LOCUS       NM_001126085            2119 bp    mRNA    linear   ROD 14-NOV-2024
DEFINITION  Rattus norvegicus LSM6 homolog, U6 small nuclear RNA and mRNA
            degradation associated (Lsm6), transcript variant 1, mRNA.
ACCESSION   NM_001126085 XM_001070778 XM_001070822 XM_001070871 XM_574220
VERSION     NM_001126085.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2119)
  AUTHORS   Bertram,K., Agafonov,D.E., Dybkov,O., Haselbach,D., Leelaram,M.N.,
            Will,C.L., Urlaub,H., Kastner,B., Luhrmann,R. and Stark,H.
  TITLE     Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for
            Activation
  JOURNAL   Cell 170 (4), 701-713 (2017)
   PUBMED   28781166
REFERENCE   2  (bases 1 to 2119)
  AUTHORS   Agafonov,D.E., Kastner,B., Dybkov,O., Hofele,R.V., Liu,W.T.,
            Urlaub,H., Luhrmann,R. and Stark,H.
  TITLE     Molecular architecture of the human U4/U6.U5 tri-snRNP
  JOURNAL   Science 351 (6280), 1416-1420 (2016)
   PUBMED   26912367
REFERENCE   3  (bases 1 to 2119)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 2119)
  AUTHORS   Wahl,M.C., Will,C.L. and Luhrmann,R.
  TITLE     The spliceosome: design principles of a dynamic RNP machine
  JOURNAL   Cell 136 (4), 701-718 (2009)
   PUBMED   19239890
  REMARK    Review article
REFERENCE   5  (bases 1 to 2119)
  AUTHORS   Chen,Y.I., Moore,R.E., Ge,H.Y., Young,M.K., Lee,T.D. and
            Stevens,S.W.
  TITLE     Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes
            expands the catalog of participating factors
  JOURNAL   Nucleic Acids Res 35 (12), 3928-3944 (2007)
   PUBMED   17537823
REFERENCE   6  (bases 1 to 2119)
  AUTHORS   Ingelfinger,D., Arndt-Jovin,D.J., Luhrmann,R. and Achsel,T.
  TITLE     The human LSm1-7 proteins colocalize with the mRNA-degrading
            enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci
  JOURNAL   RNA 8 (12), 1489-1501 (2002)
   PUBMED   12515382
REFERENCE   7  (bases 1 to 2119)
  AUTHORS   Achsel,T., Brahms,H., Kastner,B., Bachi,A., Wilm,M. and Luhrmann,R.
  TITLE     A doughnut-shaped heteromer of human Sm-like proteins binds to the
            3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in
            vitro
  JOURNAL   EMBO J 18 (20), 5789-5802 (1999)
   PUBMED   10523320
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473972.1.
            
            On or before Apr 30, 2008 this sequence version replaced
            XM_001070778.1, XM_001070822.1, XM_001070871.1, XM_574220.2.
            
            ##Evidence-Data-START##
            CDS exon combination :: CK357852.1, FM133241.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMD00132261, SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2119
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q11"
     gene            1..2119
                     /gene="Lsm6"
                     /gene_synonym="RGD1561937"
                     /note="LSM6 homolog, U6 small nuclear RNA and mRNA
                     degradation associated"
                     /db_xref="GeneID:498934"
                     /db_xref="RGD:1561937"
     exon            1..91
                     /gene="Lsm6"
                     /gene_synonym="RGD1561937"
                     /inference="alignment:Splign:2.1.0"
     exon            92..188
                     /gene="Lsm6"
                     /gene_synonym="RGD1561937"
                     /inference="alignment:Splign:2.1.0"
     exon            189..293
                     /gene="Lsm6"
                     /gene_synonym="RGD1561937"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..442
                     /gene="Lsm6"
