LOCUS       NM_001415989            1430 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Rattus norvegicus lymphocyte-specific protein 1 (Lsp1), mRNA.
ACCESSION   NM_001415989 XM_006230817
VERSION     NM_001415989.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1430)
  AUTHORS   Aiello,F.B., Guszczynski,T., Li,W., Hixon,J.A., Jiang,Q.,
            Hodge,D.L., Massignan,T., Di Lisio,C., Merchant,A., Procopio,A.D.,
            Bonetto,V. and Durum,S.K.
  TITLE     IL-7-induced phosphorylation of the adaptor Crk-like and other
            targets
  JOURNAL   Cell Signal 47, 131-141 (2018)
   PUBMED   29581031
REFERENCE   2  (bases 1 to 1430)
  AUTHORS   Chen,H., Qi,X., Qiu,P. and Zhao,J.
  TITLE     Correlation between LSP1 polymorphisms and the susceptibility to
            breast cancer
  JOURNAL   Int J Clin Exp Pathol 8 (5), 5798-5802 (2015)
   PUBMED   26191300
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1430)
  AUTHORS   Koral,K., Paranjpe,S., Bowen,W.C., Mars,W., Luo,J. and
            Michalopoulos,G.K.
  TITLE     Leukocyte-specific protein 1: a novel regulator of hepatocellular
            proliferation and migration deleted in human hepatocellular
            carcinoma
  JOURNAL   Hepatology 61 (2), 537-547 (2015)
   PUBMED   25234543
  REMARK    GeneRIF: functions as a negative regulator of proliferation and
            migration in hepatoma
REFERENCE   4  (bases 1 to 1430)
  AUTHORS   Chen,M.B., Li,C., Shen,W.X., Guo,Y.J., Shen,W. and Lu,P.H.
  TITLE     Association of a LSP1 gene rs3817198T>C polymorphism with breast
            cancer risk: evidence from 33,920 cases and 35,671 controls
  JOURNAL   Mol Biol Rep 38 (7), 4687-4695 (2011)
   PUBMED   21127985
REFERENCE   5  (bases 1 to 1430)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   6  (bases 1 to 1430)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   7  (bases 1 to 1430)
  AUTHORS   Jongstra-Bilen,J., Misener,V.L., Wang,C., Ginzberg,H., Auerbach,A.,
            Joyner,A.L., Downey,G.P. and Jongstra,J.
  TITLE     LSP1 modulates leukocyte populations in resting and inflamed
            peritoneum
  JOURNAL   Blood 96 (5), 1827-1835 (2000)
   PUBMED   10961883
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jan 6, 2023 this sequence version replaced XM_006230817.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ233963.1, FQ232610.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               JAXUCZ010000001.1  207044157-207044277
            122-268             JAXUCZ010000001.1  207067432-207067578
            269-430             JAXUCZ010000001.1  207069470-207069631
            431-527             JAXUCZ010000001.1  207071577-207071673
            528-620             JAXUCZ010000001.1  207072005-207072097
            621-664             JAXUCZ010000001.1  207072301-207072344
            665-746             JAXUCZ010000001.1  207072497-207072578
            747-881             JAXUCZ010000001.1  207073205-207073339
            882-959             JAXUCZ010000001.1  207073655-207073732
            960-1066            JAXUCZ010000001.1  207073865-207073971
            1067-1430           JAXUCZ010000001.1  207077528-207077891
FEATURES             Location/Qualifiers
     source          1..1430
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..1430
                     /gene="Lsp1"
                     /note="lymphocyte-specific protein 1"
                     /db_xref="GeneID:361680"
                     /db_xref="RGD:1306133"
     exon            1..121
                     /gene="Lsp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..1049
                     /gene="Lsp1"
                     /note="lymphocyte specific 1; 1 BAC CH230-300K22
