LOCUS       NM_001109469            4715 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus leucine rich repeat transmembrane neuronal 2
            (Lrrtm2), mRNA.
ACCESSION   NM_001109469 XM_001063319
VERSION     NM_001109469.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4715)
  AUTHORS   Loh,K.H., Stawski,P.S., Draycott,A.S., Udeshi,N.D., Lehrman,E.K.,
            Wilton,D.K., Svinkina,T., Deerinck,T.J., Ellisman,M.H., Stevens,B.,
            Carr,S.A. and Ting,A.Y.
  TITLE     Proteomic Analysis of Unbounded Cellular Compartments: Synaptic
            Clefts
  JOURNAL   Cell 166 (5), 1295-1307 (2016)
   PUBMED   27565350
REFERENCE   2  (bases 1 to 4715)
  AUTHORS   Um,J.W., Pramanik,G., Ko,J.S., Song,M.Y., Lee,D., Kim,H.,
            Park,K.S., Sudhof,T.C., Tabuchi,K. and Ko,J.
  TITLE     Calsyntenins function as synaptogenic adhesion molecules in concert
            with neurexins
  JOURNAL   Cell Rep 6 (6), 1096-1109 (2014)
   PUBMED   24613359
  REMARK    Erratum:[Cell Rep. 2024 Aug 27;43(8):114646. doi:
            10.1016/j.celrep.2024.114646.. PMID: 39110596]
REFERENCE   3  (bases 1 to 4715)
  AUTHORS   Soler-Llavina,G.J., Arstikaitis,P., Morishita,W., Ahmad,M.,
            Sudhof,T.C. and Malenka,R.C.
  TITLE     Leucine-rich repeat transmembrane proteins are essential for
            maintenance of long-term potentiation
  JOURNAL   Neuron 79 (3), 439-446 (2013)
   PUBMED   23931994
REFERENCE   4  (bases 1 to 4715)
  AUTHORS   Gauthier,J., Siddiqui,T.J., Huashan,P., Yokomaku,D., Hamdan,F.F.,
            Champagne,N., Lapointe,M., Spiegelman,D., Noreau,A.,
            Lafreniere,R.G., Fathalli,F., Joober,R., Krebs,M.O., DeLisi,L.E.,
            Mottron,L., Fombonne,E., Michaud,J.L., Drapeau,P., Carbonetto,S.,
            Craig,A.M. and Rouleau,G.A.
  TITLE     Truncating mutations in NRXN2 and NRXN1 in autism spectrum
            disorders and schizophrenia
  JOURNAL   Hum Genet 130 (4), 563-573 (2011)
   PUBMED   21424692
REFERENCE   5  (bases 1 to 4715)
  AUTHORS   Ko,J., Soler-Llavina,G.J., Fuccillo,M.V., Malenka,R.C. and
            Sudhof,T.C.
  TITLE     Neuroligins/LRRTMs prevent activity- and Ca2+/calmodulin-dependent
            synapse elimination in cultured neurons
  JOURNAL   J Cell Biol 194 (2), 323-334 (2011)
   PUBMED   21788371
REFERENCE   6  (bases 1 to 4715)
  AUTHORS   Linhoff,M.W., Lauren,J., Cassidy,R.M., Dobie,F.A., Takahashi,H.,
            Nygaard,H.B., Airaksinen,M.S., Strittmatter,S.M. and Craig,A.M.
  TITLE     An unbiased expression screen for synaptogenic proteins identifies
            the LRRTM protein family as synaptic organizers
  JOURNAL   Neuron 61 (5), 734-749 (2009)
   PUBMED   19285470
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473974.1.