                     /gene_synonym="RGD1561937"
                     /note="Sm protein F; LSM6 homolog, U6 small nuclear RNA
                     associated; LSM6 U6 small nuclear RNA and mRNA degradation
                     associated; rCG63582-like"
                     /codon_start=1
                     /product="U6 snRNA-associated Sm-like protein LSm6"
                     /protein_id="NP_001119557.1"
                     /db_xref="GeneID:498934"
                     /db_xref="RGD:1561937"
                     /translation="MSLRKQTPSDFLKQIIGRPVVVKLNSGVDYRGVLACLDGYMNIA
                     LEQTEEYVNGQLKNKYGDAFIRGNNVLYISTQKRRM"
     exon            294..407
                     /gene="Lsm6"
                     /gene_synonym="RGD1561937"
                     /inference="alignment:Splign:2.1.0"
     exon            408..2119
                     /gene="Lsm6"
                     /gene_synonym="RGD1561937"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgggaaaat gcgctgccgg gggcggtttc ggttttcggc gcgcgcgtcc gcggaggccc
       61 ggcctgtgag ggctccggat cccgctgtaa gatgagcctg gggccatgac aagtgaaatg
      121 gtgatgagtt acctgagatg ctaattaagt aacagaggag attagaactc aggtttcctg
      181 cctcccaaga ttgttaaaaa tgagtctgcg gaagcaaacc cctagtgact tcttaaagca
      241 gatcatcggg cgcccagttg tggtgaaatt aaactctggc gtggattacc gaggggtcct
      301 ggcctgcctg gatggctaca tgaatatagc attggaacag acagaggagt atgtaaacgg
      361 acagctgaag aataagtatg gagacgcatt catccgcgga aacaatgtgc tgtacataag
      421 tacacagaag aggcggatgt gaagacgcca ggagagaggc actgctcttc agcgatggat
      481 atatgatcac tcttatgatc ttggtggcct gtttttgtgg tggctggtgg gggttttgtt
      541 ttcttttgtt tttttaattg acatcagaat aagatagagg tattacatta cagattgaat
      601 cttaagcttt tcacatttgt ttcattgctt attatttctg cctgtacaga tgctaaaatt
      661 aaaacagttt gtttctcaag gattgtttta cctcaggttg caagcagtgt catttgttgg
      721 ttgagtacgc atccaactga ctaagcggta cattccgtga tcaagccgtc tggaggcttc
      781 ccttgtctct ttccctgctc actcgccatc cataacattt aaagcaggta gatgaaaacc
      841 ttctaggaag tcgtgtggtt tcagccttgt gctatagaga gacaagaggt cagaagttga
      901 gctgttggtt tagtcgctgg tgctggtatc cccacaagga gtgcagctct gtagaccctg
      961 tgggcttgta caggttggcc acagcaggtg agaaggttgt ttggaatcct caagccgtcc
     1021 tgccgatcct cctgtgcagt tcaactcttt atgttaactt gctccctgac aagagtgttg
     1081 gcagcaatgg taggttactc caatcgaggg gagctcagct gtccctccgt cactctggcc
     1141 gtgcttgagg tggtataagc gcagagtccc cgacctcggt ttccaggtgc tgagctgctt
     1201 tctgttttag caggtggtcc tggagagtgg tattccggaa cagggtcgct tggcacaggc
     1261 agagcctcca ggtcatgtga ctcctgctaa gtgcgttgtg ctgtctgtag agattgtgtt
     1321 tgggtgcttc agttgcatgg acactggggc ttttcttatc cctccttcaa tctaaacaga
     1381 atccctggct caggaggtgg gacagttttg gaacaattgc ctggctgagg gaagtaagag
     1441 agatgggaag ctagggaggg agggagggca tactttctgg agaggtgcat atatgccatt
     1501 tgtctcgttt aactagtaat cagaaacagt taataactca ggaaagacaa aaaatgtttt
     1561 gtaaggtttg atggtgtgca cactgaaaat aaaacacttt atcctaagct tcagtaattc
     1621 atcacttcct gacaggggct tgaaaaggga ccagtgtgta agtacaaatc accaatttgc
     1681 tcttttataa atggcttctt taaaggagaa aatggatgtc tctcagagtg gagcacacat
     1741 gttctcattt gtttttagag tgtgtgaggc tgccaggtta ctgtgtccct tcattcactc
     1801 actcagccgc ccctgaaagc agttgtagca tcccccacca gtctgtagca tcccgtcttc
     1861 gctcatttct tccctgacct ctcctccagc atgtgggcct ttatttccct cttgccattt
     1921 ctggcttaat agctcgactg cagaatgttg ttttcatcca tagaaccgct tttaatcaag
     1981 accgactttg ggaactgcta ccgtttttat ggtaataaag aaccatatgc atctggacca
     2041 gcacatgttg tcccctgtgc ataccttctt gtgatagaat tctgaaacaa attgtaaatg
     2101 ctaaaattac ttttcctta
//
