LOCUS       NM_001191624            6445 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Rattus norvegicus leucine-rich repeat kinase 1 (Lrrk1), mRNA.
ACCESSION   NM_001191624 XM_218760
VERSION     NM_001191624.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6445)
  AUTHORS   Xing,W., Liu,J., Cheng,S., Vogel,P., Mohan,S. and Brommage,R.
  TITLE     Targeted disruption of leucine-rich repeat kinase 1 but not
            leucine-rich repeat kinase 2 in mice causes severe osteopetrosis
  JOURNAL   J Bone Miner Res 28 (9), 1962-1974 (2013)
   PUBMED   23526378
REFERENCE   2  (bases 1 to 6445)
  AUTHORS   Berwick,D.C. and Harvey,K.
  TITLE     LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic
            proteins and membrane-localized LRP6
  JOURNAL   Hum Mol Genet 21 (22), 4966-4979 (2012)
   PUBMED   22899650
REFERENCE   3  (bases 1 to 6445)
  AUTHORS   Civiero,L., Vancraenenbroeck,R., Belluzzi,E., Beilina,A.,
            Lobbestael,E., Reyniers,L., Gao,F., Micetic,I., De Maeyer,M.,
            Bubacco,L., Baekelandt,V., Cookson,M.R., Greggio,E. and
            Taymans,J.M.
  TITLE     Biochemical characterization of highly purified leucine-rich repeat
            kinases 1 and 2 demonstrates formation of homodimers
  JOURNAL   PLoS One 7 (8), e43472 (2012)
   PUBMED   22952686
REFERENCE   4  (bases 1 to 6445)
  AUTHORS   Klein,C.L., Rovelli,G., Springer,W., Schall,C., Gasser,T. and
            Kahle,P.J.
  TITLE     Homo- and heterodimerization of ROCO kinases: LRRK2 kinase
            inhibition by the LRRK2 ROCO fragment
  JOURNAL   J Neurochem 111 (3), 703-715 (2009)
   PUBMED   19712061
REFERENCE   5  (bases 1 to 6445)
  AUTHORS   Westerlund,M., Belin,A.C., Anvret,A., Bickford,P., Olson,L. and
            Galter,D.
  TITLE     Developmental regulation of leucine-rich repeat kinase 1 and 2
            expression in the brain and other rodent and human organs:
            Implications for Parkinson's disease
  JOURNAL   Neuroscience 152 (2), 429-436 (2008)
   PUBMED   18272292
  REMARK    GeneRIF: Lrrk1 is found in many areas of the P1 rat. Lrrk1 is
            present in adult rat brain, adrenal gland, liver, lung, spleen and
            kidney and also in embryonic brain, with declining gene activity
            after birth.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            [WARNING] On Jun 10, 2024 this sequence was replaced by
            NM_001191624.2.
            
            On Jul 17, 2010 this sequence version replaced XM_218760.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.2687.1,
                                           SRR26643290.2218.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                JAXUCZ010000001.1  129383034-129383130 c
            98-261              JAXUCZ010000001.1  129345343-129345506 c
            262-433             JAXUCZ010000001.1  129333816-129333987 c
            434-613             JAXUCZ010000001.1  129329916-129330095 c
            614-762             JAXUCZ010000001.1  129328892-129329040 c
            763-989             JAXUCZ010000001.1  129303995-129304221 c
            990-1117            JAXUCZ010000001.1  129302427-129302554 c
            1118-1281           JAXUCZ010000001.1  129302167-129302330 c
            1282-1419           JAXUCZ010000001.1  129300605-129300742 c
