LOCUS       NM_001134746            2732 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus leucine rich repeat transmembrane neuronal 4
            (Lrrtm4), mRNA.
ACCESSION   NM_001134746 XM_001065407 XM_575570
VERSION     NM_001134746.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2732)
  AUTHORS   Um,J.W., Pramanik,G., Ko,J.S., Song,M.Y., Lee,D., Kim,H.,
            Park,K.S., Sudhof,T.C., Tabuchi,K. and Ko,J.
  TITLE     Calsyntenins function as synaptogenic adhesion molecules in concert
            with neurexins
  JOURNAL   Cell Rep 6 (6), 1096-1109 (2014)
   PUBMED   24613359
  REMARK    Erratum:[Cell Rep. 2024 Aug 27;43(8):114646. doi:
            10.1016/j.celrep.2024.114646.. PMID: 39110596]
REFERENCE   2  (bases 1 to 2732)
  AUTHORS   Siddiqui,T.J., Tari,P.K., Connor,S.A., Zhang,P., Dobie,F.A.,
            She,K., Kawabe,H., Wang,Y.T., Brose,N. and Craig,A.M.
  TITLE     An LRRTM4-HSPG complex mediates excitatory synapse development on
            dentate gyrus granule cells
  JOURNAL   Neuron 79 (4), 680-695 (2013)
   PUBMED   23911104
REFERENCE   3  (bases 1 to 2732)
  AUTHORS   de Wit,J., O'Sullivan,M.L., Savas,J.N., Condomitti,G.,
            Caccese,M.C., Vennekens,K.M., Yates,J.R. 3rd and Ghosh,A.
  TITLE     Unbiased discovery of glypican as a receptor for LRRTM4 in
            regulating excitatory synapse development
  JOURNAL   Neuron 79 (4), 696-711 (2013)
   PUBMED   23911103
REFERENCE   4  (bases 1 to 2732)
  AUTHORS   Schwenk,J., Harmel,N., Brechet,A., Zolles,G., Berkefeld,H.,
            Muller,C.S., Bildl,W., Baehrens,D., Huber,B., Kulik,A., Klocker,N.,
            Schulte,U. and Fakler,B.
  TITLE     High-resolution proteomics unravel architecture and molecular
            diversity of native AMPA receptor complexes
  JOURNAL   Neuron 74 (4), 621-633 (2012)
   PUBMED   22632720
REFERENCE   5  (bases 1 to 2732)
  AUTHORS   Linhoff,M.W., Lauren,J., Cassidy,R.M., Dobie,F.A., Takahashi,H.,
            Nygaard,H.B., Airaksinen,M.S., Strittmatter,S.M. and Craig,A.M.
  TITLE     An unbiased expression screen for synaptogenic proteins identifies
            the LRRTM protein family as synaptic organizers
  JOURNAL   Neuron 61 (5), 734-749 (2009)
   PUBMED   19285470
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC168219.1.
            
            On or before Sep 5, 2008 this sequence version replaced
            XM_001065407.1, XM_575570.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168219.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2732
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..2732
                     /gene="Lrrtm4"
                     /gene_synonym="RGD1560707"
                     /note="leucine rich repeat transmembrane neuronal 4"
                     /db_xref="GeneID:500219"
                     /db_xref="RGD:1560707"
     exon            1..10
                     /gene="Lrrtm4"
                     /gene_synonym="RGD1560707"
                     /inference="alignment:Splign:2.1.0"
     CDS             7..1779
                     /gene="Lrrtm4"
                     /gene_synonym="RGD1560707"
                     /note="leucine-rich repeat transmembrane neuronal protein
                     4"
                     /codon_start=1
                     /product="leucine-rich repeat transmembrane neuronal
                     protein 4 precursor"
                     /protein_id="NP_001128218.1"
                     /db_xref="GeneID:500219"
                     /db_xref="RGD:1560707"
                     /translation="MGFRLITQLKGMSVLLVLFPTLLLVMLTGAQRACPKNCRCDGKI
                     VYCESHAFADIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDE
                     DAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLI
                     ILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFS
                     KINFAHFPRLFNLRSIYLQWNRIRSVSQGLTWTWSSLHTLDLSGNDIQAIEPGTFKCL
                     PNLQKLNLDSNKLTNVSQETVNAWISLISITLSGNMWECSRSICPLFYWLKNFKGNKE
                     STMICAGPKHIQGEKVSDAVETYNICSDVQVVNTERSHLAPQTPQKPPFFPKPTIFKS
