LOCUS       NM_001127552            2728 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus LSM14A mRNA processing body assembly factor
            (Lsm14a), mRNA.
ACCESSION   NM_001127552 XM_001079562 XM_341841
VERSION     NM_001127552.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2728)
  AUTHORS   Li,Y., Chen,R., Zhou,Q., Xu,Z., Li,C., Wang,S., Mao,A., Zhang,X.,
            He,W. and Shu,H.B.
  TITLE     LSm14A is a processing body-associated sensor of viral nucleic
            acids that initiates cellular antiviral response in the early phase
            of viral infection
  JOURNAL   Proc Natl Acad Sci U S A 109 (29), 11770-11775 (2012)
   PUBMED   22745163
REFERENCE   2  (bases 1 to 2728)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 2728)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 2728)
  AUTHORS   Hu,J., Wang,F., Zhu,X., Yuan,Y., Ding,M. and Gao,S.
  TITLE     Mouse ZAR1-like (XM_359149) colocalizes with mRNA processing
            components and its dominant-negative mutant caused two-cell-stage
            embryonic arrest
  JOURNAL   Dev Dyn 239 (2), 407-424 (2010)
   PUBMED   20014101
REFERENCE   5  (bases 1 to 2728)
  AUTHORS   Tanaka,K.J., Ogawa,K., Takagi,M., Imamoto,N., Matsumoto,K. and
            Tsujimoto,M.
  TITLE     RAP55, a cytoplasmic mRNP component, represses translation in
            Xenopus oocytes
  JOURNAL   J Biol Chem 281 (52), 40096-40106 (2006)
   PUBMED   17074753
  REMARK    Erratum:[J Biol Chem. 2014 Jul 25;289(30):20490]
REFERENCE   6  (bases 1 to 2728)
  AUTHORS   Yang,W.H., Yu,J.H., Gulick,T., Bloch,K.D. and Bloch,D.B.
  TITLE     RNA-associated protein 55 (RAP55) localizes to mRNA processing
            bodies and stress granules
  JOURNAL   RNA 12 (4), 547-554 (2006)
   PUBMED   16484376
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC166537.1.
            
            On or before May 23, 2008 this sequence version replaced
            XM_341841.3, XM_001079562.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166537.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676810 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2728
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2728
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="LSM14A mRNA processing body assembly factor"
                     /db_xref="GeneID:361554"
                     /db_xref="RGD:1305695"
     exon            1..227
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..1513
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="LSM14 homolog A; LSM14A, SCD6 homolog A"
                     /codon_start=1
                     /product="protein LSM14 homolog A"
                     /protein_id="NP_001121024.1"
                     /db_xref="GeneID:361554"
                     /db_xref="RGD:1305695"
                     /translation="MSGGTPYIGSKISLISKAEIRYEGILYTIDTENSTVALAKVRSF
                     GTEDRPTDRPIPPRDEVFEYIIFRGSDIKDLTVCEPPKPQCSLPQDPAIVQSSLGSSS
                     SSFQSVGSYGPFGRMPAYSQFSPSTLVGQQFGAVGVAGSSLTSFGTEASNSGTLSQSN
                     AVGSAFTQDTRSVKPQLAQGRSSPQLDPLRKSPTMEQAVQTASAHLPAPAPVGRRSPV
                     PARPLPPTSQKAIDNQEHRRAEVHKVPRPENEQLRNDSKRQVVPGVPSAPRRGRGGHR
                     GGRGRFGIRRDGPMKFEKDFDFESANAQFNKEEIDREFHNKLKLKEDKLEKQEKPVNG
                     EDKGDSGVDTQNSEGNADEEDPLGPNCYYDKTKSFFDNISCDDNRERRPTWAEERRLN
                     AETFGIPLRPNRGRGGYRGRGGLGFRGGRGRGSGRGGTFTAPRGFRAGFRGARGGREF
                     ADFEYRTTKLLHSLQTSL"
     exon            228..391
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            392..521
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            522..644
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            645..821
