LOCUS       NM_001414997            8924 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus limbic system-associated membrane protein
            (Lsamp), transcript variant 1, mRNA.
ACCESSION   NM_001414997 XM_039088254
VERSION     NM_001414997.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8924)
  AUTHORS   Sanz,R.L., Ferraro,G.B., Girouard,M.P. and Fournier,A.E.
  TITLE     Ectodomain shedding of Limbic System-Associated Membrane Protein
            (LSAMP) by ADAM Metallopeptidases promotes neurite outgrowth in DRG
            neurons
  JOURNAL   Sci Rep 7 (1), 7961 (2017)
   PUBMED   28801670
  REMARK    GeneRIF: Neurotrimin and LSAMP were identified as ADAM10 substrates
            that are shed from the cell surface of dorsal root ganglion (DRGs)
            neurons. Overexpression of LSAMP and NTM suppresses outgrowth from
            DRG neurons.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8924)
  AUTHORS   Catania,E.H., Pimenta,A. and Levitt,P.
  TITLE     Genetic deletion of Lsamp causes exaggerated behavioral activation
            in novel environments
  JOURNAL   Behav Brain Res 188 (2), 380-390 (2008)
   PUBMED   18199495
REFERENCE   3  (bases 1 to 8924)
  AUTHORS   Pimenta,A.F. and Levitt,P.
  TITLE     Characterization of the genomic structure of the mouse limbic
            system-associated membrane protein (Lsamp) gene
  JOURNAL   Genomics 83 (5), 790-801 (2004)
   PUBMED   15081109
REFERENCE   4  (bases 1 to 8924)
  AUTHORS   Nelovkov,A., Philips,M.A., Koks,S. and Vasar,E.
  TITLE     Rats with low exploratory activity in the elevated plus-maze have
            the increased expression of limbic system-associated membrane
            protein gene in the periaqueductal grey
  JOURNAL   Neurosci Lett 352 (3), 179-182 (2003)
   PUBMED   14625014
  REMARK    GeneRIF: It is likely that LSAMP plays a role in the regulation of
            exploratory behavior of rats in the novel aversive environment.
REFERENCE   5  (bases 1 to 8924)
  AUTHORS   Pimenta,A.F., Zhukareva,V., Barbe,M.F., Reinoso,B.S., Grimley,C.,
            Henzel,W., Fischer,I. and Levitt,P.
  TITLE     The limbic system-associated membrane protein is an Ig superfamily
            member that mediates selective neuronal growth and axon targeting
  JOURNAL   Neuron 15 (2), 287-297 (1995)
   PUBMED   7646886
REFERENCE   6  (bases 1 to 8924)
  AUTHORS   Zacco,A., Cooper,V., Chantler,P.D., Fisher-Hyland,S., Horton,H.L.
            and Levitt,P.
  TITLE     Isolation, biochemical characterization and ultrastructural
            analysis of the limbic system-associated membrane protein (LAMP), a
            protein expressed by neurons comprising functional neural circuits
  JOURNAL   J Neurosci 10 (1), 73-90 (1990)
   PUBMED   1688937
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Dec 20, 2022 this sequence version replaced XM_039088254.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.66811.1,
                                           SRR26360190.2009480.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-362               JAXUCZ010000011.1  74222606-74222967   c
            363-422             JAXUCZ010000011.1  73418225-73418284   c
            423-501             JAXUCZ010000011.1  72701781-72701859   c
            502-734             JAXUCZ010000011.1  72367978-72368210   c
            735-860             JAXUCZ010000011.1  72297224-72297349   c
            861-995             JAXUCZ010000011.1  72101538-72101672   c
