LOCUS       NM_030856               3087 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus leucine rich repeat neuronal 3 (Lrrn3), mRNA.
ACCESSION   NM_030856 XM_346765
VERSION     NM_030856.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3087)
  AUTHORS   Herlan,L., Schulz,A., Schulte,L., Schulz,H., Hubner,N. and
            Kreutz,R.
  TITLE     Novel candidate genes for impaired nephron development in a rat
            model with inherited nephron deficit and albuminuria
  JOURNAL   Clin Exp Pharmacol Physiol 42 (10), 1051-1058 (2015)
   PUBMED   26192016
REFERENCE   2  (bases 1 to 3087)
  AUTHORS   Um,J.W., Pramanik,G., Ko,J.S., Song,M.Y., Lee,D., Kim,H.,
            Park,K.S., Sudhof,T.C., Tabuchi,K. and Ko,J.
  TITLE     Calsyntenins function as synaptogenic adhesion molecules in concert
            with neurexins
  JOURNAL   Cell Rep 6 (6), 1096-1109 (2014)
   PUBMED   24613359
  REMARK    Erratum:[Cell Rep. 2024 Aug 27;43(8):114646. doi:
            10.1016/j.celrep.2024.114646.. PMID: 39110596]
REFERENCE   3  (bases 1 to 3087)
  AUTHORS   Yang,J., Li,F., Qiu,L., Luo,X. and Huang,H.
  TITLE     [Role of LRRN3 in the cerebellum postnatal development in rats]
  JOURNAL   Zhong Nan Da Xue Xue Bao Yi Xue Ban 36 (5), 424-429 (2011)
   PUBMED   21685698
  REMARK    GeneRIF: LRRN3 plays an important role in postnatal cerebellum
            development.
REFERENCE   4  (bases 1 to 3087)
  AUTHORS   Fattoum,A., Roustan,C., Smyczynski,C., Der Terrossian,E. and
            Kassab,R.
  TITLE     Mapping the microtubule binding regions of calponin
  JOURNAL   Biochemistry 42 (5), 1274-1282 (2003)
   PUBMED   12564930
REFERENCE   5  (bases 1 to 3087)
  AUTHORS   Fukamachi,K., Matsuoka,Y., Ohno,H., Hamaguchi,T. and Tsuda,H.
  TITLE     Neuronal leucine-rich repeat protein-3 amplifies MAPK activation by
            epidermal growth factor through a carboxyl-terminal region
            containing endocytosis motifs
  JOURNAL   J Biol Chem 277 (46), 43549-43552 (2002)
   PUBMED   12297494
  REMARK    GeneRIF: NLRR-3 potentiates Ras-MAPK signaling by facilitating
            internalization of EGF in clathrin-coated vesicles
REFERENCE   6  (bases 1 to 3087)
  AUTHORS   Fukamachi,K., Matsuoka,Y., Kitanaka,C., Kuchino,Y. and Tsuda,H.
