LOCUS       NM_001107833            4894 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus leucine rich repeat and sterile alpha motif
            containing 1 (Lrsam1), mRNA.
ACCESSION   NM_001107833 XM_001078484 XM_231157
VERSION     NM_001107833.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4894)
  AUTHORS   Wang,Z., Hu,J., Li,G., Qu,L., He,Q., Lou,Y., Song,Q., Ma,D. and
            Chen,Y.
  TITLE     PHF23 (plant homeodomain finger protein 23) negatively regulates
            cell autophagy by promoting ubiquitination and degradation of E3
            ligase LRSAM1
  JOURNAL   Autophagy 10 (12), 2158-2170 (2014)
   PUBMED   25484098
REFERENCE   2  (bases 1 to 4894)
  AUTHORS   Huett,A., Heath,R.J., Begun,J., Sassi,S.O., Baxt,L.A., Vyas,J.M.,
            Goldberg,M.B. and Xavier,R.J.
  TITLE     The LRR and RING domain protein LRSAM1 is an E3 ligase crucial for
            ubiquitin-dependent autophagy of intracellular Salmonella
            Typhimurium
  JOURNAL   Cell Host Microbe 12 (6), 778-790 (2012)
   PUBMED   23245322
REFERENCE   3  (bases 1 to 4894)
  AUTHORS   McDonald,B. and Martin-Serrano,J.
  TITLE     Regulation of Tsg101 expression by the steadiness box: a role of
            Tsg101-associated ligase
  JOURNAL   Mol Biol Cell 19 (2), 754-763 (2008)
   PUBMED   18077552
REFERENCE   4  (bases 1 to 4894)
  AUTHORS   Amit,I., Yakir,L., Katz,M., Zwang,Y., Marmor,M.D., Citri,A.,
            Shtiegman,K., Alroy,I., Tuvia,S., Reiss,Y., Roubini,E., Cohen,M.,
            Wides,R., Bacharach,E., Schubert,U. and Yarden,Y.
  TITLE     Tal, a Tsg101-specific E3 ubiquitin ligase, regulates receptor
            endocytosis and retrovirus budding
  JOURNAL   Genes Dev 18 (14), 1737-1752 (2004)
   PUBMED   15256501
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474001.2.
            
            [WARNING] On Oct 24, 2024 this sequence was replaced by
            NM_001107833.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_231157.4, XM_001078484.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..4894
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p11"
     gene            1..4894
                     /gene="Lrsam1"
                     /gene_synonym="RGD1564403"
                     /note="leucine rich repeat and sterile alpha motif
                     containing 1"
                     /db_xref="GeneID:311866"
                     /db_xref="RGD:1564403"
     exon            1..61
                     /gene="Lrsam1"
                     /gene_synonym="RGD1564403"
                     /inference="alignment:Splign:2.1.0"
     exon            62..273
                     /gene="Lrsam1"
                     /gene_synonym="RGD1564403"
                     /inference="alignment:Splign:2.1.0"
     exon            274..370
                     /gene="Lrsam1"
                     /gene_synonym="RGD1564403"
                     /inference="alignment:Splign:2.1.0"
     CDS             299..2482
                     /gene="Lrsam1"
                     /gene_synonym="RGD1564403"
                     /EC_number="2.3.2.27"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase LRSAM1"
                     /protein_id="NP_001101303.1"
                     /db_xref="GeneID:311866"
                     /db_xref="RGD:1564403"
                     /translation="MPLFFRKRKPSEEARKRLEYQMCLAKEAGADDILDISKCELSEI
                     PFGAFATCKVLQKKVLIVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDIGQ
                     LTALQVLNVERNQLTHLPRSVGNLLQLQTLNVKDNKLKELPDTLGELRSLRTLDISEN