                     (Children's Hospital Oakland Research Institute) complete"
                     /codon_start=1
                     /product="lymphocyte-specific protein 1"
                     /protein_id="NP_001402918.1"
                     /db_xref="GeneID:361680"
                     /db_xref="RGD:1306133"
                     /translation="MAEAASDPRCQEQEELDAEDDKGLTTQWREEDEEEAAREQRQRE
                     RERQLQDQDKDEEDEGGHFLEQPGQQALVSLKSSELDEDEGFGDWSQKQEPPRQQSWE
                     NEGTAEGSEPSPSESAEEKQTEDSSHQAKVHLEESNLSHSDPNIEDDVGGSGETEEHL
                     ISHQARTPSPLALEDTAELSSPPLSPTVKLADRTESLNRSIQKSNSVKKSQPTLPIST
                     IDERLQQYTQATESAGRTPKLSRQPSIELPSMAVASTKTLWETGEVQTQSASKTPSCQ
                     DIVAGDMSKKSLWEQKGGSKISSTIKSTPSGKRYKFVATGHGKYEKVLVDEGSAP"
     exon            122..268
                     /gene="Lsp1"
                     /inference="alignment:Splign:2.1.0"
     exon            269..430
                     /gene="Lsp1"
                     /inference="alignment:Splign:2.1.0"
     exon            431..527
                     /gene="Lsp1"
                     /inference="alignment:Splign:2.1.0"
     exon            528..620
                     /gene="Lsp1"
                     /inference="alignment:Splign:2.1.0"
     exon            621..664
                     /gene="Lsp1"
                     /inference="alignment:Splign:2.1.0"
     exon            665..746
                     /gene="Lsp1"
                     /inference="alignment:Splign:2.1.0"
     exon            747..881
                     /gene="Lsp1"
                     /inference="alignment:Splign:2.1.0"
     exon            882..959
                     /gene="Lsp1"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1066
                     /gene="Lsp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1430
                     /gene="Lsp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagaagcac caggagccat aacaagtgca tccacaccga agacaccagg cccatggcag
       61 aggctgccag cgatcccaga tgccaggagc aggaagagct agatgcagaa gacgacaaag
      121 ggctcacaac tcagtggaga gaagaagatg aagaagaggc cgcccgtgag cagcgccaac
      181 gggagcgaga gaggcagctg caggaccagg acaaagatga agaagatgaa ggtggccatt
      241 tcctggaaca gccagggcag caggcactcg ttagcctgaa gtcctctgaa ctggatgaag
      301 atgagggttt tggtgactgg tctcaaaagc aggagccacc aaggcagcaa tcctgggaga
      361 atgaggggac tgcagagggg tcggaaccct ctccaagtga gagtgcagag gagaaacaaa
      421 cagaggacag ttctcaccaa gctaaagtcc acttggagga gtcaaacctg agccacagtg
      481 accccaatat agaggatgat gtcgggggtt ctggggagac agaagagcat ctgataagtc
      541 atcaggccag gacccccagc cctttggcct tggaagacac tgctgagctg agctcacctc
      601 ccctgagccc taccgtcaaa ctggctgata ggacagaatc cctgaaccgc tccattcaaa
      661 agagcaacag tgtgaagaag tctcaaccaa ccttgcccat ttccaccatc gatgagcgcc
      721 tgcagcagta cacccaggcc actgagtctg ctggccgaac tcccaagctg tcccgccagc
      781 cctccataga gctgcccagc atggctgtag ccagtaccaa gactctttgg gagacaggag
      841 aggtgcagac tcagtctgct tccaagacac cctcctgcca ggatatagta gctggagaca
      901 tgagcaagaa aagtctgtgg gaacagaaag gaggctccaa gatctcatcc accatcaaga
      961 gcaccccatc tggaaagagg tacaagtttg tggccactgg acacgggaag tacgagaaag
     1021 tgctcgtgga tgagggctca gcaccataga ccacgtatgc atcctggata gactccaacc
     1081 agatgccact cccagccctg accaagaaat tgcttcctgt tgccagtctg gcccgctctc
     1141 ctgcctccag caacccagct gccacttgcc tctcctcttg ctactggacc ctccatcttc
     1201 tatgccctct catcctctga ccaaccctcc aactctgctt ctcatcatca gctaaaggga
     1261 ccagcccata gaggagccga gagctcccaa ggaaggatgg aggagagaag gcaagcatcc
     1321 caaccagatc caaggggtaa ctgtccccat gctgaatgct caggactcca agtcctgccc
     1381 tgtttatgga tccttcgttt tgtgtaataa agtgcattga gtgtccccta
//