            1420-1532           JAXUCZ010000001.1  129298359-129298471 c
            1533-1609           JAXUCZ010000001.1  129296515-129296591 c
            1610-1739           JAXUCZ010000001.1  129292222-129292351 c
            1740-1852           JAXUCZ010000001.1  129291508-129291620 c
            1853-2067           JAXUCZ010000001.1  129290874-129291088 c
            2068-2232           JAXUCZ010000001.1  129288361-129288525 c
            2233-2405           JAXUCZ010000001.1  129287609-129287781 c
            2406-2526           JAXUCZ010000001.1  129286389-129286509 c
            2527-2686           JAXUCZ010000001.1  129285860-129286019 c
            2687-2963           JAXUCZ010000001.1  129284073-129284349 c
            2964-3135           JAXUCZ010000001.1  129280626-129280797 c
            3136-3299           JAXUCZ010000001.1  129278157-129278320 c
            3300-3439           JAXUCZ010000001.1  129277623-129277762 c
            3440-3689           JAXUCZ010000001.1  129275436-129275685 c
            3690-3856           JAXUCZ010000001.1  129273021-129273187 c
            3857-4054           JAXUCZ010000001.1  129269146-129269343 c
            4055-4332           JAXUCZ010000001.1  129267324-129267601 c
            4333-4527           JAXUCZ010000001.1  129266050-129266244 c
            4528-4679           JAXUCZ010000001.1  129265055-129265206 c
            4680-4797           JAXUCZ010000001.1  129262885-129263002 c
            4798-4914           JAXUCZ010000001.1  129261827-129261943 c
            4915-5762           JAXUCZ010000001.1  129258660-129259507 c
            5763-5864           JAXUCZ010000001.1  129258137-129258238 c
            5865-6445           JAXUCZ010000001.1  129255601-129256181 c
FEATURES             Location/Qualifiers
     source          1..6445
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..6445
                     /gene="Lrrk1"
                     /note="leucine-rich repeat kinase 1"
                     /db_xref="GeneID:308703"
                     /db_xref="RGD:1308000"
     CDS             1..6042
                     /gene="Lrrk1"
                     /EC_number="2.7.11.1"
                     /codon_start=1
                     /product="leucine-rich repeat serine/threonine-protein
                     kinase 1"
                     /protein_id="NP_001178553.1"
                     /db_xref="GeneID:308703"
                     /db_xref="RGD:1308000"
                     /translation="MAAVSQRPPSMYWCVGTEGSVVCPGPAMETHNGAEDMGSKLSLP
                     GGNSPVQSPNMEEIHTAYKQRNLSRARDLLREVCEESESPQEKGQLLSISAAHGDLET
                     VRFLLTEKRVELPMEPTDDNPAVVAAHFGHAEVVHELLESLSGPCASQRLLNWMLALA
                     CQRGHLEVVKLLVLTHGADPENYAVRKNEFPVIVRLPLYAAIKAGNEDIAIFLLRHGA
                     YFCSYILLDSPDPSKHLLRKYFIEASALPSSCPGKTALCVKWSHLKLPWVDLDWLLDI
                     SCQITELDLSANCLSSLPSIIPWGLINLKKLNLSNNHLGELPCVQSSDEIICSRLVEI
                     DISSNKLSHLPPGFLHLSKLERLTASKNYLERLFEEENATNWIGLRKLEELDLADNRL
                     TELPVQFMHSFKSLTNLNVSRNSLKSFPDPWSCPLKCCKASKNALESLPDKMAVFWKN
                     HLRDVDFSENSLKAVPLGVFQLDALMFLRLQGNLLLSLPHHEKWTCRQLKTLDLSRNQ
                     LGKNEDGLKTKRISLFTTRGRQRSGTETASVLEFPAFLSESLEVLCLNDNHLDAVPPS
                     VCLLKNLSELYLGNNPGLRELPPELGQLGNLWQLDIEDLNIGNVPAEVRKEGPKATLS
                     FLRAQLRKAEKCKLMKMILVGPPRQGKSTLLEILQTGKAPQPAHSEATVRTTKWELQR
