LOCUS       NM_001107289             539 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus LSM5 homolog, U6 small nuclear RNA and mRNA
            degradation associated (Lsm5), mRNA.
ACCESSION   NM_001107289 XM_001059585 XM_224630
VERSION     NM_001107289.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 539)
  AUTHORS   Bertram,K., Agafonov,D.E., Dybkov,O., Haselbach,D., Leelaram,M.N.,
            Will,C.L., Urlaub,H., Kastner,B., Luhrmann,R. and Stark,H.
  TITLE     Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for
            Activation
  JOURNAL   Cell 170 (4), 701-713 (2017)
   PUBMED   28781166
REFERENCE   2  (bases 1 to 539)
  AUTHORS   Agafonov,D.E., Kastner,B., Dybkov,O., Hofele,R.V., Liu,W.T.,
            Urlaub,H., Luhrmann,R. and Stark,H.
  TITLE     Molecular architecture of the human U4/U6.U5 tri-snRNP
  JOURNAL   Science 351 (6280), 1416-1420 (2016)
   PUBMED   26912367
REFERENCE   3  (bases 1 to 539)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   4  (bases 1 to 539)
  AUTHORS   Ingelfinger,D., Arndt-Jovin,D.J., Luhrmann,R. and Achsel,T.
  TITLE     The human LSm1-7 proteins colocalize with the mRNA-degrading
            enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci
  JOURNAL   RNA 8 (12), 1489-1501 (2002)
   PUBMED   12515382
REFERENCE   5  (bases 1 to 539)
  AUTHORS   Achsel,T., Brahms,H., Kastner,B., Bachi,A., Wilm,M. and Luhrmann,R.
  TITLE     A doughnut-shaped heteromer of human Sm-like proteins binds to the
            3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in
            vitro
  JOURNAL   EMBO J 18 (20), 5789-5802 (1999)
   PUBMED   10523320
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474011.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001059585.1, XM_224630.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CF249228.1, BP480036.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..539
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..539
                     /gene="Lsm5"
                     /note="LSM5 homolog, U6 small nuclear RNA and mRNA
                     degradation associated"
                     /db_xref="GeneID:306222"
                     /db_xref="RGD:1308655"
     exon            1..97
                     /gene="Lsm5"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..327
                     /gene="Lsm5"
                     /note="LSM5 homolog, U6 small nuclear RNA associated; LSM5
                     U6 small nuclear RNA and mRNA degradation associated"
                     /codon_start=1
                     /product="U6 snRNA-associated Sm-like protein LSm5"
                     /protein_id="NP_001100759.1"
                     /db_xref="GeneID:306222"
                     /db_xref="RGD:1308655"
                     /translation="MAANATTNPSQLLPLELVDKCIGSRIHIVMKSDKEIVGTLLGFD
                     DFVNMVLEDVTEFEITPEGRRITKLDQILLNGNNITMLVPGGEGPEV"
     exon            98..193
                     /gene="Lsm5"
                     /inference="alignment:Splign:2.1.0"
     exon            194..221
                     /gene="Lsm5"
                     /inference="alignment:Splign:2.1.0"
     exon            222..294
                     /gene="Lsm5"
                     /inference="alignment:Splign:2.1.0"
     exon            295..539
                     /gene="Lsm5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgctatttt aaagtctgcg ccggtgtcct tatgccactt ccggcgtggc catggcggct
       61 aacgcgacca cgaacccgtc tcaactcctg ccactagagc ttgtggacaa gtgtatagga
      121 tcaagaattc acattgtgat gaagagtgat aaagaaatcg tgggtacact tctaggattt
      181 gatgactttg tcaatatggt gttggaagat gtcacagagt ttgaaattac accagaagga
      241 agaagaatta caaaattaga tcaaattcta ctaaatggaa ataatataac aatgctggtt
      301 cctggaggag aagggcctga agtatgagtg gatttccttg acttatgctg gattctggct
      361 ttgtgttttt caaaccttta atgtttagat tctataaaat gaagtttccg ttaaagggaa
      421 acactttgaa gatatacatc catttttcta agctaatcat ggttattttg ggaaaagaag
      481 agttttgttt tgtcttgttt ttttaaagac taaaaaaata aagatggttt tggttaact
//