                     EIQRLPQMLAHVRTLETLSLDALSMVYPPPEVCGAGTAAVQQFLCKESGLDYYPPSQY
                     LLPVLEQDGAENSQDSPDGPTRRFSREEAEWQNRFSDYEKRKEQKMLEKLEFERRLDL
                     GQREHAELLQQSHSHKDEILQTVKQEQTRLEQGLSERQRCLDAERQQLQEQLKQSEQS
                     IASRIQRLLQDNQRQKKSSEILKSLENERIRMEQLMSITQEETENLRQREIAAAMQQM
                     LTESCKSRLIQMAYESQRQSLVQQACSSMAEMDKRFQQILSWQQMDQNKAISQILQES
                     VMQKAAFEALQVKKDLTHRQIRSQIRLIETELLQLTQLELKRKSLDTETLQEMVSEQR
                     WALSNLLQQLLKEKKQREEELHGILAELEAKSETKQENYWLIQYQRLLNQKPLSLKLQ
                     EEGMERQLVALLVELSAEHYLPLFAHHRITLDMLSRMGPGDLAKVGVSEAGLQHEILR
                     RARDLLDVARVQPELKPPKNEVFGVSEPPTAPQELPESVRPSAPPAELDVPTSECVVC
                     LEREAQMVFLTCGHVCCCQQCCQPLRTCPLCRQEISQRLRIYHSS"
     exon            371..427
                     /gene="Lrsam1"
                     /gene_synonym="RGD1564403"
                     /inference="alignment:Splign:2.1.0"
     exon            428..472
                     /gene="Lrsam1"
                     /gene_synonym="RGD1564403"
                     /inference="alignment:Splign:2.1.0"
     exon            473..550
                     /gene="Lrsam1"
                     /gene_synonym="RGD1564403"
                     /inference="alignment:Splign:2.1.0"
     exon            551..619
                     /gene="Lrsam1"
                     /gene_synonym="RGD1564403"
                     /inference="alignment:Splign:2.1.0"
     exon            620..704
                     /gene="Lrsam1"
                     /gene_synonym="RGD1564403"
                     /inference="alignment:Splign:2.1.0"
     exon            705..826
                     /gene="Lrsam1"
                     /gene_synonym="RGD1564403"
                     /inference="alignment:Splign:2.1.0"
     exon            827..917
                     /gene="Lrsam1"
                     /gene_synonym="RGD1564403"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1048
                     /gene="Lrsam1"
                     /gene_synonym="RGD1564403"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1078
                     /gene="Lrsam1"
                     /gene_synonym="RGD1564403"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1201
                     /gene="Lrsam1"
                     /gene_synonym="RGD1564403"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1341
                     /gene="Lrsam1"
                     /gene_synonym="RGD1564403"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1386
                     /gene="Lrsam1"
                     /gene_synonym="RGD1564403"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1457
                     /gene="Lrsam1"
                     /gene_synonym="RGD1564403"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1557
                     /gene="Lrsam1"
                     /gene_synonym="RGD1564403"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1645
                     /gene="Lrsam1"
                     /gene_synonym="RGD1564403"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1720
                     /gene="Lrsam1"
                     /gene_synonym="RGD1564403"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..1801
                     /gene="Lrsam1"
                     /gene_synonym="RGD1564403"
                     /inference="alignment:Splign:2.1.0"
     exon            1802..1897
                     /gene="Lrsam1"