                     PAGSKAKVESVEFNVWDIGGPASMATVNQCFFTDKALYVVVWNLALGEEAVANLQFWL
                     LNIEAKAPNAVVLVVGTHLDLIEAKFRVERIATLRAYVLALCRSPSGSRATGFPDITF
                     KHLHEISCKNLEGQEGLRQLIFHVTCNMKDVGSTIGCQKLAGRLIPRSYISLQEAVLA
                     EQQRRSLEDQVQYLTDRQLEQLVEQTPGNDIKDYEDLQSAISFLIETGTLLHFPDTSH
                     GLRNLYFLDPIWLSECLQRIFNIKGSRSVAKNGVIRAEDLRMLLVGTGFTQQTEEQYF
                     QFLAKFEIALPVANDSYLLPHLLPSKPGLDTHSMRHPMANTIQRVFKMSFVPVGFWQR
                     FIARMLISLAEMDLQLFENKKNTKSRNRKVTIYSFTGNQRNRCSTFRVRRNQTIYWQE
                     GLLVTFDGGYLSVESSDVNWKKKKSGGIKIVCQSEMRDFSAMAFITDHVNSLIDQWFP
                     ALTATESDGTPLMEQYVPCPVCEASWAQHADPNERSESVQYFDMEDCVLTAIEGNFIS
                     CPRHPDLPVPLQELVPELFMTDFPARLFLENSKLEHTEGENSILGQGGSGTVIYQAQY
                     QGQPVAVKRFHIKKFKNSANAPADTMLRHLRAMDAMKNFSDFRQEASMLHALQHPCIV
                     SLIGISIHPLCFALELAPLGSLNTVLSENAKDSSFMPLGHMLTQKIAYQIASGLAYLH
                     KKNIIFCDLKSDNILVWSLSVKELINIKLSDYGISRQSFHEGALGVEGTPGYQAPEIR
                     PRIVYDEKVDMFSYGMVLYELLSGQRPALGHHQLQIVKKLSKGIRPVLGQPEEVQFYR
                     LQALMMECWDTKPEKRPLALSVVSQMKDPTFATFMYMLPCGKQSSFFSSQSQEYTVVF
                     WDGKEESRNYTVVNTEKGLLEVQRMTCPGMKLSCQLKVQSSVWLATEDQKIYIYSLKG
                     MCPLSMPQQALDTPAVVTCFLAVPVIKKNSFLVLAGLADGLVAVFSMARGTPKESCSY
                     LCSHTANRSKFCIPDEDSRQNPYPVRAMEVVNSGSEVWYSNGPGLLIIDCAILDISRR
                     LEPYAAPSVVTSLVCSSDCRGEETVWCLDDKGNSLVMYHSATYQLCARYFCGDPSPLR
                     DTFSVQPSVPESPIRHITTSKEPEEECIADVSIMYSEELGMQILTHQDSLTDYCSVSS
                     YSSTPHPDPKSPTSLPSSLTSYSSVPFSANYEDPDRLQEPSVTPDRTEHDLSPMDGET
                     FSQHLQAVKVLAVQDLIWVPRHGGDIIVIGLEKDSGAQRGRVIAVLKARELNPHGVLV
                     DAAVVAKDTVVCGFANENTEWCLAVWRGWGAREFDIFYQSYEELGRLEACPRKRR"
     exon            1..97
                     /gene="Lrrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            98..261
                     /gene="Lrrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            262..433
                     /gene="Lrrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            434..613
                     /gene="Lrrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            614..762
                     /gene="Lrrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            763..989
                     /gene="Lrrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1117
                     /gene="Lrrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1281
                     /gene="Lrrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1419
                     /gene="Lrrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1532
                     /gene="Lrrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1609
                     /gene="Lrrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..1739
                     /gene="Lrrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..1852
                     /gene="Lrrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1853..2067
                     /gene="Lrrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..2232
                     /gene="Lrrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            2233..2405
