LOCUS       NP_001099857             582 aa            linear   ROD 17-FEB-2024
DEFINITION  leucine-rich repeat transmembrane neuronal protein 3 precursor
            [Rattus norvegicus].
ACCESSION   NP_001099857 XP_001074319 XP_228137
VERSION     NP_001099857.1
DBSOURCE    REFSEQ: accession NM_001106387.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 582)
  AUTHORS   Um,J.W., Choi,T.Y., Kang,H., Cho,Y.S., Choii,G., Uvarov,P.,
            Park,D., Jeong,D., Jeon,S., Lee,D., Kim,H., Lee,S.H., Bae,Y.C.,
            Choi,S.Y., Airaksinen,M.S. and Ko,J.
  TITLE     LRRTM3 Regulates Excitatory Synapse Development through Alternative
            Splicing and Neurexin Binding
  JOURNAL   Cell Rep 14 (4), 808-822 (2016)
   PUBMED   26776509
REFERENCE   2  (residues 1 to 582)
  AUTHORS   Um,J.W., Pramanik,G., Ko,J.S., Song,M.Y., Lee,D., Kim,H.,
            Park,K.S., Sudhof,T.C., Tabuchi,K. and Ko,J.
  TITLE     Calsyntenins function as synaptogenic adhesion molecules in concert
            with neurexins
  JOURNAL   Cell Rep 6 (6), 1096-1109 (2014)
   PUBMED   24613359
REFERENCE   3  (residues 1 to 582)
  AUTHORS   Majercak,J., Ray,W.J., Espeseth,A., Simon,A., Shi,X.P., Wolffe,C.,
            Getty,K., Marine,S., Stec,E., Ferrer,M., Strulovici,B., Bartz,S.,
            Gates,A., Xu,M., Huang,Q., Ma,L., Shughrue,P., Burchard,J.,
            Colussi,D., Pietrak,B., Kahana,J., Beher,D., Rosahl,T.,
            Shearman,M., Hazuda,D., Sachs,A.B., Koblan,K.S., Seabrook,G.R. and
            Stone,D.J.
  TITLE     LRRTM3 promotes processing of amyloid-precursor protein by BACE1
            and is a positional candidate gene for late-onset Alzheimer's
            disease
  JOURNAL   Proc Natl Acad Sci U S A 103 (47), 17967-17972 (2006)
   PUBMED   17098871
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000324.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XP_228137.4, XP_001074319.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760393,
                              SAMEA5760396 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..582
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p11"
     Protein         1..582
                     /product="leucine-rich repeat transmembrane neuronal
                     protein 3 precursor"
                     /note="leucine-rich repeat transmembrane neuronal protein
                     3"
                     /calculated_mol_wt=62948
     sig_peptide     1..30
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=3101
     mat_peptide     31..582
                     /product="Leucine-rich repeat transmembrane neuronal
                     protein 3. /id=PRO_0000420525"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZAL8.1)"
                     /calculated_mol_wt=62948
     Region          33..61
                     /region_name="LRRNT"
                     /note="Leucine rich repeat N-terminal domain; smart00013"
                     /db_xref="CDD:214470"
     Region          59..339
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          61..83
                     /region_name="LRR 1"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZAL8.1)"
     Region          66..86
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          84..107
                     /region_name="LRR 2"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZAL8.1)"
     Region          87..110
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          109..131
                     /region_name="LRR 3"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZAL8.1)"
     Region          111..134
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            126
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (D3ZAL8.1)"
     Region          132..155
                     /region_name="LRR 4"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZAL8.1)"
     Region          135..158
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          156..179
                     /region_name="LRR 5"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZAL8.1)"
     Region          159..182
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          181..203
                     /region_name="LRR 6"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZAL8.1)"
     Region          183..206
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          205..227
                     /region_name="LRR 7"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZAL8.1)"
     Region          207..230
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          229..251
                     /region_name="LRR 8"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZAL8.1)"
     Region          231..254
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          252..276
                     /region_name="LRR 9"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZAL8.1)"
     Region          255..279
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          277..300
                     /region_name="LRR 10"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZAL8.1)"
     Region          280..300
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            357
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (D3ZAL8.1)"
     Region          378..411
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZAL8.1)"
     Site            421..441
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZAL8.1)"
     CDS             1..582
                     /gene="Lrrtm3"
                     /coded_by="NM_001106387.2:551..2299"
                     /db_xref="GeneID:294380"
                     /db_xref="RGD:1304866"
ORIGIN      
        1 mgfnvirllr gsavavvlap tvlltmlssa ergcpkgcrc egkmvycesq klqeipssis
       61 agclglslry nslqklkynq fkglnqltwl yldhnhisni denafngirr lkelilssnr
      121 isyflnntfr pvtnlrnldl synqlhslgs eqfrglrkll slhlrsnslr tipvrifqdc
      181 rnlelldlgy nrirslarnv fagmirlkel hlehnqfskl nlalfprlvs lqnlymqwnk
      241 isvigqtmsw twsslqrldl sgneieafsg psvfqcvpnl qrlnldsnkl tfigqeilds
      301 wislndisla gniwecsrni cslvnwlksf kglrentilc aspkelqgvn vidavknysi
      361 cgksttterf dlaralpkpt fkpklprpkh eskpplpptv gasepspetd vdtehisfhk
      421 iiagsvalfl svlvillvmy vswkrypasm kqlqqrslmr rhrkkkrqsl kqmtpgtqef
      481 yvdykptnte tsemllngtg pctysksgsr eceiplsmnv stflaydqpt isycgvhhel
      541 lshktfetna qedtmeshle teldlstits agrigdhkpq la
//