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            822..887
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1070
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1242
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1474
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..2704
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaagctgct gtgaggcgcc gacggagcga gcgggcgggc gtgcggagcg gcgggcgcag
       61 cgcgggatct gcctgagtgc gagcggcggg cgacggcggc ggcgccatga gcgggggcac
      121 cccttacatc ggcagcaaga tcagcctcat ctccaaggcg gagatccgct acgagggcat
      181 cctctacacc atcgacaccg agaactccac tgtagccctc gccaaagttc gatccttcgg
      241 tacagaagac agaccaacag atcgtccaat accgcctcga gatgaagtct ttgaatatat
      301 tatattccgg ggaagtgaca ttaaagacct cactgtttgt gagccgccca aaccacagtg
      361 ttctttgcct caggacccag ctattgttca gtcttcacta ggttcgtcat cttcctcgtt
      421 ccagtcagtg ggttcctatg gaccttttgg caggatgcca gcatacagtc agttcagtcc
      481 aagtacatta gttgggcaac agtttggtgc tgttggtgtt gctgggagct ccttgacatc
      541 ctttggaaca gaagcatcaa atagtggtac cttatcccag agcaatgcag ttggttcggc
      601 cttcacgcag gatacaagat ctgtaaaacc acagctggcc caaggtcgat caagccctca
      661 gttagaccct ttgagaaaaa gtccaaccat ggaacaagca gtgcagaccg cctcggccca
      721 cttacctgct ccagcacctg ttgggagaag gagccctgta cccgccaggc ctttgccacc
      781 taccagccag aaagcaatag acaaccaaga gcacaggcga gctgaagttc acaaagtccc
      841 aaggccagaa aatgagcaac tcagaaatga cagcaagagg caagtagttc ctggagttcc
      901 ttctgctcca agaagaggac gtgggggtca tcgaggtggc aggggaagat ttggtattcg
      961 tcgagatggt ccaatgaaat ttgagaaaga ctttgacttt gaaagtgcaa atgcacaatt
     1021 taacaaggag gaaatcgaca gagagtttca taataaactt aaattaaaag aagataaact
     1081 tgagaaacaa gagaaacctg taaacggtga agacaaagga gactcgggag ttgataccca
     1141 gaacagcgag gggaatgctg atgaggaaga tccccttggg cccaactgct actacgacaa
     1201 aaccaaatcc ttcttcgaca acatctcttg tgatgataat agagaaagga gaccaacttg
     1261 ggctgaagaa agaaggttaa atgctgaaac ttttggaatc ccacttcgtc caaatcgtgg
     1321 ccgtgggggt taccgaggca gaggaggcct tggcttccgt ggtggcagag gacgtggtag
     1381 tggccgagga ggaaccttca ctgcccctcg agggtttcgt gctggattca gaggcgctcg
     1441 tgggggtagg gagtttgcag attttgaata taggacaaca aagttgctgc atagtttaca
     1501 aacaagtctc tgaacatagg tgactcctag ctcttcatgg tcctggaaag tggttcggtc
     1561 tttgtgaaga atgaagaagt gaagttgctg tctgtctgtc accagcactg ggttttgtct
     1621 gttttctgct tcacgtcaaa gctatactgc agttgctttg gggcaggaag gctcgtctta
     1681 aaacacaagc ataagtgtgt gtggagtagc aggttatgat tccttgctta gagttgaact
     1741 aaagccagct aaatggaatt gctaagtgtt ttttcttcaa tgaaaggatt tttcttatca
     1801 ctaattaatt gtattcggca attactttga gttgcctgca gataggccgt gatactgtgt
     1861 tttgagccac agaaagtttt gtgtgtgtgc gcgcgcgcgc gtgtgtgtgt gtgtgtgtgt
     1921 gtgtgtgtgt acgtgtgtgt cccataatat gaggtagctt atttcgacac ttaattaggg
     1981 tgctggatgg tagagaattt tgtcagtcaa ctatgtacac acaggtaaat actgtttctt
     2041 aggcaaaggt aactttttta tatagttgta aaattccatt atattccatt gccaaagaaa
     2101 cattaagaac tttgtatagc tgtataaaaa gcaactaatt ttttaaagaa taaacgtttt
     2161 aaagtcagca aacatacgtg tccttgcaga agtcagtgtg ctgaggagca gggatatggg
     2221 tgggtctttt tccccttgct ttccaggctt aaggtttttt atttcctttg taatgtttgg
     2281 aacacaaatg aagatttgat aactttattc cattatctaa aaagcataaa ttattcatgc
     2341 atagtgtatg gacttcgttt tgtagcaaat cacaggattt gttcaaataa cagatatttt
     2401 aagtgtgtga atgtaaataa tcatagatga gaatgtacct tgctgtattt tcaaataagt
     2461 aaccttctcc tttttaagac attaagactc gttgatctat cagttgaccc gctcctcctg
     2521 ctatgcctgg aattctgttg tggtaatgct gactcctgtt ttccatcaaa aagatggagt
     2581 tttcagaatc atctggcacc tgtaaaacat cactaacata gtgtgtaggc ctgcggccta
     2641 ccgatgactc tgtacacgtt tgttgctaac tgtaaattac taataaatct tttttgatat
     2701 ttaaaaaaaa aaaaaaaaaa aaaaaaaa
//