                     /gene="Lrrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            2406..2526
                     /gene="Lrrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            2527..2686
                     /gene="Lrrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            2687..2963
                     /gene="Lrrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            2964..3135
                     /gene="Lrrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            3136..3299
                     /gene="Lrrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            3300..3439
                     /gene="Lrrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            3440..3689
                     /gene="Lrrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            3690..3856
                     /gene="Lrrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            3857..4054
                     /gene="Lrrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            4055..4332
                     /gene="Lrrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            4333..4527
                     /gene="Lrrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            4528..4679
                     /gene="Lrrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            4680..4797
                     /gene="Lrrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            4798..4914
                     /gene="Lrrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            4915..5762
                     /gene="Lrrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            5763..5864
                     /gene="Lrrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            5865..6445
                     /gene="Lrrk1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggctgccg tgtcacagcg accacccagt atgtactggt gtgtggggac agaaggatca
       61 gttgtgtgtc cagggcctgc catggagacc cataatggtg ccgaagacat gggcagcaaa
      121 ctgtctttac caggtggcaa ctccccagtg cagagcccca acatggaaga aatccacaca
      181 gcatacaagc agagaaacct ctcccgagcc cgggacctgc tcagggaagt ttgtgaagag
      241 agcgaatccc cacaggaaaa gggccagttg ctgagcatct cagcagccca cggggatcta
      301 gagaccgttc ggttcctgct cactgagaag cgcgtggagc tgccgatgga gcccaccgat
      361 gacaacccag ctgtggtggc agcgcatttt ggacatgctg aagtagtaca cgaattgctg
      421 gagtccttat caggtccctg tgcctcgcag cggctgctga actggatgct ggccctggct
      481 tgccagcgag ggcacctgga ggttgtgaag ctgctggtcc tgacgcacgg ggctgacccg
      541 gagaactacg ccgtcaggaa gaatgagttc ccggtcattg tgaggttgcc cctctacgcg
      601 gccatcaagg cagggaatga agacattgcc atattcctgc ttcggcacgg ggcctatttc
      661 tgctcctaca tcctattgga tagccctgac ccaagcaaac atctgctcag gaagtatttc
      721 atcgaggcca gcgccctgcc cagcagctgt cccgggaaaa ccgcactttg tgtgaaatgg
      781 tcccatctta agttgccctg ggtggacctc gactggctct tagacatctc ctgtcagatc
      841 acagagcttg acctctctgc caactgcctg tcttctctcc cctccatcat tccttgggga
      901 ctgatcaatc tgaagaagct gaacctctca aacaaccacc tgggggagct gccctgtgtg
      961 caatcatcgg acgaaatcat ctgctccagg ttagttgaaa tcgacatctc cagtaacaaa
     1021 ctgtcccacc tcccgcctgg attcttgcac ctctcaaaac ttgaaaggct gactgcttcc
     1081 aaaaactatc tggagcggtt gtttgaagaa gaaaatgcca caaactggat cggcctgcgg