            
            On Oct 4, 2007 this sequence version replaced XM_001063319.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB556614.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4715
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p11"
     gene            1..4715
                     /gene="Lrrtm2"
                     /note="leucine rich repeat transmembrane neuronal 2"
                     /db_xref="GeneID:685472"
                     /db_xref="RGD:1593785"
     exon            1..398
                     /gene="Lrrtm2"
                     /inference="alignment:Splign:2.1.0"
     CDS             395..1942
                     /gene="Lrrtm2"
                     /note="leucine-rich repeat neuronal 2 protein;
                     leucine-rich repeat transmembrane neuronal protein 2"
                     /codon_start=1
                     /product="leucine-rich repeat transmembrane neuronal
                     protein 2 precursor"
                     /protein_id="NP_001102939.1"
                     /db_xref="GeneID:685472"
                     /db_xref="RGD:1593785"
                     /translation="MGLHFKWPLGAPMLAAIYAMSVVLKMLPALGMACPPKCRCEKLL
                     FYCDSQGFHSVPNATDKGSLGLSLRHNHITALERDQFASFSQLTWLHLDHNQISTVKE
                     DAFQGLYKLKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQ
                     TLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLT
                     KINFAHFLRLSSLHTLFLQWNKISNLTCGMEWTWSTLEKLDLTGNEIKAIDLTVFETM
                     PNLKILLMDNNKLNSLDSKILSSLRSLTTVGLSGNLWECSPRVCALASWLGSFQGRWE
                     HSILCHSPDHTQGEDILDAVHGFQLCWNLSTTVTAMATTYRDPTTEYTKISSSSYHVG
                     DKEIPTTAGIAVTTEEHFPEPDNAIFTQRVITGTMALLFSFFFIIFIVFISRKCCPPT
                     LRRIRQCSMIQNHRQLRSQTRLHMSNMSDQGPYSEYEPTHEGPFIIINGYGQCKCQQL
                     PYKECEV"
     exon            399..4715
                     /gene="Lrrtm2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcttttcagt aaatgcactc atgctgctcc agaagctctt ctctgcaaca agccgcccat
       61 ctgccatcaa caagttaaga ccgagagaac taacagctgc gggaaggaaa gcctgaagct
      121 ctggtgatcg gcggtaatca gggggaggaa attattaact tatagtcaaa gctgattagg
      181 ggatcagagc acgaagaaaa tgacaccaat gctttccaga ggaatatcct aaggaaaagc
      241 caattctccc taatagactt gaatcttact tgaaacgctc gggacgcaga aagcaggaaa
      301 ctggtcaagg ctcctgcatg ttaagccttt tacagactca ctgcgcggag cctgacaacc
      361 tcgactgaat gcagcctcca atgtgctcag aagaatgggc ttacatttca agtggccatt
      421 aggggcccct atgctggcag caatatatgc aatgagtgtg gtattaaaaa tgctgcctgc
      481 cctgggtatg gcgtgtccac ctaaatgccg ctgtgagaag ctgctattct actgcgactc
      541 tcagggcttc cactcagtgc caaacgccac agacaagggt tctctgggcc tgtccctgag
      601 gcacaatcac atcacagcgc ttgaaagaga tcaatttgcc agcttcagtc aactcacctg
      661 gctccactta gatcacaatc aaatttcaac agtaaaagaa gatgctttcc aaggactata
      721 taaactaaag gagttaatct taagttccaa caaaatattt tacttgccaa acacaacttt
      781 tacccaactg attaatctgc agaatttgga cctctctttt aatcagctgt catctctgca
      841 ccctgagctc ttctatggcc ttcggaagct gcagaccttg catctgcgtt ccaactccct
      901 gcggactatc ccagttcgcc tgttctggga ctgtcgtagt ctagagtttc tggatttgag
      961 cacaaaccgt ttgcgaagtt tggctcgcaa tggatttgca ggattaatca aactgaggga
     1021 gcttcatcta gagcacaatc agctgacaaa gattaatttt gctcatttcc ttcggctaag
     1081 cagtctgcac acactcttct tacaatggaa caaaatcagc aacttgacgt gtgggatgga
     1141 gtggacctgg agcactttag aaaagctaga cctaactgga aatgaaatca aagccatcga
     1201 cttgacagtg ttcgagacca tgcctaatct taaaatactt ctcatggata acaacaagtt
     1261 aaatagtctt gattccaaaa tcttaagctc cctgagatcc ctcacaaccg ttggcctctc
     1321 tggcaatctg tgggaatgca gccccagagt ctgtgctctt gcctcctggc tgggcagttt
     1381 ccaaggtcgg tgggagcatt ccatcctatg ccacagccct gaccacaccc aaggagagga
     1441 tattctagat gcagtccacg gctttcagct ctgctggaat ttatcaacca ctgtcactgc
     1501 catggctaca acttatagag atccaaccac tgaatataca aaaataagct catcaagtta
