LOCUS       NM_001108876            1216 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus LSM1 homolog, mRNA degradation associated (Lsm1),
            mRNA.
ACCESSION   NM_001108876 XM_001071427 XM_344536
VERSION     NM_001108876.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1216)
  AUTHORS   Yang G, Smibert CA, Kaplan DR and Miller FD.
  TITLE     An eIF4E1/4E-T complex determines the genesis of neurons from
            precursors by translationally repressing a proneurogenic
            transcription program
  JOURNAL   Neuron 84 (4), 723-739 (2014)
   PUBMED   25456498
REFERENCE   2  (bases 1 to 1216)
  AUTHORS   Baltz AG, Munschauer M, Schwanhausser B, Vasile A, Murakawa Y,
            Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E,
            Bonneau R, Selbach M, Dieterich C and Landthaler M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 1216)
  AUTHORS   Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein
            C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J and
            Hentze MW.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 1216)
  AUTHORS   di Penta A, Mercaldo V, Florenzano F, Munck S, Ciotti MT, Zalfa F,
            Mercanti D, Molinari M, Bagni C and Achsel T.
  TITLE     Dendritic LSm1/CBP80-mRNPs mark the early steps of transport
            commitment and translational control
  JOURNAL   J Cell Biol 184 (3), 423-435 (2009)
   PUBMED   19188494
  REMARK    GeneRIF: Results describe a novel mRNP complex, containing LSm1 and
            CBP80, that is found in neuronal dendrites throughout the central
            nervous system and in some axonal processes of the spinal cord.
REFERENCE   5  (bases 1 to 1216)
  AUTHORS   Chowdhury A and Tharun S.
  TITLE     lsm1 mutations impairing the ability of the Lsm1p-7p-Pat1p complex
            to preferentially bind to oligoadenylated RNA affect mRNA decay in
            vivo
  JOURNAL   RNA 14 (10), 2149-2158 (2008)
   PUBMED   18719247
  REMARK    GeneRIF: These results underscore the importance of Lsm1p-7p-Pat1p
            complex-mRNA interaction for mRNA decay in vivo and imply that the
            oligo(A) tail mediated enhancement of such interaction is crucial
            in that process.
REFERENCE   6  (bases 1 to 1216)
  AUTHORS   Pessa HK, Will CL, Meng X, Schneider C, Watkins NJ, Perala N,
            Nymark M, Turunen JJ, Luhrmann R and Frilander MJ.
  TITLE     Minor spliceosome components are predominantly localized in the
            nucleus
  JOURNAL   Proc Natl Acad Sci U S A 105 (25), 8655-8660 (2008)
   PUBMED   18559850
REFERENCE   7  (bases 1 to 1216)
  AUTHORS   Mullen TE and Marzluff WF.
  TITLE     Degradation of histone mRNA requires oligouridylation followed by
            decapping and simultaneous degradation of the mRNA both 5' to 3'
            and 3' to 5'
  JOURNAL   Genes Dev 22 (1), 50-65 (2008)
   PUBMED   18172165
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473970.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_344536.3, XM_001071427.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ220497.1, FQ216033.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1216
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.4"
     gene            1..1216
                     /gene="Lsm1"
                     /note="LSM1 homolog, mRNA degradation associated"
                     /db_xref="GeneID:364624"
                     /db_xref="RGD:1304967"
     exon            1..399
                     /gene="Lsm1"
                     /inference="alignment:Splign:2.1.0"
     CDS             354..755
                     /gene="Lsm1"
                     /note="LSM1 homolog, U6 small nuclear RNA associated;
                     LSM1, U6 small nuclear RNA associated; LSM1 mRNA
                     degradation associated"
                     /codon_start=1
                     /product="U6 snRNA-associated Sm-like protein LSm1"
                     /protein_id="NP_001102346.1"
                     /db_xref="GeneID:364624"
                     /db_xref="RGD:1304967"
                     /translation="MNYMPGTASLIEDIDKKHLVLLRDGRTLIGFLRSIDQFANLVLH
                     QTVERIHVGRKYGDIPRGIFVVRGENVVLLGEIDLEKESDTPLQQVSIEEILEEQRVE
                     QQSRLEAEKLKVQALKDRGLSIPRADTLDEY"
     exon            400..468
                     /gene="Lsm1"
                     /inference="alignment:Splign:2.1.0"
     exon            469..584
                     /gene="Lsm1"
                     /inference="alignment:Splign:2.1.0"
     exon            585..1216
                     /gene="Lsm1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgccgagtgc cgagcggtca tggactgtac ggatcaaccc gggcctcgga gcaggaaagc
       61 gaggcgaggg acagcgcttg tcacgagtga ggaaacgcct attctccgcc cttccgacct
      121 ggacttcact tcactgacta gaaaggaaga aaacgttgtc tgcgaccgaa cgcccggcac
      181 gcctttttca gtggatggac aggcgatacc ggaagtgggt ggggttacct gaaacgcttc
      241 cggcgactag cggtgtttga gttgcaggtg agcggcgggt tcccgtccgc gtcccgccga
      301 cgggcgattg gacgccctcg cggccgtcca gtgcagcctt gcgagagctc aaaatgaact
      361 atatgcccgg caccgccagc ctcatcgagg acatcgacaa aaagcacttg gtcctacttc
      421 gagatggaag gacacttata ggttttttaa gaagcattga tcaatttgct aacctagtgc
      481 tccatcagac tgtggagcga attcacgtgg gcagaaagta cggtgatatt cctcgaggga
      541 ttttcgtggt cagaggagaa aatgtggtcc tactaggaga aatagacttg gaaaaggaaa
      601 gtgacacgcc acttcagcaa gtctccattg aagagatcct ggaggaacag agggtagagc
      661 agcagagcag gctggaggca gagaagctga aggtccaggc ccttaaagac cggggtctct
      721 ccattcctcg tgcagacact ctggatgagt actgagtcct tgcttagaga ctgcttcaga
      781 gagcaggtgc tgtcacctgg tcacctcaca tctgaccaga gtatcacact gaaaagtgat
      841 cttattcttt cacagatgcc aacatgaaga aatcatggga tttgttttgt ttttgtttgt
      901 tttttttaca caatcattgt atattagttt tgcctttttc ttcaaacagt ctcaacacat
      961 agtcctggct gacctagaac tcactatgta aaccaggatg ccctctagct tgtgggattt
     1021 caggtgggct ctaccatccc agctttgctg tttaaagaaa cagtggcatg acctcccctc
     1081 aacacgtcac tgtggagcca agaaccgtgt ctttatattg cttttcttat ctcagagttt
     1141 acatttcttt tcaaaacata tttcatttac ttgtaaataa aaaaaatgaa gctcagaact
     1201 gtcatcttca taaaat
//