     1141 aagctggagg aactcgacct agctgacaac agactgacgg agctccctgt ccaatttatg
     1201 cactccttca agtctctcac caatctgaat gtctccagga acagcctcaa gagctttcca
     1261 gacccctggt cctgccctct gaaatgttgt aaagcctcca aaaatgctct ggaatcgctg
     1321 ccagacaaaa tggccgtctt ctggaaaaac cacctcaggg acgtggattt ctccgagaac
     1381 tctctgaaag cggtgcccct gggggttttc caacttgatg ccctcatgtt cttgaggtta
     1441 cagggaaacc tgctgttgtc actgccacat catgagaagt ggacctgcag acaactcaag
     1501 accctggacc tctccagaaa ccaacttggc aaaaatgaag atgggcttaa aacaaagcgg
     1561 atctcccttt ttaccaccag agggcgccag cgttctggaa ctgagacagc gtccgtgcta
     1621 gaattcccag cttttctaag cgagtctttg gaggtccttt gtctgaatga caaccatctt
     1681 gatgcagttc ctccgtcagt ctgcctgctg aagaacctct cagagctcta cttgggcaat
     1741 aaccctggtc tccgagagct ccctccggag ctaggccagc tgggaaacct ctggcaactg
     1801 gacattgaag atctgaacat tggcaacgtg cctgcagagg tcaggaaaga aggcccaaaa
     1861 gcaacgctgt ctttcctgcg tgctcagctg cgcaaagcag agaagtgtaa actgatgaag
     1921 atgatcctcg tgggcccccc acgccagggc aagtccacac tcctggagat cttacagaca
     1981 gggaaggccc cgcagccagc acacagcgaa gccactgtca ggaccaccaa gtgggagctc
     2041 cagagaccag caggctccaa agccaaggtt gagtctgtgg agttcaacgt ctgggacatc
     2101 gggggccctg ccagcatggc cacagtcaat cagtgcttct tcacagataa ggccctatat
     2161 gtggtggtct ggaacctggc cctgggggaa gaagctgtgg ccaacctcca gttctggctt
     2221 ctcaacattg aggccaaggc cccaaacgcc gttgtgctgg tggttgggac acatctggac
     2281 cttatcgaag ctaaattccg agtagagagg atcgcaacac tgcgtgccta cgtgctggcc
     2341 ctctgccgct caccatcggg gtccagagct acaggattcc cagacatcac tttcaaacac
     2401 ttgcacgaga tctcctgcaa gaatctggaa gggcaggagg ggctgaggca actgatcttc
     2461 catgtcacgt gcaacatgaa ggacgtgggc agcactatcg gctgtcaaaa actcgctggc
     2521 aggctgatcc ccaggagcta cataagccta caggaggctg tgctggctga acaacagcgc
     2581 cgcagcctgg aagatcaagt acagtacctg acggacaggc agctggagca gctggtggag
     2641 cagacgcctg gcaatgacat caaagactat gaggacctgc agtctgccat cagcttcctc
     2701 atagaaaccg gaaccctgct gcacttccca gacacgagcc atggcctaag gaatctctac
     2761 ttcctggatc ccatctggct ctctgaatgc ctacagagga tctttaatat caagggctcg
     2821 cggtcggtgg cgaagaatgg ggtgatccga gcagaggacc tcaggatgct gctggtgggg
     2881 acaggcttca cgcagcagac ggaggagcaa tacttccagt tccttgccaa gttcgagatt
     2941 gcccttccgg ttgccaatga cagttacctc ctaccacacc tcctcccatc caaacctggg
     3001 ctggacaccc acagcatgcg gcacccaatg gctaacacca tccagcgggt gtttaagatg
     3061 agcttcgtgc ctgttggctt ctggcaaagg ttcatagcac ggatgctgat cagcttggct
     3121 gagatggacc tgcagctttt tgaaaacaag aagaatacga aaagcaggaa ccggaaagtc
     3181 accatttaca gctttacagg gaaccagaga aaccgctgca gcacattcag agtccgaagg
     3241 aatcagacca tctactggca ggaagggctg ctggtcactt tcgatggggg ctacctcagt
     3301 gtggaatcct cagacgtgaa ctggaaaaag aaaaaaagcg gagggattaa aatcgtctgc
     3361 cagtcagaaa tgagggactt ctcagcaatg gcttttatca cagaccacgt caactccctg
     3421 atcgaccagt ggttccccgc cctgacagcc acagaaagtg acgggacccc acttatggag
     3481 cagtatgtgc cctgccccgt ctgtgaagca tcctgggccc agcatgcaga tccaaacgag
     3541 aggtcggaga gcgtgcagta cttcgatatg gaagattgtg tgctcacagc cattgaaggg
     3601 aacttcatct cctgccccag acacccagac ctcccagtgc cacttcagga gcttgtacca
     3661 gagctgttta tgactgactt cccagccagg cttttcctgg agaacagcaa gctggagcac
     3721 acagagggtg agaacagcat cctgggccaa ggtggcagtg gcacagtcat ctaccaggcc
