stimulated Lipoprotein Receptor on Tight
            Junctions of Pancreatic Ductal Epithelial Cells in
            Hypertriglyceridemic Acute Pancreatitis
  JOURNAL   Biomed Res Int 2022, 4234186 (2022)
   PUBMED   35463981
  REMARK    GeneRIF: Effects of Lipolysis-Stimulated Lipoprotein Receptor on
            Tight Junctions of Pancreatic Ductal Epithelial Cells in
            Hypertriglyceridemic Acute Pancreatitis.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 593)
  AUTHORS   Sohet,F., Lin,C., Munji,R.N., Lee,S.Y., Ruderisch,N., Soung,A.,
            Arnold,T.D., Derugin,N., Vexler,Z.S., Yen,F.T. and Daneman,R.
  TITLE     LSR/angulin-1 is a tricellular tight junction protein involved in
            blood-brain barrier formation
  JOURNAL   J Cell Biol 208 (6), 703-711 (2015)
   PUBMED   25753034
REFERENCE   3  (residues 1 to 593)
  AUTHORS   Nakatsu,D., Kano,F., Taguchi,Y., Sugawara,T., Nishizono,T.,
            Nishikawa,K., Oda,Y., Furuse,M. and Murata,M.
  TITLE     JNK1/2-dependent phosphorylation of angulin-1/LSR is required for
            the exclusive localization of angulin-1/LSR and tricellulin at
            tricellular contacts in EpH4 epithelial sheet
  JOURNAL   Genes Cells 19 (7), 565-581 (2014)
   PUBMED   24889144
REFERENCE   4  (residues 1 to 593)
  AUTHORS   Furuse,M., Oda,Y., Higashi,T., Iwamoto,N. and Masuda,S.
  TITLE     Lipolysis-stimulated lipoprotein receptor: a novel membrane protein
            of tricellular tight junctions
  JOURNAL   Ann N Y Acad Sci 1257, 54-58 (2012)
   PUBMED   22671589
REFERENCE   5  (residues 1 to 593)
  AUTHORS   Masuda,S., Oda,Y., Sasaki,H., Ikenouchi,J., Higashi,T., Akashi,M.,
            Nishi,E. and Furuse,M.
  TITLE     LSR defines cell corners for tricellular tight junction formation
            in epithelial cells
  JOURNAL   J Cell Sci 124 (Pt 4), 548-555 (2011)
   PUBMED   21245199
REFERENCE   6  (residues 1 to 593)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   7  (residues 1 to 593)
  AUTHORS   Moser,K. and White,F.M.
  TITLE     Phosphoproteomic analysis of rat liver by high capacity IMAC and
            LC-MS/MS
  JOURNAL   J Proteome Res 5 (1), 98-104 (2006)
   PUBMED   16396499
REFERENCE   8  (residues 1 to 593)
  AUTHORS   Yagil,C., Hubner,N., Monti,J., Schulz,H., Sapojnikov,M., Luft,F.C.,
            Ganten,D. and Yagil,Y.
  TITLE     Identification of hypertension-related genes through an integrated
            genomic-transcriptomic approach
  JOURNAL   Circ Res 96 (6), 617-625 (2005)
   PUBMED   15731461
REFERENCE   9  (residues 1 to 593)
  AUTHORS   Mesli,S., Javorschi,S., Berard,A.M., Landry,M., Priddle,H.,
            Kivlichan,D., Smith,A.J., Yen,F.T., Bihain,B.E. and Darmon,M.
  TITLE     Distribution of the lipolysis stimulated receptor in adult and
            embryonic murine tissues and lethality of LSR-/- embryos at 12.5 to
            14.5 days of gestation
  JOURNAL   Eur J Biochem 271 (15), 3103-3114 (2004)
   PUBMED   15265030
REFERENCE   10 (residues 1 to 593)
  AUTHORS   Yen,F.T., Masson,M., Clossais-Besnard,N., Andre,P., Grosset,J.M.,
            Bougueleret,L., Dumas,J.B., Guerassimenko,O. and Bihain,B.E.