                     /gene_synonym="RGD1564403"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..1996
                     /gene="Lrsam1"
                     /gene_synonym="RGD1564403"
                     /inference="alignment:Splign:2.1.0"
     exon            1997..2128
                     /gene="Lrsam1"
                     /gene_synonym="RGD1564403"
                     /inference="alignment:Splign:2.1.0"
     exon            2129..2210
                     /gene="Lrsam1"
                     /gene_synonym="RGD1564403"
                     /inference="alignment:Splign:2.1.0"
     exon            2211..2356
                     /gene="Lrsam1"
                     /gene_synonym="RGD1564403"
                     /inference="alignment:Splign:2.1.0"
     exon            2357..4894
                     /gene="Lrsam1"
                     /gene_synonym="RGD1564403"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggcgtctgc ggctgaggac tgcagcgctt ggtcagtggg tgagctcggg attcggaagg
       61 gaatctcaag actttgtcat cctgagttgc gtatctttct gaatttagag tttctgtcct
      121 cacttcctat gtttgaagga gacccgactt cagctcagct ttttggggcc taaggttggt
      181 atctgtggcc aagctttcag agtgattggc ccaccttgag gttcacccca gagtcggaac
      241 atcggtggag aacctcccca tacacagaac cagggtccag aagaactctc gcaggaggat
      301 gcctctcttc tttcggaagc ggaaacccag tgaggaagct cggaaacgcc tggagtacca
      361 gatgtgtctg gcaaaagaag ctggggcaga tgacatcctt gacatctcta agtgcgagct
      421 ttccgagatt ccatttgggg cttttgcaac gtgcaaagtt ctacagaaaa aggtgttgat
      481 tgtccacaca aaccatctca cctccctgct gcccaagtcc tgcagcctct tgagcctcgc
      541 caccatcaag gttctggatc tccatgacaa ccagctgaca gcccttcctg acgatattgg
      601 gcagctgaca gccctgcagg tattgaatgt agaaaggaat caactgacac acctcccacg
      661 ctctgttggg aacctgctgc agctccagac cctcaacgta aaagacaaca agctaaagga
      721 gcttccggac accctggggg agctgcggag cctgcgtacc ctcgacatca gtgaaaatga
      781 gatccagaga cttccccaga tgctggctca tgtgcggacc ctggagacgc tgagcctcga
      841 tgccttgtca atggtctacc ccccaccaga ggtgtgtggc gctggcactg cggccgtgca
      901 gcagttcctc tgcaaagagt caggcctgga ctattaccca ccttctcagt acctgctgcc
      961 agtcctggag caagatggag ccgagaactc ccaggacagc cctgatggac ccacacgcag
     1021 attctccagg gaggaggctg aatggcagaa tcggttctcc gactacgaga agcgaaagga
     1081 gcagaagatg ctggagaagc tggagttcga gcggcgcctg gacctcgggc agcgggagca
     1141 tgctgagctg ctccagcaga gccacagcca caaggacgag atcctgcaga cggtcaagca
     1201 ggagcagaca cggctcgagc agggcctgag tgagcgccag cgctgcctgg atgcagaacg
     1261 gcagcagctg caggagcagc tcaagcagtc ggagcagagc attgccagcc gcatccagag
     1321 actcctgcag gacaatcaga ggcaaaagaa gagttctgag attctgaaat cactggagaa
     1381 tgagagaata cgaatggagc agctgatgtc cattacccag gaggagaccg agaacctcag
     1441 gcagcgtgag atcgccgccg ccatgcagca gatgctgacc gagagctgta agagccggct
     1501 catccagatg gcctatgagt cccagaggca gagcctggtg cagcaggcct gttccagcat
     1561 ggctgaaatg gacaagcggt tccagcagat tctgtcatgg cagcagatgg accagaacaa
     1621 agccatcagc cagatccttc aggagagtgt gatgcagaag gctgcattcg aggctctcca
     1681 ggtaaagaaa gacctcacgc atcggcagat caggagccag attaggctaa tagaaactga
     1741 gttactgcag ctgacacagc tggagttaaa gaggaagtcc ctggacacag agacgcttca
     1801 ggagatggtc tcagagcagc gctgggcgct cagcaacctg ctccagcagc tcctcaaaga
     1861 gaagaagcag cgggaagagg agctccatgg catcctggcg gaattagagg ccaagagtga
     1921 aacgaagcag gaaaattact ggctcatcca gtaccaacgg cttttgaacc agaagccttt
     1981 gtccttgaag ctgcaggaag aaggcatgga gcggcagctg gtggccctgc tggtggagct
     2041 gtctgctgag cactacctgc ccctcttcgc ccaccaccgc atcacactgg acatgctgag
