LOCUS       NM_001106585             797 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus LSM8 homolog, U6 small nuclear RNA associated
            (Lsm8), mRNA.
ACCESSION   NM_001106585 XM_001058762 XM_216102
VERSION     NM_001106585.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 797)
  AUTHORS   Bertram K, Agafonov DE, Dybkov O, Haselbach D, Leelaram MN, Will
            CL, Urlaub H, Kastner B, Luhrmann R and Stark H.
  TITLE     Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for
            Activation
  JOURNAL   Cell 170 (4), 701-713 (2017)
   PUBMED   28781166
REFERENCE   2  (bases 1 to 797)
  AUTHORS   Agafonov DE, Kastner B, Dybkov O, Hofele RV, Liu WT, Urlaub H,
            Luhrmann R and Stark H.
  TITLE     Molecular architecture of the human U4/U6.U5 tri-snRNP
  JOURNAL   Science 351 (6280), 1416-1420 (2016)
   PUBMED   26912367
REFERENCE   3  (bases 1 to 797)
  AUTHORS   Baltz AG, Munschauer M, Schwanhausser B, Vasile A, Murakawa Y,
            Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E,
            Bonneau R, Selbach M, Dieterich C and Landthaler M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 797)
  AUTHORS   Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein
            C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J and
            Hentze MW.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 797)
  AUTHORS   Wahl MC, Will CL and Luhrmann R.
  TITLE     The spliceosome: design principles of a dynamic RNP machine
  JOURNAL   Cell 136 (4), 701-718 (2009)
   PUBMED   19239890
  REMARK    Review article
REFERENCE   6  (bases 1 to 797)
  AUTHORS   Chen YI, Moore RE, Ge HY, Young MK, Lee TD and Stevens SW.
  TITLE     Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes
            expands the catalog of participating factors
  JOURNAL   Nucleic Acids Res 35 (12), 3928-3944 (2007)
   PUBMED   17537823
REFERENCE   7  (bases 1 to 797)
  AUTHORS   Achsel T, Brahms H, Kastner B, Bachi A, Wilm M and Luhrmann R.
  TITLE     A doughnut-shaped heteromer of human Sm-like proteins binds to the
            3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in
            vitro
  JOURNAL   EMBO J 18 (20), 5789-5802 (1999)
   PUBMED   10523320
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473959.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_216102.4, XM_001058762.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ235748.1, FQ211862.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..797
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     gene            1..797
                     /gene="Lsm8"
                     /note="LSM8 homolog, U6 small nuclear RNA associated"
                     /db_xref="GeneID:296913"
                     /db_xref="RGD:1308442"
     exon            1..174
                     /gene="Lsm8"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..434
                     /gene="Lsm8"
                     /note="N-alpha-acetyltransferase 38, NatC auxiliary
                     subunit"
                     /codon_start=1
                     /product="LSM8 homolog, U6 small nuclear RNA associated"
                     /protein_id="NP_001100055.1"
                     /db_xref="GeneID:296913"
                     /db_xref="RGD:1308442"
                     /translation="MTSALENYINRTVAVITSDGRMIVGTLKGFDQTINLILDESHER
                     VFSSSQGVEQVVLGLYIVRGDNVAVIGEIDEETDSALDLGNIRAEPLNSVAH"
     exon            175..215
                     /gene="Lsm8"
                     /inference="alignment:Splign:2.1.0"
     exon            216..343
                     /gene="Lsm8"
                     /inference="alignment:Splign:2.1.0"
     exon            344..797
                     /gene="Lsm8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gattcgtcac cgctgaggcc tcagagtctc gcgatatttg cgttcgccag cgggcgcgaa
       61 tctgtacgtg tttctagcgg gcggtgtttt gtctccttgt tgctgattcc tctcagattc
      121 ccggaacctc cgggcccagc agcatgacgt ctgccttgga gaactacatc aaccgaactg
      181 ttgcagtaat aacttctgat ggcagaatga tcgtgggaac cctgaaaggt tttgaccaga
      241 ccattaactt gattctggat gaaagccacg agcgggtgtt cagctcttct cagggagtag
      301 aacaagtggt attggggtta tacattgtga gaggagataa tgtagcagtc attggggaaa
      361 tagatgaaga gacagattct gcactcgact tggggaacat ccgagcagaa cctctgaact
      421 ccgtagcaca ctgagagctt agtgtgcagg agacgtctgt aaatcctgta cagagacttc
      481 ttatgctcag agtgatgtct agattttttt atgagtgtgt aattgtggat atttgacttc
      541 atgttggtac actgtaatat gtaatttaaa tatttctacc tttttatcgg gaaacattgc
      601 ctaaattaat gtggttgctt ggtttatttt tctatcaaat gaaacaaaaa tgtaagggac
      661 attttggaaa gttacaaagt accactcttt ttggtaatgt aatatttata ggaaattggc
      721 tgtaaagaga acttagactg ttattgtaac ttagacatgc aactaacagt aataaaagac
      781 acgtttcttt ttgtggc
//