  TITLE     Molecular cloning of a lipolysis-stimulated remnant receptor
            expressed in the liver
  JOURNAL   J Biol Chem 274 (19), 13390-13398 (1999)
   PUBMED   10224102
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF119667.1, SRR26360181.952722.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..593
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     Protein         1..593
                     /product="lipolysis-stimulated lipoprotein receptor
                     precursor"
                     /note="lipolysis-stimulated remnant receptor;
                     liver-specific bHLH-Zip transcription factor 7;
                     lipolysis-stimulated receptor"
                     /calculated_mol_wt=62334
     sig_peptide     1..35
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9WU74.1)"
                     /calculated_mol_wt=3461
     mat_peptide     36..593
                     /product="Lipolysis-stimulated lipoprotein receptor.
                     /id=PRO_0000245310"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU74.1)"
                     /calculated_mol_wt=62334
     Site            207..227
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU74.1)"
     Site            283
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9WU74.1)"
     Site            308
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q86X29; propagated from
                     UniProtKB/Swiss-Prot (Q9WU74.1)"
     Site            314
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q86X29; propagated from
                     UniProtKB/Swiss-Prot (Q9WU74.1)"
     Site            332
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q86X29; propagated from
                     UniProtKB/Swiss-Prot (Q9WU74.1)"
     Region          375..578
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU74.1)"
     Site            375
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q86X29; propagated from
                     UniProtKB/Swiss-Prot (Q9WU74.1)"
     Site            379
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q86X29; propagated from
                     UniProtKB/Swiss-Prot (Q9WU74.1)"
     Site            396
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q86X29; propagated from
                     UniProtKB/Swiss-Prot (Q9WU74.1)"
     Site            407
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9WU74.1)"
     Site            410
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q86X29; propagated from
                     UniProtKB/Swiss-Prot (Q9WU74.1)"
     Site            436
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9WU74.1)"
     Site            471
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q86X29; propagated from
                     UniProtKB/Swiss-Prot (Q9WU74.1)"
     Site            473
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9WU74.1)"
     Site            478
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q86X29; propagated from
                     UniProtKB/Swiss-Prot (Q9WU74.1)"
     Site            575
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q86X29; propagated from
                     UniProtKB/Swiss-Prot (Q9WU74.1)"
     Site            587
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q86X29; propagated from
                     UniProtKB/Swiss-Prot (Q9WU74.1)"
     Site            590
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q86X29; propagated from
                     UniProtKB/Swiss-Prot (Q9WU74.1)"
     CDS             1..593
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /coded_by="NM_032616.2:217..1998"
                     /db_xref="GeneID:64355"
                     /db_xref="RGD:69236"
ORIGIN      
        1 mapaagacag apdshpatvv fvclfliifc pdpasaiqvt vsdpyhvvil fqpvtlpcty
       61 qmsntltvpi viwkyksfcr driadafspa svdnqlnaql aagnpgynpy vecqdsvrtv
      121 rvvatkqgna vtlgdyyqgr rititgnadl tfeqtawgds gvyycsvvsa qdldgnneay
      181 aelivlgrts eapellpgfr agpledwlfv vvvclaslll flllgicwcq ccphtcccyv
      241 rcpccpdkcc cpealyaagk aatsgvpsiy apsiythlsp aktpppppam ipmgppygyp
      301 gdfdrhssvg ghssqvpllr dvdgsvssev rsgyriqanq qddsmrvlyy mekelanfdp
      361 srpgppngrv eramsevtsl heddwrsrps rapaltpird eewnrhspqs prtweqeplq
      421 eqprggwgsg rprarsvdal ddinrpgste sgrssppssg rrgrayappr srsrddlydp
      481 ddprdlphsr dphyyddirs rdpradprsr qrsrdprdag frsrdpqydg rlleealkkk
      541 gsgerrrvyr eeeeeeegqy ppapppyset dsqasrerrl kknlalsres lvv
//