            996-1116            JAXUCZ010000011.1  72091574-72091694   c
            1117-1265           JAXUCZ010000011.1  72090969-72091117   c
            1266-1301           JAXUCZ010000011.1  72084437-72084472   c
            1302-1334           JAXUCZ010000011.1  72067106-72067138   c
            1335-8924           JAXUCZ010000011.1  72053285-72060874   c
FEATURES             Location/Qualifiers
     source          1..8924
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q21"
     gene            1..8924
                     /gene="Lsamp"
                     /note="limbic system-associated membrane protein"
                     /db_xref="GeneID:29561"
                     /db_xref="RGD:71102"
     exon            1..362
                     /gene="Lsamp"
                     /inference="alignment:Splign:2.1.0"
     CDS             296..1432
                     /gene="Lsamp"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="limbic system-associated membrane protein
                     isoform 1 precursor"
                     /protein_id="NP_001401926.1"
                     /db_xref="GeneID:29561"
                     /db_xref="RGD:71102"
                     /translation="MRTYWLHSVWVLGFFLSLFSLQVLAFWNQPPAEVNLSPITIPGL
                     PVRSVDFNRGTDNITVRQGDTAILRCVVEDKNSKVAWLNRSGIIFAGHDKWSLDPRVE
                     LEKRHALEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTV
                     NEGSNVTLVCMANGRPEPVITWRHLTPLGREFEGEEEYLEILGITREQSGKYECKAAN
                     EVSSADVKQVKVTVNYPPTITESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRIN
                     SANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVLFKRVLPTVPHPI
                     QEIGTTVHFKQKGPGSVRGINGSISLAVPLWLLAASLFCLLSKC"
     exon            363..422
                     /gene="Lsamp"
                     /inference="alignment:Splign:2.1.0"
     exon            423..501
                     /gene="Lsamp"
                     /inference="alignment:Splign:2.1.0"
     exon            502..734
                     /gene="Lsamp"
                     /inference="alignment:Splign:2.1.0"
     exon            735..860
                     /gene="Lsamp"
                     /inference="alignment:Splign:2.1.0"
     exon            861..995
                     /gene="Lsamp"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1116
                     /gene="Lsamp"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1265
                     /gene="Lsamp"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1301
                     /gene="Lsamp"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1334
                     /gene="Lsamp"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..8924
                     /gene="Lsamp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcatttagt tggagctgca ggggagtaag ggagaggagg gtaggaaaga agagagcggg
       61 agagctcgag gaataagagg gctctctgtg ctgacaccgg gctcggactg cgagcatcct
      121 tcagaacccg ggctcgcgct ctccgagaag agagtgaggc tgtgctggga ttcgcaggag
      181 actgctccgt acgcgtcgct ggagccggga gagccctgag ggaaaccaag ggaagcgagc
      241 tgcgcgtttt actagagagc aggagtgaga agagacggct ggagtgcttg gcgacatgag
      301 gacctactgg ctgcacagcg tctgggtgct ggggttcttc ctgtccctct tctcattgca
      361 agtcttggca ttttggaacc agcctcctgc tgaagtaaat ttgtctccaa tcacaatccc
      421 aggactgccc gttcgcagcg tggattttaa ccgaggcacg gacaacatca ccgtgaggca
      481 gggggacacg gccatcctca ggtgtgtggt agaagacaag aactcgaaag tggcctggtt
      541 gaaccgctct ggcatcatct tcgctggaca cgacaagtgg tctctggacc ctcgggttga