  TITLE     Rat neuronal leucine-rich repeat protein-3: cloning and regulation
            of the gene expression
  JOURNAL   Biochem Biophys Res Commun 287 (1), 257-263 (2001)
   PUBMED   11549284
  REMARK    GeneRIF: rNLRR-3 gene expression is regulated mainly through the
            Ras-MAPK signaling pathway in fibroblasts
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Nov 26, 2020 this sequence version replaced NM_030856.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF291437.1, SRR26643299.27261.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840116, SAMN12840132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-344               JAXUCZ010000006.1  64246950-64247293   c
            345-3087            JAXUCZ010000006.1  64216426-64219168   c
FEATURES             Location/Qualifiers
     source          1..3087
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q21"
     gene            1..3087
                     /gene="Lrrn3"
                     /gene_synonym="Nlrr3"
                     /note="leucine rich repeat neuronal 3"
                     /db_xref="GeneID:81514"
                     /db_xref="RGD:71066"
     exon            1..344
                     /gene="Lrrn3"
                     /gene_synonym="Nlrr3"
                     /inference="alignment:Splign:2.1.0"
     exon            345..3087
                     /gene="Lrrn3"
                     /gene_synonym="Nlrr3"
                     /inference="alignment:Splign:2.1.0"
     CDS             700..2823
                     /gene="Lrrn3"
                     /gene_synonym="Nlrr3"
                     /note="leucine-rich repeat neuronal protein 3; NLRR-3;
                     neuronal leucine-rich repeat protein 3; leucine rich
                     repeat protein 3, neuronal"
                     /codon_start=1
                     /product="leucine-rich repeat neuronal protein 3
                     precursor"
                     /protein_id="NP_110483.2"
                     /db_xref="GeneID:81514"
                     /db_xref="RGD:71066"
                     /translation="MKDAPLQIHVLLGLAITALVQAGDKKVDCPQLCTCEIRPWFTPR
                     SIYMEALTVDCNDLGLLNFPARLPADTQILLLQTNNIARIEHSTDFPVNLTGLDLSQN
                     NLSSVTNINVQKMSQLLSVYLEENKLTELPEKCLYGLSNLQELYVNHNLLSAISPGAF
                     VGLHNLLRLHLNSNRLQMINSKWFEALPNLEILMLGDNPILRIKDMNFQPLLKLRSLV
                     IAGINLTEVPGDALVGLENLESISFYDNRLNKVPQVALQKAVNLKFLDLNKNPINRIR
                     RGDFSNMLHLKELGINNMPELVSIDSLAVDNLPDLRKIEATNNPRLSYIHPNAFFRLP
                     KLESLMLNSNALSALYHGTIESLPNLKEISIHSNPIRCDCVIRWINMNKTNIRFMEPD
                     SLFCVDPPEFQGQNVRQVHFRDMMEICLPLIAPESFPSILDVEADSYVSLHCRATAEP
                     QPEIYWITPSGKRLLPNTLREKFYVHSEGTLDIRGITPKEGGLYTCIATNLVGADLKS
                     IMIKVGGFVPQDNNGSLNIKIRDIRANSVLVSWKANSKILKSSVKWTAFVKTEDSQAA
                     QSARIPSDVKVYNLTHLKPSTEYKICIDIPTIYQKSRKQCVNVTTKSLEHDGKENGKS
                     HTVFVACVGGLLGIIGVMCLFGCVSQEGNCESEHSYTVNHCHKPTLAFSELYPPLINL
                     WESSKEKPASLEVKATAIGVPTSMS"
ORIGIN      
        1 ctaaccacca tggaaacgag gagaaataaa gccagctagc aggatctctc ctcgctggac
       61 tgagagcttt agcctgctgc tgccggagag aggagagagt tccagtcaaa agaaggaatc
      121 ctagctgcag gctcctgcct ccttttatat tttagaaaga gagggagaga taccattgct
      181 tgcatgtgtg catatctata gtatataatt gtgtatattt tattacacat acatatgcac
      241 ctatttatac tggggcaaga agacagccat gtgattatct caaccaagga actgtgcaag