                     DAIPATLEAVSPSPGFQIPGTDHEYEHVSFHKIIAGSVALFLSVAMILLVIYVSWKRY
                     PASMKQLQQHSLMKRRRKKARESERQMNSPLQEYYVDYKPTNSETMDISVNGSGPCTY
                     TISGSRECEMPHHVKPLPYYSYDQPVIGYCQAHQPLHINKAYEAVSIEQDDSPSLELG
                     RDHSFIATIARSAAPAIYLERITN"
     exon            11..1557
                     /gene="Lrrtm4"
                     /gene_synonym="RGD1560707"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..2707
                     /gene="Lrrtm4"
                     /gene_synonym="RGD1560707"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caaaggatgg gtttccgtct aatcacgcag ctgaaaggca tgagtgtgct tctggtgcta
       61 tttcccaccc tgctgctggt tatgctgacc ggggcgcaga gagcttgccc aaagaactgc
      121 agatgtgatg gcaagattgt atactgtgag tctcacgcct ttgcagacat ccctgagaac
      181 atttccggag ggtcacaagg tttatcctta aggttcaaca gcattcagaa actcaaatcc
      241 aatcagtttg ccggccttaa ccagcttata tggctttatc ttgaccataa ttacattagc
      301 tcagtagatg aagatgcctt tcaagggatc cgcagactga aagaattaat tctaagctcc
      361 aacaaaatta cctatctgca caataaaaca tttcacccag tccccaacct ccgcaacctg
      421 gatctctcct acaacaaact tcagacctta caatctgagc agtttaaagg cctccggaaa
      481 cttatcattt tgcacttgcg atctaattct ctaaagactg tgcccataag ggtttttcaa
      541 gactgccgga accttgactt tctggatttg ggttacaatc gtctcagaag cttatctcga
      601 aatgcatttg ctggtcttct gaagttgaaa gagcttcatc tggagcataa tcagttttcc
      661 aagatcaact ttgctcattt tcctcgtctc ttcaacctgc ggtccattta cctgcaatgg
      721 aacaggatcc gctctgtcag tcaaggccta acgtggacct ggagttcctt gcataccttg
      781 gatttatcag ggaatgacat ccaagcaatc gagcctggca cgttcaaatg cctccccaat
      841 ttgcagaaat tgaatttgga ttccaacaag ctcaccaatg tctcccagga gactgtcaat
      901 gcgtggatat ccttaatatc catcaccttg tcgggaaaca tgtgggaatg tagtcggagc
      961 atctgccctc tcttctactg gctgaagaac ttcaaaggga ataaagaaag taccatgata
     1021 tgtgcagggc ctaagcacat acagggtgag aaggttagcg atgctgtgga gacttacaat
     1081 atctgctctg atgtccaggt ggtcaacaca gaaagatcac acctggcgcc tcaaactccc
     1141 cagaagcccc cgttcttccc caaacctacc atcttcaaat cggatgccat cccagccaca
     1201 ctggaggcag tgagcccatc cccgggcttt caaattccag gtacggatca tgagtatgag
     1261 catgtgtctt ttcacaaaat cattgcaggg agcgtggctc tgttcctctc ggtggccatg
     1321 attctcctgg tgatctatgt gtcttggaaa cggtacccag ccagcatgaa acaactccaa
     1381 cagcactcac ttatgaagag gagacggaaa aaggcgaggg agtccgagag acaaatgaat
     1441 tcccctttac aggaatacta cgtggactac aagccgacga actctgagac catggatata
     1501 tcggttaatg gatctggtcc ctgcacatat accatctctg gctccaggga gtgtgagatg
     1561 ccccaccatg tgaagccctt gccgtattac agctatgatc aaccagtgat tgggtactgc
     1621 caagcccacc agccccttca catcaacaag gcatatgaag ctgtgtccat agagcaggac
     1681 gacagcccca gtttggagct tgggagagac cacagcttca tcgccaccat agccaggtcg
     1741 gctgcacctg ccatttacct ggagagaata acaaactaac agcaaagcta acttcttgat
     1801 gaagagctca cagggaaagg gaggcctcca ccacagagga gatgaggtgt ccggctcaag
     1861 agttcaatga tcctgtacag aagtttaagg actagtgaga agcaaacccc aaactgctta
     1921 tgaagttggg cagctgatga acctgccatc gacccgggag gacacagaac ttctttgctt
     1981 taaaacacaa aacaaataca agcactcccg gatgtaaata gtcaagagtg ttaagttctt
     2041 ataaaaatag atttcaccct agctatctat aggtttgttt gtatatttga tttttctaca
     2101 atgcatggtt cctgggctgg agaaccacag tggggagggt gggaattttg gggaaacaac
     2161 acaatttttc ttgtaaggtg tgcataacac tcacagacct tttcccctat gttttcattt
     2221 tatttttcct ttaaaatctg gttttaccct tttatttgtt ttatttttct taatttcctg
     2281 gttgagtgac tttctacttc tcaatatcag tacctacatg gtaccaaaag aagatttgtt
     2341 ttttgcattg acctaaagta aagaaagttg actacaacgt tcaataaact actggaatga
     2401 gttaaataca tcgaagtgta tattcactca atacacatta tagacaatat taggagctct
     2461 ggtttcttcc ctcatctgta tcaaccatga tagcccgacc tgtgaacaca tggatgggga
     2521 cgaacctgcg tactaccctc aatgaagaga gcggctctgt gaacaatggc catgattcct
     2581 gtggatggca ctgtcatggg atgaatttct aaattcaaaa tgatgtgtaa tattgctttt
     2641 aaatttaatt atcacatagc ttttgtgtaa tttttatcaa taaaagaaaa aatgttgaaa
     2701 aataaaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