      601 gctggagaaa cgccatgctc tggaatacag cctccgaatc cagaaggtgg atgtctatga
      661 tgaaggatcc tacacatgct cagttcagac acagcatgag cccaagacct ctcaagttta
      721 cttgattgta caagttccac caaagatctc caacatctcc tcggatgtca ctgtgaatga
      781 gggcagcaat gtaaccctgg tctgcatggc caatgggcgc cctgaacctg ttatcacctg
      841 gagacacctt acaccacttg gaagagaatt tgaaggagaa gaagaatatc tggagatcct
      901 aggcatcacc agggaacagt caggcaaata tgagtgcaag gctgccaacg aggtctcctc
      961 cgcggatgtc aaacaagtca aggtcactgt gaactatcca cccaccatca cagagtctaa
     1021 gagcaatgaa gccaccacag gacgacaagc ttccctcaaa tgtgaagcct cagcggtgcc
     1081 tgcacctgac tttgagtggt accgggatga caccaggata aacagtgcaa acggccttga
     1141 gattaagagc actgagggcc agtcctccct gacggtgacc aacgtcactg aggaacacta
     1201 cggcaactat acctgtgtgg ctgccaacaa gctcggcgtc accaatgcca gcctagtcct
     1261 tttcaagcgt gttttaccca cagtccccca ccctattcaa gaaattggta ccaccgtgca
     1321 cttcaagcaa aaaggacccg ggtcggtgag aggaatcaac ggatccatca gtctggccgt
     1381 accactgtgg ctgctggcag cgtccctgtt ctgccttctc agcaaatgtt aatagaataa
     1441 aaatttaaaa ataattacaa aaacacacaa aaatgcgtca cacagataca gagagagaga
     1501 gagagagaaa gtacaagatg gggggagact attgtttcac aagattgtgt gtttataaat
     1561 gaagggggga tatgaaaaaa aatgaagaaa atacaacact aaaaacactt ttaagatcct
     1621 tcaataaaaa tctgagtata atatagggtg ggaaaacctc tcccagaata tgtgtctatc
     1681 ttctaagcaa atgactgctg tgtaaagatt ccatcctgct aaggacatct gatgttgtac
     1741 acatgagact attcaaggag taccagatgg atattaactc cccccacact ttatccttcc
     1801 ttcatccatt ttcatctgtg gggaaaaaaa gatggtcttg cctttggtgt ttatatttcc
     1861 ataatctttt tattctgttt ttcatttgag ctgatgtgta gccattttgg actatcaaag
     1921 gaaacctgtg tccagtcttt cgcgggctcc cctgcctcca ttacctctct aacttttaag
     1981 aacatcccct ttcccctcca gtgtgttcta tcctccagca cacccattcc aaatattccc
     2041 tttttctcta ccccacctcc ctttgccccg gcaacccaga acactagtca tgccgccaca
     2101 gaggctagga agtgtcctca tctcctccac tgtgcgcgtg tgctcaagtc cctcactctc
     2161 acgtagatgt acatgtgtgt gagcgtgtat gtgtccttct ctaaagcatg ccaggggaat
     2221 ggtccatgtg tacatagact cattgtgctg tagatactgt cctgcactgt agttgtgagg
     2281 tgtggctgtc acaagtggct gggggagatg ggctggatgg gagtcgtgga gcagaatccc
     2341 tccccccttc gtggctgtca cgtgacatca gtgtgcattc aaaccaagct gtgcaccttc
     2401 tgagggcagg accctgtgcc cttcctggtc tcattttcag aacccagctg ggagtccctc
     2461 agaatatcac tgtacatgaa agtgcctact attaacgggg tgagcagaca gggacggatc
     2521 catggcctgg atgacatgac ctaggggagg aagaagacgg tctctgattt cactcttatt
     2581 tcataaacct ggagtatccg taagtttcat ggctttctaa aggctcagcc tcactgcaga
     2641 gaggagcagt gccaattgag caaatctcca gaaacaagtg ggtatctgaa tgataacccc
     2701 caagggaagg acgagcccat ggtgacccta ggcaggcctg cattgcccct tcactaatct
     2761 tcaagtaatc tgcatttgcc ccataatgcc accgattgga gattattgac ccaatcaaat
     2821 actgtgaagg agacatgaac agtagacaga cacccgaatc ttctctagag gtggttaaac
     2881 gtctgatgca aagtattggt catcacagaa taggaatttc cggctttgat ctcctttgtg
     2941 gatgctcgtc ctccagttca aggctaacgc ttgctttatt ggctttctac ccaactgctg
     3001 atgggtgtgg caccattacc catagaggcc agtcagcatc ctaaaccagg ccactagggc
     3061 acggatttta ttcactttcc ctactctgtt tagactcaca tctgtgagag ccctcttgac
     3121 gctaacactg agagccgagc tacttgctta accacaggaa gcaagggatg atgagtccaa
     3181 acagaagtag agccattcca aagtcctgca tcaccacaat gccaatagtg ttggcctggg
     3241 ggtggggttc ttaaaggaag gctgcctctc tgcatgtggg tatctctgct aggaaaacag
     3301 ccactgcttt cccttaagac tgtatagaag cacccaaagt gactcacctt agaaaggatg