     1561 ccatgtagga gacaaagaaa ttccaactac tgcaggcata gcagttacta cagaggaaca
     1621 ctttcctgaa ccagacaatg ccatctttac tcagcgagta attacaggaa caatggcttt
     1681 attgttttct ttctttttta ttatttttat agtgttcatt tccaggaagt gctgccctcc
     1741 cactttaaga agaattaggc agtgctcaat gattcagaac cacaggcagc tccgatccca
     1801 aacacgactc catatgtcaa acatgtcaga ccaaggaccg tatagtgagt acgagcccac
     1861 ccatgaagga cctttcatca tcattaatgg ttatggacag tgcaagtgtc agcagctacc
     1921 atacaaggaa tgtgaagtat aatatctgct caccatcaaa aaccacacca gataagtaac
     1981 ctattttaca tagtagaggc tacatacaca cctgattttt accaatggtg acactaagcc
     2041 taattttcca aatcaagtgg agacttgagt ttttgaagtg ttaaagtatt tttaattttt
     2101 ttaatgaaaa catattttaa gtgttaaatg aagcaatgct catattaatt tgcacttttg
     2161 ttggaaagtc taaatgctta cttcaatata aaacatttca tgtatgtaat tatatacaat
     2221 tgtatgtaaa catttgcgct aaggtctcca tatgtttttt ttgttttgtt ttgtttttta
     2281 ctgaaaacag ttccaaaaga agctactaaa caaatatagg taggggaaaa aacctgtttg
     2341 attattattc tccatcctat ggaccactgg cttcctactt aaaaaggaga tggcaaagtt
     2401 ttcttgtaag ataatgtggt atttactcaa actataattt actgccagca tcagaagtag
     2461 acttatatgt gtgcttaaga ctggtaaata gtaaacgtta ttctttcagt ttggcttggc
     2521 ttaataaaca gtatctaagt tacatcatga aaccagcacc ttttatataa ctctaataaa
     2581 actgggtgac tctttaatat atttcaacaa taaatccaag caattataaa aggatctcat
     2641 tataataaat caatactaaa taactacact gacttcctat acaactctag tttgacttat
     2701 aatggacatg ctgatttttc tgccacttag cctattattt taaactagta ttaaattacc
     2761 attttactaa ttaacttact aaatcctcta ttgtgtaaaa atttgcattt gggaaagaga
     2821 aaaactgagt caacttaaca atcctgatat actccatcca gtttgaaata catcccttct
     2881 catgattgaa gatgccttga caaactgttg aagcctcttc cttctgcctt tttctgttct
     2941 ttaaacttca aagatccaaa ttaaaaataa ttggctacta aaggtgccta accctgattt
     3001 gttataaaaa aaaaaaacca caaaaaatta ctttcaaaat atgatgttaa agcttgacct
     3061 ttaataaaca tacacattta ttttaatcgc tacttccaag agaggaccaa cctatttctg
     3121 aggcaaattt taaggcagag cttttgacac tgacccctgc catcacacag cagcgagtga
     3181 aggcagcatg agtgtgaggg taagaacagg taaagggtga gagcccggct ctcaggttag
     3241 tggaagttac caggcagcaa acgtgattac gtacaatttg caccaaatga gtgatgctca
     3301 gggacctgta tgatatggga ggagactcag cagtgtaaat tcgaacactc taatcacagt
     3361 aacaactgac aacaatgcta catttttcat gaggaaccac aagtgttcaa ttctgacttc
     3421 tttaagtcaa acaatggcac actggggagc taagactcaa gttaccaatc cacatacaat
     3481 ttttttctac aaagaaggct ccacatatag gagaaaacag agaatcatta ctttgatttc
     3541 agaaaggaaa agaaaacaag catttttata tggaaaaata tctaagtcct taaagaaaga
     3601 cattattata acacagtatc cttcattcaa ggctgatttt ctctccggac ctggattgaa
     3661 aatgttacta tagacctaga ttcaatcata atttttctcc tttaacactg aaaaatatac
     3721 ccacattcca aatctcttag caaaaagcaa acaattcagg tttcagtgaa aatgtgctct
     3781 ttttttttct tttaaggtgg gtaaattagt tggcaaagcc tcagtgcagt tcaattcact
     3841 tgatcttgag tggcaagcat ttcatctcct gataaaccag acgttgggtt cgtctgagcg
     3901 gagacagatg ctggttttcc ggcatggagc atagcacact gattccccac tgaggagctg
     3961 catcagaagc cctattacaa atgagctctg tgggctagga tttcacagct catttatcgt
     4021 ggtgaccact gccgtttgtc aggtgataga cagcttgttc gcaatacagt tttgagcatg
     4081 caagactcca ctggccctaa aaggatgagt ggttttcatc atttcaaatc acaagcaaaa
     4141 ttaattcaaa ctgtgagtta aaaagtaaga aatattaact agcaactcca attaacccta
     4201 aagaacatag ttagtaaagt ggatttgtat gtagcatagc aagccactta gtatccgagg
     4261 aaagagaaca gtgccaaaag ccaccaatgc aaactgtggg ggaaggggag cacatatatc
     4321 tctttcggtc cacatttcct tccacttttt ttccacttaa agcacagttg ccttctctac
     4381 ttgcctgcag aacacaaggt cccatttagt tggtatgtat ttgcattgcg gtatctgtgc
     4441 tgccaactgg ccagagtagc aaaaccatgt gtatgtagtt cctagccaca aaagcgaggt
     4501 tctgggtagg gttttatctc gtaagcatta ccacccaact ttccctctcc cgttttaagt
     4561 tagtgaaaaa tgatcatcag aagtcagaaa ataacgtctc agaaaaatga agtgtagtta
     4621 ggaatccaaa attagtttgc aactactgtt acttattttt gtagcctaca gggaattcaa
     4681 gcttaccttt ctaaaaagag tgggttggta aatct
//