      301 cgggggcacc ggaggagggc tatccctgca tcttctaagg caagaataat gcctctatct
      361 gcaagtactg gacaagcatg ggatctgaat cacagactta acgctaaatg aattgctcca
      421 tatcctgcga ccatctatac atacaccatc ttcaaagagt ccattgatac ccgatcgctg
      481 aggagacagc aggcatctct tctccacgat gcatgcaagt tttggaaaat acatgtgtgg
      541 cactcacaag tatttccatg aagcaaagtc ctgcagtctt gtggcattca tcatttaaca
      601 aatgcgaaca ctcccttcat cagtcagctc ctactgaact taactggcgg tgactggaat
      661 cctcaagggc ctgctacatt tctgaagaca aaagctaaga tgaaggacgc accactccaa
      721 atccacgtgc tacttggcct ggctatcacc gcactcgtac aagccggaga taaaaaagtg
      781 gattgccccc agttatgtac atgtgagatc aggccttggt tcactcccag atccatctat
      841 atggaagcat tgacagtgga ctgtaatgat ttagggcttt taaacttccc ggccagattg
      901 cctgcagaca cacagatttt gctcctgcag actaacaata ttgcaagaat tgaacattcc
      961 acagactttc cagtaaacct tactggcctg gacttatctc agaacaattt atcttcggtc
     1021 actaatatta atgtacaaaa gatgtcccag cttctttctg tatacctaga ggaaaacaag
     1081 ctaacggagc tgcctgaaaa gtgtctgtat ggactgagta acttgcagga gctttacgtc
     1141 aatcacaact tgctgtctgc catctctccc ggagccttcg ttggcctaca taaccttctt
     1201 cgacttcatc tcaactcaaa cagactgcag atgatcaaca gtaagtggtt tgaggctctt
     1261 cctaatcttg agattctgat gctcggggac aaccccatcc tcagaatcaa ggacatgaac
     1321 tttcagcctc ttctcaagct ccgcagcctg gttatcgctg gcataaacct cacggaagta
     1381 ccaggtgacg ccttggttgg actggaaaac ctggaaagca tctcttttta tgataatagg
     1441 cttaataagg taccccaggt tgctcttcaa aaagctgtca acctcaagtt tttggatcta
     1501 aataaaaacc ctattaacag aatacgaagg ggtgatttta gcaatatgct acacttgaag
     1561 gagttgggga taaacaatat gcctgaactt gtctccattg acagtctcgc tgtggataac
     1621 ttgccagatt tgagaaaaat agaagctact aacaacccca ggttgtctta cattcaccct
     1681 aatgcatttt tcagactccc aaagctagaa tctctcatgc tgaacagcaa cgccctcagt
     1741 gccctctacc atggtaccat agagtctttg ccaaacctca aggaaatcag catacacagc
     1801 aatcccatcc ggtgtgactg tgtaatccgc tggattaaca tgaacaaaac caacattcgg
     1861 tttatggaac cagattctct gttctgtgtg gacccacctg aattccaagg ccagaatgtt
     1921 cgacaagtgc atttcaggga tatgatggaa atctgcctcc ctcttatagc tcctgagagc
     1981 tttccttcca tcctggatgt agaagctgac agctatgtgt cgcttcactg cagagccact
     2041 gcagaacccc agcctgaaat ctactggatc acaccttctg gtaaaagact attgccaaac
     2101 actctgagag agaagttcta tgttcattct gaaggcacac tagacataag aggcataacc
     2161 ccaaaggaag gtgggttgta cacctgcata gctactaacc tagtcggtgc tgacttgaag
     2221 tctattatga tcaaagtggg aggttttgtt cctcaggata acaacgggtc attgaatatt
     2281 aaaataagag atatccgggc caattctgtt ctggtgtctt ggaaagcaaa ctctaaaatt
     2341 ctcaaatcca gtgttaagtg gacagccttt gttaagactg aagactccca ggctgcccaa
     2401 agtgctcgaa taccatctga tgtcaaggta tacaatctta ctcatctgaa accttctact
     2461 gagtacaaaa tttgtattga tattcccacc atctatcaga aaagcagaaa acaatgtgtg
     2521 aatgtgacca cgaaaagtct ggagcatgac ggaaaagaaa atggaaagag tcacacagta
     2581 tttgtggcct gcgttggagg tcttctgggg atcattggtg taatgtgtct tttcggctgt
     2641 gtctcacaag aagggaactg tgagagtgaa cacagctata ctgtgaacca ctgtcacaag
     2701 ccaaccttgg cattcagtga gctttaccct cctctaatca acctctggga gtccagcaaa
     2761 gaaaaaccgg catcgttgga agtaaaagca actgctatag gtgtgccgac aagtatgtcc
     2821 taaaacagcc aaccaaacct ccttcaaaga aaagctggag atggcggcag tgcttaaaaa
     2881 tcaacaacaa aaaataggca gaggaatgtc actttctcaa aggaagactc agcatcgcca
     2941 atgctgctcc tgaccaaggg aaagagaggt gaaagttcgg cattttaatt gactggcttc
     3001 aaagggtact gtggcaacca aataaaacaa ctccattttc tagacctttc atgtaacttt
     3061 tctgtcagga ctgcagttaa tgtgaac
//
