LOCUS       NM_001139494             877 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus leucine rich transmembrane and
            O-methyltransferase domain containing (Lrtomt), mRNA.
ACCESSION   NM_001139494 XM_001067959 XM_218970
VERSION     NM_001139494.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 877)
  AUTHORS   Cunningham,C.L., Wu,Z., Jafari,A., Zhao,B., Schrode,K.,
            Harkins-Perry,S., Lauer,A. and Muller,U.
  TITLE     The murine catecholamine methyltransferase mTOMT is essential for
            mechanotransduction by cochlear hair cells
  JOURNAL   Elife 6, e24318 (2017)
   PUBMED   28504928
  REMARK    Erratum:[Elife. 2017 Nov 08;6:e33307. doi: 10.7554/eLife.33307..
            PMID: 29116042]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 877)
  AUTHORS   Ahmed,Z.M., Masmoudi,S., Kalay,E., Belyantseva,I.A., Mosrati,M.A.,
            Collin,R.W., Riazuddin,S., Hmani-Aifa,M., Venselaar,H., Kawar,M.N.,
            Tlili,A., van der Zwaag,B., Khan,S.Y., Ayadi,L., Riazuddin,S.A.,
            Morell,R.J., Griffith,A.J., Charfedine,I., Caylan,R., Oostrik,J.,
            Karaguzel,A., Ghorbel,A., Riazuddin,S., Friedman,T.B., Ayadi,H. and
            Kremer,H.
  TITLE     Mutations of LRTOMT, a fusion gene with alternative reading frames,
            cause nonsyndromic deafness in humans
  JOURNAL   Nat Genet 40 (11), 1335-1340 (2008)
   PUBMED   18953341
REFERENCE   3  (bases 1 to 877)
  AUTHORS   Du,X., Schwander,M., Moresco,E.M., Viviani,P., Haller,C.,
            Hildebrand,M.S., Pak,K., Tarantino,L., Roberts,A., Richardson,H.,
            Koob,G., Najmabadi,H., Ryan,A.F., Smith,R.J., Muller,U. and
            Beutler,B.
  TITLE     A catechol-O-methyltransferase that is essential for auditory
            function in mice and humans
  JOURNAL   Proc Natl Acad Sci U S A 105 (38), 14609-14614 (2008)
   PUBMED   18794526
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from EU627093.1.
            
            On or before Nov 19, 2008 this sequence version replaced
            XM_001067959.1, XM_218970.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU627093.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00155313,
                                           SAMN09345330 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..877
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..877
                     /gene="Lrtomt"
                     /gene_synonym="RGD1561509; Tomt"
                     /note="leucine rich transmembrane and O-methyltransferase
                     domain containing"
                     /db_xref="GeneID:308868"
                     /db_xref="RGD:1561509"
     exon            1..275
                     /gene="Lrtomt"
                     /gene_synonym="RGD1561509; Tomt"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..793
                     /gene="Lrtomt"
                     /gene_synonym="RGD1561509; Tomt"
                     /EC_number="2.1.1.6"
                     /note="leucine rich transmembrane and 0-methyltransferase
                     domain containing; O-methyltransferase domain containing;
                     protein LRTOMT2; catechol O-methyltransferase 2"
                     /codon_start=1
                     /product="transmembrane O-methyltransferase homolog"
                     /protein_id="NP_001132966.1"
                     /db_xref="GeneID:308868"
                     /db_xref="RGD:1561509"
                     /translation="MSPAIALAFLPLVVTLLVRYRHHFRLLVRTVLLRSFRDCLSGLR
                     IEERAFSYVITHALPGDPGHILTTLDHWSSCCEYLSHMGPIKGQILMRLVEEKAPACV
                     LELGTHCGYSTLLIARALPPGSRLLTVERDSRTAAVAEKVIRLAGFDEQMVELIAGSS
                     EEVIPRLRAQHQLNRADLVLLAHRPRYYLRDLQLLEAHALLPHGATVLADHVLFPGAP
                     RFLQYTKSCGRYRCRLHHTSLPDFPAIKDGIAQLTYTGPG"
     exon            276..472
                     /gene="Lrtomt"
                     /gene_synonym="RGD1561509; Tomt"
                     /inference="alignment:Splign:2.1.0"
     exon            473..877
                     /gene="Lrtomt"
                     /gene_synonym="RGD1561509; Tomt"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacccaggta gggacaatgt cccctgccat tgcactggca ttcctgccac tcgtggtaac
       61 actgctggtg agataccggc atcatttccg actgctggtg cgtacagtcc tgctgagaag
      121 ctttcgagac tgcctgtcag gacttcgaat tgaggagcgg gccttcagct atgtgatcac
      181 ccacgccctg cctggagacc ctggtcacat cctcacaact ctagaccact ggagcagctg
      241 ctgcgagtac ctgagccaca tgggccctat taaaggtcag attctgatgc ggctagtgga
      301 agagaaggcc cctgcttgcg tgctggagct gggcacccac tgcggatact ctacactgct
      361 tattgcccga gccttgcccc ctgggagccg acttctcacc gtggagcggg actcacggac
      421 agcagcagtg gctgaaaaag tcatccggct agctggcttc gatgagcaaa tggtggagct
      481 cattgcaggc agctcagagg aagtgatccc acgtctaaga gctcagcacc agctgaatcg
      541 ggcagatctg gtgctcctgg cacatcgacc tcgatattat ttaagagatc tgcagctact
      601 ggaggcccat gctctgctcc cacatggtgc cactgtattg gctgatcatg tgctttttcc
      661 tggtgcaccc cgcttcctac aatataccaa gagctgtggt cgctatcgct gccgcctcca
      721 ccacaccagc ctccccgact tccctgccat caaggatggc atagcccaac tcacctatac
      781 tggacctggc tgaggtccag gacctgggat ctttactaat acaagcccaa ccccactcga
      841 gcagacctca aaatatcccc tttccctttc tgtttag
//
