LOCUS       NM_001106611             709 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus LSM3 homolog, U6 small nuclear RNA and mRNA
            degradation associated (Lsm3), mRNA.
ACCESSION   NM_001106611 XM_001073506 XM_216220
VERSION     NM_001106611.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 709)
  AUTHORS   Bertram K, Agafonov DE, Dybkov O, Haselbach D, Leelaram MN, Will
            CL, Urlaub H, Kastner B, Luhrmann R and Stark H.
  TITLE     Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for
            Activation
  JOURNAL   Cell 170 (4), 701-713 (2017)
   PUBMED   28781166
REFERENCE   2  (bases 1 to 709)
  AUTHORS   Agafonov DE, Kastner B, Dybkov O, Hofele RV, Liu WT, Urlaub H,
            Luhrmann R and Stark H.
  TITLE     Molecular architecture of the human U4/U6.U5 tri-snRNP
  JOURNAL   Science 351 (6280), 1416-1420 (2016)
   PUBMED   26912367
REFERENCE   3  (bases 1 to 709)
  AUTHORS   Baltz AG, Munschauer M, Schwanhausser B, Vasile A, Murakawa Y,
            Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E,
            Bonneau R, Selbach M, Dieterich C and Landthaler M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 709)
  AUTHORS   Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein
            C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J and
            Hentze MW.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 709)
  AUTHORS   Wahl MC, Will CL and Luhrmann R.
  TITLE     The spliceosome: design principles of a dynamic RNP machine
  JOURNAL   Cell 136 (4), 701-718 (2009)
   PUBMED   19239890
  REMARK    Review article
REFERENCE   6  (bases 1 to 709)
  AUTHORS   Chen YI, Moore RE, Ge HY, Young MK, Lee TD and Stevens SW.
  TITLE     Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes
            expands the catalog of participating factors
  JOURNAL   Nucleic Acids Res 35 (12), 3928-3944 (2007)
   PUBMED   17537823
REFERENCE   7  (bases 1 to 709)
  AUTHORS   Jurica MS, Licklider LJ, Gygi SR, Grigorieff N and Moore MJ.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   8  (bases 1 to 709)
  AUTHORS   Achsel T, Brahms H, Kastner B, Bachi A, Wilm M and Luhrmann R.
  TITLE     A doughnut-shaped heteromer of human Sm-like proteins binds to the
            3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in
            vitro
  JOURNAL   EMBO J 18 (20), 5789-5802 (1999)
   PUBMED   10523320
REFERENCE   9  (bases 1 to 709)
  AUTHORS   Salgado-Garrido J, Bragado-Nilsson E, Kandels-Lewis S and Seraphin
            B.
  TITLE     Sm and Sm-like proteins assemble in two related complexes of deep
            evolutionary origin
  JOURNAL   EMBO J 18 (12), 3451-3462 (1999)
   PUBMED   10369684
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473957.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001073506.1, XM_216220.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ222680.1, FM115383.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..709
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..709
                     /gene="Lsm3"
                     /note="LSM3 homolog, U6 small nuclear RNA and mRNA
                     degradation associated"
                     /db_xref="GeneID:297455"
                     /db_xref="RGD:1305971"
     exon            1..121
                     /gene="Lsm3"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..409
                     /gene="Lsm3"
                     /note="LSM3 homolog, U6 small nuclear RNA associated; LSM3
                     U6 small nuclear RNA and mRNA degradation associated"
                     /codon_start=1
                     /product="U6 snRNA-associated Sm-like protein LSm3"
                     /protein_id="NP_001100081.1"
                     /db_xref="GeneID:297455"
                     /db_xref="RGD:1305971"
                     /translation="MADDVDQQQTTNTVEEPLDLIRLSLDERIYVKMRNDRELRGRLH
                     AYDQHLNMILGDVEETVTTIEIDEETYEEIYKSTKRNIPMLFVRGDGVVLVAPPLRVG
                     "
     exon            122..232
                     /gene="Lsm3"
                     /inference="alignment:Splign:2.1.0"
     exon            233..328
                     /gene="Lsm3"
                     /inference="alignment:Splign:2.1.0"
     exon            329..709
                     /gene="Lsm3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagggacaaa aatagtgtag ttcgccttcc agtgcgtggc ggcccaacgt ttcctagtgt
       61 ctgctctcgc gagaggtgga aagggcgcag cgtttgaaac atggcggacg acgtagatca
      121 gcaacagacc accaataccg tagaggagcc cctggatctt ataagactca gcttggatga
      181 gcgaatttat gtgaaaatga gaaatgaccg agagcttcga ggcagattac atgcttacga
      241 tcaacattta aatatgattc tgggagatgt agaagaaact gtgacgacga tagagattga
      301 tgaggagacg tatgaagaga tatataaatc cacaaaacgg aatatcccca tgctcttcgt
      361 ccggggagat ggtgttgttc tagtcgcccc tccattgaga gttggctgag acaaaaatgg
      421 agcctgcgta gggaagtgga gactttgcct cttgagatgt acaggacact cccagagaga
      481 gaagctcaca cgcatctgat agtcagaaat gacccgagga tccctctacc ctcaaagaag
      541 ttcatttgca agtaactcac aagctctcca gctaaatggc ctgccccttt ctccagccct
      601 ccagtcagtg tgaccgcctt gctcttcagg agttggtttg cccattgttc ttgcagttac
      661 tttcaggatg tttttcttta aattaaattt gatgtttcct tttttagta
//
