LOCUS       NM_001401076             495 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus LSM7 homolog, U6 small nuclear RNA and mRNA
            degradation associated (Lsm7), transcript variant 3, mRNA.
ACCESSION   NM_001401076 XM_006240958
VERSION     NM_001401076.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Bertram,K., Agafonov,D.E., Dybkov,O., Haselbach,D., Leelaram,M.N.,
            Will,C.L., Urlaub,H., Kastner,B., Luhrmann,R. and Stark,H.
  TITLE     Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for
            Activation
  JOURNAL   Cell 170 (4), 701-713 (2017)
   PUBMED   28781166
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Agafonov,D.E., Kastner,B., Dybkov,O., Hofele,R.V., Liu,W.T.,
            Urlaub,H., Luhrmann,R. and Stark,H.
  TITLE     Molecular architecture of the human U4/U6.U5 tri-snRNP
  JOURNAL   Science 351 (6280), 1416-1420 (2016)
   PUBMED   26912367
REFERENCE   3  (bases 1 to 495)
  AUTHORS   Wahl,M.C., Will,C.L. and Luhrmann,R.
  TITLE     The spliceosome: design principles of a dynamic RNP machine
  JOURNAL   Cell 136 (4), 701-718 (2009)
   PUBMED   19239890
  REMARK    Review article
REFERENCE   4  (bases 1 to 495)
  AUTHORS   Chen,Y.I., Moore,R.E., Ge,H.Y., Young,M.K., Lee,T.D. and
            Stevens,S.W.
  TITLE     Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes
            expands the catalog of participating factors
  JOURNAL   Nucleic Acids Res 35 (12), 3928-3944 (2007)
   PUBMED   17537823
REFERENCE   5  (bases 1 to 495)
  AUTHORS   Achsel,T., Brahms,H., Kastner,B., Bachi,A., Wilm,M. and Luhrmann,R.
  TITLE     A doughnut-shaped heteromer of human Sm-like proteins binds to the
            3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in
            vitro
  JOURNAL   EMBO J 18 (20), 5789-5802 (1999)
   PUBMED   10523320
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Feb 1, 2022 this sequence version replaced XM_006240958.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.1370492.1,
                                           SRR26360172.417660.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                JAXUCZ010000007.1  9507373-9507401
            30-138              JAXUCZ010000007.1  9507905-9508013
            139-210             JAXUCZ010000007.1  9508784-9508855
            211-495             JAXUCZ010000007.1  9509503-9509787
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..495
                     /gene="Lsm7"
                     /note="LSM7 homolog, U6 small nuclear RNA and mRNA
                     degradation associated"
                     /db_xref="GeneID:362829"
                     /db_xref="RGD:1305354"
     exon            1..29
                     /gene="Lsm7"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..353
                     /gene="Lsm7"
                     /note="isoform 3 is encoded by transcript variant 3; U6
                     snRNA-associated Sm-like protein LSm7; LSM7 homolog, U6
                     small nuclear RNA associated; LSM7 U6 small nuclear RNA
                     and mRNA degradation associated"
                     /codon_start=1
                     /product="U6 snRNA-associated Sm-like protein LSm7 isoform
                     3"
                     /protein_id="NP_001388005.1"
                     /db_xref="GeneID:362829"
                     /db_xref="RGD:1305354"
                     /translation="MARPTFQQDKEKKKKESILDLSKYIDKTIRVKFQGGREASGILK
                     GFDPLLNLVLDGTIEYMRDPDDQYKLTEDTRQLGLVVCRGTSVVLICPQDGMEAIPNP
                     FVQQQDT"
     exon            30..138
                     /gene="Lsm7"
                     /inference="alignment:Splign:2.1.0"
     exon            139..210
                     /gene="Lsm7"
                     /inference="alignment:Splign:2.1.0"
     exon            211..495
                     /gene="Lsm7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagaacgac gcgcggcgac aagatggcgc gtcccacctt ccagcaggac aaagagaaaa
       61 agaagaaaga aagcatcttg gacctgtcca agtatattga taagaccatt cgagtcaagt
      121 tccagggtgg ccgggaagcc agcggcatcc tgaaagggtt tgacccactg ctcaacctgg
      181 tgctggatgg gaccattgaa tacatgcgag accccgatga ccagtacaag ctgacagagg
      241 acactcggca gctggggctc gtagtgtgcc gtggcacctc ggtggtgctc atctgcccgc
      301 aggatggcat ggaggccatc cctaacccct ttgtgcagca gcaggacact tagcagcagt
      361 ggagggtggc ccagccccag gggccttcct tctatggggt gaacttctgt ttgatgtctt
      421 ggtctttttt tcttgttttg ttttgttttg ttttttaata aaattgccca tgtgagcatc
      481 cctgtccctc cccca
//