     2101 ccggatgggt cctggagatc tggctaaggt gggtgtctca gaagcaggcc tgcaacatga
     2161 aatcctgcga agagcccggg acctgctgga tgtggccagg gtccaaccag agttgaaacc
     2221 acccaagaat gaggtctttg gtgtctctga gccccccaca gcccctcagg agcttcctga
     2281 gtccgtgaga ccatctgccc cgccagctga actggacgtg ccgacctcag agtgtgttgt
     2341 gtgcctggaa cgtgaggccc agatggtctt cctcacctgc ggccatgtct gctgctgcca
     2401 gcagtgctgc cagccgctgc gcacctgccc actgtgccgc caggagatct cccagcgcct
     2461 ccggatctac cacagcagct gaacgcacag ccacccacca gcctggccct tcctcagcac
     2521 catctccacc tctgctggac ttccattccc cacattcccc agactagggc aagactgcca
     2581 taggccaagc caccacccgc caccccgaca ccccctgctc tgagcactaa gcaggcaggt
     2641 ccgatgcccc tggcctgagg catagctatt ccgaatagtg aacaagaaac agggcagatc
     2701 tgctggtggt ggaaccttgt ggcacaggat caagatccag ggtatggagg tggccctgca
     2761 ggactcagga atccatgata ctaggcaagc aagcctcagt gctgcagcca gctgtctgcc
     2821 cctcctggag gtgtccctat ctatggaatg catcagccgt cctgtcctta ggtggggcaa
     2881 tgtctctggg aagaagtggg ctgtgcaaga ctcctcggcc ctcctttgct tcatgctgaa
     2941 cacccgccct cccatatctg caccgcatag gcaggttgat tcaaaacagg agtaccagta
     3001 agtccgactc cctcccagag tcacccctgg gtccgtggga acttggggga ggtaggagta
     3061 ggcagagtcc aggcgagctc tggggaaaag ggccagagct gctgtgcctg ggtaaaggta
     3121 aggcagtgag acattgccca gtggagagtt aggcagtgcc ctcttaaaca gagagcatgg
     3181 ggagcagagc cagggacggg cttcagtact gggaagcagc ctgcactcag gggatggggc
     3241 aggttgtgtt ccctgcagtg cttatcctag gtgagggctg ccacagcacc cggaaggcat
     3301 gttaacgctc aggtgggcgt ccgccctcac cagctgtaca ggagtccctg tgacatgaga
     3361 cccttctgcc cctcccagta gagtgtatgg cctaaggcat gagctcagca atgactacca
     3421 cttgacaggc tggggggggg gggggcgggg actagccatt ggcacctagc atggaccggg
     3481 aacccaccct catggtggac actggagttg atcagccatt aggaggctgt cacccaaaag
     3541 ctgtggtctc tcccctcctc tctgagcctc agtttcctcc tctaggacag tgtgagaacg
     3601 ggttagagaa agagacctca gtaaagtggt tggcatttgg aagtctgcat ccccagaact
     3661 cacagggcca ggccagtgtg cagtcacagc actgaggagg ctgaagtcag accctggccc
     3721 tcaccagaca gccagacaat ccgaattagt gagttccagg ctaatgcgac ctctcaaacc
     3781 gcaaggcgga atggcctgga tcctttggct tctgcatgca catgcaaatc tgtacctgta
     3841 cacacacgtg caggtacgca gatcagggac ctggcagctc atatgatgag cccaagagag
     3901 ctgaggtaaa tggatcccta gacaccctag gcccagctct cccccacccc agcagcacat
     3961 aagaaaatga gctttaaata aagcgtttat tggtgagcag aagcttatac agtttgcata
     4021 gattcttcat accataactg gaaggatgga gacccccaag gcactagaga aagaagtcag
     4081 tactcgatgg agtgagggcc ggggactggg tgtccctgag caccggccac gtcctatggg
     4141 tctgaggcct gtatctgggg agcaggtcca cagaacagag acctcatcct ggggccttgt
     4201 agtggcagtt tctactttgg tctcccaacc ccggcagcag agtctgggga ggcccaaggt
     4261 gacagtcatc tacttgactg acccttggtt tgacccttgc gactaagagg gaaagataag
     4321 cccaaatggt tcacaaggac aatggaagaa gggtctggaa ttgtcagggt taggtgacgt
     4381 gagttacaga gaccaaggat gctctgcagt gtctcaaagc catggccctc aatgttcccg
     4441 tggagcttct ccagcttccc ggcatgcagt gagacagcct acacccaacc ctgcagttgt
     4501 cagcccaaag taggggtaga taaccagaca gatgcacagc agtgggcacc caagactgca
     4561 acctcagcta ccttcacttt gccatcctgg ccttcgaccc tcccaaagac cctcccctca
     4621 ggacacttcc cctgcacaga cttaacacat tctgggcctt tctcattcca tcgctcccct
     4681 accagacccc taagccccgc cctcccgcac cagtaacccg caaagtgtgg ccagtgagca
     4741 ctctagtgtc tgtctaacct tgggacctgc agggagtggg caggacagag gccaggcctc
     4801 cgcctcttcc ttgccactta ggcaaggggc cccagagtga gatgacagct ttccagcttc
     4861 ctagacatga gttgcaccaa tgctttcatc tacc
//
