LOCUS       NM_001106073             911 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus LSM4 homolog, U6 small nuclear RNA and mRNA
            degradation associated (Lsm4), mRNA.
ACCESSION   NM_001106073 XM_001067054 XM_214318
VERSION     NM_001106073.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 911)
  AUTHORS   Xue Y, Guo Y, Luo S, Zhou W, Xiang J, Zhu Y, Xiang Z and Shen J.
  TITLE     Aberrantly Methylated-Differentially Expressed Genes Identify Novel
            Atherosclerosis Risk Subtypes
  JOURNAL   Front Genet 11, 569572 (2020)
   PUBMED   33381146
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 911)
  AUTHORS   Bertram K, Agafonov DE, Dybkov O, Haselbach D, Leelaram MN, Will
            CL, Urlaub H, Kastner B, Luhrmann R and Stark H.
  TITLE     Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for
            Activation
  JOURNAL   Cell 170 (4), 701-713 (2017)
   PUBMED   28781166
REFERENCE   3  (bases 1 to 911)
  AUTHORS   Agafonov DE, Kastner B, Dybkov O, Hofele RV, Liu WT, Urlaub H,
            Luhrmann R and Stark H.
  TITLE     Molecular architecture of the human U4/U6.U5 tri-snRNP
  JOURNAL   Science 351 (6280), 1416-1420 (2016)
   PUBMED   26912367
REFERENCE   4  (bases 1 to 911)
  AUTHORS   Baltz AG, Munschauer M, Schwanhausser B, Vasile A, Murakawa Y,
            Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E,
            Bonneau R, Selbach M, Dieterich C and Landthaler M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 911)
  AUTHORS   Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein
            C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J and
            Hentze MW.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 911)
  AUTHORS   Wahl MC, Will CL and Luhrmann R.
  TITLE     The spliceosome: design principles of a dynamic RNP machine
  JOURNAL   Cell 136 (4), 701-718 (2009)
   PUBMED   19239890
  REMARK    Review article
REFERENCE   7  (bases 1 to 911)
  AUTHORS   di Penta A, Mercaldo V, Florenzano F, Munck S, Ciotti MT, Zalfa F,
            Mercanti D, Molinari M, Bagni C and Achsel T.
  TITLE     Dendritic LSm1/CBP80-mRNPs mark the early steps of transport
            commitment and translational control
  JOURNAL   J Cell Biol 184 (3), 423-435 (2009)
   PUBMED   19188494
REFERENCE   8  (bases 1 to 911)
  AUTHORS   Chen YI, Moore RE, Ge HY, Young MK, Lee TD and Stevens SW.
  TITLE     Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes
            expands the catalog of participating factors
  JOURNAL   Nucleic Acids Res 35 (12), 3928-3944 (2007)
   PUBMED   17537823
REFERENCE   9  (bases 1 to 911)
  AUTHORS   Furst J, Schedlbauer A, Gandini R, Garavaglia ML, Saino S,
            Gschwentner M, Sarg B, Lindner H, Jakab M, Ritter M, Bazzini C,
            Botta G, Meyer G, Kontaxis G, Tilly BC, Konrat R and Paulmichl M.
  TITLE     ICln159 folds into a pleckstrin homology domain-like structure.
            Interaction with kinases and the splicing factor LSm4
  JOURNAL   J Biol Chem 280 (35), 31276-31282 (2005)
   PUBMED   15905169
REFERENCE   10 (bases 1 to 911)
  AUTHORS   Achsel T, Brahms H, Kastner B, Bachi A, Wilm M and Luhrmann R.
  TITLE     A doughnut-shaped heteromer of human Sm-like proteins binds to the
            3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in
            vitro
  JOURNAL   EMBO J 18 (20), 5789-5802 (1999)
   PUBMED   10523320
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474031.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_214318.4, XM_001067054.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB577954.1, SRR8487227.111171.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132294, SAMEA5756307
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..911
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..911
                     /gene="Lsm4"
                     /note="LSM4 homolog, U6 small nuclear RNA and mRNA
                     degradation associated"
                     /db_xref="GeneID:290647"
                     /db_xref="RGD:1306808"
     exon            1..192
                     /gene="Lsm4"
                     /inference="alignment:Splign:2.1.0"
     CDS             190..606
                     /gene="Lsm4"
                     /note="LSM4 homolog, U6 small nuclear RNA associated; LSM4
                     U6 small nuclear RNA and mRNA degradation associated"
                     /codon_start=1
                     /product="U6 snRNA-associated Sm-like protein LSm4"
                     /protein_id="NP_001099543.1"
                     /db_xref="GeneID:290647"
                     /db_xref="RGD:1306808"
                     /translation="MLPLSLLKTAQNHPMLVELKNGETYNGHLVSCDNWMNINLREVI
                     CTSRDGDKFWRMPECYIRGSTIKYLRIPDEIIDMVREEAAKGRGRGGPQQQKQQKGRG
                     MGGAGRGVFGGRGRGGIPGAGRGQPEKKPGRQAGKQ"
     exon            193..234
                     /gene="Lsm4"
                     /inference="alignment:Splign:2.1.0"
     exon            235..333
                     /gene="Lsm4"
                     /inference="alignment:Splign:2.1.0"
     exon            334..514
                     /gene="Lsm4"
                     /inference="alignment:Splign:2.1.0"
     exon            515..911
                     /gene="Lsm4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaatacgac gcgatacgcc gccgcgttat gtaggcaccg ccttatcccg ttccgattgg
       61 atcggtccat ttagtcactc gctgattggt tatagtttct gccagtcttt ttcaggctgg
      121 agcgcgcggt agactgccgg tgggagtgcg agtggctgtg cagcggcgga agttatctct
      181 gcagggaaga tgcttccctt gtcgctgctg aagacagccc agaatcaccc catgctggtg
      241 gagctgaaga atggggagac ctacaacggg cacctggtga gctgcgacaa ctggatgaac
      301 atcaaccttc gagaagtgat ctgcacatcg agggacggtg acaagttctg gaggatgccc
      361 gagtgctaca tccgaggcag caccatcaag tacctgcgta tcccggatga gatcattgac
      421 atggtgaggg aagaggccgc caagggccga gggcgaggag gaccgcagca gcagaagcag
      481 cagaaaggcc gaggcatggg tggcgctggc agaggtgtgt ttggtggccg gggccggggt
      541 ggcatccctg gtgcaggccg aggccagccg gagaagaagc cagggcggca ggcaggcaag
      601 cagtgagcag tcccagcctg aactgagtcc aggaaggtgg gtgaggagac ctccgggcgc
      661 ctttgcgtga agccccactt ggcgtctgat ccagtgaaat ccctgactgg ccacttactc
      721 agtttctgga aggttcccag tctgagttga ctgttaagcc ttggatgtcc tttgaagggc
      781 tggcttcttc caggcttgtt tgagtttcat gttggagctg caggctccgc acatggtggt
      841 ttacctgtcc tttcccagcc ccacccccta cgttttctgt tggaaaaaat aaaggcaaac
      901 accacagaag g
//