     3361 gagggttact gctgaggtca taatgcgatg tcaactaaca gagctgaggc acatcaagtt
     3421 ttctaacctt tgaaatggct gtcaaatgaa gggggaaaaa gaaagaaaga aaaggaggaa
     3481 ggaaggaaag aagaaaggaa ggaaggagga aggaaagaag gaattggaat aggattttat
     3541 atttcttcta aggaattaca tcatttagtt tataaaatct gtcacatcct gtcttcacgg
     3601 tttgcagttt tgacatgatc cagaggacag acagggctca ggatacataa aagtatttat
     3661 ggaagatcaa gagttaggat aggaatttct atccaagagg gtagctggta aagcataggg
     3721 aaggtgtgcg atattctaac atgatatatt gacaatcaag gatgtctcta gcagtctagt
     3781 cctcttgtag aagagctgaa ggatatgagt ttcccatgtt aaagagtctg ccacatcctt
     3841 aaggaaaatc ttagaagaag agtgcatgct ggccaagata gaaggaataa gaaaaaaatc
     3901 atttagcatt agtttcagaa atggataccc gtgacaatgc acctggtctt cagggtcccc
     3961 atcctatttt aaggacaagc actgggttct gtgggcggag tctctccttt ggaaagaatt
     4021 cctgggcacg tcaataccat tccttccatt tgttttattg taatgccccg tagaacaaac
     4081 agctaaagat tcttttaaaa tgtgatgttg gcccatatct ccaacaagat ttttaagagt
     4141 gtctctcccc tgtggagaaa acctgggtct caccatatgc cccataggtt cgagaaggtt
     4201 gctaagtcaa ccttcttgaa gaaacgttct ttgaagcacg gttagaatca ctagggccag
     4261 atgacataca ccaagatgcc atatacttgt cagagacatt catcagactg ctgcaaatcc
     4321 ttccaatgag ctcacacgct catcaaaatg caaacaagtg attggaacaa ataggtaggg
     4381 tggagtgaag gaaggcaccc ataagcctgg accacccacg gatttcgtat cctttgccag
     4441 gattcctaag acaacatctt cagccttagt tttctgttta aaaaatagaa attaccttga
     4501 ctcagggcag gccccaaaga aggataactc ttctggattc tgtaactgca gaactgtctg
     4561 ttctccttgc agttggtgat cgaaacgact ttacccagtg agaggcatat cgttcttgtg
     4621 aaacttaaaa tctcttactc caaaggaatg acagcttatg gaaaagtaga tagatgtgtt
     4681 ttctgttcag aaggatttcc tccttagctc ttaccttctc ttccaagtca gacagctatt
     4741 tcccccctta ccaggaacac tttttttcct ttaacttcac agacaactaa ggcaattcaa
     4801 agagacctta taacaatact cgtgattttg atgttcttgg aggactgaca cgaaagtgtg
     4861 tttcgcctcc aaagatggac tttacctcct ctgccgacag aaactaaacc cctcagcatg
     4921 caaggccctt ttgagttctt tcttctcctc ccatagtcac agggtcctct tcgagatgac
     4981 tgtgatgtga cagcttttta ttggctgctc gtcctaaagt tttaattttg ttctttatag
     5041 gctttgagtt ctttgtgcaa aaacaaaaaa atatgtgtgt atgtattgct ttagctctta
     5101 tctttacaaa tgatatattt acaataatgt atgtattata aaaatgtaga acggttgctt
     5161 aaacgtgaaa ggaagagagg tattggattt ggtttattta aaaaaaaaca aaaaagtgct
     5221 atgcttaatt tagaaaaaat gtggatgcct ttttgtccac tttgttatta tttgtttaaa
     5281 ggaaatttgc ttatgagacc gtgtgccgtg ggatgaacca tgccctcatg cttttcttta
     5341 tcctcattct cagcctgggt ttagtcttgc ttccgctgta aactgccaga ttttataacg
     5401 atgtaagagc agtgttacat ctgacctaaa aagctattaa aactctgaag acaaacaaac
     5461 ctaccagaaa aaaaaaagag atagaccccc aagttaagaa acacaaacct actttaggaa
     5521 atctcttttg tgcttaagta ttaaaaatgt ttctcctcca gagacttcgt ctgcccaagt
     5581 gatgtaaatt ccccattatg gttgacatca catctgtaaa catctcacta aaggcaaaat
     5641 gaattcacat ttacgtgcat gccagtggga agaaaagtaa accattctcc ttggcgttta
     5701 gctaggctgt tccaatgtca ccaactgaac ctcaagaaag aatttggttt tgcccaccgt
     5761 gtagatcact ttcttcttgg caaggcagct ggcgttcata tgtggcttag ggttagcatt
     5821 catgccagcg aaatgtttat ggatattgta gaaaacttat tctaaaatcc ctgatttctc
     5881 gtcagcgcat ttgcataccg tgctgattaa taaattaggc accaatcatg tgtaaatcaa
     5941 tgtaaatcac tagtttatgt acatgatata aactatgtaa acttcatttt tcaggcaaag
     6001 cccaagttca gctaaaccta taaatcttaa agaaaaagaa gccaaaataa gagggacaaa
     6061 agccgaagct ttttacaggt cagtggtctt agaagaaagc ctgaagtccc aaacatggct