     3781 cagtaccagg gccagcctgt ggctgtgaag agattccaca tcaagaagtt caagaattct
     3841 gctaatgccc cggcagacac catgctgagg cacctgagag ccatggatgc catgaagaac
     3901 ttctcggatt tccgtcagga ggccagcatg ctgcatgcct tgcagcaccc ctgcattgtg
     3961 tcactcatcg gcatcagcat ccaccccctc tgcttcgccc tggagctcgc cccgctgggc
     4021 agcctcaaca ctgtgctgtc tgagaatgcc aaagattctt cctttatgcc cctgggacac
     4081 atgctcaccc aaaaaatagc ctaccagatt gcctcgggcc tggcctacct gcacaagaag
     4141 aacatcatct tctgtgacct caagtcagac aacatcctgg tgtggtcact gagcgtcaag
     4201 gagctcatca acatcaaact gtcagactac ggcatctcga ggcagtcctt tcacgagggg
     4261 gccctgggtg tggagggcac cccaggctac caggctccag agatcaggcc tcgcattgtg
     4321 tatgacgaga aggtagacat gttctcctat ggcatggtgc tgtatgagct gctctcagga
     4381 cagcgtcctg cgctgggcca ccaccaactt cagattgtca agaagttgtc caagggcatc
     4441 cgcccagtgc tggggcagcc agaggaagtg caattctatc gactgcaggc gctcatgatg
     4501 gagtgctggg acacgaagcc ggagaagcgt cccctggccc tgtctgtggt gagccagatg
     4561 aaagacccaa ccttcgccac cttcatgtac atgctgccct gtgggaagca gtcgtccttc
     4621 ttctcatccc agagccagga gtacactgtg gtgttctggg atgggaagga ggagtcaagg
     4681 aattacacgg tggtcaacac cgagaagggc cttctggaag tacagaggat gacctgtcct
     4741 gggatgaagc tgagctgtca gctcaaggtc cagagctcag tgtggctagc caccgaggac
     4801 cagaaaatct atatctacag ccttaagggt atgtgcccat taagcatgcc ccagcaggcc
     4861 ctggacacgc cggctgttgt cacctgtttc ttggcagtac ctgttattaa aaagaactcc
     4921 tttctggtgc tggctggcct ggctgatgga ctcgtggctg tgttttctat ggcacggggc
     4981 accccaaaag aaagctgctc ctacctgtgc tcgcacacag ccaacaggtc caagttctgc
     5041 atcccagacg aagactcacg gcagaacccc tacccagtga gggcaatgga agtggtcaac
     5101 agcgggtctg aggtctggta cagcaatggg ccaggcctcc tcatcatcga ctgtgccatc
     5161 ctggacatca gcaggcggct ggagccctat gcagccccat ctgtggtcac atcacttgtg
     5221 tgcagctcag actgcagagg agaggagaca gtctggtgcc tggacgacaa gggcaattcc
     5281 ttagtgatgt accattcagc cacctaccag ctgtgtgccc ggtacttctg cggggacccc
     5341 agtcctctca gggacacgtt ttctgtacag ccctcagtcc cagaaagccc aatccgtcac
     5401 ataaccacct caaaggagcc tgaggaagag tgcatcgccg acgtgagcat catgtacagc
     5461 gaggagctgg gcatgcagat cctcacccac caggactcgc tcactgacta ctgctccgta
     5521 tcctcgtact catccacacc ccacccagac cccaagtccc ccaccagcct gcccagctcc
     5581 ctcaccagct attccagtgt gcctttctcc gccaattatg aagacccaga caggctgcag
     5641 gagcccagcg tcacccctga cagaactgag catgatctga gccccatgga tggggagacg
     5701 ttcagccaac acctgcaggc tgtgaaggtg cttgctgtcc aagacctcat ttgggtccct
     5761 agacatggtg gagatatcat tgtcatcggc ctggagaagg attcgggtgc ccagcggggc
     5821 agggtcatcg ctgttttaaa agccagagag ctcaatccgc atggggtcct ggtggatgcg
     5881 gcagtggtgg caaaggacac cgtagtgtgc ggctttgcaa acgaaaacac agagtggtgc
     5941 ctggctgtct ggaggggctg gggcgccagg gagtttgaca tcttctacca gtcctatgag
     6001 gagctgggcc ggctggaggc gtgtcctcgc aagagaaggt aatgcctacg gaagggcctc
     6061 cgcgcggagc cagcaggtgc gcggagccag caggtccgag ccactgcctg acccctcagc
     6121 tacagccctc ctagggcaca gaagacaaac gggttctttg ctaagccttc tgctaagaag
     6181 ggctgagaag ctaggagctg ctggtagttt gggagttctc aggttctgtg gggaaagtta
     6241 tcagcccatg ggaagccaca gggtctggtt gagagaggcc tcctctcgcc tcttccctag
     6301 gcttccagga gccggggaga gtgaccccat tccaaacctt tccagcataa tgaatgggcc
     6361 tgtccgttct tctaccgcca ggcctccaat ggaattacac tacagagtct tggttgagga
     6421 gcagttcggg gtaaggtggg aggag
//