     6121 gccttagcca aaggaagcag acatccagaa cacttagagg cccttccagc caagtgcagc
     6181 ccgctctcct tagttcttgc tgcctcagtg aagattctct agcctgaccc aaccaaccct
     6241 aggcaaatgg aaggaaagag gactagggta tgaaggactc ctatagccag attgtaggtt
     6301 tcttgtcagc taatacatat tatattgtat ctttatttaa atagttccaa cagattcacc
     6361 agtacttaca ggaacagatt atcacacact acccattttt ttggtctgct ttacacttaa
     6421 ccacactcaa gaattacctt tgtatcctaa tttgaacaaa tttggcgatg taagaaatat
     6481 attatatcct tgagtaatat cttgctggag ctccctgaat ttttattatt attattatta
     6541 ttattattat tattattatt attactacta ctactactat tttctctggc agccttgtgt
     6601 atctacatgc ccgtgggttt taagtaaggc acagagtcat ttgaatagag agtgtcacag
     6661 gtgtattctc ttagcctttc tgaagtacct gctgatttaa gtgccccata tacctttact
     6721 ctaatcaaaa caactgatag attcatcaaa agagattata taaatgttct accagactat
     6781 tgtagaaaga aatctgggtc acactgaggc ttacatttag ctactgaggc caaaaggcac
     6841 ctgtaacatg aaaggtgtta tcaggattgg agtcaggaga ataggattat tgctttgggt
     6901 ctcgacacgc aaaaaagcca catgatgctg tcactggtaa tttatttccc attcctggaa
     6961 ttttagttct ctcatctgga aagtctagaa atgaaatgac acttcatggt ctctcccacc
     7021 tctaaactct ctgattctga atatgaatta aaattcatta aatgctgcca ccgacgcaag
     7081 ggcccacaca gagccatttg ctggtgtctg gtttttctct aagcctattc ccccaccccc
     7141 atctctacaa cttagctctt tctagaacac aggggctctg gaccccttct ggtatttctt
     7201 ttctgagcaa aatttcttag agatatagag gaaggacatt ttcatattaa agtgagggca
     7261 tcaaaatagc tgagatggct ttcttgttcg taatattggg aaatgtaaca gttgaacggt
     7321 cgcctaatag tctttcatag gaaggaaaat ggccagattg gacattatgg acgtaataaa
     7381 tgaggaagtt gcgaatgtga gaggaaacat cagctttctc ttattcttgg ccaagtgctt
     7441 cattacggta aatgcgtgtc actgggcgtt ctcggctggt cccaagcaag ttcaaaaagg
     7501 ctgttttgtg agaaacaggc aagggaaggg gtttcttaca gaagtttctt gaaacttgac
     7561 taagaaatag gctgtgaaat tgaccaagta cttagagaga ggcctctttt tttttttttt
     7621 taacagattg aattagttca gtttaaaagc agctatgagt gaaacaggac acaaaagcct
     7681 atcggggagg caaggttgaa agagagtgag agttgtaaaa gctaaaacct aatgtgaaag
     7741 ttaagtttcc agaaagtggg gtcaaacaag aagagttgcc ggagcggtaa acaagggatt
     7801 gttctgttgg gccacgtact gagcagacag cgtaggtccc acttcttcat cccattctgt
     7861 cttcaacatt cagcttaaca ccttgtccgg tcaccttttt catgcatctc cccaaagagc
     7921 acaaggaata gggctctcct ggacaccgaa gagcagagtt cactcattca tcacctccag
     7981 atttaggatc actgtttaga tgaggatatg cagtgtgttc acaataccct ggacactgta
     8041 gttgggagag agacccgccc actaaacaac tccccaatct catccatctt ccctaggcac
     8101 agcgctttgg atggtgcttc tgagtccacc ctacggctac attcttccca gcacaaaacc
     8161 tccctgtgta ataactaggc acggtaaaaa aaaaaaatct gcttcttgca aatgaaaaaa
     8221 cccatggagc tagcttcctg gcgtaccaca gaacccctcg ccgtcagtca gaagcctctt
     8281 ttgaactccc ttacctaagt cattgctctt caccagaaca cgattatggt ttgttctggt
     8341 gaacgttgac caccttctgc tccataagta tttgctggga ggggggaggc taaagggagg
     8401 aaataaaagg gggagggaag gatacctccc acttctcccc acccctgctt cacccgtccc
     8461 cttccattcg ctctcctgaa ggttgtataa atcctgttct tggttaaacg tctcctcatt
     8521 aacagtgtta tatacatata aatatatata taaaatatat tcctttttcc agccctgtag
     8581 acatgaactg atcttccctt gatgatataa aaacatggcc attttttggt tcgattgttt
     8641 tgccgctcaa gttcctttat ttttgtttat tgggtggata tttttccctg aatactagct
     8701 ctgtgaagga aaagtttaaa aaacaaaaaa acaaaaacaa aacaaaacaa aacaaaaaaa
     8761 aaaccgcgat gtgtgtaaaa aaattaagat gaaagaaaag cctctttttt ttccatttta
     8821 aatgtattta aattctggtt ctctcttctg ttactttaca cgtatgaatg ctctgctctt
     8881 ctgtgacctt aaaacaaaat gaaataaacg tgaaaaggag atgt
//
